Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8Y4_LEIMA

TriTrypDb:

LmjF.26.2080 , LMJLV39_260027300 , LMJSD75_260025700

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8Y4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.533
CLV_C14_Caspase3-7	325	329	PF00656	0.483
CLV_NRD_NRD_1	38	40	PF00675	0.542
CLV_NRD_NRD_1	78	80	PF00675	0.625
CLV_PCSK_KEX2_1	37	39	PF00082	0.542
CLV_PCSK_KEX2_1	80	82	PF00082	0.605
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.542
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.586
CLV_PCSK_SKI1_1	43	47	PF00082	0.537
DEG_Nend_UBRbox_4	1	3	PF02207	0.506
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.479
DOC_MAPK_gen_1	237	246	PF00069	0.508
DOC_MAPK_MEF2A_6	240	248	PF00069	0.704
DOC_PP2B_LxvP_1	343	346	PF13499	0.493
DOC_PP2B_LxvP_1	355	358	PF13499	0.424
DOC_USP7_MATH_1	160	164	PF00917	0.566
DOC_USP7_MATH_1	177	181	PF00917	0.672
DOC_USP7_MATH_1	25	29	PF00917	0.543
DOC_USP7_MATH_1	260	264	PF00917	0.693
DOC_USP7_MATH_1	304	308	PF00917	0.515
DOC_USP7_MATH_1	83	87	PF00917	0.641
DOC_USP7_MATH_1	89	93	PF00917	0.577
DOC_USP7_UBL2_3	186	190	PF12436	0.554
DOC_USP7_UBL2_3	261	265	PF12436	0.594
DOC_USP7_UBL2_3	274	278	PF12436	0.609
DOC_USP7_UBL2_3	33	37	PF12436	0.550
DOC_USP7_UBL2_3	55	59	PF12436	0.525
DOC_WW_Pin1_4	116	121	PF00397	0.590
DOC_WW_Pin1_4	123	128	PF00397	0.569
DOC_WW_Pin1_4	15	20	PF00397	0.483
DOC_WW_Pin1_4	197	202	PF00397	0.608
DOC_WW_Pin1_4	214	219	PF00397	0.712
DOC_WW_Pin1_4	220	225	PF00397	0.623
DOC_WW_Pin1_4	266	271	PF00397	0.648
DOC_WW_Pin1_4	285	290	PF00397	0.572
DOC_WW_Pin1_4	341	346	PF00397	0.462
DOC_WW_Pin1_4	4	9	PF00397	0.488
LIG_14-3-3_CanoR_1	237	246	PF00244	0.588
LIG_14-3-3_CanoR_1	247	253	PF00244	0.655
LIG_14-3-3_CanoR_1	38	47	PF00244	0.540
LIG_BRCT_BRCA1_1	205	209	PF00533	0.671
LIG_FHA_1	100	106	PF00498	0.668
LIG_FHA_1	137	143	PF00498	0.570
LIG_FHA_1	198	204	PF00498	0.710
LIG_FHA_1	243	249	PF00498	0.636
LIG_FHA_2	319	325	PF00498	0.616
LIG_LIR_Apic_2	213	218	PF02991	0.672
LIG_LIR_LC3C_4	288	292	PF02991	0.677
LIG_LIR_Nem_3	108	112	PF02991	0.567
LIG_LIR_Nem_3	206	212	PF02991	0.671
LIG_LIR_Nem_3	300	305	PF02991	0.472
LIG_MYND_1	19	23	PF01753	0.522
LIG_Pex14_2	356	360	PF04695	0.436
LIG_SH2_STAT5	301	304	PF00017	0.569
LIG_SH3_2	17	22	PF14604	0.515
LIG_SH3_3	114	120	PF00018	0.577
LIG_SH3_3	121	127	PF00018	0.588
LIG_SH3_3	14	20	PF00018	0.508
LIG_SH3_3	156	162	PF00018	0.501
LIG_SH3_3	267	273	PF00018	0.642
LIG_SH3_3	339	345	PF00018	0.541
LIG_SUMO_SIM_par_1	288	294	PF11976	0.568
LIG_TRAF2_1	176	179	PF00917	0.666
LIG_TRAF2_1	28	31	PF00917	0.553
LIG_TRAF2_1	321	324	PF00917	0.524
MOD_CDK_SPK_2	266	271	PF00069	0.720
MOD_CDK_SPxxK_3	15	22	PF00069	0.514
MOD_CK1_1	180	186	PF00069	0.742
MOD_CK1_1	188	194	PF00069	0.622
MOD_CK1_1	205	211	PF00069	0.772
MOD_CK1_1	269	275	PF00069	0.600
MOD_CK1_1	51	57	PF00069	0.661
MOD_CK1_1	65	71	PF00069	0.618
MOD_CK1_1	7	13	PF00069	0.498
MOD_CK1_1	92	98	PF00069	0.637
MOD_CK2_1	25	31	PF00069	0.549
MOD_CK2_1	260	266	PF00069	0.573
MOD_CK2_1	318	324	PF00069	0.620
MOD_CK2_1	94	100	PF00069	0.655
MOD_GlcNHglycan	130	133	PF01048	0.648
MOD_GlcNHglycan	190	193	PF01048	0.640
MOD_GlcNHglycan	212	215	PF01048	0.653
MOD_GlcNHglycan	224	227	PF01048	0.564
MOD_GlcNHglycan	70	73	PF01048	0.637
MOD_GlcNHglycan	85	88	PF01048	0.499
MOD_GSK3_1	112	119	PF00069	0.550
MOD_GSK3_1	130	137	PF00069	0.586
MOD_GSK3_1	178	185	PF00069	0.722
MOD_GSK3_1	188	195	PF00069	0.616
MOD_GSK3_1	197	204	PF00069	0.536
MOD_GSK3_1	210	217	PF00069	0.542
MOD_GSK3_1	235	242	PF00069	0.578
MOD_GSK3_1	246	253	PF00069	0.603
MOD_GSK3_1	260	267	PF00069	0.716
MOD_GSK3_1	51	58	PF00069	0.646
MOD_GSK3_1	61	68	PF00069	0.623
MOD_GSK3_1	7	14	PF00069	0.499
MOD_LATS_1	220	226	PF00433	0.670
MOD_LATS_1	24	30	PF00433	0.545
MOD_N-GLC_1	326	331	PF02516	0.446
MOD_N-GLC_1	39	44	PF02516	0.543
MOD_N-GLC_1	68	73	PF02516	0.720
MOD_NEK2_1	182	187	PF00069	0.641
MOD_NEK2_1	203	208	PF00069	0.700
MOD_NEK2_1	246	251	PF00069	0.508
MOD_NEK2_1	290	295	PF00069	0.721
MOD_NEK2_1	326	331	PF00069	0.468
MOD_NEK2_2	89	94	PF00069	0.629
MOD_OFUCOSY	93	98	PF10250	0.528
MOD_PIKK_1	250	256	PF00454	0.583
MOD_PIKK_1	26	32	PF00454	0.552
MOD_PKA_1	38	44	PF00069	0.544
MOD_PKA_2	105	111	PF00069	0.594
MOD_PKA_2	239	245	PF00069	0.582
MOD_PKA_2	246	252	PF00069	0.594
MOD_PKA_2	25	31	PF00069	0.549
MOD_PKA_2	38	44	PF00069	0.513
MOD_PKA_2	51	57	PF00069	0.495
MOD_Plk_1	177	183	PF00069	0.719
MOD_Plk_1	326	332	PF00069	0.447
MOD_Plk_4	136	142	PF00069	0.646
MOD_Plk_4	326	332	PF00069	0.469
MOD_ProDKin_1	116	122	PF00069	0.594
MOD_ProDKin_1	123	129	PF00069	0.567
MOD_ProDKin_1	15	21	PF00069	0.486
MOD_ProDKin_1	197	203	PF00069	0.608
MOD_ProDKin_1	214	220	PF00069	0.714
MOD_ProDKin_1	266	272	PF00069	0.648
MOD_ProDKin_1	285	291	PF00069	0.565
MOD_ProDKin_1	341	347	PF00069	0.452
MOD_ProDKin_1	4	10	PF00069	0.490
MOD_SUMO_for_1	47	50	PF00179	0.526
MOD_SUMO_rev_2	50	56	PF00179	0.530
TRG_ENDOCYTIC_2	109	112	PF00928	0.569
TRG_ER_diArg_1	170	173	PF00400	0.609
TRG_ER_diArg_1	74	77	PF00400	0.711
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBU5	Leptomonas seymouri	48%	100%
A0A3S7X039	Leishmania donovani	89%	100%
A4HF52	Leishmania braziliensis	64%	100%
A4I2D6	Leishmania infantum	89%	100%
E9AYI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%