Apt1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8Z3_LEIMA

TriTrypDb:

LmjF.26.1990 , LMJLV39_260026400 , LMJSD75_260024800

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Z3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.442
CLV_NRD_NRD_1	13	15	PF00675	0.589
CLV_NRD_NRD_1	142	144	PF00675	0.587
CLV_NRD_NRD_1	168	170	PF00675	0.622
CLV_NRD_NRD_1	212	214	PF00675	0.622
CLV_PCSK_KEX2_1	13	15	PF00082	0.700
CLV_PCSK_KEX2_1	142	144	PF00082	0.673
CLV_PCSK_KEX2_1	168	170	PF00082	0.622
CLV_PCSK_KEX2_1	212	214	PF00082	0.622
CLV_PCSK_KEX2_1	67	69	PF00082	0.434
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.434
CLV_PCSK_PC7_1	138	144	PF00082	0.661
CLV_PCSK_SKI1_1	127	131	PF00082	0.403
CLV_PCSK_SKI1_1	146	150	PF00082	0.546
DOC_CKS1_1	96	101	PF01111	0.511
DOC_MAPK_gen_1	210	220	PF00069	0.593
DOC_MAPK_MEF2A_6	213	222	PF00069	0.587
DOC_PP1_RVXF_1	89	96	PF00149	0.641
DOC_SPAK_OSR1_1	94	98	PF12202	0.453
DOC_USP7_MATH_1	152	156	PF00917	0.752
DOC_USP7_MATH_1	17	21	PF00917	0.768
DOC_USP7_MATH_1	194	198	PF00917	0.534
DOC_WW_Pin1_4	167	172	PF00397	0.645
DOC_WW_Pin1_4	95	100	PF00397	0.519
LIG_14-3-3_CanoR_1	212	220	PF00244	0.677
LIG_BRCT_BRCA1_1	215	219	PF00533	0.620
LIG_BRCT_BRCA1_1	51	55	PF00533	0.459
LIG_FHA_1	213	219	PF00498	0.681
LIG_FHA_1	48	54	PF00498	0.437
LIG_FHA_2	98	104	PF00498	0.509
LIG_LIR_Apic_2	59	63	PF02991	0.524
LIG_LIR_Gen_1	125	135	PF02991	0.539
LIG_LIR_Gen_1	216	226	PF02991	0.631
LIG_LIR_Nem_3	125	131	PF02991	0.438
LIG_LIR_Nem_3	216	222	PF02991	0.673
LIG_OCRL_FandH_1	105	117	PF00620	0.429
LIG_PDZ_Class_2	221	226	PF00595	0.626
LIG_PTB_Apo_2	89	96	PF02174	0.444
LIG_REV1ctd_RIR_1	175	184	PF16727	0.647
LIG_SH2_STAP1	203	207	PF00017	0.686
LIG_SH2_STAT3	203	206	PF00017	0.631
LIG_SH3_2	144	149	PF14604	0.591
LIG_SH3_3	141	147	PF00018	0.652
MOD_CK1_1	208	214	PF00069	0.523
MOD_CK1_1	4	10	PF00069	0.590
MOD_GlcNHglycan	154	157	PF01048	0.627
MOD_GlcNHglycan	207	210	PF01048	0.495
MOD_GlcNHglycan	21	26	PF01048	0.511
MOD_GlcNHglycan	215	218	PF01048	0.585
MOD_GSK3_1	163	170	PF00069	0.664
MOD_GSK3_1	17	24	PF00069	0.672
MOD_GSK3_1	208	215	PF00069	0.492
MOD_GSK3_1	9	16	PF00069	0.694
MOD_N-GLC_1	173	178	PF02516	0.655
MOD_NEK2_1	122	127	PF00069	0.472
MOD_NEK2_1	163	168	PF00069	0.640
MOD_NEK2_1	218	223	PF00069	0.612
MOD_NEK2_1	46	51	PF00069	0.490
MOD_NEK2_2	104	109	PF00069	0.440
MOD_PIKK_1	62	68	PF00454	0.521
MOD_PKA_1	13	19	PF00069	0.573
MOD_PKA_1	212	218	PF00069	0.610
MOD_PKA_2	13	19	PF00069	0.560
MOD_PKA_2	211	217	PF00069	0.636
MOD_Plk_1	173	179	PF00069	0.656
MOD_Plk_4	173	179	PF00069	0.762
MOD_ProDKin_1	167	173	PF00069	0.643
MOD_ProDKin_1	95	101	PF00069	0.516
TRG_ER_diArg_1	141	143	PF00400	0.675
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIW3	Leptomonas seymouri	63%	100%
A0A1X0P7C9	Trypanosomatidae	42%	100%
A0A3R7LKB3	Trypanosoma rangeli	41%	100%
A0A3S7X011	Leishmania donovani	96%	100%
A4HF43	Leishmania braziliensis	73%	100%
A4I2C7	Leishmania infantum	96%	100%
E9AYH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BJ41	Trypanosoma cruzi	40%	100%