Yip1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8X2_LEIMA

TriTrypDb:

LmjF.26.2200 , LMJLV39_260028600 , LMJSD75_260027000

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005802	trans-Golgi network	4	2
GO:0016020	membrane	2	7
GO:0031984	organelle subcompartment	2	2
GO:0098791	Golgi apparatus subcompartment	3	2
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	5

Expansion

Sequence features

Q4Q8X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8X2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	7
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0007030	Golgi organization	5	2
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0016192	vesicle-mediated transport	4	7
GO:0046907	intracellular transport	3	7
GO:0048193	Golgi vesicle transport	5	7
GO:0048280	vesicle fusion with Golgi apparatus	6	2
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0051649	establishment of localization in cell	3	7
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	232	234	PF00675	0.604
CLV_NRD_NRD_1	56	58	PF00675	0.557
CLV_NRD_NRD_1	8	10	PF00675	0.633
CLV_PCSK_KEX2_1	232	234	PF00082	0.629
CLV_PCSK_KEX2_1	56	58	PF00082	0.557
CLV_PCSK_KEX2_1	8	10	PF00082	0.633
CLV_PCSK_SKI1_1	372	376	PF00082	0.466
CLV_PCSK_SKI1_1	379	383	PF00082	0.470
CLV_PCSK_SKI1_1	435	439	PF00082	0.411
CLV_PCSK_SKI1_1	480	484	PF00082	0.504
DEG_SPOP_SBC_1	103	107	PF00917	0.822
DEG_SPOP_SBC_1	123	127	PF00917	0.583
DOC_CDC14_PxL_1	513	521	PF14671	0.411
DOC_CYCLIN_RxL_1	432	439	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.411
DOC_MAPK_MEF2A_6	444	451	PF00069	0.699
DOC_MAPK_MEF2A_6	480	489	PF00069	0.349
DOC_MAPK_NFAT4_5	480	488	PF00069	0.346
DOC_PIKK_1	359	367	PF02985	0.685
DOC_PP1_RVXF_1	415	421	PF00149	0.439
DOC_PP2B_LxvP_1	224	227	PF13499	0.659
DOC_USP7_MATH_1	103	107	PF00917	0.822
DOC_USP7_MATH_1	123	127	PF00917	0.583
DOC_USP7_MATH_1	141	145	PF00917	0.629
DOC_USP7_MATH_1	23	27	PF00917	0.748
DOC_USP7_MATH_1	41	45	PF00917	0.688
DOC_USP7_MATH_1	68	72	PF00917	0.771
DOC_WW_Pin1_4	149	154	PF00397	0.771
DOC_WW_Pin1_4	275	280	PF00397	0.816
DOC_WW_Pin1_4	293	298	PF00397	0.661
DOC_WW_Pin1_4	39	44	PF00397	0.723
LIG_14-3-3_CanoR_1	171	179	PF00244	0.679
LIG_14-3-3_CanoR_1	56	60	PF00244	0.737
LIG_Actin_WH2_2	465	482	PF00022	0.610
LIG_BIR_II_1	1	5	PF00653	0.777
LIG_BRCT_BRCA1_1	271	275	PF00533	0.657
LIG_EH_1	382	386	PF12763	0.679
LIG_FHA_1	461	467	PF00498	0.411
LIG_FHA_1	496	502	PF00498	0.459
LIG_FHA_1	50	56	PF00498	0.752
LIG_FHA_1	522	528	PF00498	0.436
LIG_GBD_Chelix_1	452	460	PF00786	0.499
LIG_LIR_Apic_2	11	16	PF02991	0.755
LIG_LIR_Apic_2	118	123	PF02991	0.756
LIG_LIR_Gen_1	509	520	PF02991	0.546
LIG_LIR_Gen_1	523	531	PF02991	0.513
LIG_LIR_Nem_3	421	427	PF02991	0.411
LIG_LIR_Nem_3	455	461	PF02991	0.389
LIG_LIR_Nem_3	509	515	PF02991	0.546
LIG_LIR_Nem_3	523	528	PF02991	0.513
LIG_LIR_Nem_3	82	86	PF02991	0.738
LIG_LYPXL_S_1	515	519	PF13949	0.411
LIG_LYPXL_yS_3	516	519	PF13949	0.353
LIG_MYND_3	361	365	PF01753	0.682
LIG_NRBOX	407	413	PF00104	0.411
LIG_Pex14_2	313	317	PF04695	0.604
LIG_Pex14_2	521	525	PF04695	0.411
LIG_PTB_Apo_2	106	113	PF02174	0.819
LIG_PTB_Phospho_1	106	112	PF10480	0.820
LIG_REV1ctd_RIR_1	431	439	PF16727	0.411
LIG_SH2_CRK	13	17	PF00017	0.742
LIG_SH2_CRK	458	462	PF00017	0.411
LIG_SH2_PTP2	120	123	PF00017	0.759
LIG_SH2_SRC	13	16	PF00017	0.772
LIG_SH2_STAP1	291	295	PF00017	0.776
LIG_SH2_STAT3	236	239	PF00017	0.787
LIG_SH2_STAT5	120	123	PF00017	0.759
LIG_SH2_STAT5	241	244	PF00017	0.772
LIG_SH2_STAT5	34	37	PF00017	0.766
LIG_SH2_STAT5	512	515	PF00017	0.411
LIG_SH2_STAT5	85	88	PF00017	0.733
LIG_SH3_3	213	219	PF00018	0.720
LIG_SH3_3	240	246	PF00018	0.755
LIG_SH3_3	279	285	PF00018	0.745
LIG_SH3_3	378	384	PF00018	0.663
LIG_SH3_3	511	517	PF00018	0.411
LIG_SUMO_SIM_anti_2	407	413	PF11976	0.411
LIG_SUMO_SIM_par_1	320	328	PF11976	0.607
LIG_SUMO_SIM_par_1	386	391	PF11976	0.618
LIG_TRFH_1	458	462	PF08558	0.411
LIG_TYR_ITIM	456	461	PF00017	0.411
LIG_TYR_ITIM	514	519	PF00017	0.411
LIG_UBA3_1	411	417	PF00899	0.416
LIG_WRC_WIRS_1	522	527	PF05994	0.436
LIG_WW_3	175	179	PF00397	0.759
MOD_CK1_1	105	111	PF00069	0.747
MOD_CK1_1	137	143	PF00069	0.766
MOD_CK1_1	189	195	PF00069	0.777
MOD_CK1_1	21	27	PF00069	0.773
MOD_CK1_1	244	250	PF00069	0.799
MOD_CK1_1	307	313	PF00069	0.745
MOD_CK1_1	44	50	PF00069	0.771
MOD_CMANNOS	492	495	PF00535	0.411
MOD_GlcNHglycan	117	120	PF01048	0.549
MOD_GlcNHglycan	139	142	PF01048	0.589
MOD_GlcNHglycan	143	146	PF01048	0.650
MOD_GlcNHglycan	147	150	PF01048	0.600
MOD_GlcNHglycan	167	170	PF01048	0.575
MOD_GlcNHglycan	190	194	PF01048	0.588
MOD_GlcNHglycan	20	23	PF01048	0.607
MOD_GlcNHglycan	204	207	PF01048	0.489
MOD_GlcNHglycan	247	250	PF01048	0.548
MOD_GlcNHglycan	258	261	PF01048	0.492
MOD_GlcNHglycan	271	274	PF01048	0.578
MOD_GlcNHglycan	28	31	PF01048	0.550
MOD_GlcNHglycan	282	285	PF01048	0.602
MOD_GlcNHglycan	292	296	PF01048	0.540
MOD_GlcNHglycan	306	309	PF01048	0.451
MOD_GlcNHglycan	310	313	PF01048	0.539
MOD_GlcNHglycan	326	330	PF01048	0.541
MOD_GlcNHglycan	339	342	PF01048	0.468
MOD_GlcNHglycan	420	423	PF01048	0.546
MOD_GlcNHglycan	43	46	PF01048	0.500
MOD_GlcNHglycan	48	51	PF01048	0.470
MOD_GlcNHglycan	492	495	PF01048	0.363
MOD_GlcNHglycan	96	99	PF01048	0.540
MOD_GSK3_1	133	140	PF00069	0.768
MOD_GSK3_1	141	148	PF00069	0.747
MOD_GSK3_1	185	192	PF00069	0.772
MOD_GSK3_1	196	203	PF00069	0.717
MOD_GSK3_1	210	217	PF00069	0.680
MOD_GSK3_1	241	248	PF00069	0.763
MOD_GSK3_1	271	278	PF00069	0.766
MOD_GSK3_1	303	310	PF00069	0.725
MOD_GSK3_1	39	46	PF00069	0.761
MOD_GSK3_1	55	62	PF00069	0.816
MOD_GSK3_1	94	101	PF00069	0.723
MOD_N-GLC_1	123	128	PF02516	0.586
MOD_N-GLC_1	197	202	PF02516	0.571
MOD_N-GLC_1	280	285	PF02516	0.589
MOD_N-GLC_1	355	360	PF02516	0.401
MOD_NEK2_1	165	170	PF00069	0.734
MOD_NEK2_1	325	330	PF00069	0.710
MOD_NEK2_1	404	409	PF00069	0.411
MOD_NEK2_1	436	441	PF00069	0.429
MOD_NEK2_1	451	456	PF00069	0.353
MOD_NEK2_1	520	525	PF00069	0.513
MOD_PIKK_1	124	130	PF00454	0.771
MOD_PIKK_1	170	176	PF00454	0.682
MOD_PIKK_1	207	213	PF00454	0.756
MOD_PIKK_1	226	232	PF00454	0.626
MOD_PK_1	386	392	PF00069	0.700
MOD_PKA_2	137	143	PF00069	0.789
MOD_PKA_2	170	176	PF00069	0.738
MOD_PKA_2	254	260	PF00069	0.789
MOD_PKA_2	26	32	PF00069	0.778
MOD_PKA_2	308	314	PF00069	0.715
MOD_PKA_2	55	61	PF00069	0.710
MOD_Plk_1	197	203	PF00069	0.789
MOD_Plk_4	180	186	PF00069	0.791
MOD_Plk_4	210	216	PF00069	0.842
MOD_Plk_4	320	326	PF00069	0.600
MOD_Plk_4	436	442	PF00069	0.411
MOD_Plk_4	460	466	PF00069	0.403
MOD_Plk_4	471	477	PF00069	0.415
MOD_Plk_4	483	489	PF00069	0.411
MOD_Plk_4	496	502	PF00069	0.513
MOD_ProDKin_1	149	155	PF00069	0.772
MOD_ProDKin_1	275	281	PF00069	0.817
MOD_ProDKin_1	293	299	PF00069	0.661
MOD_ProDKin_1	39	45	PF00069	0.723
TRG_DiLeu_BaEn_1	509	514	PF01217	0.546
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.686
TRG_ENDOCYTIC_2	424	427	PF00928	0.411
TRG_ENDOCYTIC_2	458	461	PF00928	0.411
TRG_ENDOCYTIC_2	512	515	PF00928	0.353
TRG_ENDOCYTIC_2	516	519	PF00928	0.353
TRG_ENDOCYTIC_2	522	525	PF00928	0.353
TRG_ENDOCYTIC_2	83	86	PF00928	0.740
TRG_ER_diArg_1	55	57	PF00400	0.829
TRG_ER_diArg_1	8	10	PF00400	0.833
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAG4	Leptomonas seymouri	48%	95%
A0A3S7X055	Leishmania donovani	94%	100%
A4HF64	Leishmania braziliensis	79%	100%
A4I2E7	Leishmania infantum	94%	100%
E9AYK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%