Methylated-DNA--protein-cysteine methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methylated-DNA-[protein]-cysteine S-methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q912_LEIMA

TriTrypDb:

LmjF.26.1800 , LMJLV39_260024400 , LMJSD75_260022900

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q912

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q912

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0032259	methylation	2	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	6	10
GO:0008168	methyltransferase activity	4	10
GO:0008172	S-methyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	9	11	PF00675	0.660
CLV_PCSK_KEX2_1	9	11	PF00082	0.660
CLV_PCSK_SKI1_1	131	135	PF00082	0.465
CLV_PCSK_SKI1_1	155	159	PF00082	0.410
DEG_SPOP_SBC_1	232	236	PF00917	0.540
DEG_SPOP_SBC_1	29	33	PF00917	0.641
DOC_CKS1_1	60	65	PF01111	0.402
DOC_CYCLIN_RxL_1	196	206	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	158	164	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	201	207	PF00134	0.511
DOC_MAPK_gen_1	107	116	PF00069	0.485
DOC_MAPK_MEF2A_6	155	162	PF00069	0.461
DOC_PP2B_LxvP_1	158	161	PF13499	0.454
DOC_PP2B_LxvP_1	201	204	PF13499	0.511
DOC_SPAK_OSR1_1	247	251	PF12202	0.532
DOC_USP7_MATH_1	117	121	PF00917	0.425
DOC_USP7_UBL2_3	19	23	PF12436	0.683
DOC_WW_Pin1_4	109	114	PF00397	0.398
DOC_WW_Pin1_4	32	37	PF00397	0.578
DOC_WW_Pin1_4	59	64	PF00397	0.401
LIG_14-3-3_CanoR_1	107	113	PF00244	0.499
LIG_14-3-3_CanoR_1	131	136	PF00244	0.427
LIG_14-3-3_CanoR_1	179	183	PF00244	0.497
LIG_14-3-3_CanoR_1	231	239	PF00244	0.540
LIG_APCC_ABBA_1	67	72	PF00400	0.448
LIG_BIR_III_4	72	76	PF00653	0.477
LIG_FHA_1	148	154	PF00498	0.474
LIG_FHA_1	234	240	PF00498	0.540
LIG_FHA_1	48	54	PF00498	0.451
LIG_LIR_Gen_1	172	183	PF02991	0.523
LIG_LIR_Nem_3	172	178	PF02991	0.513
LIG_LIR_Nem_3	187	193	PF02991	0.430
LIG_NRBOX	152	158	PF00104	0.388
LIG_NRP_CendR_1	280	281	PF00754	0.703
LIG_SH2_CRK	190	194	PF00017	0.476
LIG_SH2_GRB2like	139	142	PF00017	0.508
LIG_SH2_SRC	70	73	PF00017	0.467
LIG_SH2_STAT5	139	142	PF00017	0.394
LIG_SH2_STAT5	56	59	PF00017	0.372
LIG_SH2_STAT5	70	73	PF00017	0.334
LIG_SH3_1	23	29	PF00018	0.643
LIG_SH3_3	222	228	PF00018	0.502
LIG_SH3_3	23	29	PF00018	0.774
LIG_SH3_3	57	63	PF00018	0.496
LIG_TYR_ITIM	188	193	PF00017	0.540
MOD_CDK_SPxxK_3	32	39	PF00069	0.608
MOD_CK1_1	184	190	PF00069	0.540
MOD_CK1_1	235	241	PF00069	0.532
MOD_GlcNHglycan	119	122	PF01048	0.417
MOD_GlcNHglycan	183	186	PF01048	0.302
MOD_GlcNHglycan	205	208	PF01048	0.335
MOD_GlcNHglycan	32	35	PF01048	0.621
MOD_GlcNHglycan	43	46	PF01048	0.581
MOD_GlcNHglycan	84	87	PF01048	0.555
MOD_GSK3_1	108	115	PF00069	0.460
MOD_GSK3_1	140	147	PF00069	0.379
MOD_GSK3_1	15	22	PF00069	0.670
MOD_GSK3_1	165	172	PF00069	0.365
MOD_GSK3_1	174	181	PF00069	0.519
MOD_GSK3_1	231	238	PF00069	0.483
MOD_GSK3_1	269	276	PF00069	0.607
MOD_GSK3_1	28	35	PF00069	0.678
MOD_NEK2_1	171	176	PF00069	0.547
MOD_NEK2_1	178	183	PF00069	0.554
MOD_NEK2_1	233	238	PF00069	0.540
MOD_PIKK_1	169	175	PF00454	0.319
MOD_PKA_1	19	25	PF00069	0.614
MOD_PKA_1	9	15	PF00069	0.692
MOD_PKA_2	178	184	PF00069	0.540
MOD_PKA_2	9	15	PF00069	0.636
MOD_Plk_1	269	275	PF00069	0.580
MOD_Plk_4	131	137	PF00069	0.460
MOD_ProDKin_1	109	115	PF00069	0.401
MOD_ProDKin_1	32	38	PF00069	0.575
MOD_ProDKin_1	59	65	PF00069	0.403
TRG_DiLeu_BaEn_1	152	157	PF01217	0.473
TRG_DiLeu_LyEn_5	152	157	PF01217	0.462
TRG_ENDOCYTIC_2	190	193	PF00928	0.459
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Q0	Leptomonas seymouri	57%	99%
A0A1X0P7S0	Trypanosomatidae	31%	100%
A0A3Q8IFY3	Leishmania donovani	91%	99%
A0A3R7ML39	Trypanosoma rangeli	32%	100%
A4HF26	Leishmania braziliensis	80%	99%
A4I2B3	Leishmania infantum	89%	99%
E9AYG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
V5AV65	Trypanosoma cruzi	33%	100%