LeishMANIAdb
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Methylated-DNA--protein-cysteine methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Methylated-DNA--protein-cysteine methyltransferase
Gene product:
methylated-DNA-[protein]-cysteine S-methyltransferase, putative
Species:
Leishmania major
UniProt:
Q4Q912_LEIMA
TriTrypDb:
LmjF.26.1800 , LMJLV39_260024400 * , LMJSD75_260022900 *
Length:
281

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4Q912
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q912

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 10
GO:0006259 DNA metabolic process 4 10
GO:0006281 DNA repair 5 10
GO:0006725 cellular aromatic compound metabolic process 3 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0006950 response to stress 2 10
GO:0006974 DNA damage response 4 10
GO:0008152 metabolic process 1 10
GO:0009987 cellular process 1 10
GO:0032259 methylation 2 10
GO:0033554 cellular response to stress 3 10
GO:0034641 cellular nitrogen compound metabolic process 3 10
GO:0043170 macromolecule metabolic process 3 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0044260 obsolete cellular macromolecule metabolic process 3 10
GO:0046483 heterocycle metabolic process 3 10
GO:0050896 response to stimulus 1 10
GO:0051716 cellular response to stimulus 2 10
GO:0071704 organic substance metabolic process 2 10
GO:0090304 nucleic acid metabolic process 4 10
GO:1901360 organic cyclic compound metabolic process 3 10
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity 6 10
GO:0008168 methyltransferase activity 4 10
GO:0008172 S-methyltransferase activity 5 10
GO:0016740 transferase activity 2 10
GO:0016741 transferase activity, transferring one-carbon groups 3 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 9 11 PF00675 0.660
CLV_PCSK_KEX2_1 9 11 PF00082 0.660
CLV_PCSK_SKI1_1 131 135 PF00082 0.465
CLV_PCSK_SKI1_1 155 159 PF00082 0.410
DEG_SPOP_SBC_1 232 236 PF00917 0.540
DEG_SPOP_SBC_1 29 33 PF00917 0.641
DOC_CKS1_1 60 65 PF01111 0.402
DOC_CYCLIN_RxL_1 196 206 PF00134 0.511
DOC_CYCLIN_yCln2_LP_2 158 164 PF00134 0.402
DOC_CYCLIN_yCln2_LP_2 201 207 PF00134 0.511
DOC_MAPK_gen_1 107 116 PF00069 0.485
DOC_MAPK_MEF2A_6 155 162 PF00069 0.461
DOC_PP2B_LxvP_1 158 161 PF13499 0.454
DOC_PP2B_LxvP_1 201 204 PF13499 0.511
DOC_SPAK_OSR1_1 247 251 PF12202 0.532
DOC_USP7_MATH_1 117 121 PF00917 0.425
DOC_USP7_UBL2_3 19 23 PF12436 0.683
DOC_WW_Pin1_4 109 114 PF00397 0.398
DOC_WW_Pin1_4 32 37 PF00397 0.578
DOC_WW_Pin1_4 59 64 PF00397 0.401
LIG_14-3-3_CanoR_1 107 113 PF00244 0.499
LIG_14-3-3_CanoR_1 131 136 PF00244 0.427
LIG_14-3-3_CanoR_1 179 183 PF00244 0.497
LIG_14-3-3_CanoR_1 231 239 PF00244 0.540
LIG_APCC_ABBA_1 67 72 PF00400 0.448
LIG_BIR_III_4 72 76 PF00653 0.477
LIG_FHA_1 148 154 PF00498 0.474
LIG_FHA_1 234 240 PF00498 0.540
LIG_FHA_1 48 54 PF00498 0.451
LIG_LIR_Gen_1 172 183 PF02991 0.523
LIG_LIR_Nem_3 172 178 PF02991 0.513
LIG_LIR_Nem_3 187 193 PF02991 0.430
LIG_NRBOX 152 158 PF00104 0.388
LIG_NRP_CendR_1 280 281 PF00754 0.703
LIG_SH2_CRK 190 194 PF00017 0.476
LIG_SH2_GRB2like 139 142 PF00017 0.508
LIG_SH2_SRC 70 73 PF00017 0.467
LIG_SH2_STAT5 139 142 PF00017 0.394
LIG_SH2_STAT5 56 59 PF00017 0.372
LIG_SH2_STAT5 70 73 PF00017 0.334
LIG_SH3_1 23 29 PF00018 0.643
LIG_SH3_3 222 228 PF00018 0.502
LIG_SH3_3 23 29 PF00018 0.774
LIG_SH3_3 57 63 PF00018 0.496
LIG_TYR_ITIM 188 193 PF00017 0.540
MOD_CDK_SPxxK_3 32 39 PF00069 0.608
MOD_CK1_1 184 190 PF00069 0.540
MOD_CK1_1 235 241 PF00069 0.532
MOD_GlcNHglycan 119 122 PF01048 0.417
MOD_GlcNHglycan 183 186 PF01048 0.302
MOD_GlcNHglycan 205 208 PF01048 0.335
MOD_GlcNHglycan 32 35 PF01048 0.621
MOD_GlcNHglycan 43 46 PF01048 0.581
MOD_GlcNHglycan 84 87 PF01048 0.555
MOD_GSK3_1 108 115 PF00069 0.460
MOD_GSK3_1 140 147 PF00069 0.379
MOD_GSK3_1 15 22 PF00069 0.670
MOD_GSK3_1 165 172 PF00069 0.365
MOD_GSK3_1 174 181 PF00069 0.519
MOD_GSK3_1 231 238 PF00069 0.483
MOD_GSK3_1 269 276 PF00069 0.607
MOD_GSK3_1 28 35 PF00069 0.678
MOD_NEK2_1 171 176 PF00069 0.547
MOD_NEK2_1 178 183 PF00069 0.554
MOD_NEK2_1 233 238 PF00069 0.540
MOD_PIKK_1 169 175 PF00454 0.319
MOD_PKA_1 19 25 PF00069 0.614
MOD_PKA_1 9 15 PF00069 0.692
MOD_PKA_2 178 184 PF00069 0.540
MOD_PKA_2 9 15 PF00069 0.636
MOD_Plk_1 269 275 PF00069 0.580
MOD_Plk_4 131 137 PF00069 0.460
MOD_ProDKin_1 109 115 PF00069 0.401
MOD_ProDKin_1 32 38 PF00069 0.575
MOD_ProDKin_1 59 65 PF00069 0.403
TRG_DiLeu_BaEn_1 152 157 PF01217 0.473
TRG_DiLeu_LyEn_5 152 157 PF01217 0.462
TRG_ENDOCYTIC_2 190 193 PF00928 0.459
TRG_Pf-PMV_PEXEL_1 155 159 PF00026 0.469

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7Q0 Leptomonas seymouri 57% 99%
A0A1X0P7S0 Trypanosomatidae 31% 100%
A0A3Q8IFY3 Leishmania donovani 91% 99%
A0A3R7ML39 Trypanosoma rangeli 32% 100%
A4HF26 Leishmania braziliensis 80% 99%
A4I2B3 Leishmania infantum 89% 99%
E9AYG0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%
V5AV65 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS