Putative electon transport protein SCO1/SCO2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

electon transport protein SCO1/SCO2, putative

Species:

Leishmania major

UniProt:

Q4Q8Z5_LEIMA

TriTrypDb:

LmjF.26.1970 , LMJLV39_260026200 , LMJSD75_260024600

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	10
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q8Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Z5

Function

Biological processes
Term	Name	Level	Count
GO:0008535	respiratory chain complex IV assembly	7	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0017004	cytochrome complex assembly	6	2
GO:0022607	cellular component assembly	4	2
GO:0033108	mitochondrial respiratory chain complex assembly	6	2
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.627
CLV_C14_Caspase3-7	7	11	PF00656	0.353
CLV_NRD_NRD_1	219	221	PF00675	0.292
CLV_NRD_NRD_1	36	38	PF00675	0.366
CLV_NRD_NRD_1	73	75	PF00675	0.180
CLV_PCSK_FUR_1	34	38	PF00082	0.332
CLV_PCSK_KEX2_1	131	133	PF00082	0.248
CLV_PCSK_KEX2_1	219	221	PF00082	0.292
CLV_PCSK_KEX2_1	36	38	PF00082	0.367
CLV_PCSK_KEX2_1	73	75	PF00082	0.248
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.271
CLV_PCSK_SKI1_1	107	111	PF00082	0.236
CLV_PCSK_SKI1_1	47	51	PF00082	0.374
CLV_PCSK_SKI1_1	73	77	PF00082	0.244
DOC_CYCLIN_yClb5_NLxxxL_5	252	261	PF00134	0.575
DOC_MAPK_gen_1	34	42	PF00069	0.549
DOC_MAPK_gen_1	81	89	PF00069	0.511
DOC_MAPK_MEF2A_6	81	89	PF00069	0.511
DOC_MAPK_RevD_3	22	37	PF00069	0.272
DOC_PP1_RVXF_1	165	171	PF00149	0.430
DOC_PP4_FxxP_1	170	173	PF00568	0.430
DOC_PP4_FxxP_1	52	55	PF00568	0.583
DOC_USP7_MATH_1	48	52	PF00917	0.627
DOC_USP7_UBL2_3	110	114	PF12436	0.436
DOC_WW_Pin1_4	131	136	PF00397	0.424
DOC_WW_Pin1_4	143	148	PF00397	0.412
DOC_WW_Pin1_4	51	56	PF00397	0.588
LIG_14-3-3_CanoR_1	47	53	PF00244	0.644
LIG_14-3-3_CanoR_1	73	80	PF00244	0.446
LIG_BIR_II_1	1	5	PF00653	0.343
LIG_CtBP_PxDLS_1	99	103	PF00389	0.448
LIG_deltaCOP1_diTrp_1	119	125	PF00928	0.430
LIG_FHA_1	21	27	PF00498	0.287
LIG_FHA_2	153	159	PF00498	0.429
LIG_FHA_2	202	208	PF00498	0.486
LIG_FHA_2	74	80	PF00498	0.421
LIG_LIR_Apic_2	119	123	PF02991	0.430
LIG_LIR_Apic_2	51	55	PF02991	0.665
LIG_LIR_Gen_1	205	214	PF02991	0.489
LIG_LIR_Nem_3	119	124	PF02991	0.430
LIG_LIR_Nem_3	197	203	PF02991	0.436
LIG_LIR_Nem_3	205	211	PF02991	0.486
LIG_LIR_Nem_3	212	217	PF02991	0.455
LIG_PCNA_PIPBox_1	105	114	PF02747	0.448
LIG_Pex14_1	121	125	PF04695	0.430
LIG_Pex14_1	17	21	PF04695	0.272
LIG_Pex14_1	210	214	PF04695	0.479
LIG_Pex14_1	84	88	PF04695	0.417
LIG_SH2_CRK	214	218	PF00017	0.471
LIG_SH2_STAP1	214	218	PF00017	0.471
LIG_SH2_STAT5	141	144	PF00017	0.417
LIG_SH2_STAT5	169	172	PF00017	0.426
LIG_SH2_STAT5	183	186	PF00017	0.396
LIG_SH2_STAT5	192	195	PF00017	0.417
LIG_SH2_STAT5	203	206	PF00017	0.377
LIG_SH2_STAT5	86	89	PF00017	0.482
LIG_SH3_3	52	58	PF00018	0.580
LIG_SUMO_SIM_par_1	27	32	PF11976	0.272
LIG_SUMO_SIM_par_1	65	71	PF11976	0.526
LIG_TRAF2_1	173	176	PF00917	0.493
LIG_TRAF2_1	268	271	PF00917	0.617
LIG_UBA3_1	124	131	PF00899	0.471
LIG_WRC_WIRS_1	49	54	PF05994	0.659
MOD_CDK_SPK_2	143	148	PF00069	0.437
MOD_CDK_SPxK_1	131	137	PF00069	0.430
MOD_CK1_1	143	149	PF00069	0.500
MOD_CK1_1	201	207	PF00069	0.525
MOD_CK1_1	51	57	PF00069	0.625
MOD_CK2_1	152	158	PF00069	0.430
MOD_CK2_1	201	207	PF00069	0.482
MOD_CMANNOS	14	17	PF00535	0.272
MOD_Cter_Amidation	71	74	PF01082	0.251
MOD_GSK3_1	198	205	PF00069	0.520
MOD_GSK3_1	25	32	PF00069	0.281
MOD_GSK3_1	279	286	PF00069	0.665
MOD_NEK2_1	152	157	PF00069	0.471
MOD_NEK2_1	89	94	PF00069	0.426
MOD_NEK2_2	280	285	PF00069	0.661
MOD_PIKK_1	152	158	PF00454	0.430
MOD_PKA_1	73	79	PF00069	0.448
MOD_PKA_2	198	204	PF00069	0.520
MOD_PKA_2	227	233	PF00069	0.525
MOD_PKA_2	73	79	PF00069	0.448
MOD_Plk_1	185	191	PF00069	0.424
MOD_Plk_2-3	176	182	PF00069	0.431
MOD_Plk_4	185	191	PF00069	0.440
MOD_Plk_4	25	31	PF00069	0.289
MOD_Plk_4	256	262	PF00069	0.536
MOD_ProDKin_1	131	137	PF00069	0.424
MOD_ProDKin_1	143	149	PF00069	0.412
MOD_ProDKin_1	51	57	PF00069	0.582
MOD_SUMO_rev_2	259	269	PF00179	0.563
MOD_SUMO_rev_2	38	46	PF00179	0.585
MOD_SUMO_rev_2	65	71	PF00179	0.436
TRG_DiLeu_BaEn_1	180	185	PF01217	0.430
TRG_ENDOCYTIC_2	169	172	PF00928	0.417
TRG_ENDOCYTIC_2	214	217	PF00928	0.473
TRG_ENDOCYTIC_2	86	89	PF00928	0.418
TRG_ER_diArg_1	218	220	PF00400	0.492
TRG_ER_diArg_1	33	36	PF00400	0.540
TRG_ER_diArg_1	73	75	PF00400	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G6	Leptomonas seymouri	84%	66%
A0A0N0P3R3	Leptomonas seymouri	42%	92%
A0A1X0NWD3	Trypanosomatidae	28%	96%
A0A3Q8ID19	Leishmania donovani	97%	66%
A0A3R7L4G0	Trypanosoma rangeli	29%	100%
A0A3R7N2E4	Trypanosoma rangeli	76%	72%
A0A3S5H5E9	Leishmania donovani	39%	92%
A0A3S5H786	Leishmania donovani	32%	100%
A4H427	Leishmania braziliensis	39%	96%
A4HF41	Leishmania braziliensis	94%	100%
A4HSB1	Leishmania infantum	39%	92%
A4HYS6	Leishmania infantum	32%	100%
A4I2C5	Leishmania infantum	97%	66%
A6H784	Bos taurus	36%	100%
C9ZX87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	74%
E9AID5	Leishmania braziliensis	32%	100%
E9AK94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	97%
E9AUM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AYH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O43819	Homo sapiens	37%	100%
O97196	Leishmania major	39%	100%
Q1RKK4	Rickettsia bellii (strain RML369-C)	29%	100%
Q4QCW2	Leishmania major	32%	100%
Q4UKW2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	32%	100%
Q4UNH4	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	28%	100%
Q8VYP0	Arabidopsis thaliana	41%	86%
Q92JM5	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	27%	100%
Q9ZEB4	Rickettsia prowazekii (strain Madrid E)	25%	100%
V5BA25	Trypanosoma cruzi	73%	71%
V5BQS4	Trypanosoma cruzi	31%	85%