Integrase catalytic domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein , putative

Species:

Leishmania major

UniProt:

Q4Q8Z6_LEIMA

TriTrypDb:

LmjF.26.1960 , LMJLV39_260026100 , LMJSD75_260024500

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0005875	microtubule associated complex	2	3
GO:0030286	dynein complex	3	3
GO:0032991	protein-containing complex	1	3
GO:1902494	catalytic complex	2	3

Expansion

Sequence features

Q4Q8Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Z6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	3
GO:0003777	microtubule motor activity	2	3
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0008569	minus-end-directed microtubule motor activity	3	3
GO:0045505	dynein intermediate chain binding	3	3
GO:0051959	dynein light intermediate chain binding	3	3
GO:0140657	ATP-dependent activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.489
CLV_C14_Caspase3-7	368	372	PF00656	0.522
CLV_NRD_NRD_1	157	159	PF00675	0.550
CLV_NRD_NRD_1	229	231	PF00675	0.465
CLV_NRD_NRD_1	433	435	PF00675	0.625
CLV_NRD_NRD_1	478	480	PF00675	0.527
CLV_NRD_NRD_1	662	664	PF00675	0.588
CLV_PCSK_FUR_1	229	233	PF00082	0.521
CLV_PCSK_KEX2_1	156	158	PF00082	0.553
CLV_PCSK_KEX2_1	229	231	PF00082	0.528
CLV_PCSK_KEX2_1	366	368	PF00082	0.530
CLV_PCSK_KEX2_1	478	480	PF00082	0.527
CLV_PCSK_KEX2_1	505	507	PF00082	0.656
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.628
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.574
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.665
CLV_PCSK_SKI1_1	106	110	PF00082	0.579
CLV_PCSK_SKI1_1	121	125	PF00082	0.479
CLV_PCSK_SKI1_1	315	319	PF00082	0.610
CLV_PCSK_SKI1_1	498	502	PF00082	0.578
CLV_PCSK_SKI1_1	635	639	PF00082	0.710
CLV_PCSK_SKI1_1	663	667	PF00082	0.584
DEG_APCC_DBOX_1	155	163	PF00400	0.603
DEG_APCC_DBOX_1	314	322	PF00400	0.602
DEG_APCC_DBOX_1	662	670	PF00400	0.487
DOC_CDC14_PxL_1	666	674	PF14671	0.601
DOC_CYCLIN_yCln2_LP_2	547	553	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	623	629	PF00134	0.581
DOC_MAPK_gen_1	156	164	PF00069	0.654
DOC_MAPK_gen_1	229	236	PF00069	0.513
DOC_MAPK_gen_1	495	504	PF00069	0.555
DOC_MAPK_gen_1	660	669	PF00069	0.600
DOC_MAPK_MEF2A_6	319	328	PF00069	0.659
DOC_MAPK_MEF2A_6	383	390	PF00069	0.413
DOC_MAPK_MEF2A_6	495	504	PF00069	0.621
DOC_PP1_RVXF_1	212	219	PF00149	0.561
DOC_PP1_RVXF_1	597	603	PF00149	0.544
DOC_PP2B_LxvP_1	547	550	PF13499	0.414
DOC_USP7_MATH_1	114	118	PF00917	0.662
DOC_USP7_MATH_1	15	19	PF00917	0.633
DOC_USP7_MATH_1	169	173	PF00917	0.459
DOC_USP7_MATH_1	20	24	PF00917	0.628
DOC_USP7_MATH_1	267	271	PF00917	0.718
DOC_USP7_MATH_1	415	419	PF00917	0.457
DOC_USP7_MATH_1	773	777	PF00917	0.784
DOC_USP7_UBL2_3	599	603	PF12436	0.536
DOC_USP7_UBL2_3	660	664	PF12436	0.696
DOC_WW_Pin1_4	18	23	PF00397	0.651
DOC_WW_Pin1_4	220	225	PF00397	0.511
DOC_WW_Pin1_4	256	261	PF00397	0.697
DOC_WW_Pin1_4	43	48	PF00397	0.606
DOC_WW_Pin1_4	603	608	PF00397	0.557
LIG_14-3-3_CanoR_1	171	175	PF00244	0.655
LIG_14-3-3_CanoR_1	325	335	PF00244	0.575
LIG_14-3-3_CanoR_1	403	412	PF00244	0.570
LIG_14-3-3_CanoR_1	448	456	PF00244	0.547
LIG_14-3-3_CanoR_1	479	485	PF00244	0.587
LIG_14-3-3_CanoR_1	531	539	PF00244	0.563
LIG_14-3-3_CanoR_1	799	806	PF00244	0.733
LIG_Actin_WH2_2	145	162	PF00022	0.589
LIG_APCC_ABBA_1	189	194	PF00400	0.578
LIG_APCC_ABBA_1	593	598	PF00400	0.505
LIG_BIR_II_1	1	5	PF00653	0.792
LIG_BIR_III_2	356	360	PF00653	0.648
LIG_BIR_III_4	371	375	PF00653	0.465
LIG_BIR_III_4	397	401	PF00653	0.509
LIG_CtBP_PxDLS_1	224	228	PF00389	0.533
LIG_FHA_1	122	128	PF00498	0.552
LIG_FHA_1	144	150	PF00498	0.623
LIG_FHA_1	328	334	PF00498	0.385
LIG_FHA_1	499	505	PF00498	0.572
LIG_FHA_1	603	609	PF00498	0.516
LIG_FHA_1	64	70	PF00498	0.614
LIG_FHA_2	195	201	PF00498	0.566
LIG_FHA_2	366	372	PF00498	0.573
LIG_FHA_2	457	463	PF00498	0.521
LIG_FHA_2	645	651	PF00498	0.685
LIG_FHA_2	724	730	PF00498	0.751
LIG_GBD_Chelix_1	615	623	PF00786	0.443
LIG_LIR_Gen_1	197	206	PF02991	0.461
LIG_LIR_Gen_1	3	14	PF02991	0.644
LIG_LIR_Gen_1	399	409	PF02991	0.538
LIG_LIR_Gen_1	508	518	PF02991	0.492
LIG_LIR_Gen_1	519	529	PF02991	0.509
LIG_LIR_Gen_1	530	539	PF02991	0.508
LIG_LIR_Gen_1	674	684	PF02991	0.635
LIG_LIR_LC3C_4	261	266	PF02991	0.676
LIG_LIR_Nem_3	166	170	PF02991	0.498
LIG_LIR_Nem_3	197	202	PF02991	0.658
LIG_LIR_Nem_3	38	42	PF02991	0.411
LIG_LIR_Nem_3	399	404	PF02991	0.530
LIG_LIR_Nem_3	508	514	PF02991	0.486
LIG_LIR_Nem_3	519	525	PF02991	0.416
LIG_LIR_Nem_3	674	679	PF02991	0.743
LIG_NRBOX	468	474	PF00104	0.565
LIG_PTB_Apo_2	302	309	PF02174	0.616
LIG_SH2_CRK	511	515	PF00017	0.577
LIG_SH2_GRB2like	641	644	PF00017	0.713
LIG_SH2_NCK_1	597	601	PF00017	0.494
LIG_SH2_NCK_1	676	680	PF00017	0.680
LIG_SH2_PTP2	401	404	PF00017	0.517
LIG_SH2_SRC	174	177	PF00017	0.449
LIG_SH2_SRC	192	195	PF00017	0.455
LIG_SH2_SRC	676	679	PF00017	0.694
LIG_SH2_STAP1	192	196	PF00017	0.605
LIG_SH2_STAP1	532	536	PF00017	0.510
LIG_SH2_STAT3	758	761	PF00017	0.584
LIG_SH2_STAT5	174	177	PF00017	0.437
LIG_SH2_STAT5	401	404	PF00017	0.482
LIG_SH2_STAT5	511	514	PF00017	0.536
LIG_SH2_STAT5	553	556	PF00017	0.538
LIG_SH3_3	257	263	PF00018	0.663
LIG_SH3_3	348	354	PF00018	0.591
LIG_SH3_3	678	684	PF00018	0.754
LIG_SH3_3	766	772	PF00018	0.729
LIG_SH3_3	774	780	PF00018	0.721
LIG_SH3_3	781	787	PF00018	0.810
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.544
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.490
LIG_SUMO_SIM_par_1	186	195	PF11976	0.417
LIG_SUMO_SIM_par_1	274	280	PF11976	0.397
LIG_SUMO_SIM_par_1	552	559	PF11976	0.578
LIG_SUMO_SIM_par_1	57	63	PF11976	0.481
LIG_TRAF2_1	459	462	PF00917	0.613
LIG_UBA3_1	335	339	PF00899	0.595
MOD_CDC14_SPxK_1	259	262	PF00782	0.543
MOD_CDC14_SPxK_1	46	49	PF00782	0.635
MOD_CDK_SPxK_1	256	262	PF00069	0.554
MOD_CDK_SPxK_1	43	49	PF00069	0.621
MOD_CK1_1	18	24	PF00069	0.751
MOD_CK1_1	2	8	PF00069	0.813
MOD_CK1_1	447	453	PF00069	0.369
MOD_CK1_1	798	804	PF00069	0.819
MOD_CK2_1	114	120	PF00069	0.624
MOD_CK2_1	194	200	PF00069	0.543
MOD_CK2_1	2	8	PF00069	0.638
MOD_CK2_1	289	295	PF00069	0.591
MOD_CK2_1	326	332	PF00069	0.579
MOD_CK2_1	456	462	PF00069	0.578
MOD_CK2_1	524	530	PF00069	0.591
MOD_CK2_1	644	650	PF00069	0.681
MOD_DYRK1A_RPxSP_1	256	260	PF00069	0.657
MOD_GlcNHglycan	116	119	PF01048	0.642
MOD_GlcNHglycan	176	179	PF01048	0.590
MOD_GlcNHglycan	23	26	PF01048	0.641
MOD_GlcNHglycan	252	255	PF01048	0.803
MOD_GlcNHglycan	405	408	PF01048	0.610
MOD_GlcNHglycan	518	521	PF01048	0.476
MOD_GlcNHglycan	572	575	PF01048	0.579
MOD_GlcNHglycan	590	593	PF01048	0.455
MOD_GlcNHglycan	629	632	PF01048	0.720
MOD_GlcNHglycan	696	699	PF01048	0.642
MOD_GlcNHglycan	742	745	PF01048	0.803
MOD_GlcNHglycan	777	780	PF01048	0.796
MOD_GSK3_1	170	177	PF00069	0.632
MOD_GSK3_1	250	257	PF00069	0.758
MOD_GSK3_1	267	274	PF00069	0.658
MOD_GSK3_1	556	563	PF00069	0.570
MOD_GSK3_1	566	573	PF00069	0.554
MOD_GSK3_1	598	605	PF00069	0.473
MOD_GSK3_1	700	707	PF00069	0.765
MOD_GSK3_1	724	731	PF00069	0.780
MOD_GSK3_1	734	741	PF00069	0.846
MOD_GSK3_1	789	796	PF00069	0.756
MOD_GSK3_1	797	804	PF00069	0.612
MOD_N-GLC_1	608	613	PF02516	0.586
MOD_N-GLC_1	75	80	PF02516	0.660
MOD_N-GLC_1	754	759	PF02516	0.799
MOD_N-GLC_2	305	307	PF02516	0.630
MOD_NEK2_1	170	175	PF00069	0.606
MOD_NEK2_1	225	230	PF00069	0.565
MOD_NEK2_1	303	308	PF00069	0.488
MOD_NEK2_1	509	514	PF00069	0.530
MOD_NEK2_1	602	607	PF00069	0.554
MOD_NEK2_1	608	613	PF00069	0.542
MOD_NEK2_1	705	710	PF00069	0.836
MOD_NEK2_1	730	735	PF00069	0.854
MOD_NEK2_1	740	745	PF00069	0.879
MOD_NEK2_1	754	759	PF00069	0.561
MOD_PIKK_1	121	127	PF00454	0.583
MOD_PIKK_1	608	614	PF00454	0.551
MOD_PIKK_1	721	727	PF00454	0.707
MOD_PIKK_1	78	84	PF00454	0.703
MOD_PIKK_1	94	100	PF00454	0.377
MOD_PKA_2	170	176	PF00069	0.596
MOD_PKA_2	447	453	PF00069	0.456
MOD_PKA_2	509	515	PF00069	0.410
MOD_PKA_2	530	536	PF00069	0.583
MOD_PKA_2	798	804	PF00069	0.861
MOD_PKB_1	256	264	PF00069	0.772
MOD_Plk_1	131	137	PF00069	0.594
MOD_Plk_1	192	198	PF00069	0.613
MOD_Plk_1	2	8	PF00069	0.638
MOD_Plk_1	360	366	PF00069	0.542
MOD_Plk_1	498	504	PF00069	0.575
MOD_Plk_1	541	547	PF00069	0.541
MOD_Plk_1	566	572	PF00069	0.503
MOD_Plk_1	677	683	PF00069	0.701
MOD_Plk_1	75	81	PF00069	0.630
MOD_Plk_1	754	760	PF00069	0.721
MOD_Plk_1	801	807	PF00069	0.831
MOD_Plk_2-3	650	656	PF00069	0.699
MOD_Plk_4	170	176	PF00069	0.530
MOD_Plk_4	360	366	PF00069	0.549
MOD_Plk_4	521	527	PF00069	0.532
MOD_Plk_4	542	548	PF00069	0.561
MOD_Plk_4	549	555	PF00069	0.513
MOD_Plk_4	560	566	PF00069	0.347
MOD_Plk_4	700	706	PF00069	0.784
MOD_ProDKin_1	18	24	PF00069	0.651
MOD_ProDKin_1	220	226	PF00069	0.512
MOD_ProDKin_1	256	262	PF00069	0.694
MOD_ProDKin_1	43	49	PF00069	0.608
MOD_ProDKin_1	603	609	PF00069	0.556
MOD_SUMO_rev_2	332	341	PF00179	0.494
MOD_SUMO_rev_2	438	447	PF00179	0.424
MOD_SUMO_rev_2	46	54	PF00179	0.594
MOD_SUMO_rev_2	649	658	PF00179	0.578
TRG_DiLeu_BaEn_1	313	318	PF01217	0.534
TRG_DiLeu_BaEn_1	427	432	PF01217	0.553
TRG_DiLeu_BaEn_4	440	446	PF01217	0.511
TRG_DiLeu_BaEn_4	461	467	PF01217	0.504
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.522
TRG_ENDOCYTIC_2	401	404	PF00928	0.517
TRG_ENDOCYTIC_2	511	514	PF00928	0.497
TRG_ENDOCYTIC_2	532	535	PF00928	0.574
TRG_ENDOCYTIC_2	597	600	PF00928	0.422
TRG_ENDOCYTIC_2	676	679	PF00928	0.670
TRG_ER_diArg_1	156	158	PF00400	0.387
TRG_ER_diArg_1	229	232	PF00400	0.533
TRG_NES_CRM1_1	179	194	PF08389	0.464
TRG_NLS_MonoExtN_4	229	234	PF00514	0.485
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHD7	Leptomonas seymouri	70%	97%
A0A0N1ILZ8	Leptomonas seymouri	23%	86%
A0A1X0P7D5	Trypanosomatidae	20%	77%
A0A1X0P8A9	Trypanosomatidae	37%	96%
A0A3S7X009	Leishmania donovani	87%	100%
A0A422N0G0	Trypanosoma rangeli	34%	100%
A0A422NQU4	Trypanosoma rangeli	22%	98%
A4HF40	Leishmania braziliensis	67%	92%
A4I2C4	Leishmania infantum	87%	100%
C9ZX89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZX90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AYH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%