Deoxyhypusine hydroxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

deoxyhypusine hydroxylase, putative

Species:

Leishmania major

UniProt:

Q4Q901_LEIMA

TriTrypDb:

LmjF.26.1910 , LMJLV39_260025500 , LMJSD75_260024000

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q901

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q901

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008283	cell population proliferation	2	2
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	3	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	2
GO:0018193	peptidyl-amino acid modification	5	11
GO:0018205	peptidyl-lysine modification	6	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004497	monooxygenase activity	3	11
GO:0005488	binding	1	11
GO:0005506	iron ion binding	6	2
GO:0016491	oxidoreductase activity	2	11
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	11
GO:0019135	deoxyhypusine monooxygenase activity	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	2
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.394
CLV_C14_Caspase3-7	55	59	PF00656	0.265
CLV_NRD_NRD_1	12	14	PF00675	0.491
CLV_NRD_NRD_1	201	203	PF00675	0.321
CLV_PCSK_KEX2_1	201	203	PF00082	0.321
DEG_COP1_1	73	82	PF00400	0.390
DOC_MAPK_MEF2A_6	299	308	PF00069	0.265
DOC_MAPK_MEF2A_6	42	51	PF00069	0.448
DOC_USP7_MATH_1	125	129	PF00917	0.197
DOC_USP7_MATH_1	25	29	PF00917	0.375
DOC_USP7_MATH_1	3	7	PF00917	0.508
DOC_USP7_MATH_1	70	74	PF00917	0.390
DOC_USP7_UBL2_3	14	18	PF12436	0.509
DOC_WW_Pin1_4	105	110	PF00397	0.387
DOC_WW_Pin1_4	162	167	PF00397	0.403
LIG_14-3-3_CanoR_1	210	218	PF00244	0.472
LIG_14-3-3_CanoR_1	247	252	PF00244	0.305
LIG_14-3-3_CanoR_1	84	94	PF00244	0.390
LIG_Actin_WH2_2	26	44	PF00022	0.483
LIG_BIR_II_1	1	5	PF00653	0.572
LIG_BRCT_BRCA1_1	164	168	PF00533	0.396
LIG_BRCT_BRCA1_1	230	234	PF00533	0.313
LIG_FHA_1	130	136	PF00498	0.392
LIG_FHA_1	281	287	PF00498	0.393
LIG_FHA_1	46	52	PF00498	0.372
LIG_FHA_1	55	61	PF00498	0.207
LIG_FHA_2	121	127	PF00498	0.340
LIG_FHA_2	143	149	PF00498	0.386
LIG_FHA_2	180	186	PF00498	0.406
LIG_FHA_2	290	296	PF00498	0.355
LIG_FHA_2	6	12	PF00498	0.424
LIG_FHA_2	87	93	PF00498	0.302
LIG_LIR_Gen_1	15	22	PF02991	0.453
LIG_LIR_Gen_1	158	167	PF02991	0.476
LIG_LIR_Gen_1	88	99	PF02991	0.270
LIG_LIR_Nem_3	15	19	PF02991	0.393
LIG_LIR_Nem_3	158	162	PF02991	0.518
LIG_LIR_Nem_3	165	171	PF02991	0.518
LIG_LIR_Nem_3	197	203	PF02991	0.334
LIG_LIR_Nem_3	88	94	PF02991	0.270
LIG_MYND_3	284	288	PF01753	0.309
LIG_MYND_3	79	83	PF01753	0.390
LIG_SH2_CRK	16	20	PF00017	0.360
LIG_SH2_CRK	91	95	PF00017	0.249
LIG_SH2_NCK_1	91	95	PF00017	0.249
LIG_SH2_STAP1	16	20	PF00017	0.371
LIG_SH3_3	148	154	PF00018	0.441
LIG_SH3_3	19	25	PF00018	0.379
LIG_SUMO_SIM_par_1	179	185	PF11976	0.283
LIG_SUMO_SIM_par_1	300	307	PF11976	0.265
LIG_SUMO_SIM_par_1	47	52	PF11976	0.397
LIG_TRAF2_1	182	185	PF00917	0.450
LIG_TRAF2_1	8	11	PF00917	0.468
LIG_TYR_ITSM	87	94	PF00017	0.373
LIG_UBA3_1	254	259	PF00899	0.343
MOD_CK1_1	119	125	PF00069	0.385
MOD_CK1_1	194	200	PF00069	0.427
MOD_CK1_1	289	295	PF00069	0.340
MOD_CK2_1	120	126	PF00069	0.348
MOD_CK2_1	152	158	PF00069	0.548
MOD_CK2_1	171	177	PF00069	0.623
MOD_CK2_1	179	185	PF00069	0.393
MOD_CK2_1	289	295	PF00069	0.355
MOD_CK2_1	5	11	PF00069	0.468
MOD_CK2_1	70	76	PF00069	0.348
MOD_CK2_1	92	98	PF00069	0.249
MOD_GlcNHglycan	1	4	PF01048	0.650
MOD_GlcNHglycan	118	121	PF01048	0.450
MOD_GlcNHglycan	154	157	PF01048	0.505
MOD_GlcNHglycan	168	171	PF01048	0.277
MOD_GlcNHglycan	192	196	PF01048	0.413
MOD_GlcNHglycan	230	233	PF01048	0.246
MOD_GlcNHglycan	72	75	PF01048	0.292
MOD_GSK3_1	1	8	PF00069	0.618
MOD_GSK3_1	116	123	PF00069	0.340
MOD_GSK3_1	125	132	PF00069	0.190
MOD_GSK3_1	158	165	PF00069	0.431
MOD_GSK3_1	166	173	PF00069	0.460
MOD_GSK3_1	190	197	PF00069	0.378
MOD_N-GLC_2	5	7	PF02516	0.375
MOD_NEK2_1	1	6	PF00069	0.564
MOD_NEK2_1	142	147	PF00069	0.531
MOD_NEK2_1	190	195	PF00069	0.386
MOD_NEK2_1	86	91	PF00069	0.327
MOD_NEK2_2	125	130	PF00069	0.178
MOD_NEK2_2	205	210	PF00069	0.270
MOD_PIKK_1	247	253	PF00454	0.284
MOD_PKA_2	129	135	PF00069	0.259
MOD_PKA_2	246	252	PF00069	0.384
MOD_PKA_2	298	304	PF00069	0.265
MOD_PKA_2	86	92	PF00069	0.333
MOD_Plk_1	125	131	PF00069	0.178
MOD_Plk_1	226	232	PF00069	0.344
MOD_Plk_2-3	158	164	PF00069	0.433
MOD_Plk_4	45	51	PF00069	0.359
MOD_Plk_4	56	62	PF00069	0.240
MOD_ProDKin_1	105	111	PF00069	0.387
MOD_ProDKin_1	162	168	PF00069	0.405
MOD_SUMO_for_1	258	261	PF00179	0.284
TRG_DiLeu_BaEn_1	15	20	PF01217	0.339
TRG_DiLeu_BaEn_3	261	267	PF01217	0.343
TRG_ENDOCYTIC_2	16	19	PF00928	0.345
TRG_ENDOCYTIC_2	203	206	PF00928	0.273
TRG_ENDOCYTIC_2	91	94	PF00928	0.249
TRG_ER_diArg_1	196	199	PF00400	0.456
TRG_ER_diArg_1	200	202	PF00400	0.320
TRG_NES_CRM1_1	39	52	PF08389	0.268
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.200

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I695	Leptomonas seymouri	85%	97%
A0A0S4J984	Bodo saltans	46%	100%
A0A1X0P8G1	Trypanosomatidae	60%	94%
A0A3R7KQN3	Trypanosoma rangeli	67%	100%
A0A3S7X004	Leishmania donovani	96%	100%
A1CED0	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	43%	97%
A1DFW7	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	42%	97%
A2QXL3	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	41%	96%
A4HF36	Leishmania braziliensis	92%	98%
A4I2C0	Leishmania infantum	96%	100%
A5JZ19	Plasmodium vivax (strain Salvador I)	34%	94%
C9ZX93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
D9IFD5	Leishmania donovani	96%	100%
E9AYH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P0CN10	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	37%	90%
P0CN11	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	37%	90%
P47120	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q0UHL8	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	40%	99%
Q0VC53	Bos taurus	42%	100%
Q17949	Caenorhabditis elegans	41%	100%
Q1E9L2	Coccidioides immitis (strain RS)	38%	97%
Q297S2	Drosophila pseudoobscura pseudoobscura	43%	100%
Q2H0C0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	44%	94%
Q2QLW3	Oryza sativa subsp. japonica	43%	100%
Q2QXB3	Oryza sativa subsp. japonica	41%	100%
Q2UMQ8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	42%	96%
Q4HZ35	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	39%	96%
Q4PHU4	Ustilago maydis (strain 521 / FGSC 9021)	38%	90%
Q4WHG5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	42%	97%
Q556G4	Dictyostelium discoideum	40%	100%
Q59Z14	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	100%
Q5AW32	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	41%	97%
Q5PPJ4	Rattus norvegicus	42%	100%
Q5ZIP3	Gallus gallus	43%	100%
Q66KT3	Xenopus laevis	40%	100%
Q6BKA6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	41%	100%
Q6CHJ7	Yarrowia lipolytica (strain CLIB 122 / E 150)	43%	100%
Q6CV81	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	38%	100%
Q6FUV3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	38%	100%
Q752Z8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	38%	100%
Q7S891	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	100%
Q7ZUX6	Danio rerio	42%	100%
Q8SV71	Encephalitozoon cuniculi (strain GB-M1)	41%	100%
Q94JW0	Arabidopsis thaliana	43%	100%
Q96WP5	Lentinula edodes	42%	98%
Q99LN9	Mus musculus	42%	100%
Q9BU89	Homo sapiens	43%	100%
Q9P6K9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
Q9V9U4	Drosophila melanogaster	43%	100%
V5BF70	Trypanosoma cruzi	65%	100%