PQ-loop repeat-containing protein 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PQ loop repeat, putative

Species:

Leishmania major

UniProt:

Q4Q8Y8_LEIMA

TriTrypDb:

LmjF.26.2040 , LMJLV39_260026900 , LMJSD75_260025300

Length:

356

Annotations

LeishMANIAdb annotations

Shows homology to LAAT transporters found in mammals (SLC66 family).. Localization: Lysosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	2
GO:0005802	trans-Golgi network	4	2
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	9
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0031984	organelle subcompartment	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0098791	Golgi apparatus subcompartment	3	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q8Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Y8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006869	lipid transport	5	2
GO:0009987	cellular process	1	2
GO:0015748	organophosphate ester transport	5	2
GO:0015914	phospholipid transport	6	2
GO:0016043	cellular component organization	3	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0016482	cytosolic transport	4	2
GO:0034204	lipid translocation	4	2
GO:0042147	retrograde transport, endosome to Golgi	5	2
GO:0045332	phospholipid translocation	5	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071702	organic substance transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097035	regulation of membrane lipid distribution	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	269	271	PF00675	0.283
CLV_PCSK_KEX2_1	268	270	PF00082	0.283
CLV_PCSK_KEX2_1	329	331	PF00082	0.371
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.401
CLV_PCSK_PC7_1	265	271	PF00082	0.321
CLV_PCSK_PC7_1	325	331	PF00082	0.387
CLV_PCSK_SKI1_1	298	302	PF00082	0.521
DEG_COP1_1	139	147	PF00400	0.608
DEG_Nend_UBRbox_2	1	3	PF02207	0.398
DEG_SPOP_SBC_1	118	122	PF00917	0.650
DEG_SPOP_SBC_1	158	162	PF00917	0.663
DOC_CKS1_1	208	213	PF01111	0.460
DOC_MAPK_gen_1	329	336	PF00069	0.597
DOC_MAPK_MEF2A_6	5	14	PF00069	0.334
DOC_MAPK_RevD_3	316	330	PF00069	0.444
DOC_PP1_RVXF_1	288	295	PF00149	0.385
DOC_PP1_RVXF_1	3	9	PF00149	0.378
DOC_PP2B_LxvP_1	258	261	PF13499	0.291
DOC_USP7_MATH_1	119	123	PF00917	0.664
DOC_USP7_MATH_1	158	162	PF00917	0.691
DOC_USP7_MATH_1	38	42	PF00917	0.291
DOC_WW_Pin1_4	143	148	PF00397	0.678
DOC_WW_Pin1_4	171	176	PF00397	0.653
DOC_WW_Pin1_4	207	212	PF00397	0.513
DOC_WW_Pin1_4	34	39	PF00397	0.479
LIG_14-3-3_CanoR_1	268	278	PF00244	0.483
LIG_Actin_WH2_2	250	267	PF00022	0.385
LIG_APCC_ABBA_1	309	314	PF00400	0.319
LIG_CtBP_PxDLS_1	175	179	PF00389	0.639
LIG_FHA_1	147	153	PF00498	0.708
LIG_FHA_1	270	276	PF00498	0.483
LIG_FHA_1	28	34	PF00498	0.558
LIG_FHA_1	313	319	PF00498	0.294
LIG_FHA_1	47	53	PF00498	0.270
LIG_FHA_2	107	113	PF00498	0.548
LIG_HP1_1	38	42	PF01393	0.325
LIG_LIR_Apic_2	205	211	PF02991	0.451
LIG_LIR_Gen_1	188	198	PF02991	0.545
LIG_LIR_Nem_3	188	194	PF02991	0.589
LIG_LIR_Nem_3	34	39	PF02991	0.469
LIG_NBox_RRM_1	8	18	PF00076	0.343
LIG_NRBOX	274	280	PF00104	0.367
LIG_NRBOX	60	66	PF00104	0.308
LIG_Pex14_2	191	195	PF04695	0.600
LIG_REV1ctd_RIR_1	193	201	PF16727	0.528
LIG_SH2_CRK	216	220	PF00017	0.466
LIG_SH2_CRK	233	237	PF00017	0.268
LIG_SH2_CRK	249	253	PF00017	0.385
LIG_SH2_CRK	324	328	PF00017	0.573
LIG_SH2_CRK	36	40	PF00017	0.291
LIG_SH2_STAP1	296	300	PF00017	0.321
LIG_SH2_STAT3	20	23	PF00017	0.329
LIG_SH2_STAT3	296	299	PF00017	0.321
LIG_SH2_STAT5	20	23	PF00017	0.345
LIG_SH2_STAT5	218	221	PF00017	0.359
LIG_SH2_STAT5	249	252	PF00017	0.291
LIG_SH2_STAT5	293	296	PF00017	0.330
LIG_SH2_STAT5	55	58	PF00017	0.347
LIG_SH3_3	10	16	PF00018	0.325
LIG_SH3_3	141	147	PF00018	0.632
LIG_SUMO_SIM_anti_2	255	261	PF11976	0.325
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.305
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.291
LIG_SUMO_SIM_par_1	276	282	PF11976	0.325
LIG_SUMO_SIM_par_1	41	47	PF11976	0.291
LIG_TYR_ITIM	214	219	PF00017	0.546
LIG_TYR_ITIM	231	236	PF00017	0.293
LIG_TYR_ITIM	247	252	PF00017	0.291
LIG_TYR_ITIM	321	326	PF00017	0.459
MOD_CK1_1	146	152	PF00069	0.708
MOD_CK1_1	171	177	PF00069	0.695
MOD_CK2_1	106	112	PF00069	0.696
MOD_GlcNHglycan	100	105	PF01048	0.387
MOD_GlcNHglycan	161	164	PF01048	0.556
MOD_GlcNHglycan	169	173	PF01048	0.528
MOD_GlcNHglycan	180	183	PF01048	0.383
MOD_GSK3_1	113	120	PF00069	0.755
MOD_GSK3_1	174	181	PF00069	0.708
MOD_GSK3_1	269	276	PF00069	0.454
MOD_GSK3_1	34	41	PF00069	0.498
MOD_NEK2_1	279	284	PF00069	0.291
MOD_NEK2_1	312	317	PF00069	0.387
MOD_NEK2_1	44	49	PF00069	0.370
MOD_PIKK_1	27	33	PF00454	0.527
MOD_PK_1	29	35	PF00069	0.569
MOD_PKA_1	268	274	PF00069	0.484
MOD_PKA_1	329	335	PF00069	0.550
MOD_PKA_2	268	274	PF00069	0.507
MOD_PKA_2	329	335	PF00069	0.555
MOD_PKA_2	93	99	PF00069	0.593
MOD_Plk_1	140	146	PF00069	0.699
MOD_Plk_1	202	208	PF00069	0.508
MOD_Plk_4	202	208	PF00069	0.503
MOD_Plk_4	273	279	PF00069	0.465
MOD_Plk_4	312	318	PF00069	0.313
MOD_Plk_4	38	44	PF00069	0.295
MOD_ProDKin_1	143	149	PF00069	0.680
MOD_ProDKin_1	171	177	PF00069	0.650
MOD_ProDKin_1	207	213	PF00069	0.514
MOD_ProDKin_1	34	40	PF00069	0.479
MOD_SUMO_for_1	328	331	PF00179	0.596
TRG_DiLeu_BaEn_1	331	336	PF01217	0.560
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.405
TRG_ENDOCYTIC_2	216	219	PF00928	0.459
TRG_ENDOCYTIC_2	233	236	PF00928	0.317
TRG_ENDOCYTIC_2	249	252	PF00928	0.291
TRG_ENDOCYTIC_2	323	326	PF00928	0.537
TRG_ENDOCYTIC_2	36	39	PF00928	0.328
TRG_ENDOCYTIC_2	53	56	PF00928	0.287
TRG_ER_diArg_1	268	270	PF00400	0.521
TRG_NES_CRM1_1	299	314	PF08389	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVE3	Leptomonas seymouri	51%	100%
A0A3Q8IDX3	Leishmania donovani	90%	97%
A0A422N3F4	Trypanosoma rangeli	39%	100%
A4HF48	Leishmania braziliensis	70%	100%
A4I2D2	Leishmania infantum	90%	97%
C9ZX76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	89%
E9AYI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%