Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8Y9_LEIMA

TriTrypDb:

LmjF.26.2030 , LMJLV39_260026800 , LMJSD75_260025200

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Y9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	517	521	PF00656	0.730
CLV_C14_Caspase3-7	664	668	PF00656	0.588
CLV_NRD_NRD_1	357	359	PF00675	0.537
CLV_NRD_NRD_1	40	42	PF00675	0.548
CLV_NRD_NRD_1	491	493	PF00675	0.483
CLV_NRD_NRD_1	585	587	PF00675	0.634
CLV_PCSK_KEX2_1	357	359	PF00082	0.539
CLV_PCSK_KEX2_1	40	42	PF00082	0.566
CLV_PCSK_KEX2_1	585	587	PF00082	0.578
CLV_PCSK_SKI1_1	123	127	PF00082	0.694
CLV_PCSK_SKI1_1	331	335	PF00082	0.424
CLV_PCSK_SKI1_1	595	599	PF00082	0.472
CLV_PCSK_SKI1_1	768	772	PF00082	0.436
CLV_PCSK_SKI1_1	91	95	PF00082	0.438
CLV_Separin_Metazoa	148	152	PF03568	0.512
DEG_APCC_DBOX_1	40	48	PF00400	0.606
DEG_APCC_DBOX_1	67	75	PF00400	0.438
DEG_Nend_UBRbox_3	1	3	PF02207	0.431
DOC_CKS1_1	154	159	PF01111	0.491
DOC_CKS1_1	588	593	PF01111	0.428
DOC_CKS1_1	62	67	PF01111	0.467
DOC_CYCLIN_RxL_1	328	337	PF00134	0.439
DOC_CYCLIN_RxL_1	765	775	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.499
DOC_MAPK_gen_1	357	364	PF00069	0.475
DOC_MAPK_gen_1	37	46	PF00069	0.560
DOC_PP1_RVXF_1	674	680	PF00149	0.503
DOC_PP2B_LxvP_1	115	118	PF13499	0.533
DOC_PP4_FxxP_1	7	10	PF00568	0.717
DOC_USP7_MATH_1	178	182	PF00917	0.682
DOC_USP7_MATH_1	187	191	PF00917	0.758
DOC_USP7_MATH_1	388	392	PF00917	0.393
DOC_USP7_MATH_1	501	505	PF00917	0.751
DOC_USP7_MATH_1	518	522	PF00917	0.653
DOC_USP7_MATH_1	524	528	PF00917	0.601
DOC_USP7_MATH_1	617	621	PF00917	0.392
DOC_USP7_MATH_1	626	630	PF00917	0.377
DOC_USP7_MATH_1	704	708	PF00917	0.538
DOC_USP7_MATH_1	753	757	PF00917	0.628
DOC_WW_Pin1_4	134	139	PF00397	0.695
DOC_WW_Pin1_4	153	158	PF00397	0.386
DOC_WW_Pin1_4	174	179	PF00397	0.467
DOC_WW_Pin1_4	189	194	PF00397	0.611
DOC_WW_Pin1_4	587	592	PF00397	0.452
DOC_WW_Pin1_4	61	66	PF00397	0.519
DOC_WW_Pin1_4	787	792	PF00397	0.557
LIG_14-3-3_CanoR_1	123	131	PF00244	0.504
LIG_14-3-3_CanoR_1	222	230	PF00244	0.380
LIG_14-3-3_CanoR_1	248	255	PF00244	0.489
LIG_14-3-3_CanoR_1	40	44	PF00244	0.523
LIG_14-3-3_CanoR_1	45	50	PF00244	0.437
LIG_14-3-3_CanoR_1	6	10	PF00244	0.542
LIG_14-3-3_CanoR_1	676	680	PF00244	0.506
LIG_Actin_WH2_2	25	42	PF00022	0.521
LIG_Actin_WH2_2	682	700	PF00022	0.469
LIG_APCC_ABBA_1	556	561	PF00400	0.498
LIG_BIR_III_4	12	16	PF00653	0.494
LIG_BIR_III_4	58	62	PF00653	0.545
LIG_BRCT_BRCA1_1	772	776	PF00533	0.306
LIG_Clathr_ClatBox_1	263	267	PF01394	0.462
LIG_DLG_GKlike_1	45	53	PF00625	0.408
LIG_FHA_1	105	111	PF00498	0.439
LIG_FHA_1	145	151	PF00498	0.483
LIG_FHA_1	154	160	PF00498	0.463
LIG_FHA_1	193	199	PF00498	0.543
LIG_FHA_1	214	220	PF00498	0.341
LIG_FHA_1	287	293	PF00498	0.431
LIG_FHA_1	298	304	PF00498	0.355
LIG_FHA_1	425	431	PF00498	0.624
LIG_FHA_1	454	460	PF00498	0.460
LIG_FHA_1	524	530	PF00498	0.718
LIG_FHA_1	537	543	PF00498	0.336
LIG_FHA_1	765	771	PF00498	0.532
LIG_FHA_1	778	784	PF00498	0.437
LIG_FHA_2	135	141	PF00498	0.502
LIG_FHA_2	201	207	PF00498	0.420
LIG_FHA_2	455	461	PF00498	0.440
LIG_FHA_2	591	597	PF00498	0.396
LIG_FHA_2	759	765	PF00498	0.527
LIG_FHA_2	9	15	PF00498	0.486
LIG_GBD_Chelix_1	258	266	PF00786	0.398
LIG_LIR_Apic_2	5	10	PF02991	0.446
LIG_LIR_Gen_1	260	269	PF02991	0.461
LIG_LIR_Gen_1	322	330	PF02991	0.397
LIG_LIR_Gen_1	42	49	PF02991	0.457
LIG_LIR_Nem_3	260	264	PF02991	0.450
LIG_LIR_Nem_3	322	326	PF02991	0.374
LIG_LIR_Nem_3	42	46	PF02991	0.555
LIG_MYND_2	142	146	PF01753	0.471
LIG_PDZ_Class_1	787	792	PF00595	0.627
LIG_SH2_NCK_1	318	322	PF00017	0.399
LIG_SH2_NCK_1	407	411	PF00017	0.507
LIG_SH2_PTP2	323	326	PF00017	0.434
LIG_SH2_SRC	726	729	PF00017	0.443
LIG_SH2_STAP1	350	354	PF00017	0.620
LIG_SH2_STAP1	690	694	PF00017	0.333
LIG_SH2_STAT5	323	326	PF00017	0.399
LIG_SH2_STAT5	441	444	PF00017	0.530
LIG_SH2_STAT5	480	483	PF00017	0.401
LIG_SH2_STAT5	592	595	PF00017	0.409
LIG_SH2_STAT5	726	729	PF00017	0.443
LIG_SH3_1	151	157	PF00018	0.455
LIG_SH3_2	118	123	PF14604	0.477
LIG_SH3_3	115	121	PF00018	0.596
LIG_SH3_3	136	142	PF00018	0.661
LIG_SH3_3	151	157	PF00018	0.298
LIG_SH3_3	374	380	PF00018	0.510
LIG_SH3_3	585	591	PF00018	0.596
LIG_SH3_3	64	70	PF00018	0.519
LIG_SUMO_SIM_anti_2	596	601	PF11976	0.505
LIG_SUMO_SIM_anti_2	603	608	PF11976	0.429
LIG_SUMO_SIM_par_1	286	293	PF11976	0.365
LIG_SUMO_SIM_par_1	45	51	PF11976	0.421
LIG_TRAF2_1	412	415	PF00917	0.612
LIG_TRAF2_1	514	517	PF00917	0.687
LIG_TRAF2_1	761	764	PF00917	0.563
LIG_UBA3_1	378	384	PF00899	0.396
LIG_WW_1	642	645	PF00397	0.379
MOD_CDK_SPK_2	63	68	PF00069	0.469
MOD_CDK_SPxxK_3	153	160	PF00069	0.492
MOD_CDK_SPxxK_3	61	68	PF00069	0.471
MOD_CK1_1	174	180	PF00069	0.434
MOD_CK1_1	270	276	PF00069	0.633
MOD_CK1_1	312	318	PF00069	0.464
MOD_CK1_1	353	359	PF00069	0.661
MOD_CK1_1	365	371	PF00069	0.420
MOD_CK1_1	391	397	PF00069	0.396
MOD_CK1_1	579	585	PF00069	0.625
MOD_CK1_1	707	713	PF00069	0.565
MOD_CK1_1	8	14	PF00069	0.571
MOD_CK2_1	134	140	PF00069	0.513
MOD_CK2_1	200	206	PF00069	0.407
MOD_CK2_1	363	369	PF00069	0.479
MOD_CK2_1	45	51	PF00069	0.459
MOD_CK2_1	454	460	PF00069	0.431
MOD_CK2_1	564	570	PF00069	0.600
MOD_CK2_1	718	724	PF00069	0.395
MOD_CK2_1	758	764	PF00069	0.538
MOD_CK2_1	8	14	PF00069	0.479
MOD_GlcNHglycan	173	176	PF01048	0.488
MOD_GlcNHglycan	184	187	PF01048	0.598
MOD_GlcNHglycan	189	192	PF01048	0.668
MOD_GlcNHglycan	272	275	PF01048	0.550
MOD_GlcNHglycan	303	306	PF01048	0.467
MOD_GlcNHglycan	311	314	PF01048	0.548
MOD_GlcNHglycan	336	339	PF01048	0.420
MOD_GlcNHglycan	365	368	PF01048	0.456
MOD_GlcNHglycan	465	468	PF01048	0.431
MOD_GlcNHglycan	503	506	PF01048	0.732
MOD_GlcNHglycan	520	523	PF01048	0.618
MOD_GlcNHglycan	525	529	PF01048	0.562
MOD_GlcNHglycan	578	581	PF01048	0.721
MOD_GlcNHglycan	619	622	PF01048	0.521
MOD_GlcNHglycan	667	671	PF01048	0.689
MOD_GlcNHglycan	785	788	PF01048	0.538
MOD_GSK3_1	100	107	PF00069	0.421
MOD_GSK3_1	119	126	PF00069	0.579
MOD_GSK3_1	174	181	PF00069	0.518
MOD_GSK3_1	270	277	PF00069	0.555
MOD_GSK3_1	297	304	PF00069	0.300
MOD_GSK3_1	346	353	PF00069	0.588
MOD_GSK3_1	358	365	PF00069	0.526
MOD_GSK3_1	520	527	PF00069	0.721
MOD_GSK3_1	536	543	PF00069	0.383
MOD_GSK3_1	575	582	PF00069	0.624
MOD_GSK3_1	692	699	PF00069	0.446
MOD_GSK3_1	707	714	PF00069	0.541
MOD_GSK3_1	718	725	PF00069	0.439
MOD_GSK3_1	758	765	PF00069	0.557
MOD_GSK3_1	777	784	PF00069	0.446
MOD_N-GLC_1	236	241	PF02516	0.449
MOD_N-GLC_1	309	314	PF02516	0.501
MOD_N-GLC_2	169	171	PF02516	0.311
MOD_NEK2_1	200	205	PF00069	0.530
MOD_NEK2_1	236	241	PF00069	0.449
MOD_NEK2_1	334	339	PF00069	0.344
MOD_NEK2_1	39	44	PF00069	0.527
MOD_NEK2_1	431	436	PF00069	0.652
MOD_NEK2_1	488	493	PF00069	0.416
MOD_NEK2_1	536	541	PF00069	0.490
MOD_NEK2_1	600	605	PF00069	0.393
MOD_NEK2_1	693	698	PF00069	0.482
MOD_NEK2_1	722	727	PF00069	0.456
MOD_NEK2_1	783	788	PF00069	0.566
MOD_PIKK_1	178	184	PF00454	0.563
MOD_PIKK_1	367	373	PF00454	0.369
MOD_PIKK_1	579	585	PF00454	0.612
MOD_PIKK_1	704	710	PF00454	0.526
MOD_PIKK_1	777	783	PF00454	0.391
MOD_PKA_2	221	227	PF00069	0.396
MOD_PKA_2	247	253	PF00069	0.449
MOD_PKA_2	270	276	PF00069	0.480
MOD_PKA_2	39	45	PF00069	0.539
MOD_PKA_2	5	11	PF00069	0.477
MOD_PKA_2	518	524	PF00069	0.629
MOD_PKA_2	564	570	PF00069	0.504
MOD_PKA_2	653	659	PF00069	0.627
MOD_PKA_2	675	681	PF00069	0.500
MOD_PKA_2	722	728	PF00069	0.448
MOD_PKA_2	781	787	PF00069	0.592
MOD_Plk_1	236	242	PF00069	0.449
MOD_Plk_1	286	292	PF00069	0.469
MOD_Plk_1	350	356	PF00069	0.645
MOD_Plk_1	524	530	PF00069	0.517
MOD_Plk_1	595	601	PF00069	0.442
MOD_Plk_1	762	768	PF00069	0.495
MOD_Plk_2-3	424	430	PF00069	0.594
MOD_Plk_4	200	206	PF00069	0.407
MOD_Plk_4	319	325	PF00069	0.448
MOD_Plk_4	350	356	PF00069	0.674
MOD_Plk_4	413	419	PF00069	0.630
MOD_Plk_4	595	601	PF00069	0.446
MOD_Plk_4	626	632	PF00069	0.284
MOD_Plk_4	675	681	PF00069	0.488
MOD_Plk_4	707	713	PF00069	0.550
MOD_Plk_4	722	728	PF00069	0.425
MOD_Plk_4	753	759	PF00069	0.638
MOD_ProDKin_1	134	140	PF00069	0.689
MOD_ProDKin_1	153	159	PF00069	0.379
MOD_ProDKin_1	174	180	PF00069	0.476
MOD_ProDKin_1	189	195	PF00069	0.609
MOD_ProDKin_1	587	593	PF00069	0.452
MOD_ProDKin_1	61	67	PF00069	0.511
MOD_SUMO_rev_2	657	663	PF00179	0.493
TRG_DiLeu_BaEn_1	51	56	PF01217	0.459
TRG_DiLeu_BaEn_2	259	265	PF01217	0.435
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.537
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.467
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.482
TRG_DiLeu_BaLyEn_6	765	770	PF01217	0.440
TRG_ENDOCYTIC_2	323	326	PF00928	0.324
TRG_ENDOCYTIC_2	690	693	PF00928	0.323
TRG_ER_diArg_1	39	41	PF00400	0.547
TRG_NES_CRM1_1	256	268	PF08389	0.406
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P479	Leptomonas seymouri	60%	100%
A0A1X0P8E3	Trypanosomatidae	31%	100%
A0A3Q8IDS4	Leishmania donovani	92%	100%
A0A3R7LMQ0	Trypanosoma rangeli	34%	100%
A4HF47	Leishmania braziliensis	79%	100%
A4I2D1	Leishmania infantum	91%	100%
C9ZX77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	96%
E9AYI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BJ35	Trypanosoma cruzi	33%	100%