Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q911_LEIMA

TriTrypDb:

LmjF.26.1810 , LMJLV39_260024500 , LMJSD75_260023000

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q911

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q911

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.500
CLV_NRD_NRD_1	208	210	PF00675	0.514
CLV_NRD_NRD_1	317	319	PF00675	0.585
CLV_NRD_NRD_1	323	325	PF00675	0.553
CLV_NRD_NRD_1	352	354	PF00675	0.584
CLV_NRD_NRD_1	429	431	PF00675	0.518
CLV_NRD_NRD_1	61	63	PF00675	0.429
CLV_NRD_NRD_1	64	66	PF00675	0.438
CLV_PCSK_FUR_1	427	431	PF00082	0.533
CLV_PCSK_FUR_1	62	66	PF00082	0.496
CLV_PCSK_KEX2_1	208	210	PF00082	0.514
CLV_PCSK_KEX2_1	225	227	PF00082	0.640
CLV_PCSK_KEX2_1	317	319	PF00082	0.586
CLV_PCSK_KEX2_1	323	325	PF00082	0.552
CLV_PCSK_KEX2_1	331	333	PF00082	0.507
CLV_PCSK_KEX2_1	429	431	PF00082	0.567
CLV_PCSK_KEX2_1	61	63	PF00082	0.433
CLV_PCSK_KEX2_1	64	66	PF00082	0.451
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.580
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.508
CLV_PCSK_PC7_1	57	63	PF00082	0.496
CLV_PCSK_SKI1_1	326	330	PF00082	0.520
DEG_APCC_DBOX_1	159	167	PF00400	0.511
DEG_APCC_DBOX_1	225	233	PF00400	0.531
DEG_SPOP_SBC_1	17	21	PF00917	0.517
DEG_SPOP_SBC_1	390	394	PF00917	0.647
DOC_CKS1_1	408	413	PF01111	0.611
DOC_MAPK_gen_1	135	144	PF00069	0.608
DOC_MAPK_gen_1	454	463	PF00069	0.487
DOC_MAPK_MEF2A_6	138	146	PF00069	0.581
DOC_PP2B_LxvP_1	257	260	PF13499	0.603
DOC_PP2B_LxvP_1	34	37	PF13499	0.553
DOC_PP4_FxxP_1	387	390	PF00568	0.540
DOC_PP4_FxxP_1	439	442	PF00568	0.473
DOC_PP4_FxxP_1	75	78	PF00568	0.470
DOC_USP7_MATH_1	158	162	PF00917	0.682
DOC_USP7_MATH_1	169	173	PF00917	0.563
DOC_USP7_MATH_1	252	256	PF00917	0.643
DOC_USP7_MATH_1	28	32	PF00917	0.633
DOC_USP7_MATH_1	388	392	PF00917	0.678
DOC_USP7_MATH_1	404	408	PF00917	0.561
DOC_USP7_UBL2_3	466	470	PF12436	0.360
DOC_WW_Pin1_4	190	195	PF00397	0.626
DOC_WW_Pin1_4	210	215	PF00397	0.585
DOC_WW_Pin1_4	220	225	PF00397	0.757
DOC_WW_Pin1_4	232	237	PF00397	0.801
DOC_WW_Pin1_4	260	265	PF00397	0.621
DOC_WW_Pin1_4	279	284	PF00397	0.662
DOC_WW_Pin1_4	344	349	PF00397	0.550
DOC_WW_Pin1_4	379	384	PF00397	0.677
DOC_WW_Pin1_4	407	412	PF00397	0.672
LIG_14-3-3_CanoR_1	125	130	PF00244	0.608
LIG_14-3-3_CanoR_1	138	143	PF00244	0.548
LIG_14-3-3_CanoR_1	200	204	PF00244	0.648
LIG_14-3-3_CanoR_1	246	256	PF00244	0.662
LIG_Actin_WH2_2	150	166	PF00022	0.458
LIG_APCC_ABBAyCdc20_2	71	77	PF00400	0.480
LIG_BIR_III_4	292	296	PF00653	0.494
LIG_BRCT_BRCA1_1	383	387	PF00533	0.515
LIG_CSL_BTD_1	304	307	PF09270	0.542
LIG_FHA_1	124	130	PF00498	0.637
LIG_FHA_1	260	266	PF00498	0.635
LIG_FHA_1	267	273	PF00498	0.663
LIG_FHA_1	408	414	PF00498	0.601
LIG_FHA_1	6	12	PF00498	0.628
LIG_FHA_2	145	151	PF00498	0.440
LIG_FHA_2	44	50	PF00498	0.518
LIG_LIR_Apic_2	384	390	PF02991	0.507
LIG_LIR_Apic_2	400	404	PF02991	0.626
LIG_LIR_Apic_2	72	78	PF02991	0.485
LIG_LIR_Gen_1	446	451	PF02991	0.451
LIG_LIR_Nem_3	148	154	PF02991	0.391
LIG_LIR_Nem_3	446	450	PF02991	0.473
LIG_MAD2	474	482	PF02301	0.549
LIG_RPA_C_Fungi	312	324	PF08784	0.565
LIG_SH2_CRK	401	405	PF00017	0.642
LIG_SH2_CRK	447	451	PF00017	0.447
LIG_SH2_CRK	99	103	PF00017	0.496
LIG_SH2_STAP1	170	174	PF00017	0.536
LIG_SH2_STAP1	447	451	PF00017	0.447
LIG_SH2_STAT3	86	89	PF00017	0.538
LIG_SH2_STAT5	153	156	PF00017	0.473
LIG_SH2_STAT5	401	404	PF00017	0.672
LIG_SH2_STAT5	443	446	PF00017	0.597
LIG_SH2_STAT5	447	450	PF00017	0.584
LIG_SH2_STAT5	67	70	PF00017	0.447
LIG_SH3_1	208	214	PF00018	0.515
LIG_SH3_2	211	216	PF14604	0.683
LIG_SH3_3	208	214	PF00018	0.673
LIG_SH3_3	349	355	PF00018	0.705
LIG_SH3_3	8	14	PF00018	0.810
LIG_SUMO_SIM_anti_2	255	260	PF11976	0.511
LIG_SUMO_SIM_anti_2	418	424	PF11976	0.653
LIG_SUMO_SIM_par_1	140	148	PF11976	0.512
LIG_TRAF2_1	482	485	PF00917	0.686
MOD_CDC14_SPxK_1	197	200	PF00782	0.677
MOD_CDC14_SPxK_1	213	216	PF00782	0.696
MOD_CDC14_SPxK_1	223	226	PF00782	0.556
MOD_CDC14_SPxK_1	347	350	PF00782	0.562
MOD_CDK_SPK_2	220	225	PF00069	0.580
MOD_CDK_SPK_2	236	241	PF00069	0.634
MOD_CDK_SPK_2	279	284	PF00069	0.638
MOD_CDK_SPxK_1	190	196	PF00069	0.653
MOD_CDK_SPxK_1	210	216	PF00069	0.532
MOD_CDK_SPxK_1	220	226	PF00069	0.524
MOD_CDK_SPxK_1	344	350	PF00069	0.553
MOD_CDK_SPxxK_3	234	241	PF00069	0.597
MOD_CK1_1	101	107	PF00069	0.585
MOD_CK1_1	137	143	PF00069	0.719
MOD_CK1_1	16	22	PF00069	0.634
MOD_CK1_1	172	178	PF00069	0.693
MOD_CK1_1	186	192	PF00069	0.672
MOD_CK1_1	247	253	PF00069	0.636
MOD_CK1_1	263	269	PF00069	0.505
MOD_CK1_1	391	397	PF00069	0.676
MOD_CK1_1	407	413	PF00069	0.527
MOD_CK2_1	144	150	PF00069	0.403
MOD_GlcNHglycan	15	18	PF01048	0.620
MOD_GlcNHglycan	159	163	PF01048	0.616
MOD_GlcNHglycan	173	177	PF01048	0.602
MOD_GlcNHglycan	20	23	PF01048	0.519
MOD_GlcNHglycan	252	255	PF01048	0.803
MOD_GlcNHglycan	279	282	PF01048	0.767
MOD_GlcNHglycan	319	322	PF01048	0.586
MOD_GlcNHglycan	383	386	PF01048	0.646
MOD_GSK3_1	13	20	PF00069	0.814
MOD_GSK3_1	134	141	PF00069	0.731
MOD_GSK3_1	183	190	PF00069	0.634
MOD_GSK3_1	220	227	PF00069	0.699
MOD_GSK3_1	232	239	PF00069	0.629
MOD_GSK3_1	244	251	PF00069	0.670
MOD_GSK3_1	259	266	PF00069	0.567
MOD_GSK3_1	445	452	PF00069	0.560
MOD_GSK3_1	98	105	PF00069	0.570
MOD_LATS_1	315	321	PF00433	0.649
MOD_N-GLC_1	260	265	PF02516	0.594
MOD_N-GLC_1	423	428	PF02516	0.430
MOD_NEK2_1	185	190	PF00069	0.690
MOD_NEK2_1	245	250	PF00069	0.757
MOD_NEK2_1	423	428	PF00069	0.467
MOD_NEK2_1	85	90	PF00069	0.611
MOD_PIKK_1	245	251	PF00454	0.613
MOD_PIKK_1	402	408	PF00454	0.642
MOD_PIKK_1	449	455	PF00454	0.466
MOD_PIKK_1	85	91	PF00454	0.552
MOD_PK_1	125	131	PF00069	0.556
MOD_PK_1	138	144	PF00069	0.562
MOD_PK_1	284	290	PF00069	0.525
MOD_PK_1	98	104	PF00069	0.578
MOD_PKA_1	317	323	PF00069	0.574
MOD_PKA_2	124	130	PF00069	0.600
MOD_PKA_2	134	140	PF00069	0.565
MOD_PKA_2	199	205	PF00069	0.716
MOD_PKA_2	245	251	PF00069	0.666
MOD_PKA_2	317	323	PF00069	0.574
MOD_PKB_1	96	104	PF00069	0.630
MOD_Plk_1	374	380	PF00069	0.559
MOD_Plk_1	445	451	PF00069	0.510
MOD_Plk_4	252	258	PF00069	0.609
MOD_Plk_4	30	36	PF00069	0.508
MOD_Plk_4	404	410	PF00069	0.597
MOD_Plk_4	416	422	PF00069	0.708
MOD_ProDKin_1	190	196	PF00069	0.626
MOD_ProDKin_1	210	216	PF00069	0.588
MOD_ProDKin_1	220	226	PF00069	0.758
MOD_ProDKin_1	232	238	PF00069	0.800
MOD_ProDKin_1	260	266	PF00069	0.622
MOD_ProDKin_1	279	285	PF00069	0.663
MOD_ProDKin_1	344	350	PF00069	0.553
MOD_ProDKin_1	379	385	PF00069	0.675
MOD_ProDKin_1	407	413	PF00069	0.666
MOD_SUMO_for_1	283	286	PF00179	0.595
MOD_SUMO_rev_2	490	497	PF00179	0.763
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.578
TRG_ENDOCYTIC_2	447	450	PF00928	0.628
TRG_ENDOCYTIC_2	67	70	PF00928	0.447
TRG_ENDOCYTIC_2	99	102	PF00928	0.576
TRG_ER_diArg_1	217	220	PF00400	0.596
TRG_ER_diArg_1	427	430	PF00400	0.578
TRG_ER_diArg_1	472	475	PF00400	0.559
TRG_ER_diArg_1	54	57	PF00400	0.409
TRG_ER_diArg_1	60	62	PF00400	0.420
TRG_ER_diArg_1	64	66	PF00400	0.429
TRG_ER_diArg_1	96	99	PF00400	0.628
TRG_NLS_Bipartite_1	317	335	PF00514	0.538
TRG_NLS_MonoCore_2	352	357	PF00514	0.553
TRG_NLS_MonoExtN_4	350	357	PF00514	0.604
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B6	Leptomonas seymouri	36%	86%
A0A3Q8ID10	Leishmania donovani	87%	100%
A4HF27	Leishmania braziliensis	65%	85%
A4I2B4	Leishmania infantum	87%	100%
E9AYG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%