Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8Y7_LEIMA

TriTrypDb:

LmjF.26.2050 , LMJLV39_260027000 , LMJSD75_260025400

Length:

888

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.716
CLV_C14_Caspase3-7	335	339	PF00656	0.679
CLV_C14_Caspase3-7	356	360	PF00656	0.693
CLV_C14_Caspase3-7	683	687	PF00656	0.703
CLV_C14_Caspase3-7	702	706	PF00656	0.558
CLV_C14_Caspase3-7	755	759	PF00656	0.721
CLV_NRD_NRD_1	216	218	PF00675	0.675
CLV_NRD_NRD_1	223	225	PF00675	0.608
CLV_NRD_NRD_1	29	31	PF00675	0.523
CLV_NRD_NRD_1	434	436	PF00675	0.684
CLV_NRD_NRD_1	454	456	PF00675	0.639
CLV_NRD_NRD_1	496	498	PF00675	0.694
CLV_NRD_NRD_1	637	639	PF00675	0.723
CLV_NRD_NRD_1	715	717	PF00675	0.655
CLV_PCSK_KEX2_1	216	218	PF00082	0.675
CLV_PCSK_KEX2_1	223	225	PF00082	0.608
CLV_PCSK_KEX2_1	29	31	PF00082	0.523
CLV_PCSK_KEX2_1	434	436	PF00082	0.631
CLV_PCSK_KEX2_1	454	456	PF00082	0.645
CLV_PCSK_KEX2_1	496	498	PF00082	0.694
CLV_PCSK_KEX2_1	636	638	PF00082	0.767
CLV_PCSK_KEX2_1	715	717	PF00082	0.662
CLV_PCSK_KEX2_1	866	868	PF00082	0.646
CLV_PCSK_PC1ET2_1	636	638	PF00082	0.767
CLV_PCSK_PC1ET2_1	866	868	PF00082	0.646
CLV_PCSK_PC7_1	25	31	PF00082	0.495
CLV_PCSK_SKI1_1	13	17	PF00082	0.702
CLV_PCSK_SKI1_1	201	205	PF00082	0.697
CLV_PCSK_SKI1_1	224	228	PF00082	0.712
CLV_PCSK_SKI1_1	25	29	PF00082	0.704
CLV_PCSK_SKI1_1	30	34	PF00082	0.621
CLV_PCSK_SKI1_1	37	41	PF00082	0.523
CLV_PCSK_SKI1_1	497	501	PF00082	0.699
CLV_PCSK_SKI1_1	710	714	PF00082	0.639
CLV_PCSK_SKI1_1	754	758	PF00082	0.653
DEG_APCC_DBOX_1	12	20	PF00400	0.703
DEG_Nend_UBRbox_2	1	3	PF02207	0.731
DEG_SCF_FBW7_1	785	790	PF00400	0.628
DEG_SPOP_SBC_1	144	148	PF00917	0.556
DOC_CDC14_PxL_1	620	628	PF14671	0.697
DOC_CKS1_1	380	385	PF01111	0.788
DOC_CKS1_1	551	556	PF01111	0.775
DOC_CKS1_1	71	76	PF01111	0.680
DOC_CKS1_1	782	787	PF01111	0.688
DOC_CYCLIN_RxL_1	217	228	PF00134	0.588
DOC_CYCLIN_RxL_1	710	723	PF00134	0.647
DOC_CYCLIN_RxL_1	748	761	PF00134	0.643
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.713
DOC_CYCLIN_yCln2_LP_2	881	887	PF00134	0.682
DOC_MAPK_gen_1	216	227	PF00069	0.690
DOC_MAPK_MEF2A_6	326	334	PF00069	0.611
DOC_MAPK_MEF2A_6	42	50	PF00069	0.634
DOC_PP1_RVXF_1	714	721	PF00149	0.506
DOC_PP2B_LxvP_1	135	138	PF13499	0.598
DOC_PP2B_LxvP_1	317	320	PF13499	0.734
DOC_PP2B_LxvP_1	459	462	PF13499	0.818
DOC_PP2B_LxvP_1	57	60	PF13499	0.666
DOC_PP2B_LxvP_1	729	732	PF13499	0.720
DOC_PP2B_LxvP_1	881	884	PF13499	0.724
DOC_PP4_FxxP_1	71	74	PF00568	0.567
DOC_PP4_MxPP_1	411	414	PF00568	0.599
DOC_USP7_MATH_1	144	148	PF00917	0.646
DOC_USP7_MATH_1	465	469	PF00917	0.797
DOC_USP7_MATH_1	52	56	PF00917	0.677
DOC_USP7_MATH_1	58	62	PF00917	0.668
DOC_USP7_MATH_1	793	797	PF00917	0.775
DOC_USP7_MATH_1	86	90	PF00917	0.675
DOC_WW_Pin1_4	110	115	PF00397	0.709
DOC_WW_Pin1_4	136	141	PF00397	0.686
DOC_WW_Pin1_4	237	242	PF00397	0.591
DOC_WW_Pin1_4	371	376	PF00397	0.806
DOC_WW_Pin1_4	379	384	PF00397	0.632
DOC_WW_Pin1_4	42	47	PF00397	0.694
DOC_WW_Pin1_4	510	515	PF00397	0.797
DOC_WW_Pin1_4	550	555	PF00397	0.772
DOC_WW_Pin1_4	597	602	PF00397	0.578
DOC_WW_Pin1_4	60	65	PF00397	0.690
DOC_WW_Pin1_4	70	75	PF00397	0.622
DOC_WW_Pin1_4	727	732	PF00397	0.733
DOC_WW_Pin1_4	778	783	PF00397	0.794
DOC_WW_Pin1_4	821	826	PF00397	0.600
DOC_WW_Pin1_4	87	92	PF00397	0.579
LIG_14-3-3_CanoR_1	121	129	PF00244	0.622
LIG_14-3-3_CanoR_1	18	26	PF00244	0.698
LIG_14-3-3_CanoR_1	279	288	PF00244	0.582
LIG_14-3-3_CanoR_1	326	334	PF00244	0.749
LIG_14-3-3_CanoR_1	341	345	PF00244	0.566
LIG_14-3-3_CanoR_1	381	387	PF00244	0.775
LIG_14-3-3_CanoR_1	496	505	PF00244	0.697
LIG_14-3-3_CanoR_1	506	514	PF00244	0.597
LIG_14-3-3_CanoR_1	596	603	PF00244	0.772
LIG_14-3-3_CanoR_1	679	685	PF00244	0.594
LIG_14-3-3_CanoR_1	715	721	PF00244	0.649
LIG_14-3-3_CanoR_1	77	85	PF00244	0.670
LIG_14-3-3_CanoR_1	808	816	PF00244	0.688
LIG_14-3-3_CanoR_1	832	837	PF00244	0.756
LIG_Actin_WH2_2	732	750	PF00022	0.744
LIG_Actin_WH2_2	853	868	PF00022	0.659
LIG_BIR_III_2	427	431	PF00653	0.630
LIG_BIR_III_4	423	427	PF00653	0.638
LIG_BIR_III_4	490	494	PF00653	0.722
LIG_DLG_GKlike_1	716	724	PF00625	0.654
LIG_DLG_GKlike_1	748	756	PF00625	0.637
LIG_FHA_1	107	113	PF00498	0.719
LIG_FHA_1	158	164	PF00498	0.703
LIG_FHA_1	237	243	PF00498	0.761
LIG_FHA_1	325	331	PF00498	0.685
LIG_FHA_1	467	473	PF00498	0.839
LIG_FHA_1	498	504	PF00498	0.749
LIG_FHA_1	513	519	PF00498	0.603
LIG_FHA_1	679	685	PF00498	0.650
LIG_FHA_1	71	77	PF00498	0.669
LIG_FHA_1	724	730	PF00498	0.740
LIG_FHA_1	795	801	PF00498	0.656
LIG_FHA_1	828	834	PF00498	0.663
LIG_FHA_2	396	402	PF00498	0.730
LIG_FHA_2	700	706	PF00498	0.781
LIG_LIR_Apic_2	370	376	PF02991	0.654
LIG_LIR_Apic_2	68	74	PF02991	0.569
LIG_LIR_Gen_1	151	158	PF02991	0.496
LIG_LIR_Nem_3	346	351	PF02991	0.777
LIG_LIR_Nem_3	69	75	PF02991	0.568
LIG_LIR_Nem_3	697	703	PF02991	0.565
LIG_LIR_Nem_3	751	756	PF02991	0.589
LIG_MYND_1	457	461	PF01753	0.609
LIG_NRBOX	522	528	PF00104	0.575
LIG_Pex14_2	713	717	PF04695	0.716
LIG_PTAP_UEV_1	731	736	PF05743	0.582
LIG_RPA_C_Fungi	853	865	PF08784	0.654
LIG_SH2_CRK	373	377	PF00017	0.693
LIG_SH2_CRK	620	624	PF00017	0.698
LIG_SH2_NCK_1	373	377	PF00017	0.623
LIG_SH2_PTP2	551	554	PF00017	0.704
LIG_SH2_SRC	232	235	PF00017	0.682
LIG_SH2_STAP1	153	157	PF00017	0.704
LIG_SH2_STAP1	743	747	PF00017	0.717
LIG_SH2_STAT5	232	235	PF00017	0.787
LIG_SH2_STAT5	351	354	PF00017	0.741
LIG_SH2_STAT5	551	554	PF00017	0.704
LIG_SH3_3	130	136	PF00018	0.653
LIG_SH3_3	352	358	PF00018	0.695
LIG_SH3_3	372	378	PF00018	0.567
LIG_SH3_3	458	464	PF00018	0.708
LIG_SH3_3	513	519	PF00018	0.564
LIG_SH3_3	549	555	PF00018	0.701
LIG_SH3_3	585	591	PF00018	0.745
LIG_SH3_3	729	735	PF00018	0.754
LIG_SH3_3	776	782	PF00018	0.789
LIG_SH3_CIN85_PxpxPR_1	136	141	PF14604	0.554
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.681
LIG_SUMO_SIM_par_1	107	113	PF11976	0.659
LIG_SUMO_SIM_par_1	796	802	PF11976	0.587
LIG_TRAF2_1	368	371	PF00917	0.763
LIG_WW_2	461	464	PF00397	0.607
MOD_CDK_SPK_2	136	141	PF00069	0.682
MOD_CDK_SPK_2	379	384	PF00069	0.800
MOD_CDK_SPK_2	87	92	PF00069	0.772
MOD_CDK_SPxxK_3	237	244	PF00069	0.594
MOD_CDK_SPxxK_3	374	381	PF00069	0.719
MOD_CDK_SPxxK_3	70	77	PF00069	0.706
MOD_CK1_1	151	157	PF00069	0.509
MOD_CK1_1	343	349	PF00069	0.605
MOD_CK1_1	374	380	PF00069	0.819
MOD_CK1_1	508	514	PF00069	0.630
MOD_CK1_1	521	527	PF00069	0.468
MOD_CK1_1	604	610	PF00069	0.544
MOD_CK1_1	719	725	PF00069	0.732
MOD_CK1_1	730	736	PF00069	0.628
MOD_CK1_1	781	787	PF00069	0.792
MOD_CK1_1	849	855	PF00069	0.724
MOD_CK2_1	365	371	PF00069	0.669
MOD_CK2_1	471	477	PF00069	0.660
MOD_CK2_1	650	656	PF00069	0.677
MOD_Cter_Amidation	432	435	PF01082	0.594
MOD_Cter_Amidation	494	497	PF01082	0.686
MOD_DYRK1A_RPxSP_1	42	46	PF00069	0.622
MOD_GlcNHglycan	122	125	PF01048	0.574
MOD_GlcNHglycan	153	156	PF01048	0.725
MOD_GlcNHglycan	293	296	PF01048	0.783
MOD_GlcNHglycan	30	33	PF01048	0.660
MOD_GlcNHglycan	317	320	PF01048	0.804
MOD_GlcNHglycan	335	338	PF01048	0.773
MOD_GlcNHglycan	367	370	PF01048	0.660
MOD_GlcNHglycan	523	526	PF01048	0.497
MOD_GlcNHglycan	54	57	PF01048	0.688
MOD_GlcNHglycan	567	570	PF01048	0.717
MOD_GlcNHglycan	644	647	PF01048	0.706
MOD_GlcNHglycan	671	674	PF01048	0.805
MOD_GlcNHglycan	692	695	PF01048	0.652
MOD_GlcNHglycan	732	735	PF01048	0.647
MOD_GlcNHglycan	776	779	PF01048	0.719
MOD_GSK3_1	106	113	PF00069	0.711
MOD_GSK3_1	120	127	PF00069	0.556
MOD_GSK3_1	144	151	PF00069	0.516
MOD_GSK3_1	232	239	PF00069	0.745
MOD_GSK3_1	315	322	PF00069	0.642
MOD_GSK3_1	365	372	PF00069	0.677
MOD_GSK3_1	403	410	PF00069	0.792
MOD_GSK3_1	506	513	PF00069	0.693
MOD_GSK3_1	595	602	PF00069	0.783
MOD_GSK3_1	657	664	PF00069	0.745
MOD_GSK3_1	690	697	PF00069	0.562
MOD_GSK3_1	716	723	PF00069	0.651
MOD_GSK3_1	730	737	PF00069	0.562
MOD_GSK3_1	748	755	PF00069	0.464
MOD_GSK3_1	774	781	PF00069	0.710
MOD_GSK3_1	783	790	PF00069	0.645
MOD_GSK3_1	827	834	PF00069	0.757
MOD_GSK3_1	846	853	PF00069	0.450
MOD_N-GLC_1	447	452	PF02516	0.690
MOD_NEK2_1	678	683	PF00069	0.698
MOD_NEK2_1	720	725	PF00069	0.675
MOD_NEK2_1	752	757	PF00069	0.713
MOD_NEK2_1	827	832	PF00069	0.723
MOD_NEK2_2	67	72	PF00069	0.572
MOD_PIKK_1	157	163	PF00454	0.701
MOD_PIKK_1	263	269	PF00454	0.705
MOD_PIKK_1	319	325	PF00454	0.810
MOD_PIKK_1	353	359	PF00454	0.776
MOD_PIKK_1	601	607	PF00454	0.564
MOD_PIKK_1	625	631	PF00454	0.699
MOD_PKA_2	120	126	PF00069	0.619
MOD_PKA_2	17	23	PF00069	0.697
MOD_PKA_2	28	34	PF00069	0.504
MOD_PKA_2	325	331	PF00069	0.750
MOD_PKA_2	340	346	PF00069	0.542
MOD_PKA_2	365	371	PF00069	0.678
MOD_PKA_2	505	511	PF00069	0.624
MOD_PKA_2	595	601	PF00069	0.781
MOD_PKA_2	678	684	PF00069	0.594
MOD_PKA_2	807	813	PF00069	0.724
MOD_PKA_2	831	837	PF00069	0.726
MOD_PKB_1	23	31	PF00069	0.706
MOD_PKB_1	504	512	PF00069	0.591
MOD_Plk_1	1	7	PF00069	0.664
MOD_Plk_1	106	112	PF00069	0.691
MOD_Plk_1	369	375	PF00069	0.695
MOD_Plk_1	850	856	PF00069	0.651
MOD_Plk_2-3	407	413	PF00069	0.633
MOD_Plk_2-3	650	656	PF00069	0.621
MOD_Plk_4	106	112	PF00069	0.707
MOD_Plk_4	124	130	PF00069	0.718
MOD_Plk_4	148	154	PF00069	0.552
MOD_Plk_4	343	349	PF00069	0.750
MOD_Plk_4	412	418	PF00069	0.686
MOD_Plk_4	67	73	PF00069	0.779
MOD_Plk_4	720	726	PF00069	0.699
MOD_Plk_4	738	744	PF00069	0.541
MOD_Plk_4	748	754	PF00069	0.551
MOD_ProDKin_1	110	116	PF00069	0.709
MOD_ProDKin_1	136	142	PF00069	0.687
MOD_ProDKin_1	237	243	PF00069	0.591
MOD_ProDKin_1	371	377	PF00069	0.804
MOD_ProDKin_1	379	385	PF00069	0.624
MOD_ProDKin_1	42	48	PF00069	0.698
MOD_ProDKin_1	510	516	PF00069	0.793
MOD_ProDKin_1	550	556	PF00069	0.774
MOD_ProDKin_1	597	603	PF00069	0.576
MOD_ProDKin_1	60	66	PF00069	0.691
MOD_ProDKin_1	70	76	PF00069	0.621
MOD_ProDKin_1	727	733	PF00069	0.737
MOD_ProDKin_1	778	784	PF00069	0.794
MOD_ProDKin_1	821	827	PF00069	0.601
MOD_ProDKin_1	87	93	PF00069	0.578
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.560
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.787
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.730
TRG_DiLeu_BaLyEn_6	454	459	PF01217	0.567
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.705
TRG_DiLeu_BaLyEn_6	764	769	PF01217	0.669
TRG_ENDOCYTIC_2	153	156	PF00928	0.686
TRG_ENDOCYTIC_2	351	354	PF00928	0.770
TRG_ENDOCYTIC_2	620	623	PF00928	0.697
TRG_ER_diArg_1	216	218	PF00400	0.675
TRG_ER_diArg_1	223	225	PF00400	0.608
TRG_ER_diArg_1	23	26	PF00400	0.722
TRG_ER_diArg_1	434	436	PF00400	0.643
TRG_ER_diArg_1	453	455	PF00400	0.677
TRG_ER_diArg_1	503	506	PF00400	0.600
TRG_ER_diArg_1	586	589	PF00400	0.562
TRG_ER_diArg_1	714	716	PF00400	0.675
TRG_NES_CRM1_1	576	590	PF08389	0.722
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.690
TRG_Pf-PMV_PEXEL_1	223	228	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	754	758	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICB4	Leishmania donovani	84%	87%
A4HF49	Leishmania braziliensis	59%	99%
A4I2D3	Leishmania infantum	84%	99%
E9AYI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%