FtsJ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8X7_LEIMA

TriTrypDb:

LmjF.26.2150 , LMJLV39_260028000 , LMJSD75_260026400

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8X7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0032259	methylation	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008168	methyltransferase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016741	transferase activity, transferring one-carbon groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.453
CLV_C14_Caspase3-7	326	330	PF00656	0.612
CLV_C14_Caspase3-7	430	434	PF00656	0.481
CLV_NRD_NRD_1	121	123	PF00675	0.513
CLV_NRD_NRD_1	198	200	PF00675	0.380
CLV_NRD_NRD_1	291	293	PF00675	0.625
CLV_NRD_NRD_1	427	429	PF00675	0.601
CLV_NRD_NRD_1	43	45	PF00675	0.544
CLV_NRD_NRD_1	524	526	PF00675	0.440
CLV_NRD_NRD_1	540	542	PF00675	0.747
CLV_NRD_NRD_1	543	545	PF00675	0.738
CLV_NRD_NRD_1	64	66	PF00675	0.542
CLV_PCSK_FUR_1	289	293	PF00082	0.580
CLV_PCSK_FUR_1	522	526	PF00082	0.425
CLV_PCSK_FUR_1	541	545	PF00082	0.755
CLV_PCSK_KEX2_1	121	123	PF00082	0.469
CLV_PCSK_KEX2_1	291	293	PF00082	0.625
CLV_PCSK_KEX2_1	43	45	PF00082	0.550
CLV_PCSK_KEX2_1	524	526	PF00082	0.430
CLV_PCSK_KEX2_1	540	542	PF00082	0.640
CLV_PCSK_KEX2_1	543	545	PF00082	0.638
CLV_PCSK_KEX2_1	552	554	PF00082	0.600
CLV_PCSK_KEX2_1	64	66	PF00082	0.542
CLV_PCSK_KEX2_1	92	94	PF00082	0.710
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.653
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.710
CLV_PCSK_PC7_1	117	123	PF00082	0.495
CLV_PCSK_SKI1_1	121	125	PF00082	0.393
CLV_PCSK_SKI1_1	354	358	PF00082	0.486
CLV_PCSK_SKI1_1	478	482	PF00082	0.548
DEG_Nend_UBRbox_3	1	3	PF02207	0.667
DEG_SPOP_SBC_1	450	454	PF00917	0.527
DOC_MAPK_gen_1	291	300	PF00069	0.629
DOC_MAPK_gen_1	482	489	PF00069	0.464
DOC_MAPK_RevD_3	77	93	PF00069	0.622
DOC_PP2B_LxvP_1	348	351	PF13499	0.484
DOC_PP2B_LxvP_1	5	8	PF13499	0.744
DOC_USP7_MATH_1	150	154	PF00917	0.528
DOC_USP7_MATH_1	301	305	PF00917	0.660
DOC_USP7_MATH_1	314	318	PF00917	0.728
DOC_USP7_MATH_1	80	84	PF00917	0.734
DOC_WW_Pin1_4	328	333	PF00397	0.709
DOC_WW_Pin1_4	392	397	PF00397	0.608
DOC_WW_Pin1_4	452	457	PF00397	0.533
DOC_WW_Pin1_4	465	470	PF00397	0.686
DOC_WW_Pin1_4	78	83	PF00397	0.739
LIG_14-3-3_CanoR_1	199	208	PF00244	0.399
LIG_14-3-3_CanoR_1	30	35	PF00244	0.499
LIG_14-3-3_CanoR_1	463	469	PF00244	0.734
LIG_14-3-3_CanoR_1	51	61	PF00244	0.539
LIG_14-3-3_CanoR_1	71	79	PF00244	0.507
LIG_14-3-3_CanoR_1	84	91	PF00244	0.628
LIG_BRCT_BRCA1_1	38	42	PF00533	0.456
LIG_deltaCOP1_diTrp_1	511	520	PF00928	0.382
LIG_EVH1_1	7	11	PF00568	0.633
LIG_FHA_1	100	106	PF00498	0.658
LIG_FHA_1	122	128	PF00498	0.374
LIG_FHA_1	21	27	PF00498	0.608
LIG_FHA_1	252	258	PF00498	0.612
LIG_FHA_1	407	413	PF00498	0.407
LIG_FHA_1	443	449	PF00498	0.527
LIG_FHA_1	466	472	PF00498	0.632
LIG_FHA_1	546	552	PF00498	0.760
LIG_FHA_1	68	74	PF00498	0.449
LIG_FHA_2	12	18	PF00498	0.704
LIG_FHA_2	143	149	PF00498	0.654
LIG_FHA_2	200	206	PF00498	0.603
LIG_LIR_Gen_1	205	215	PF02991	0.529
LIG_LIR_Gen_1	377	385	PF02991	0.418
LIG_LIR_Nem_3	174	180	PF02991	0.410
LIG_LIR_Nem_3	205	211	PF02991	0.513
LIG_LIR_Nem_3	39	45	PF02991	0.401
LIG_LIR_Nem_3	501	506	PF02991	0.471
LIG_PALB2_WD40_1	341	349	PF16756	0.358
LIG_REV1ctd_RIR_1	129	135	PF16727	0.525
LIG_SH2_STAP1	253	257	PF00017	0.473
LIG_SH2_STAT5	170	173	PF00017	0.442
LIG_SH2_STAT5	25	28	PF00017	0.491
LIG_SH2_STAT5	253	256	PF00017	0.478
LIG_SH2_STAT5	322	325	PF00017	0.583
LIG_SH2_STAT5	34	37	PF00017	0.333
LIG_SH2_STAT5	359	362	PF00017	0.497
LIG_SH2_STAT5	418	421	PF00017	0.353
LIG_SH3_3	212	218	PF00018	0.532
LIG_SH3_3	338	344	PF00018	0.428
LIG_SH3_3	421	427	PF00018	0.573
LIG_SH3_3	5	11	PF00018	0.677
LIG_SH3_3	76	82	PF00018	0.730
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.509
LIG_WW_3	425	429	PF00397	0.616
MOD_CDC14_SPxK_1	81	84	PF00782	0.685
MOD_CDK_SPK_2	452	457	PF00069	0.533
MOD_CDK_SPxK_1	78	84	PF00069	0.743
MOD_CK1_1	140	146	PF00069	0.707
MOD_CK1_1	235	241	PF00069	0.563
MOD_CK1_1	304	310	PF00069	0.525
MOD_CK1_1	330	336	PF00069	0.669
MOD_CK1_1	452	458	PF00069	0.594
MOD_CK1_1	467	473	PF00069	0.603
MOD_CK1_1	72	78	PF00069	0.661
MOD_CK2_1	11	17	PF00069	0.760
MOD_CK2_1	142	148	PF00069	0.657
MOD_GlcNHglycan	152	155	PF01048	0.504
MOD_GlcNHglycan	19	23	PF01048	0.562
MOD_GlcNHglycan	224	227	PF01048	0.566
MOD_GlcNHglycan	249	252	PF01048	0.622
MOD_GlcNHglycan	260	263	PF01048	0.472
MOD_GlcNHglycan	268	271	PF01048	0.413
MOD_GlcNHglycan	301	304	PF01048	0.617
MOD_GlcNHglycan	306	309	PF01048	0.666
MOD_GlcNHglycan	314	317	PF01048	0.717
MOD_GlcNHglycan	332	335	PF01048	0.420
MOD_GlcNHglycan	397	400	PF01048	0.680
MOD_GlcNHglycan	533	536	PF01048	0.643
MOD_GlcNHglycan	54	57	PF01048	0.522
MOD_GlcNHglycan	75	78	PF01048	0.617
MOD_GSK3_1	137	144	PF00069	0.710
MOD_GSK3_1	20	27	PF00069	0.573
MOD_GSK3_1	213	220	PF00069	0.538
MOD_GSK3_1	247	254	PF00069	0.647
MOD_GSK3_1	260	267	PF00069	0.456
MOD_GSK3_1	323	330	PF00069	0.670
MOD_GSK3_1	355	362	PF00069	0.509
MOD_GSK3_1	461	468	PF00069	0.683
MOD_GSK3_1	69	76	PF00069	0.633
MOD_GSK3_1	80	87	PF00069	0.612
MOD_LATS_1	119	125	PF00433	0.493
MOD_N-GLC_1	1	6	PF02516	0.699
MOD_N-GLC_1	138	143	PF02516	0.627
MOD_N-GLC_1	222	227	PF02516	0.517
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NEK2_1	198	203	PF00069	0.545
MOD_NEK2_1	24	29	PF00069	0.543
MOD_NEK2_1	246	251	PF00069	0.528
MOD_NEK2_1	260	265	PF00069	0.529
MOD_NEK2_1	312	317	PF00069	0.729
MOD_NEK2_1	327	332	PF00069	0.612
MOD_NEK2_1	36	41	PF00069	0.357
MOD_NEK2_1	419	424	PF00069	0.406
MOD_NEK2_1	451	456	PF00069	0.526
MOD_NEK2_1	461	466	PF00069	0.626
MOD_NEK2_1	73	78	PF00069	0.533
MOD_PIKK_1	121	127	PF00454	0.514
MOD_PIKK_1	213	219	PF00454	0.530
MOD_PIKK_1	92	98	PF00454	0.701
MOD_PKA_1	121	127	PF00069	0.512
MOD_PKA_1	199	205	PF00069	0.424
MOD_PKA_1	92	98	PF00069	0.703
MOD_PKA_2	121	127	PF00069	0.517
MOD_PKA_2	198	204	PF00069	0.412
MOD_PKA_2	312	318	PF00069	0.598
MOD_PKA_2	462	468	PF00069	0.598
MOD_PKA_2	92	98	PF00069	0.631
MOD_Plk_1	107	113	PF00069	0.479
MOD_Plk_1	204	210	PF00069	0.508
MOD_Plk_1	296	302	PF00069	0.563
MOD_Plk_1	36	42	PF00069	0.461
MOD_Plk_4	107	113	PF00069	0.543
MOD_Plk_4	20	26	PF00069	0.652
MOD_Plk_4	204	210	PF00069	0.521
MOD_Plk_4	260	266	PF00069	0.599
MOD_Plk_4	301	307	PF00069	0.488
MOD_Plk_4	355	361	PF00069	0.510
MOD_Plk_4	374	380	PF00069	0.195
MOD_ProDKin_1	328	334	PF00069	0.710
MOD_ProDKin_1	392	398	PF00069	0.606
MOD_ProDKin_1	452	458	PF00069	0.531
MOD_ProDKin_1	465	471	PF00069	0.683
MOD_ProDKin_1	78	84	PF00069	0.742
MOD_SUMO_rev_2	141	151	PF00179	0.607
TRG_DiLeu_LyEn_5	192	197	PF01217	0.477
TRG_ENDOCYTIC_2	506	509	PF00928	0.488
TRG_ER_diArg_1	121	123	PF00400	0.513
TRG_ER_diArg_1	289	292	PF00400	0.633
TRG_ER_diArg_1	401	404	PF00400	0.495
TRG_ER_diArg_1	42	44	PF00400	0.563
TRG_ER_diArg_1	521	524	PF00400	0.433
TRG_ER_diArg_1	539	541	PF00400	0.588
TRG_NLS_Bipartite_1	540	556	PF00514	0.687
TRG_NLS_MonoExtC_3	551	557	PF00514	0.731
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL5	Leptomonas seymouri	47%	97%
A0A1X0P8D1	Trypanosomatidae	31%	100%
A0A3S7X044	Leishmania donovani	91%	100%
A0A422N0J7	Trypanosoma rangeli	33%	100%
A4HF59	Leishmania braziliensis	75%	100%
A4I2E3	Leishmania infantum	92%	100%
C9ZX64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AYJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BJ25	Trypanosoma cruzi	32%	100%