Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q909_LEIMA

TriTrypDb:

LmjF.26.1830 , LMJLV39_260024700 , LMJSD75_260023200

Length:

753

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q909

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q909

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.582
CLV_C14_Caspase3-7	211	215	PF00656	0.663
CLV_C14_Caspase3-7	537	541	PF00656	0.615
CLV_NRD_NRD_1	132	134	PF00675	0.615
CLV_NRD_NRD_1	149	151	PF00675	0.429
CLV_NRD_NRD_1	191	193	PF00675	0.552
CLV_NRD_NRD_1	219	221	PF00675	0.705
CLV_NRD_NRD_1	231	233	PF00675	0.700
CLV_NRD_NRD_1	291	293	PF00675	0.715
CLV_NRD_NRD_1	320	322	PF00675	0.624
CLV_NRD_NRD_1	590	592	PF00675	0.575
CLV_NRD_NRD_1	720	722	PF00675	0.692
CLV_NRD_NRD_1	739	741	PF00675	0.519
CLV_PCSK_FUR_1	150	154	PF00082	0.573
CLV_PCSK_FUR_1	737	741	PF00082	0.612
CLV_PCSK_KEX2_1	131	133	PF00082	0.625
CLV_PCSK_KEX2_1	148	150	PF00082	0.427
CLV_PCSK_KEX2_1	152	154	PF00082	0.513
CLV_PCSK_KEX2_1	190	192	PF00082	0.540
CLV_PCSK_KEX2_1	219	221	PF00082	0.705
CLV_PCSK_KEX2_1	231	233	PF00082	0.700
CLV_PCSK_KEX2_1	291	293	PF00082	0.715
CLV_PCSK_KEX2_1	320	322	PF00082	0.624
CLV_PCSK_KEX2_1	719	721	PF00082	0.699
CLV_PCSK_KEX2_1	739	741	PF00082	0.540
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.586
CLV_PCSK_PC7_1	145	151	PF00082	0.497
CLV_PCSK_PC7_1	716	722	PF00082	0.604
CLV_PCSK_SKI1_1	89	93	PF00082	0.587
DEG_SCF_FBW7_2	391	396	PF00400	0.638
DEG_SPOP_SBC_1	273	277	PF00917	0.783
DEG_SPOP_SBC_1	281	285	PF00917	0.762
DEG_SPOP_SBC_1	555	559	PF00917	0.542
DEG_SPOP_SBC_1	688	692	PF00917	0.614
DOC_ANK_TNKS_1	499	506	PF00023	0.665
DOC_CKS1_1	594	599	PF01111	0.680
DOC_CYCLIN_RxL_1	500	514	PF00134	0.618
DOC_MAPK_gen_1	231	239	PF00069	0.569
DOC_PP2B_LxvP_1	467	470	PF13499	0.707
DOC_PP2B_LxvP_1	99	102	PF13499	0.763
DOC_PP4_FxxP_1	685	688	PF00568	0.697
DOC_PP4_MxPP_1	663	666	PF00568	0.557
DOC_USP7_MATH_1	103	107	PF00917	0.779
DOC_USP7_MATH_1	160	164	PF00917	0.633
DOC_USP7_MATH_1	205	209	PF00917	0.661
DOC_USP7_MATH_1	240	244	PF00917	0.753
DOC_USP7_MATH_1	261	265	PF00917	0.663
DOC_USP7_MATH_1	282	286	PF00917	0.749
DOC_USP7_MATH_1	347	351	PF00917	0.607
DOC_USP7_MATH_1	375	379	PF00917	0.686
DOC_USP7_MATH_1	41	45	PF00917	0.610
DOC_USP7_MATH_1	449	453	PF00917	0.629
DOC_USP7_MATH_1	524	528	PF00917	0.547
DOC_USP7_MATH_1	54	58	PF00917	0.566
DOC_USP7_MATH_1	555	559	PF00917	0.542
DOC_USP7_MATH_1	611	615	PF00917	0.675
DOC_USP7_MATH_1	641	645	PF00917	0.718
DOC_USP7_MATH_1	688	692	PF00917	0.676
DOC_USP7_MATH_1	694	698	PF00917	0.668
DOC_USP7_MATH_1	82	86	PF00917	0.607
DOC_WW_Pin1_4	107	112	PF00397	0.604
DOC_WW_Pin1_4	269	274	PF00397	0.733
DOC_WW_Pin1_4	35	40	PF00397	0.683
DOC_WW_Pin1_4	371	376	PF00397	0.653
DOC_WW_Pin1_4	389	394	PF00397	0.568
DOC_WW_Pin1_4	455	460	PF00397	0.708
DOC_WW_Pin1_4	471	476	PF00397	0.658
DOC_WW_Pin1_4	52	57	PF00397	0.623
DOC_WW_Pin1_4	520	525	PF00397	0.682
DOC_WW_Pin1_4	529	534	PF00397	0.601
DOC_WW_Pin1_4	59	64	PF00397	0.612
DOC_WW_Pin1_4	590	595	PF00397	0.678
DOC_WW_Pin1_4	627	632	PF00397	0.590
LIG_14-3-3_CanoR_1	132	138	PF00244	0.635
LIG_14-3-3_CanoR_1	28	35	PF00244	0.573
LIG_14-3-3_CanoR_1	437	442	PF00244	0.603
LIG_14-3-3_CanoR_1	47	56	PF00244	0.669
LIG_14-3-3_CanoR_1	560	568	PF00244	0.685
LIG_14-3-3_CanoR_1	571	580	PF00244	0.674
LIG_BRCT_BRCA1_1	344	348	PF00533	0.534
LIG_BRCT_BRCA1_1	473	477	PF00533	0.615
LIG_BRCT_BRCA1_1	84	88	PF00533	0.637
LIG_CSL_BTD_1	467	470	PF09270	0.707
LIG_EVH1_1	60	64	PF00568	0.608
LIG_EVH1_1	99	103	PF00568	0.770
LIG_EVH1_2	677	681	PF00568	0.555
LIG_FHA_1	265	271	PF00498	0.688
LIG_FHA_1	30	36	PF00498	0.750
LIG_FHA_1	328	334	PF00498	0.639
LIG_FHA_1	359	365	PF00498	0.630
LIG_FHA_1	375	381	PF00498	0.502
LIG_FHA_1	409	415	PF00498	0.627
LIG_FHA_2	16	22	PF00498	0.579
LIG_HOMEOBOX	599	602	PF00046	0.655
LIG_LIR_Apic_2	527	533	PF02991	0.554
LIG_LIR_Gen_1	2	13	PF02991	0.567
LIG_LIR_Gen_1	478	485	PF02991	0.528
LIG_LIR_Nem_3	180	185	PF02991	0.630
LIG_LIR_Nem_3	2	8	PF02991	0.563
LIG_LIR_Nem_3	478	483	PF02991	0.646
LIG_LIR_Nem_3	85	91	PF02991	0.638
LIG_MAD2	89	97	PF02301	0.530
LIG_MYND_1	97	101	PF01753	0.554
LIG_Pex14_2	681	685	PF04695	0.549
LIG_Rb_LxCxE_1	283	302	PF01857	0.600
LIG_SH2_CRK	182	186	PF00017	0.621
LIG_SH2_NCK_1	182	186	PF00017	0.621
LIG_SH2_NCK_1	494	498	PF00017	0.587
LIG_SH2_STAP1	659	663	PF00017	0.663
LIG_SH2_STAT3	659	662	PF00017	0.702
LIG_SH2_STAT3	673	676	PF00017	0.616
LIG_SH2_STAT5	216	219	PF00017	0.704
LIG_SH2_STAT5	418	421	PF00017	0.603
LIG_SH3_1	591	597	PF00018	0.700
LIG_SH3_1	94	100	PF00018	0.695
LIG_SH3_3	246	252	PF00018	0.689
LIG_SH3_3	276	282	PF00018	0.655
LIG_SH3_3	338	344	PF00018	0.774
LIG_SH3_3	377	383	PF00018	0.613
LIG_SH3_3	40	46	PF00018	0.701
LIG_SH3_3	445	451	PF00018	0.679
LIG_SH3_3	498	504	PF00018	0.662
LIG_SH3_3	50	56	PF00018	0.701
LIG_SH3_3	58	64	PF00018	0.577
LIG_SH3_3	591	597	PF00018	0.700
LIG_SH3_3	628	634	PF00018	0.656
LIG_SH3_3	672	678	PF00018	0.687
LIG_SH3_3	94	100	PF00018	0.741
LIG_TRAF2_1	174	177	PF00917	0.670
LIG_WW_2	102	105	PF00397	0.628
LIG_WW_2	97	100	PF00397	0.554
LIG_WW_3	664	668	PF00397	0.658
LIG_WW_3	726	730	PF00397	0.684
MOD_CDK_SPK_2	627	632	PF00069	0.539
MOD_CK1_1	107	113	PF00069	0.630
MOD_CK1_1	164	170	PF00069	0.741
MOD_CK1_1	203	209	PF00069	0.686
MOD_CK1_1	212	218	PF00069	0.635
MOD_CK1_1	264	270	PF00069	0.790
MOD_CK1_1	272	278	PF00069	0.786
MOD_CK1_1	374	380	PF00069	0.633
MOD_CK1_1	55	61	PF00069	0.666
MOD_CK1_1	562	568	PF00069	0.726
MOD_CK1_1	593	599	PF00069	0.663
MOD_CK1_1	692	698	PF00069	0.702
MOD_CK1_1	80	86	PF00069	0.640
MOD_CK2_1	170	176	PF00069	0.706
MOD_DYRK1A_RPxSP_1	627	631	PF00069	0.533
MOD_GlcNHglycan	172	176	PF01048	0.625
MOD_GlcNHglycan	261	264	PF01048	0.738
MOD_GlcNHglycan	29	32	PF01048	0.577
MOD_GlcNHglycan	336	339	PF01048	0.673
MOD_GlcNHglycan	349	352	PF01048	0.574
MOD_GlcNHglycan	419	422	PF01048	0.656
MOD_GlcNHglycan	49	52	PF01048	0.535
MOD_GlcNHglycan	637	640	PF01048	0.589
MOD_GlcNHglycan	659	662	PF01048	0.693
MOD_GlcNHglycan	694	697	PF01048	0.668
MOD_GlcNHglycan	80	83	PF01048	0.602
MOD_GSK3_1	103	110	PF00069	0.808
MOD_GSK3_1	160	167	PF00069	0.704
MOD_GSK3_1	200	207	PF00069	0.708
MOD_GSK3_1	261	268	PF00069	0.816
MOD_GSK3_1	269	276	PF00069	0.743
MOD_GSK3_1	282	289	PF00069	0.683
MOD_GSK3_1	320	327	PF00069	0.707
MOD_GSK3_1	371	378	PF00069	0.652
MOD_GSK3_1	451	458	PF00069	0.662
MOD_GSK3_1	471	478	PF00069	0.710
MOD_GSK3_1	520	527	PF00069	0.657
MOD_GSK3_1	55	62	PF00069	0.642
MOD_GSK3_1	555	562	PF00069	0.632
MOD_GSK3_1	567	574	PF00069	0.746
MOD_GSK3_1	665	672	PF00069	0.700
MOD_GSK3_1	688	695	PF00069	0.670
MOD_GSK3_1	73	80	PF00069	0.556
MOD_N-GLC_1	273	278	PF02516	0.664
MOD_N-GLC_1	334	339	PF02516	0.565
MOD_N-GLC_1	731	736	PF02516	0.648
MOD_NEK2_1	170	175	PF00069	0.562
MOD_NEK2_1	265	270	PF00069	0.716
MOD_NEK2_1	512	517	PF00069	0.664
MOD_NEK2_1	583	588	PF00069	0.671
MOD_NEK2_1	642	647	PF00069	0.695
MOD_NEK2_2	261	266	PF00069	0.583
MOD_NEK2_2	315	320	PF00069	0.691
MOD_OFUCOSY	355	362	PF10250	0.531
MOD_PIKK_1	221	227	PF00454	0.693
MOD_PIKK_1	408	414	PF00454	0.671
MOD_PIKK_1	478	484	PF00454	0.530
MOD_PKA_1	320	326	PF00069	0.611
MOD_PKA_1	719	725	PF00069	0.622
MOD_PKA_2	164	170	PF00069	0.645
MOD_PKA_2	203	209	PF00069	0.590
MOD_PKA_2	221	227	PF00069	0.577
MOD_PKA_2	27	33	PF00069	0.575
MOD_PKA_2	320	326	PF00069	0.645
MOD_PKA_2	342	348	PF00069	0.567
MOD_PKA_2	559	565	PF00069	0.655
MOD_PKA_2	712	718	PF00069	0.730
MOD_PKA_2	719	725	PF00069	0.666
MOD_PKA_2	745	751	PF00069	0.696
MOD_PKB_1	131	139	PF00069	0.571
MOD_PKB_1	435	443	PF00069	0.528
MOD_Plk_1	240	246	PF00069	0.692
MOD_Plk_2-3	15	21	PF00069	0.576
MOD_Plk_4	212	218	PF00069	0.609
MOD_Plk_4	265	271	PF00069	0.675
MOD_Plk_4	329	335	PF00069	0.572
MOD_Plk_4	375	381	PF00069	0.558
MOD_Plk_4	4	10	PF00069	0.534
MOD_Plk_4	437	443	PF00069	0.624
MOD_Plk_4	525	531	PF00069	0.701
MOD_ProDKin_1	107	113	PF00069	0.600
MOD_ProDKin_1	269	275	PF00069	0.734
MOD_ProDKin_1	35	41	PF00069	0.677
MOD_ProDKin_1	371	377	PF00069	0.653
MOD_ProDKin_1	389	395	PF00069	0.568
MOD_ProDKin_1	455	461	PF00069	0.709
MOD_ProDKin_1	471	477	PF00069	0.660
MOD_ProDKin_1	52	58	PF00069	0.624
MOD_ProDKin_1	520	526	PF00069	0.682
MOD_ProDKin_1	529	535	PF00069	0.601
MOD_ProDKin_1	59	65	PF00069	0.615
MOD_ProDKin_1	590	596	PF00069	0.681
MOD_ProDKin_1	627	633	PF00069	0.592
MOD_SUMO_rev_2	121	128	PF00179	0.612
TRG_ENDOCYTIC_2	182	185	PF00928	0.628
TRG_ER_diArg_1	131	133	PF00400	0.583
TRG_ER_diArg_1	147	150	PF00400	0.462
TRG_ER_diArg_1	153	156	PF00400	0.568
TRG_ER_diArg_1	190	192	PF00400	0.544
TRG_ER_diArg_1	231	233	PF00400	0.813
TRG_ER_diArg_1	236	239	PF00400	0.732
TRG_ER_diArg_1	319	321	PF00400	0.623
TRG_ER_diArg_1	434	437	PF00400	0.529
TRG_ER_diArg_1	516	519	PF00400	0.636
TRG_ER_diArg_1	719	721	PF00400	0.726
TRG_ER_diArg_1	737	740	PF00400	0.563
TRG_NLS_MonoExtN_4	149	156	PF00514	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7G5	Leishmania donovani	83%	86%
A4I2B6	Leishmania infantum	85%	100%
E9AIS3	Leishmania braziliensis	57%	87%
E9AYG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	86%