Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8Z4_LEIMA

TriTrypDb:

LmjF.26.1980 , LMJLV39_260026300 , LMJSD75_260024700

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Z4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.604
CLV_NRD_NRD_1	131	133	PF00675	0.542
CLV_NRD_NRD_1	134	136	PF00675	0.562
CLV_NRD_NRD_1	158	160	PF00675	0.422
CLV_NRD_NRD_1	17	19	PF00675	0.556
CLV_NRD_NRD_1	24	26	PF00675	0.620
CLV_NRD_NRD_1	3	5	PF00675	0.669
CLV_NRD_NRD_1	32	34	PF00675	0.633
CLV_PCSK_FUR_1	132	136	PF00082	0.468
CLV_PCSK_KEX2_1	133	135	PF00082	0.476
CLV_PCSK_KEX2_1	158	160	PF00082	0.594
CLV_PCSK_KEX2_1	17	19	PF00082	0.552
CLV_PCSK_KEX2_1	24	26	PF00082	0.623
CLV_PCSK_KEX2_1	3	5	PF00082	0.666
CLV_PCSK_KEX2_1	32	34	PF00082	0.642
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.476
CLV_PCSK_SKI1_1	126	130	PF00082	0.538
CLV_PCSK_SKI1_1	158	162	PF00082	0.590
DOC_CKS1_1	48	53	PF01111	0.755
DOC_MAPK_gen_1	112	122	PF00069	0.551
DOC_MAPK_gen_1	161	170	PF00069	0.553
DOC_MAPK_gen_1	181	189	PF00069	0.600
DOC_MAPK_gen_1	32	38	PF00069	0.691
DOC_MAPK_HePTP_8	160	172	PF00069	0.603
DOC_MAPK_MEF2A_6	163	172	PF00069	0.601
DOC_USP7_MATH_1	76	80	PF00917	0.706
DOC_USP7_UBL2_3	129	133	PF12436	0.537
DOC_WW_Pin1_4	47	52	PF00397	0.678
DOC_WW_Pin1_4	91	96	PF00397	0.644
LIG_14-3-3_CanoR_1	115	121	PF00244	0.580
LIG_14-3-3_CanoR_1	17	22	PF00244	0.739
LIG_14-3-3_CanoR_1	200	205	PF00244	0.600
LIG_14-3-3_CanoR_1	24	29	PF00244	0.685
LIG_14-3-3_CanoR_1	32	37	PF00244	0.589
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_CSL_BTD_1	8	11	PF09270	0.713
LIG_FHA_1	95	101	PF00498	0.689
LIG_FHA_2	200	206	PF00498	0.607
LIG_FHA_2	65	71	PF00498	0.791
LIG_LIR_Gen_1	125	131	PF02991	0.476
LIG_LIR_Nem_3	125	130	PF02991	0.484
LIG_LIR_Nem_3	169	175	PF02991	0.536
LIG_LIR_Nem_3	50	56	PF02991	0.688
LIG_PDZ_Class_2	201	206	PF00595	0.615
LIG_SH2_CRK	192	196	PF00017	0.489
LIG_SH2_STAT5	201	204	PF00017	0.623
LIG_SH3_3	35	41	PF00018	0.721
LIG_SH3_3	42	48	PF00018	0.590
LIG_SH3_3	95	101	PF00018	0.529
LIG_SUMO_SIM_par_1	96	102	PF11976	0.683
LIG_WRC_WIRS_1	201	206	PF05994	0.650
MOD_CK1_1	20	26	PF00069	0.745
MOD_CK1_1	94	100	PF00069	0.647
MOD_CK2_1	199	205	PF00069	0.596
MOD_CK2_1	64	70	PF00069	0.728
MOD_Cter_Amidation	30	33	PF01082	0.755
MOD_GlcNHglycan	175	178	PF01048	0.547
MOD_GlcNHglycan	55	59	PF01048	0.791
MOD_GSK3_1	16	23	PF00069	0.734
MOD_GSK3_1	171	178	PF00069	0.589
MOD_GSK3_1	190	197	PF00069	0.290
MOD_N-GLC_2	165	167	PF02516	0.397
MOD_NEK2_1	111	116	PF00069	0.633
MOD_NEK2_1	168	173	PF00069	0.504
MOD_NEK2_1	75	80	PF00069	0.560
MOD_PK_1	17	23	PF00069	0.743
MOD_PKA_1	17	23	PF00069	0.546
MOD_PKA_1	24	30	PF00069	0.604
MOD_PKA_1	3	9	PF00069	0.711
MOD_PKA_1	32	38	PF00069	0.608
MOD_PKA_2	111	117	PF00069	0.606
MOD_PKA_2	16	22	PF00069	0.554
MOD_PKA_2	199	205	PF00069	0.557
MOD_PKA_2	24	30	PF00069	0.598
MOD_PKA_2	3	9	PF00069	0.711
MOD_PKA_2	32	38	PF00069	0.589
MOD_Plk_1	168	174	PF00069	0.552
MOD_Plk_2-3	64	70	PF00069	0.557
MOD_Plk_4	148	154	PF00069	0.601
MOD_Plk_4	168	174	PF00069	0.495
MOD_Plk_4	94	100	PF00069	0.647
MOD_ProDKin_1	47	53	PF00069	0.681
MOD_ProDKin_1	91	97	PF00069	0.644
TRG_ENDOCYTIC_2	201	204	PF00928	0.576
TRG_ER_diArg_1	131	134	PF00400	0.573
TRG_ER_diArg_1	158	160	PF00400	0.422
TRG_ER_diArg_1	16	18	PF00400	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P8F5	Trypanosomatidae	23%	91%
A0A1X0P8T2	Trypanosomatidae	25%	91%
A0A3Q8IPD3	Leishmania donovani	90%	100%
A4HF42	Leishmania braziliensis	70%	94%
A4I2C6	Leishmania infantum	90%	100%
E9AYH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%