PHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8Z1_LEIMA

TriTrypDb:

LmjF.26.2010 , LMJLV39_260026600 , LMJSD75_260025000

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Z1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.427
CLV_C14_Caspase3-7	302	306	PF00656	0.635
CLV_C14_Caspase3-7	580	584	PF00656	0.648
CLV_NRD_NRD_1	130	132	PF00675	0.663
CLV_NRD_NRD_1	147	149	PF00675	0.379
CLV_NRD_NRD_1	157	159	PF00675	0.417
CLV_NRD_NRD_1	464	466	PF00675	0.630
CLV_NRD_NRD_1	473	475	PF00675	0.650
CLV_NRD_NRD_1	520	522	PF00675	0.649
CLV_NRD_NRD_1	554	556	PF00675	0.752
CLV_NRD_NRD_1	558	560	PF00675	0.694
CLV_NRD_NRD_1	569	571	PF00675	0.561
CLV_NRD_NRD_1	573	575	PF00675	0.540
CLV_NRD_NRD_1	634	636	PF00675	0.705
CLV_NRD_NRD_1	653	655	PF00675	0.591
CLV_NRD_NRD_1	698	700	PF00675	0.707
CLV_NRD_NRD_1	709	711	PF00675	0.633
CLV_PCSK_FUR_1	554	558	PF00082	0.726
CLV_PCSK_KEX2_1	130	132	PF00082	0.670
CLV_PCSK_KEX2_1	147	149	PF00082	0.372
CLV_PCSK_KEX2_1	362	364	PF00082	0.628
CLV_PCSK_KEX2_1	371	373	PF00082	0.461
CLV_PCSK_KEX2_1	440	442	PF00082	0.624
CLV_PCSK_KEX2_1	450	452	PF00082	0.644
CLV_PCSK_KEX2_1	519	521	PF00082	0.716
CLV_PCSK_KEX2_1	554	556	PF00082	0.801
CLV_PCSK_KEX2_1	557	559	PF00082	0.795
CLV_PCSK_KEX2_1	569	571	PF00082	0.658
CLV_PCSK_KEX2_1	573	575	PF00082	0.597
CLV_PCSK_KEX2_1	634	636	PF00082	0.678
CLV_PCSK_KEX2_1	652	654	PF00082	0.599
CLV_PCSK_KEX2_1	697	699	PF00082	0.692
CLV_PCSK_KEX2_1	711	713	PF00082	0.562
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.604
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.417
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.581
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.556
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.630
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.816
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.615
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.670
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.556
CLV_PCSK_PC7_1	554	560	PF00082	0.717
CLV_PCSK_PC7_1	569	575	PF00082	0.567
CLV_PCSK_SKI1_1	268	272	PF00082	0.598
CLV_PCSK_SKI1_1	440	444	PF00082	0.582
CLV_PCSK_SKI1_1	64	68	PF00082	0.462
DEG_SPOP_SBC_1	249	253	PF00917	0.669
DEG_SPOP_SBC_1	692	696	PF00917	0.653
DEG_SPOP_SBC_1	716	720	PF00917	0.712
DOC_CKS1_1	141	146	PF01111	0.468
DOC_MAPK_gen_1	147	155	PF00069	0.503
DOC_MAPK_gen_1	362	369	PF00069	0.583
DOC_MAPK_gen_1	371	379	PF00069	0.468
DOC_PP4_MxPP_1	687	690	PF00568	0.575
DOC_USP7_MATH_1	132	136	PF00917	0.469
DOC_USP7_MATH_1	199	203	PF00917	0.599
DOC_USP7_MATH_1	206	210	PF00917	0.623
DOC_USP7_MATH_1	235	239	PF00917	0.673
DOC_USP7_MATH_1	249	253	PF00917	0.539
DOC_USP7_MATH_1	256	260	PF00917	0.614
DOC_USP7_MATH_1	269	273	PF00917	0.470
DOC_USP7_MATH_1	278	282	PF00917	0.561
DOC_USP7_MATH_1	290	294	PF00917	0.576
DOC_USP7_MATH_1	47	51	PF00917	0.553
DOC_USP7_MATH_1	496	500	PF00917	0.684
DOC_USP7_MATH_1	540	544	PF00917	0.675
DOC_USP7_MATH_1	579	583	PF00917	0.703
DOC_USP7_MATH_1	680	684	PF00917	0.722
DOC_USP7_MATH_1	693	697	PF00917	0.606
DOC_USP7_MATH_1	704	708	PF00917	0.602
DOC_USP7_MATH_1	716	720	PF00917	0.628
DOC_USP7_UBL2_3	443	447	PF12436	0.669
DOC_USP7_UBL2_3	519	523	PF12436	0.724
DOC_WW_Pin1_4	140	145	PF00397	0.418
DOC_WW_Pin1_4	227	232	PF00397	0.506
DOC_WW_Pin1_4	283	288	PF00397	0.653
DOC_WW_Pin1_4	303	308	PF00397	0.495
DOC_WW_Pin1_4	31	36	PF00397	0.630
DOC_WW_Pin1_4	623	628	PF00397	0.667
DOC_WW_Pin1_4	645	650	PF00397	0.710
LIG_14-3-3_CanoR_1	123	132	PF00244	0.531
LIG_14-3-3_CanoR_1	268	278	PF00244	0.608
LIG_14-3-3_CanoR_1	363	368	PF00244	0.518
LIG_14-3-3_CanoR_1	458	463	PF00244	0.635
LIG_14-3-3_CanoR_1	506	511	PF00244	0.628
LIG_BRCT_BRCA1_1	134	138	PF00533	0.436
LIG_BRCT_BRCA1_1	216	220	PF00533	0.616
LIG_BRCT_BRCA1_1	266	270	PF00533	0.605
LIG_BRCT_BRCA1_1	53	57	PF00533	0.492
LIG_CSL_BTD_1	228	231	PF09270	0.612
LIG_DLG_GKlike_1	506	514	PF00625	0.626
LIG_FAT_LD_1	106	114	PF03623	0.417
LIG_FHA_1	116	122	PF00498	0.493
LIG_FHA_1	162	168	PF00498	0.503
LIG_FHA_1	269	275	PF00498	0.644
LIG_FHA_1	313	319	PF00498	0.594
LIG_FHA_1	364	370	PF00498	0.475
LIG_FHA_1	598	604	PF00498	0.653
LIG_FHA_2	300	306	PF00498	0.656
LIG_FHA_2	337	343	PF00498	0.460
LIG_FHA_2	40	46	PF00498	0.677
LIG_FHA_2	416	422	PF00498	0.681
LIG_LIR_Gen_1	135	145	PF02991	0.352
LIG_LIR_Gen_1	161	167	PF02991	0.507
LIG_LIR_Nem_3	135	141	PF02991	0.497
LIG_LIR_Nem_3	161	166	PF02991	0.512
LIG_LIR_Nem_3	227	232	PF02991	0.659
LIG_LIR_Nem_3	54	60	PF02991	0.489
LIG_LIR_Nem_3	6	12	PF02991	0.370
LIG_PCNA_TLS_4	395	402	PF02747	0.614
LIG_PTB_Apo_2	273	280	PF02174	0.665
LIG_PTB_Phospho_1	273	279	PF10480	0.663
LIG_Rb_pABgroove_1	108	116	PF01858	0.363
LIG_SH2_CRK	163	167	PF00017	0.505
LIG_SH2_NCK_1	76	80	PF00017	0.470
LIG_SH2_PTP2	60	63	PF00017	0.468
LIG_SH2_STAP1	163	167	PF00017	0.505
LIG_SH2_STAT5	112	115	PF00017	0.437
LIG_SH2_STAT5	163	166	PF00017	0.512
LIG_SH2_STAT5	19	22	PF00017	0.486
LIG_SH2_STAT5	401	404	PF00017	0.653
LIG_SH2_STAT5	60	63	PF00017	0.459
LIG_SH3_2	624	629	PF14604	0.669
LIG_SH3_3	215	221	PF00018	0.617
LIG_SH3_3	225	231	PF00018	0.542
LIG_SH3_3	349	355	PF00018	0.568
LIG_SH3_3	621	627	PF00018	0.685
LIG_SH3_3	685	691	PF00018	0.703
LIG_SH3_3	83	89	PF00018	0.628
LIG_TRAF2_1	183	186	PF00917	0.368
LIG_TRAF2_1	628	631	PF00917	0.652
LIG_UBA3_1	152	159	PF00899	0.505
LIG_WW_3	462	466	PF00397	0.641
LIG_WW_3	626	630	PF00397	0.627
MOD_CDC14_SPxK_1	34	37	PF00782	0.632
MOD_CDC14_SPxK_1	626	629	PF00782	0.645
MOD_CDK_SPxK_1	31	37	PF00069	0.632
MOD_CDK_SPxK_1	623	629	PF00069	0.652
MOD_CDK_SPxxK_3	140	147	PF00069	0.483
MOD_CDK_SPxxK_3	227	234	PF00069	0.510
MOD_CDK_SPxxK_3	645	652	PF00069	0.712
MOD_CK1_1	119	125	PF00069	0.543
MOD_CK1_1	140	146	PF00069	0.355
MOD_CK1_1	190	196	PF00069	0.436
MOD_CK1_1	227	233	PF00069	0.582
MOD_CK1_1	298	304	PF00069	0.521
MOD_CK1_1	31	37	PF00069	0.600
MOD_CK1_1	365	371	PF00069	0.449
MOD_CK1_1	380	386	PF00069	0.613
MOD_CK1_1	388	394	PF00069	0.595
MOD_CK1_1	409	415	PF00069	0.659
MOD_CK1_1	487	493	PF00069	0.700
MOD_CK1_1	494	500	PF00069	0.639
MOD_CK1_1	50	56	PF00069	0.451
MOD_CK1_1	582	588	PF00069	0.706
MOD_CK1_1	589	595	PF00069	0.640
MOD_CK1_1	596	602	PF00069	0.571
MOD_CK1_1	659	665	PF00069	0.596
MOD_CK1_1	682	688	PF00069	0.722
MOD_CK1_1	718	724	PF00069	0.708
MOD_CK1_1	98	104	PF00069	0.478
MOD_CK2_1	143	149	PF00069	0.487
MOD_CK2_1	336	342	PF00069	0.460
MOD_CK2_1	388	394	PF00069	0.670
MOD_CK2_1	39	45	PF00069	0.646
MOD_CK2_1	50	56	PF00069	0.435
MOD_CK2_1	98	104	PF00069	0.478
MOD_Cter_Amidation	360	363	PF01082	0.599
MOD_Cter_Amidation	567	570	PF01082	0.666
MOD_Cter_Amidation	708	711	PF01082	0.647
MOD_GlcNHglycan	100	103	PF01048	0.400
MOD_GlcNHglycan	118	121	PF01048	0.412
MOD_GlcNHglycan	134	137	PF01048	0.340
MOD_GlcNHglycan	237	240	PF01048	0.664
MOD_GlcNHglycan	242	245	PF01048	0.620
MOD_GlcNHglycan	258	261	PF01048	0.531
MOD_GlcNHglycan	271	274	PF01048	0.593
MOD_GlcNHglycan	411	414	PF01048	0.661
MOD_GlcNHglycan	426	432	PF01048	0.555
MOD_GlcNHglycan	460	463	PF01048	0.587
MOD_GlcNHglycan	477	480	PF01048	0.606
MOD_GlcNHglycan	490	493	PF01048	0.628
MOD_GlcNHglycan	496	499	PF01048	0.560
MOD_GlcNHglycan	506	509	PF01048	0.488
MOD_GlcNHglycan	526	529	PF01048	0.755
MOD_GlcNHglycan	542	545	PF01048	0.682
MOD_GlcNHglycan	563	569	PF01048	0.611
MOD_GlcNHglycan	592	595	PF01048	0.590
MOD_GlcNHglycan	658	661	PF01048	0.693
MOD_GlcNHglycan	671	677	PF01048	0.555
MOD_GlcNHglycan	682	685	PF01048	0.649
MOD_GlcNHglycan	702	705	PF01048	0.523
MOD_GlcNHglycan	706	709	PF01048	0.679
MOD_GlcNHglycan	79	82	PF01048	0.463
MOD_GSK3_1	115	122	PF00069	0.383
MOD_GSK3_1	161	168	PF00069	0.504
MOD_GSK3_1	186	193	PF00069	0.401
MOD_GSK3_1	206	213	PF00069	0.546
MOD_GSK3_1	250	257	PF00069	0.580
MOD_GSK3_1	260	267	PF00069	0.611
MOD_GSK3_1	290	297	PF00069	0.653
MOD_GSK3_1	299	306	PF00069	0.588
MOD_GSK3_1	377	384	PF00069	0.611
MOD_GSK3_1	385	392	PF00069	0.607
MOD_GSK3_1	454	461	PF00069	0.587
MOD_GSK3_1	46	53	PF00069	0.561
MOD_GSK3_1	480	487	PF00069	0.713
MOD_GSK3_1	490	497	PF00069	0.608
MOD_GSK3_1	498	505	PF00069	0.509
MOD_GSK3_1	579	586	PF00069	0.704
MOD_GSK3_1	588	595	PF00069	0.615
MOD_GSK3_1	612	619	PF00069	0.692
MOD_GSK3_1	638	645	PF00069	0.658
MOD_GSK3_1	678	685	PF00069	0.715
MOD_GSK3_1	700	707	PF00069	0.667
MOD_GSK3_1	715	722	PF00069	0.584
MOD_N-GLC_1	377	382	PF02516	0.593
MOD_N-GLC_1	416	421	PF02516	0.682
MOD_N-GLC_1	535	540	PF02516	0.625
MOD_N-GLC_1	704	709	PF02516	0.703
MOD_N-GLC_2	262	264	PF02516	0.610
MOD_NEK2_1	114	119	PF00069	0.549
MOD_NEK2_1	174	179	PF00069	0.489
MOD_NEK2_1	210	215	PF00069	0.549
MOD_NEK2_1	336	341	PF00069	0.496
MOD_NEK2_1	377	382	PF00069	0.593
MOD_NEK2_1	386	391	PF00069	0.602
MOD_NEK2_1	46	51	PF00069	0.504
MOD_NEK2_1	587	592	PF00069	0.659
MOD_PIKK_1	166	172	PF00454	0.488
MOD_PIKK_1	174	180	PF00454	0.415
MOD_PIKK_1	199	205	PF00454	0.620
MOD_PIKK_1	336	342	PF00454	0.504
MOD_PIKK_1	612	618	PF00454	0.646
MOD_PKA_1	362	368	PF00069	0.489
MOD_PKA_1	519	525	PF00069	0.673
MOD_PKA_1	611	617	PF00069	0.582
MOD_PKA_1	698	704	PF00069	0.587
MOD_PKA_2	122	128	PF00069	0.579
MOD_PKA_2	214	220	PF00069	0.617
MOD_PKA_2	233	239	PF00069	0.495
MOD_PKA_2	362	368	PF00069	0.489
MOD_PKA_2	386	392	PF00069	0.682
MOD_PKA_2	519	525	PF00069	0.581
MOD_PKA_2	698	704	PF00069	0.615
MOD_PKA_2	77	83	PF00069	0.457
MOD_Plk_1	406	412	PF00069	0.647
MOD_Plk_1	535	541	PF00069	0.578
MOD_Plk_1	582	588	PF00069	0.663
MOD_Plk_1	672	678	PF00069	0.645
MOD_Plk_4	137	143	PF00069	0.350
MOD_Plk_4	161	167	PF00069	0.507
MOD_Plk_4	187	193	PF00069	0.403
MOD_Plk_4	214	220	PF00069	0.617
MOD_Plk_4	224	230	PF00069	0.546
MOD_Plk_4	295	301	PF00069	0.526
MOD_ProDKin_1	140	146	PF00069	0.418
MOD_ProDKin_1	227	233	PF00069	0.508
MOD_ProDKin_1	283	289	PF00069	0.653
MOD_ProDKin_1	303	309	PF00069	0.494
MOD_ProDKin_1	31	37	PF00069	0.632
MOD_ProDKin_1	623	629	PF00069	0.667
MOD_ProDKin_1	645	651	PF00069	0.711
MOD_SUMO_rev_2	217	227	PF00179	0.523
MOD_SUMO_rev_2	432	442	PF00179	0.574
TRG_DiLeu_BaEn_4	672	678	PF01217	0.688
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.545
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.518
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.643
TRG_ENDOCYTIC_2	163	166	PF00928	0.512
TRG_ER_diArg_1	130	132	PF00400	0.626
TRG_ER_diArg_1	554	557	PF00400	0.724
TRG_ER_diArg_1	558	561	PF00400	0.689
TRG_ER_diArg_1	569	571	PF00400	0.572
TRG_ER_diArg_1	574	577	PF00400	0.522
TRG_ER_diArg_1	634	636	PF00400	0.674
TRG_ER_diArg_1	652	654	PF00400	0.555
TRG_ER_diArg_1	710	713	PF00400	0.585
TRG_NLS_Bipartite_1	555	577	PF00514	0.671
TRG_NLS_Bipartite_1	697	714	PF00514	0.648
TRG_NLS_MonoCore_2	554	559	PF00514	0.726
TRG_NLS_MonoCore_2	572	577	PF00514	0.544
TRG_NLS_MonoExtC_3	518	523	PF00514	0.614
TRG_NLS_MonoExtC_3	554	559	PF00514	0.726
TRG_NLS_MonoExtC_3	572	577	PF00514	0.544
TRG_NLS_MonoExtN_4	472	478	PF00514	0.670
TRG_NLS_MonoExtN_4	554	560	PF00514	0.731
TRG_NLS_MonoExtN_4	570	577	PF00514	0.562
TRG_NLS_MonoExtN_4	607	614	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7G6	Leishmania donovani	86%	100%
A4HF45	Leishmania braziliensis	60%	100%
A4I2C9	Leishmania infantum	86%	100%
E9AYI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%