Sedlin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Sedlin

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q903_LEIMA

TriTrypDb:

LmjF.26.1890 , LMJLV39_260025300 , LMJSD75_260023800

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q903

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q903

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.423
CLV_PCSK_SKI1_1	159	163	PF00082	0.402
CLV_PCSK_SKI1_1	30	34	PF00082	0.494
DOC_CYCLIN_yCln2_LP_2	33	39	PF00134	0.528
DOC_PP1_RVXF_1	51	57	PF00149	0.403
DOC_PP4_FxxP_1	199	202	PF00568	0.434
DOC_USP7_MATH_1	119	123	PF00917	0.718
DOC_USP7_MATH_1	228	232	PF00917	0.589
DOC_USP7_MATH_1	73	77	PF00917	0.686
DOC_USP7_MATH_1	80	84	PF00917	0.693
DOC_USP7_MATH_1	98	102	PF00917	0.555
DOC_WW_Pin1_4	114	119	PF00397	0.545
DOC_WW_Pin1_4	133	138	PF00397	0.622
DOC_WW_Pin1_4	16	21	PF00397	0.379
DOC_WW_Pin1_4	198	203	PF00397	0.444
DOC_WW_Pin1_4	25	30	PF00397	0.393
DOC_WW_Pin1_4	32	37	PF00397	0.424
LIG_14-3-3_CanoR_1	152	157	PF00244	0.437
LIG_14-3-3_CanoR_1	24	29	PF00244	0.426
LIG_14-3-3_CanoR_1	260	265	PF00244	0.567
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_BRCT_BRCA1_1	154	158	PF00533	0.321
LIG_BRCT_BRCA1_1	292	296	PF00533	0.426
LIG_deltaCOP1_diTrp_1	270	273	PF00928	0.659
LIG_EH_1	196	200	PF12763	0.431
LIG_FHA_1	104	110	PF00498	0.493
LIG_FHA_1	164	170	PF00498	0.436
LIG_FHA_1	17	23	PF00498	0.372
LIG_FHA_1	228	234	PF00498	0.660
LIG_FHA_1	287	293	PF00498	0.505
LIG_FHA_1	3	9	PF00498	0.377
LIG_FHA_1	49	55	PF00498	0.402
LIG_FHA_1	69	75	PF00498	0.588
LIG_FHA_2	296	302	PF00498	0.466
LIG_LIR_Apic_2	25	29	PF02991	0.380
LIG_LIR_Apic_2	270	276	PF02991	0.657
LIG_NRBOX	143	149	PF00104	0.394
LIG_NRBOX	299	305	PF00104	0.413
LIG_SH2_CRK	26	30	PF00017	0.488
LIG_SH2_NCK_1	188	192	PF00017	0.348
LIG_SH2_PTP2	45	48	PF00017	0.457
LIG_SH2_STAT3	241	244	PF00017	0.591
LIG_SH2_STAT5	26	29	PF00017	0.468
LIG_SH2_STAT5	45	48	PF00017	0.267
LIG_SH3_3	33	39	PF00018	0.528
LIG_SUMO_SIM_par_1	12	17	PF11976	0.390
LIG_SUMO_SIM_par_1	165	170	PF11976	0.461
LIG_SUMO_SIM_par_1	19	25	PF11976	0.390
LIG_SUMO_SIM_par_1	287	293	PF11976	0.527
LIG_WRC_WIRS_1	304	309	PF05994	0.513
MOD_CAAXbox	314	317	PF01239	0.595
MOD_CDK_SPK_2	25	30	PF00069	0.393
MOD_CK1_1	101	107	PF00069	0.621
MOD_CK1_1	117	123	PF00069	0.614
MOD_CK1_1	136	142	PF00069	0.415
MOD_CK1_1	2	8	PF00069	0.473
MOD_CK1_1	263	269	PF00069	0.604
MOD_CK1_1	305	311	PF00069	0.545
MOD_CK2_1	102	108	PF00069	0.614
MOD_CK2_1	295	301	PF00069	0.469
MOD_GlcNHglycan	100	103	PF01048	0.741
MOD_GlcNHglycan	126	129	PF01048	0.540
MOD_GlcNHglycan	159	162	PF01048	0.360
MOD_GlcNHglycan	191	194	PF01048	0.409
MOD_GlcNHglycan	218	221	PF01048	0.651
MOD_GlcNHglycan	279	282	PF01048	0.502
MOD_GlcNHglycan	83	86	PF01048	0.605
MOD_GSK3_1	113	120	PF00069	0.662
MOD_GSK3_1	159	166	PF00069	0.369
MOD_GSK3_1	259	266	PF00069	0.603
MOD_GSK3_1	282	289	PF00069	0.544
MOD_GSK3_1	303	310	PF00069	0.563
MOD_GSK3_1	98	105	PF00069	0.668
MOD_N-GLC_1	124	129	PF02516	0.584
MOD_N-GLC_1	98	103	PF02516	0.763
MOD_NEK2_1	124	129	PF00069	0.499
MOD_NEK2_1	147	152	PF00069	0.419
MOD_NEK2_1	167	172	PF00069	0.439
MOD_NEK2_1	22	27	PF00069	0.449
MOD_NEK2_1	269	274	PF00069	0.626
MOD_NEK2_1	290	295	PF00069	0.433
MOD_NEK2_1	303	308	PF00069	0.465
MOD_NEK2_1	68	73	PF00069	0.498
MOD_NEK2_2	48	53	PF00069	0.349
MOD_PIKK_1	228	234	PF00454	0.727
MOD_PIKK_1	240	246	PF00454	0.525
MOD_PIKK_1	247	253	PF00454	0.446
MOD_PIKK_1	295	301	PF00454	0.485
MOD_PK_1	260	266	PF00069	0.545
MOD_PKA_2	259	265	PF00069	0.565
MOD_PKA_2	68	74	PF00069	0.391
MOD_Plk_1	269	275	PF00069	0.656
MOD_Plk_1	48	54	PF00069	0.340
MOD_Plk_1	92	98	PF00069	0.626
MOD_Plk_4	119	125	PF00069	0.546
MOD_Plk_4	163	169	PF00069	0.468
MOD_Plk_4	92	98	PF00069	0.701
MOD_ProDKin_1	114	120	PF00069	0.546
MOD_ProDKin_1	133	139	PF00069	0.611
MOD_ProDKin_1	16	22	PF00069	0.374
MOD_ProDKin_1	198	204	PF00069	0.444
MOD_ProDKin_1	25	31	PF00069	0.401
MOD_ProDKin_1	32	38	PF00069	0.422
TRG_DiLeu_BaEn_1	108	113	PF01217	0.521
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.600
TRG_DiLeu_LyEn_5	17	22	PF01217	0.466
TRG_ER_diArg_1	151	154	PF00400	0.349
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P7	Leptomonas seymouri	58%	94%
A0A1X0P7Q6	Trypanosomatidae	35%	100%
A0A3Q8ICA3	Leishmania donovani	91%	100%
A4HF34	Leishmania braziliensis	75%	99%
A4I2B8	Leishmania infantum	91%	100%
E9AYG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AV59	Trypanosoma cruzi	35%	100%