4HBT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioesterase-like superfamily, putative

Species:

Leishmania major

UniProt:

Q4Q8Z8_LEIMA

TriTrypDb:

LmjF.26.1940 , LMJLV39_260025800 , LMJSD75_260024300

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Z8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.458
CLV_NRD_NRD_1	203	205	PF00675	0.312
CLV_NRD_NRD_1	228	230	PF00675	0.605
CLV_NRD_NRD_1	274	276	PF00675	0.578
CLV_NRD_NRD_1	71	73	PF00675	0.526
CLV_PCSK_KEX2_1	189	191	PF00082	0.427
CLV_PCSK_KEX2_1	228	230	PF00082	0.605
CLV_PCSK_KEX2_1	71	73	PF00082	0.526
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.427
CLV_PCSK_SKI1_1	135	139	PF00082	0.482
CLV_PCSK_SKI1_1	162	166	PF00082	0.358
CLV_PCSK_SKI1_1	275	279	PF00082	0.520
DEG_SPOP_SBC_1	166	170	PF00917	0.434
DEG_SPOP_SBC_1	183	187	PF00917	0.502
DOC_CKS1_1	284	289	PF01111	0.657
DOC_CKS1_1	56	61	PF01111	0.652
DOC_CYCLIN_yCln2_LP_2	164	167	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.549
DOC_MAPK_gen_1	118	127	PF00069	0.491
DOC_MAPK_gen_1	149	159	PF00069	0.491
DOC_MAPK_gen_1	204	212	PF00069	0.441
DOC_MAPK_gen_1	8	17	PF00069	0.548
DOC_PP1_RVXF_1	118	125	PF00149	0.434
DOC_PP1_RVXF_1	133	139	PF00149	0.270
DOC_PP2B_LxvP_1	164	167	PF13499	0.491
DOC_PP2B_LxvP_1	31	34	PF13499	0.577
DOC_PP4_FxxP_1	172	175	PF00568	0.458
DOC_PP4_FxxP_1	66	69	PF00568	0.522
DOC_USP7_MATH_1	183	187	PF00917	0.508
DOC_USP7_MATH_1	297	301	PF00917	0.687
DOC_USP7_MATH_1	38	42	PF00917	0.627
DOC_USP7_UBL2_3	201	205	PF12436	0.491
DOC_WW_Pin1_4	175	180	PF00397	0.441
DOC_WW_Pin1_4	283	288	PF00397	0.650
DOC_WW_Pin1_4	334	339	PF00397	0.782
DOC_WW_Pin1_4	55	60	PF00397	0.650
LIG_14-3-3_CanoR_1	120	125	PF00244	0.458
LIG_14-3-3_CanoR_1	156	166	PF00244	0.421
LIG_14-3-3_CanoR_1	251	257	PF00244	0.560
LIG_14-3-3_CanoR_1	320	329	PF00244	0.652
LIG_14-3-3_CanoR_1	330	335	PF00244	0.691
LIG_APCC_ABBAyCdc20_2	189	195	PF00400	0.491
LIG_BIR_II_1	1	5	PF00653	0.599
LIG_BIR_III_3	1	5	PF00653	0.549
LIG_BRCT_BRCA1_1	168	172	PF00533	0.491
LIG_eIF4E_1	93	99	PF01652	0.545
LIG_FHA_1	159	165	PF00498	0.370
LIG_FHA_1	28	34	PF00498	0.548
LIG_FHA_1	284	290	PF00498	0.725
LIG_FHA_1	330	336	PF00498	0.662
LIG_FHA_1	38	44	PF00498	0.491
LIG_FHA_2	322	328	PF00498	0.637
LIG_HCF-1_HBM_1	282	285	PF13415	0.483
LIG_LIR_Apic_2	169	175	PF02991	0.454
LIG_LIR_Gen_1	77	88	PF02991	0.433
LIG_LIR_Nem_3	100	105	PF02991	0.438
LIG_LIR_Nem_3	123	127	PF02991	0.487
LIG_LIR_Nem_3	77	83	PF02991	0.444
LIG_Pex14_2	66	70	PF04695	0.522
LIG_PTB_Apo_2	104	111	PF02174	0.370
LIG_PTB_Phospho_1	104	110	PF10480	0.370
LIG_SH2_CRK	93	97	PF00017	0.452
LIG_SH2_SRC	193	196	PF00017	0.491
LIG_SH2_STAP1	222	226	PF00017	0.500
LIG_SH2_STAT5	110	113	PF00017	0.223
LIG_SH2_STAT5	193	196	PF00017	0.491
LIG_SH2_STAT5	285	288	PF00017	0.531
LIG_SH2_STAT5	93	96	PF00017	0.406
LIG_SH3_1	72	78	PF00018	0.545
LIG_SH3_3	173	179	PF00018	0.421
LIG_SH3_3	239	245	PF00018	0.660
LIG_SH3_3	332	338	PF00018	0.728
LIG_SH3_3	53	59	PF00018	0.637
LIG_SH3_3	72	78	PF00018	0.505
LIG_SH3_3	81	87	PF00018	0.391
LIG_TRAF2_1	304	307	PF00917	0.680
LIG_TRAF2_1	310	313	PF00917	0.633
MOD_CDK_SPK_2	55	60	PF00069	0.650
MOD_CDK_SPxxK_3	55	62	PF00069	0.430
MOD_CK1_1	141	147	PF00069	0.423
MOD_CK1_1	178	184	PF00069	0.365
MOD_CK1_1	333	339	PF00069	0.754
MOD_CK1_1	344	350	PF00069	0.625
MOD_CK2_1	267	273	PF00069	0.467
MOD_CMANNOS	65	68	PF00535	0.482
MOD_Cter_Amidation	202	205	PF01082	0.491
MOD_GlcNHglycan	27	30	PF01048	0.583
MOD_GlcNHglycan	279	282	PF01048	0.609
MOD_GlcNHglycan	299	302	PF01048	0.640
MOD_GlcNHglycan	307	310	PF01048	0.732
MOD_GSK3_1	174	181	PF00069	0.366
MOD_GSK3_1	21	28	PF00069	0.561
MOD_GSK3_1	329	336	PF00069	0.766
MOD_GSK3_1	33	40	PF00069	0.420
MOD_NEK2_1	143	148	PF00069	0.377
MOD_NEK2_1	266	271	PF00069	0.576
MOD_NEK2_1	329	334	PF00069	0.700
MOD_PIKK_1	78	84	PF00454	0.500
MOD_PKA_2	21	27	PF00069	0.557
MOD_PKA_2	322	328	PF00069	0.648
MOD_PKA_2	329	335	PF00069	0.680
MOD_PKB_1	118	126	PF00069	0.491
MOD_PKB_1	249	257	PF00069	0.651
MOD_PKB_1	328	336	PF00069	0.555
MOD_Plk_1	141	147	PF00069	0.423
MOD_Plk_1	266	272	PF00069	0.532
MOD_Plk_2-3	267	273	PF00069	0.538
MOD_Plk_4	120	126	PF00069	0.482
MOD_Plk_4	27	33	PF00069	0.471
MOD_Plk_4	330	336	PF00069	0.695
MOD_Plk_4	38	44	PF00069	0.527
MOD_ProDKin_1	175	181	PF00069	0.441
MOD_ProDKin_1	283	289	PF00069	0.653
MOD_ProDKin_1	334	340	PF00069	0.777
MOD_ProDKin_1	55	61	PF00069	0.651
MOD_SUMO_for_1	220	223	PF00179	0.568
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.540
TRG_ENDOCYTIC_2	110	113	PF00928	0.370
TRG_ENDOCYTIC_2	93	96	PF00928	0.406
TRG_ER_diArg_1	133	136	PF00400	0.491
TRG_ER_diArg_1	190	192	PF00400	0.441
TRG_ER_diArg_1	20	23	PF00400	0.553
TRG_ER_diArg_1	228	230	PF00400	0.605
TRG_ER_diArg_1	59	62	PF00400	0.583
TRG_ER_diArg_1	70	72	PF00400	0.506
TRG_NES_CRM1_1	86	101	PF08389	0.472
TRG_Pf-PMV_PEXEL_1	190	195	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.423
TRG_PTS1	353	356	PF00515	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E3	Leptomonas seymouri	45%	100%
A0A3Q8ICX4	Leishmania donovani	91%	100%
A4I2C2	Leishmania infantum	93%	100%
E9AYH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5D437	Trypanosoma cruzi	33%	100%