ELMO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Engulfment and cell motility domain-containing protein

Species:

Leishmania major

UniProt:

Q4Q907_LEIMA

TriTrypDb:

LmjF.26.1850 , LMJLV39_260024900 , LMJSD75_260023400

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	9
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q907

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q907

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.460
CLV_NRD_NRD_1	157	159	PF00675	0.481
CLV_NRD_NRD_1	332	334	PF00675	0.353
CLV_NRD_NRD_1	56	58	PF00675	0.434
CLV_PCSK_KEX2_1	150	152	PF00082	0.460
CLV_PCSK_KEX2_1	157	159	PF00082	0.492
CLV_PCSK_KEX2_1	332	334	PF00082	0.353
CLV_PCSK_KEX2_1	56	58	PF00082	0.435
CLV_PCSK_SKI1_1	266	270	PF00082	0.370
CLV_PCSK_SKI1_1	57	61	PF00082	0.481
DEG_SCF_FBW7_1	10	17	PF00400	0.509
DEG_SPOP_SBC_1	4	8	PF00917	0.514
DOC_CKS1_1	11	16	PF01111	0.558
DOC_CKS1_1	20	25	PF01111	0.466
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.642
DOC_MAPK_gen_1	199	207	PF00069	0.593
DOC_MAPK_gen_1	84	93	PF00069	0.613
DOC_PP2B_LxvP_1	131	134	PF13499	0.650
DOC_PP2B_LxvP_1	415	418	PF13499	0.651
DOC_PP4_FxxP_1	20	23	PF00568	0.499
DOC_USP7_MATH_1	16	20	PF00917	0.556
DOC_USP7_MATH_1	215	219	PF00917	0.533
DOC_USP7_MATH_1	287	291	PF00917	0.471
DOC_USP7_MATH_1	4	8	PF00917	0.550
DOC_USP7_MATH_1	43	47	PF00917	0.731
DOC_USP7_MATH_1	59	63	PF00917	0.691
DOC_USP7_UBL2_3	409	413	PF12436	0.653
DOC_WW_Pin1_4	10	15	PF00397	0.516
DOC_WW_Pin1_4	163	168	PF00397	0.671
DOC_WW_Pin1_4	19	24	PF00397	0.472
DOC_WW_Pin1_4	192	197	PF00397	0.529
DOC_WW_Pin1_4	220	225	PF00397	0.512
DOC_WW_Pin1_4	98	103	PF00397	0.667
LIG_14-3-3_CanoR_1	132	138	PF00244	0.650
LIG_14-3-3_CanoR_1	84	93	PF00244	0.572
LIG_Actin_WH2_2	230	246	PF00022	0.528
LIG_Actin_WH2_2	303	320	PF00022	0.502
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BIR_III_1	1	5	PF00653	0.512
LIG_BIR_III_3	1	5	PF00653	0.512
LIG_BRCT_BRCA1_1	230	234	PF00533	0.586
LIG_BRCT_BRCA1_1	402	406	PF00533	0.599
LIG_FHA_1	118	124	PF00498	0.650
LIG_FHA_1	164	170	PF00498	0.673
LIG_FHA_1	20	26	PF00498	0.323
LIG_FHA_1	292	298	PF00498	0.506
LIG_FHA_1	314	320	PF00498	0.528
LIG_FHA_2	116	122	PF00498	0.742
LIG_FHA_2	193	199	PF00498	0.501
LIG_FHA_2	85	91	PF00498	0.517
LIG_LIR_Apic_2	17	23	PF02991	0.499
LIG_LIR_Gen_1	311	322	PF02991	0.496
LIG_LIR_Nem_3	221	225	PF02991	0.494
LIG_LIR_Nem_3	231	237	PF02991	0.459
LIG_LIR_Nem_3	282	286	PF02991	0.501
LIG_LIR_Nem_3	311	317	PF02991	0.488
LIG_LIR_Nem_3	351	357	PF02991	0.530
LIG_LIR_Nem_3	392	396	PF02991	0.482
LIG_LIR_Nem_3	9	15	PF02991	0.428
LIG_MLH1_MIPbox_1	402	406	PF16413	0.616
LIG_PCNA_PIPBox_1	205	214	PF02747	0.511
LIG_Pex14_2	379	383	PF04695	0.482
LIG_Pex14_2	402	406	PF04695	0.524
LIG_PTB_Apo_2	259	266	PF02174	0.475
LIG_REV1ctd_RIR_1	403	413	PF16727	0.640
LIG_REV1ctd_RIR_1	91	97	PF16727	0.522
LIG_SH2_CRK	222	226	PF00017	0.547
LIG_SH2_CRK	314	318	PF00017	0.482
LIG_SH2_SRC	145	148	PF00017	0.607
LIG_SH2_STAT5	140	143	PF00017	0.631
LIG_SH2_STAT5	145	148	PF00017	0.633
LIG_SH2_STAT5	284	287	PF00017	0.482
LIG_SH3_1	96	102	PF00018	0.668
LIG_SH3_3	8	14	PF00018	0.578
LIG_SH3_3	96	102	PF00018	0.668
LIG_SUMO_SIM_par_1	284	290	PF11976	0.496
LIG_TRAF2_1	65	68	PF00917	0.635
LIG_WRC_WIRS_1	402	407	PF05994	0.514
MOD_CDK_SPxxK_3	192	199	PF00069	0.530
MOD_CK1_1	101	107	PF00069	0.666
MOD_CK1_1	163	169	PF00069	0.697
MOD_CK1_1	19	25	PF00069	0.463
MOD_CK1_1	218	224	PF00069	0.486
MOD_CK1_1	360	366	PF00069	0.529
MOD_CK1_1	46	52	PF00069	0.709
MOD_CK1_1	6	12	PF00069	0.538
MOD_CK2_1	115	121	PF00069	0.766
MOD_CK2_1	84	90	PF00069	0.514
MOD_Cter_Amidation	330	333	PF01082	0.302
MOD_Cter_Amidation	54	57	PF01082	0.501
MOD_GlcNHglycan	163	166	PF01048	0.419
MOD_GlcNHglycan	217	220	PF01048	0.282
MOD_GlcNHglycan	359	362	PF01048	0.358
MOD_GlcNHglycan	397	400	PF01048	0.412
MOD_GlcNHglycan	46	49	PF01048	0.572
MOD_GSK3_1	10	17	PF00069	0.525
MOD_GSK3_1	2	9	PF00069	0.534
MOD_GSK3_1	287	294	PF00069	0.482
MOD_GSK3_1	400	407	PF00069	0.544
MOD_N-GLC_1	200	205	PF02516	0.358
MOD_NEK2_1	343	348	PF00069	0.553
MOD_NEK2_1	357	362	PF00069	0.562
MOD_NEK2_1	405	410	PF00069	0.603
MOD_NEK2_2	16	21	PF00069	0.414
MOD_NEK2_2	182	187	PF00069	0.632
MOD_PIKK_1	292	298	PF00454	0.534
MOD_Plk_1	182	188	PF00069	0.608
MOD_Plk_1	200	206	PF00069	0.562
MOD_Plk_1	411	417	PF00069	0.674
MOD_Plk_4	133	139	PF00069	0.628
MOD_Plk_4	141	147	PF00069	0.591
MOD_Plk_4	279	285	PF00069	0.513
MOD_Plk_4	392	398	PF00069	0.490
MOD_Plk_4	401	407	PF00069	0.501
MOD_ProDKin_1	10	16	PF00069	0.514
MOD_ProDKin_1	163	169	PF00069	0.664
MOD_ProDKin_1	19	25	PF00069	0.472
MOD_ProDKin_1	192	198	PF00069	0.529
MOD_ProDKin_1	220	226	PF00069	0.512
MOD_ProDKin_1	98	104	PF00069	0.667
MOD_SUMO_rev_2	273	282	PF00179	0.557
TRG_DiLeu_BaEn_2	89	95	PF01217	0.579
TRG_ENDOCYTIC_2	222	225	PF00928	0.538
TRG_ENDOCYTIC_2	314	317	PF00928	0.490
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	187	192	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILP2	Leptomonas seymouri	66%	100%
A0A1X0P7Q3	Trypanosomatidae	34%	93%
A0A3Q8IDR4	Leishmania donovani	93%	100%
A0A422NQV3	Trypanosoma rangeli	39%	100%
A4HF30	Leishmania braziliensis	82%	100%
A4I273	Leishmania infantum	93%	100%
C9ZXA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AYG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BAK6	Trypanosoma cruzi	40%	88%