ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 2

Species:

Leishmania major

UniProt:

Q4Q906_LEIMA

TriTrypDb:

LmjF.26.1860 , LMJLV39_260025000 , LMJSD75_260023500

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	10
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q906

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q906

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.502
CLV_MEL_PAP_1	259	265	PF00089	0.548
CLV_NRD_NRD_1	158	160	PF00675	0.730
CLV_NRD_NRD_1	341	343	PF00675	0.589
CLV_NRD_NRD_1	393	395	PF00675	0.523
CLV_PCSK_KEX2_1	327	329	PF00082	0.541
CLV_PCSK_KEX2_1	376	378	PF00082	0.661
CLV_PCSK_KEX2_1	395	397	PF00082	0.464
CLV_PCSK_KEX2_1	506	508	PF00082	0.782
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.543
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.672
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.414
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.782
CLV_PCSK_SKI1_1	152	156	PF00082	0.706
CLV_PCSK_SKI1_1	160	164	PF00082	0.738
CLV_PCSK_SKI1_1	211	215	PF00082	0.715
CLV_PCSK_SKI1_1	225	229	PF00082	0.599
CLV_PCSK_SKI1_1	343	347	PF00082	0.583
CLV_PCSK_SKI1_1	368	372	PF00082	0.481
DEG_APCC_DBOX_1	395	403	PF00400	0.277
DEG_Kelch_actinfilin_1	528	532	PF01344	0.234
DEG_SPOP_SBC_1	492	496	PF00917	0.468
DOC_CKS1_1	32	37	PF01111	0.491
DOC_MAPK_DCC_7	249	259	PF00069	0.310
DOC_MAPK_gen_1	159	166	PF00069	0.537
DOC_MAPK_gen_1	339	348	PF00069	0.299
DOC_MAPK_JIP1_4	160	166	PF00069	0.534
DOC_MAPK_MEF2A_6	251	259	PF00069	0.309
DOC_MAPK_RevD_3	532	548	PF00069	0.371
DOC_PP2B_LxvP_1	277	280	PF13499	0.330
DOC_PP2B_LxvP_1	4	7	PF13499	0.551
DOC_PP2B_PxIxI_1	254	260	PF00149	0.315
DOC_PP4_FxxP_1	242	245	PF00568	0.290
DOC_USP7_MATH_1	102	106	PF00917	0.504
DOC_USP7_MATH_1	150	154	PF00917	0.466
DOC_USP7_MATH_1	17	21	PF00917	0.615
DOC_USP7_MATH_1	22	26	PF00917	0.467
DOC_USP7_MATH_1	311	315	PF00917	0.365
DOC_USP7_MATH_1	36	40	PF00917	0.584
DOC_USP7_MATH_1	458	462	PF00917	0.352
DOC_USP7_MATH_1	515	519	PF00917	0.551
DOC_USP7_MATH_1	520	524	PF00917	0.485
DOC_USP7_MATH_1	535	539	PF00917	0.469
DOC_USP7_UBL2_3	207	211	PF12436	0.475
DOC_WW_Pin1_4	132	137	PF00397	0.514
DOC_WW_Pin1_4	138	143	PF00397	0.466
DOC_WW_Pin1_4	237	242	PF00397	0.319
DOC_WW_Pin1_4	27	32	PF00397	0.528
LIG_14-3-3_CanoR_1	159	165	PF00244	0.532
LIG_14-3-3_CanoR_1	485	493	PF00244	0.518
LIG_Actin_WH2_2	363	378	PF00022	0.395
LIG_deltaCOP1_diTrp_1	73	78	PF00928	0.414
LIG_FHA_1	161	167	PF00498	0.517
LIG_FHA_1	369	375	PF00498	0.296
LIG_FHA_1	384	390	PF00498	0.353
LIG_FHA_1	40	46	PF00498	0.404
LIG_FHA_1	538	544	PF00498	0.265
LIG_FHA_2	57	63	PF00498	0.505
LIG_GBD_Chelix_1	366	374	PF00786	0.573
LIG_LIR_Apic_2	240	245	PF02991	0.292
LIG_LIR_Gen_1	304	313	PF02991	0.279
LIG_LIR_Gen_1	404	413	PF02991	0.293
LIG_LIR_Gen_1	451	460	PF02991	0.417
LIG_LIR_Gen_1	522	532	PF02991	0.372
LIG_LIR_Nem_3	304	308	PF02991	0.268
LIG_LIR_Nem_3	325	329	PF02991	0.417
LIG_LIR_Nem_3	398	403	PF02991	0.366
LIG_LIR_Nem_3	404	409	PF02991	0.288
LIG_LIR_Nem_3	451	457	PF02991	0.417
LIG_LIR_Nem_3	522	527	PF02991	0.513
LIG_LIR_Nem_3	75	81	PF02991	0.364
LIG_Pex14_1	74	78	PF04695	0.366
LIG_Pex14_2	301	305	PF04695	0.272
LIG_Pex14_2	406	410	PF04695	0.272
LIG_Rb_pABgroove_1	397	405	PF01858	0.274
LIG_SH2_CRK	329	333	PF00017	0.288
LIG_SH2_GRB2like	147	150	PF00017	0.449
LIG_SH2_NCK_1	329	333	PF00017	0.288
LIG_SH2_SRC	147	150	PF00017	0.449
LIG_SH2_SRC	53	56	PF00017	0.497
LIG_SH2_STAP1	147	151	PF00017	0.504
LIG_SH2_STAP1	303	307	PF00017	0.356
LIG_SH2_STAP1	362	366	PF00017	0.345
LIG_SH2_STAP1	403	407	PF00017	0.363
LIG_SH2_STAT5	333	336	PF00017	0.276
LIG_SH2_STAT5	53	56	PF00017	0.457
LIG_SH3_3	10	16	PF00018	0.495
LIG_SUMO_SIM_anti_2	540	545	PF11976	0.417
LIG_SUMO_SIM_par_1	444	451	PF11976	0.420
LIG_TYR_ITIM	331	336	PF00017	0.308
MOD_CK1_1	168	174	PF00069	0.487
MOD_CK1_1	39	45	PF00069	0.474
MOD_CK1_1	425	431	PF00069	0.315
MOD_CK1_1	56	62	PF00069	0.499
MOD_CK2_1	22	28	PF00069	0.502
MOD_CK2_1	353	359	PF00069	0.418
MOD_CK2_1	385	391	PF00069	0.418
MOD_GlcNHglycan	105	108	PF01048	0.733
MOD_GlcNHglycan	109	112	PF01048	0.743
MOD_GlcNHglycan	152	155	PF01048	0.708
MOD_GlcNHglycan	19	22	PF01048	0.716
MOD_GlcNHglycan	24	27	PF01048	0.713
MOD_GlcNHglycan	265	268	PF01048	0.662
MOD_GlcNHglycan	313	316	PF01048	0.493
MOD_GlcNHglycan	38	41	PF01048	0.658
MOD_GlcNHglycan	424	427	PF01048	0.533
MOD_GlcNHglycan	471	474	PF01048	0.718
MOD_GlcNHglycan	495	498	PF01048	0.620
MOD_GlcNHglycan	510	513	PF01048	0.705
MOD_GlcNHglycan	517	520	PF01048	0.702
MOD_GlcNHglycan	537	540	PF01048	0.208
MOD_GSK3_1	103	110	PF00069	0.522
MOD_GSK3_1	128	135	PF00069	0.592
MOD_GSK3_1	191	198	PF00069	0.507
MOD_GSK3_1	27	34	PF00069	0.513
MOD_GSK3_1	405	412	PF00069	0.374
MOD_GSK3_1	418	425	PF00069	0.368
MOD_GSK3_1	49	56	PF00069	0.470
MOD_GSK3_1	515	522	PF00069	0.525
MOD_LATS_1	209	215	PF00433	0.524
MOD_NEK2_1	126	131	PF00069	0.471
MOD_NEK2_1	197	202	PF00069	0.577
MOD_NEK2_1	235	240	PF00069	0.331
MOD_NEK2_1	263	268	PF00069	0.432
MOD_NEK2_1	383	388	PF00069	0.401
MOD_NEK2_1	493	498	PF00069	0.500
MOD_NEK2_1	82	87	PF00069	0.383
MOD_NEK2_2	405	410	PF00069	0.327
MOD_NEK2_2	501	506	PF00069	0.398
MOD_PIKK_1	220	226	PF00454	0.479
MOD_PIKK_1	485	491	PF00454	0.446
MOD_PKA_1	211	217	PF00069	0.430
MOD_PKA_1	506	512	PF00069	0.577
MOD_PKA_2	506	512	PF00069	0.579
MOD_Plk_1	191	197	PF00069	0.548
MOD_Plk_1	458	464	PF00069	0.422
MOD_Plk_2-3	385	391	PF00069	0.345
MOD_Plk_4	385	391	PF00069	0.325
MOD_Plk_4	405	411	PF00069	0.335
MOD_Plk_4	49	55	PF00069	0.469
MOD_ProDKin_1	132	138	PF00069	0.513
MOD_ProDKin_1	237	243	PF00069	0.313
MOD_ProDKin_1	27	33	PF00069	0.528
MOD_SUMO_rev_2	73	81	PF00179	0.389
TRG_DiLeu_BaEn_1	77	82	PF01217	0.443
TRG_ENDOCYTIC_2	333	336	PF00928	0.322
TRG_ENDOCYTIC_2	403	406	PF00928	0.322
TRG_ER_diArg_1	285	288	PF00400	0.344
TRG_ER_diArg_1	393	396	PF00400	0.312
TRG_ER_diLys_1	547	550	PF00400	0.693
TRG_NES_CRM1_1	297	310	PF08389	0.363
TRG_NES_CRM1_1	379	391	PF08389	0.363
TRG_NES_CRM1_1	455	466	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.718
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG5	Leptomonas seymouri	64%	96%
A0A0S4IT25	Bodo saltans	45%	80%
A0A1X0P7G8	Trypanosomatidae	43%	89%
A0A3Q8IDW3	Leishmania donovani	96%	100%
A0A422NQN2	Trypanosoma rangeli	43%	91%
A4HF31	Leishmania braziliensis	88%	100%
A4I274	Leishmania infantum	96%	100%
C9ZX99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	91%
E9AYG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%