Methyltransf_11 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q8Z2_LEIMA

TriTrypDb:

LmjF.26.2000 , LMJLV39_260026500 , LMJSD75_260024900

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	9
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q8Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Z2

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.589
CLV_NRD_NRD_1	23	25	PF00675	0.446
CLV_NRD_NRD_1	343	345	PF00675	0.578
CLV_NRD_NRD_1	49	51	PF00675	0.763
CLV_PCSK_KEX2_1	121	123	PF00082	0.502
CLV_PCSK_KEX2_1	187	189	PF00082	0.553
CLV_PCSK_KEX2_1	343	345	PF00082	0.509
CLV_PCSK_KEX2_1	49	51	PF00082	0.742
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.523
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.552
CLV_PCSK_SKI1_1	172	176	PF00082	0.490
CLV_PCSK_SKI1_1	217	221	PF00082	0.489
CLV_PCSK_SKI1_1	306	310	PF00082	0.513
CLV_Separin_Metazoa	191	195	PF03568	0.336
DEG_Nend_UBRbox_3	1	3	PF02207	0.741
DEG_SPOP_SBC_1	219	223	PF00917	0.206
DOC_MAPK_gen_1	121	129	PF00069	0.291
DOC_MAPK_gen_1	24	32	PF00069	0.536
DOC_PP2B_LxvP_1	190	193	PF13499	0.348
DOC_USP7_MATH_1	58	62	PF00917	0.529
DOC_WW_Pin1_4	83	88	PF00397	0.362
LIG_14-3-3_CanoR_1	257	263	PF00244	0.306
LIG_14-3-3_CanoR_1	7	15	PF00244	0.712
LIG_14-3-3_CanoR_1	95	100	PF00244	0.411
LIG_APCC_ABBA_1	209	214	PF00400	0.314
LIG_BRCT_BRCA1_1	140	144	PF00533	0.258
LIG_BRCT_BRCA1_1	153	157	PF00533	0.258
LIG_FHA_1	175	181	PF00498	0.317
LIG_FHA_1	220	226	PF00498	0.297
LIG_FHA_1	31	37	PF00498	0.374
LIG_FHA_1	39	45	PF00498	0.304
LIG_FHA_1	91	97	PF00498	0.462
LIG_FHA_2	57	63	PF00498	0.473
LIG_LIR_Apic_2	100	106	PF02991	0.325
LIG_LIR_Apic_2	115	119	PF02991	0.297
LIG_LIR_Apic_2	175	179	PF02991	0.288
LIG_LIR_Gen_1	152	161	PF02991	0.285
LIG_LIR_Nem_3	152	156	PF02991	0.294
LIG_LIR_Nem_3	223	229	PF02991	0.272
LIG_LIR_Nem_3	238	243	PF02991	0.240
LIG_LYPXL_S_1	225	229	PF13949	0.543
LIG_LYPXL_yS_3	226	229	PF13949	0.348
LIG_PCNA_yPIPBox_3	251	263	PF02747	0.297
LIG_Pex14_2	153	157	PF04695	0.348
LIG_SH2_CRK	103	107	PF00017	0.405
LIG_SH2_CRK	116	120	PF00017	0.159
LIG_SH2_CRK	176	180	PF00017	0.348
LIG_SH2_CRK	27	31	PF00017	0.427
LIG_SH2_STAP1	92	96	PF00017	0.406
LIG_SH2_STAT5	176	179	PF00017	0.314
LIG_SH2_STAT5	85	88	PF00017	0.346
LIG_SH2_STAT5	92	95	PF00017	0.387
LIG_SH3_3	162	168	PF00018	0.297
LIG_SH3_3	249	255	PF00018	0.258
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.314
LIG_SUMO_SIM_anti_2	41	46	PF11976	0.229
LIG_SUMO_SIM_par_1	269	276	PF11976	0.264
MOD_CK1_1	166	172	PF00069	0.313
MOD_CK1_1	337	343	PF00069	0.297
MOD_CK1_1	38	44	PF00069	0.249
MOD_CK1_1	65	71	PF00069	0.486
MOD_CK1_1	88	94	PF00069	0.415
MOD_CK2_1	133	139	PF00069	0.271
MOD_CK2_1	276	282	PF00069	0.276
MOD_CK2_1	56	62	PF00069	0.474
MOD_CK2_1	95	101	PF00069	0.387
MOD_Cter_Amidation	119	122	PF01082	0.520
MOD_Cter_Amidation	170	173	PF01082	0.543
MOD_GlcNHglycan	169	172	PF01048	0.530
MOD_GlcNHglycan	37	40	PF01048	0.354
MOD_GSK3_1	13	20	PF00069	0.719
MOD_GSK3_1	163	170	PF00069	0.213
MOD_GSK3_1	56	63	PF00069	0.555
MOD_NEK2_1	138	143	PF00069	0.270
MOD_NEK2_1	258	263	PF00069	0.298
MOD_NEK2_1	334	339	PF00069	0.300
MOD_PIKK_1	163	169	PF00454	0.206
MOD_PIKK_1	90	96	PF00454	0.455
MOD_PK_1	95	101	PF00069	0.439
MOD_PKA_1	172	178	PF00069	0.328
MOD_PKA_2	6	12	PF00069	0.683
MOD_PKB_1	95	103	PF00069	0.362
MOD_Plk_1	285	291	PF00069	0.365
MOD_Plk_2-3	276	282	PF00069	0.348
MOD_Plk_2-3	314	320	PF00069	0.310
MOD_Plk_4	133	139	PF00069	0.272
MOD_Plk_4	258	264	PF00069	0.377
MOD_Plk_4	276	282	PF00069	0.219
MOD_Plk_4	337	343	PF00069	0.282
MOD_Plk_4	38	44	PF00069	0.366
MOD_ProDKin_1	83	89	PF00069	0.363
MOD_SUMO_rev_2	213	219	PF00179	0.354
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.283
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.258
TRG_ENDOCYTIC_2	226	229	PF00928	0.272
TRG_ENDOCYTIC_2	27	30	PF00928	0.386
TRG_ENDOCYTIC_2	80	83	PF00928	0.348
TRG_ER_diArg_1	342	344	PF00400	0.270
TRG_ER_diArg_1	48	50	PF00400	0.515
TRG_NLS_MonoExtC_3	120	125	PF00514	0.275
TRG_NLS_MonoExtN_4	119	126	PF00514	0.390
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D1	Leptomonas seymouri	72%	99%
A0A1X0P7E4	Trypanosomatidae	52%	95%
A0A3S7X035	Leishmania donovani	95%	99%
A0A422N3J7	Trypanosoma rangeli	55%	100%
A4HF44	Leishmania braziliensis	81%	98%
A4I2C8	Leishmania infantum	95%	99%
C9ZX82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	94%
E9AYI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
V5AUM3	Trypanosoma cruzi	54%	84%