TLC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TLC domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q900_LEIMA

TriTrypDb:

LmjF.26.1920 , LMJLV39_260025600 , LMJSD75_260024100

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q900

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q900

Function

Biological processes
Term	Name	Level	Count
GO:0042592	homeostatic process	3	2
GO:0048878	chemical homeostasis	4	2
GO:0055088	lipid homeostasis	5	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	271	273	PF00082	0.362
CLV_PCSK_KEX2_1	302	304	PF00082	0.517
CLV_PCSK_KEX2_1	47	49	PF00082	0.359
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.412
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.529
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.359
CLV_PCSK_SKI1_1	47	51	PF00082	0.408
DOC_CKS1_1	10	15	PF01111	0.429
DOC_MAPK_MEF2A_6	241	250	PF00069	0.314
DOC_USP7_MATH_1	225	229	PF00917	0.216
DOC_USP7_MATH_1	293	297	PF00917	0.705
DOC_USP7_UBL2_3	297	301	PF12436	0.641
DOC_WW_Pin1_4	9	14	PF00397	0.369
LIG_14-3-3_CanoR_1	103	112	PF00244	0.407
LIG_APCC_ABBA_1	141	146	PF00400	0.530
LIG_BRCT_BRCA1_1	106	110	PF00533	0.407
LIG_BRCT_BRCA1_1	158	162	PF00533	0.497
LIG_CaM_NSCaTE_8	218	225	PF13499	0.236
LIG_FHA_1	178	184	PF00498	0.467
LIG_FHA_1	34	40	PF00498	0.464
LIG_FHA_2	191	197	PF00498	0.494
LIG_LIR_Apic_2	8	13	PF02991	0.291
LIG_LIR_Gen_1	113	120	PF02991	0.383
LIG_LIR_Gen_1	137	144	PF02991	0.494
LIG_LIR_Gen_1	180	188	PF02991	0.503
LIG_LIR_Gen_1	90	101	PF02991	0.269
LIG_LIR_Nem_3	113	118	PF02991	0.327
LIG_LIR_Nem_3	137	141	PF02991	0.454
LIG_LIR_Nem_3	145	151	PF02991	0.418
LIG_LIR_Nem_3	180	185	PF02991	0.491
LIG_LIR_Nem_3	196	202	PF02991	0.370
LIG_LIR_Nem_3	90	96	PF02991	0.230
LIG_MLH1_MIPbox_1	106	110	PF16413	0.407
LIG_Pex14_2	118	122	PF04695	0.321
LIG_Pex14_2	266	270	PF04695	0.557
LIG_SH2_CRK	203	207	PF00017	0.474
LIG_SH2_CRK	93	97	PF00017	0.274
LIG_SH2_GRB2like	119	122	PF00017	0.474
LIG_SH2_NCK_1	93	97	PF00017	0.294
LIG_SH2_PTP2	138	141	PF00017	0.407
LIG_SH2_STAP1	7	11	PF00017	0.312
LIG_SH2_STAT5	109	112	PF00017	0.275
LIG_SH2_STAT5	138	141	PF00017	0.451
LIG_SH2_STAT5	152	155	PF00017	0.481
LIG_SH2_STAT5	197	200	PF00017	0.369
LIG_SH2_STAT5	213	216	PF00017	0.307
LIG_SH2_STAT5	263	266	PF00017	0.262
LIG_SH2_STAT5	33	36	PF00017	0.423
LIG_SUMO_SIM_par_1	251	256	PF11976	0.262
LIG_WRC_WIRS_1	131	136	PF05994	0.451
MOD_CDK_SPxxK_3	9	16	PF00069	0.394
MOD_CK1_1	102	108	PF00069	0.309
MOD_CK1_1	173	179	PF00069	0.570
MOD_CK2_1	190	196	PF00069	0.482
MOD_GlcNHglycan	106	109	PF01048	0.407
MOD_GlcNHglycan	172	175	PF01048	0.338
MOD_GlcNHglycan	223	226	PF01048	0.485
MOD_GlcNHglycan	287	290	PF01048	0.434
MOD_GlcNHglycan	4	7	PF01048	0.618
MOD_GlcNHglycan	72	75	PF01048	0.315
MOD_GSK3_1	130	137	PF00069	0.461
MOD_GSK3_1	173	180	PF00069	0.470
MOD_GSK3_1	2	9	PF00069	0.425
MOD_GSK3_1	221	228	PF00069	0.274
MOD_N-GLC_1	120	125	PF02516	0.207
MOD_N-GLC_2	189	191	PF02516	0.207
MOD_N-GLC_2	66	68	PF02516	0.328
MOD_NEK2_1	134	139	PF00069	0.494
MOD_NEK2_1	156	161	PF00069	0.417
MOD_NEK2_1	163	168	PF00069	0.411
MOD_NEK2_1	184	189	PF00069	0.478
MOD_NEK2_1	209	214	PF00069	0.302
MOD_NEK2_1	253	258	PF00069	0.413
MOD_NEK2_1	70	75	PF00069	0.286
MOD_NEK2_1	92	97	PF00069	0.321
MOD_PIKK_1	177	183	PF00454	0.474
MOD_PK_1	60	66	PF00069	0.438
MOD_PKA_1	47	53	PF00069	0.588
MOD_PKA_2	47	53	PF00069	0.588
MOD_PKA_2	99	105	PF00069	0.276
MOD_Plk_1	120	126	PF00069	0.415
MOD_Plk_4	130	136	PF00069	0.436
MOD_Plk_4	163	169	PF00069	0.516
MOD_Plk_4	209	215	PF00069	0.294
MOD_Plk_4	253	259	PF00069	0.413
MOD_Plk_4	6	12	PF00069	0.354
MOD_Plk_4	60	66	PF00069	0.437
MOD_ProDKin_1	9	15	PF00069	0.371
MOD_SUMO_rev_2	281	286	PF00179	0.696
MOD_SUMO_rev_2	295	304	PF00179	0.676
TRG_ENDOCYTIC_2	138	141	PF00928	0.518
TRG_ENDOCYTIC_2	203	206	PF00928	0.395
TRG_ENDOCYTIC_2	263	266	PF00928	0.277
TRG_ENDOCYTIC_2	93	96	PF00928	0.227
TRG_ENDOCYTIC_2	98	101	PF00928	0.227
TRG_ER_diLys_1	301	304	PF00400	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEH5	Leptomonas seymouri	66%	100%
A0A0S4IR24	Bodo saltans	34%	98%
A0A1X0P7L3	Trypanosomatidae	39%	100%
A0A3S7X033	Leishmania donovani	94%	100%
A0A422NQS0	Trypanosoma rangeli	39%	100%
A4HF37	Leishmania braziliensis	77%	100%
C9ZX92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AYH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DB81	Trypanosoma cruzi	38%	100%