AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA ATPase domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q8X1_LEIMA

TriTrypDb:

LmjF.26.2210 , LMJLV39_260028700 , LMJSD75_260027100

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8X1

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	2
GO:0000076	DNA replication checkpoint signaling	6	2
GO:0007093	mitotic cell cycle checkpoint signaling	4	2
GO:0007165	signal transduction	2	2
GO:0007346	regulation of mitotic cell cycle	5	2
GO:0009987	cellular process	1	2
GO:0010389	regulation of G2/M transition of mitotic cell cycle	7	2
GO:0010564	regulation of cell cycle process	5	2
GO:0010948	negative regulation of cell cycle process	6	2
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	8	2
GO:0022402	cell cycle process	2	2
GO:0031570	DNA integrity checkpoint signaling	5	2
GO:0033314	mitotic DNA replication checkpoint signaling	6	2
GO:0035556	intracellular signal transduction	3	2
GO:0044774	mitotic DNA integrity checkpoint signaling	5	2
GO:0044818	mitotic G2/M transition checkpoint	5	2
GO:0045786	negative regulation of cell cycle	5	2
GO:0045930	negative regulation of mitotic cell cycle	6	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051726	regulation of cell cycle	4	2
GO:0065007	biological regulation	1	2
GO:1901987	regulation of cell cycle phase transition	6	2
GO:1901988	negative regulation of cell cycle phase transition	7	2
GO:1901990	regulation of mitotic cell cycle phase transition	6	2
GO:1901991	negative regulation of mitotic cell cycle phase transition	7	2
GO:1902749	regulation of cell cycle G2/M phase transition	7	2
GO:1902750	negative regulation of cell cycle G2/M phase transition	8	2
GO:1903047	mitotic cell cycle process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003688	DNA replication origin binding	7	2
GO:0003690	double-stranded DNA binding	5	2
GO:0005488	binding	1	2
GO:0043565	sequence-specific DNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:1990837	sequence-specific double-stranded DNA binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.563
CLV_C14_Caspase3-7	39	43	PF00656	0.541
CLV_C14_Caspase3-7	642	646	PF00656	0.564
CLV_NRD_NRD_1	13	15	PF00675	0.635
CLV_NRD_NRD_1	149	151	PF00675	0.605
CLV_NRD_NRD_1	29	31	PF00675	0.537
CLV_NRD_NRD_1	412	414	PF00675	0.485
CLV_NRD_NRD_1	507	509	PF00675	0.569
CLV_NRD_NRD_1	538	540	PF00675	0.326
CLV_NRD_NRD_1	72	74	PF00675	0.353
CLV_NRD_NRD_1	729	731	PF00675	0.357
CLV_PCSK_FUR_1	11	15	PF00082	0.602
CLV_PCSK_KEX2_1	119	121	PF00082	0.485
CLV_PCSK_KEX2_1	13	15	PF00082	0.635
CLV_PCSK_KEX2_1	252	254	PF00082	0.567
CLV_PCSK_KEX2_1	29	31	PF00082	0.537
CLV_PCSK_KEX2_1	411	413	PF00082	0.498
CLV_PCSK_KEX2_1	520	522	PF00082	0.359
CLV_PCSK_KEX2_1	72	74	PF00082	0.353
CLV_PCSK_KEX2_1	836	838	PF00082	0.383
CLV_PCSK_KEX2_1	97	99	PF00082	0.349
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.474
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.568
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.498
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.359
CLV_PCSK_PC1ET2_1	836	838	PF00082	0.383
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.349
CLV_PCSK_PC7_1	115	121	PF00082	0.470
CLV_PCSK_SKI1_1	150	154	PF00082	0.598
CLV_PCSK_SKI1_1	219	223	PF00082	0.601
CLV_PCSK_SKI1_1	272	276	PF00082	0.520
CLV_PCSK_SKI1_1	337	341	PF00082	0.404
CLV_PCSK_SKI1_1	436	440	PF00082	0.361
CLV_PCSK_SKI1_1	539	543	PF00082	0.350
CLV_PCSK_SKI1_1	97	101	PF00082	0.424
CLV_Separin_Metazoa	860	864	PF03568	0.370
DEG_COP1_1	35	43	PF00400	0.488
DEG_SCF_FBW7_1	153	160	PF00400	0.591
DEG_SCF_FBW7_1	181	186	PF00400	0.602
DEG_SPOP_SBC_1	326	330	PF00917	0.519
DEG_SPOP_SBC_1	403	407	PF00917	0.541
DEG_SPOP_SBC_1	582	586	PF00917	0.479
DOC_ANK_TNKS_1	389	396	PF00023	0.451
DOC_CDC14_PxL_1	463	471	PF14671	0.290
DOC_CKS1_1	154	159	PF01111	0.569
DOC_CYCLIN_RxL_1	148	158	PF00134	0.591
DOC_CYCLIN_RxL_1	537	546	PF00134	0.350
DOC_MAPK_DCC_7	411	421	PF00069	0.435
DOC_MAPK_DCC_7	461	471	PF00069	0.296
DOC_MAPK_gen_1	520	529	PF00069	0.466
DOC_MAPK_gen_1	539	545	PF00069	0.424
DOC_MAPK_MEF2A_6	412	421	PF00069	0.426
DOC_MAPK_MEF2A_6	761	770	PF00069	0.440
DOC_PP1_RVXF_1	781	787	PF00149	0.416
DOC_PP4_FxxP_1	446	449	PF00568	0.371
DOC_USP7_MATH_1	161	165	PF00917	0.600
DOC_USP7_MATH_1	183	187	PF00917	0.561
DOC_USP7_MATH_1	199	203	PF00917	0.581
DOC_USP7_MATH_1	214	218	PF00917	0.658
DOC_USP7_MATH_1	225	229	PF00917	0.581
DOC_USP7_MATH_1	230	234	PF00917	0.545
DOC_USP7_MATH_1	324	328	PF00917	0.557
DOC_USP7_MATH_1	331	335	PF00917	0.472
DOC_USP7_MATH_1	347	351	PF00917	0.377
DOC_USP7_MATH_1	364	368	PF00917	0.444
DOC_USP7_MATH_1	386	390	PF00917	0.422
DOC_USP7_MATH_1	398	402	PF00917	0.477
DOC_USP7_MATH_1	404	408	PF00917	0.456
DOC_USP7_MATH_1	511	515	PF00917	0.481
DOC_USP7_MATH_1	582	586	PF00917	0.479
DOC_USP7_MATH_1	661	665	PF00917	0.593
DOC_USP7_MATH_1	676	680	PF00917	0.557
DOC_USP7_MATH_1	68	72	PF00917	0.366
DOC_USP7_MATH_1	738	742	PF00917	0.469
DOC_WW_Pin1_4	153	158	PF00397	0.586
DOC_WW_Pin1_4	171	176	PF00397	0.546
DOC_WW_Pin1_4	179	184	PF00397	0.559
DOC_WW_Pin1_4	19	24	PF00397	0.664
DOC_WW_Pin1_4	195	200	PF00397	0.554
DOC_WW_Pin1_4	221	226	PF00397	0.597
DOC_WW_Pin1_4	243	248	PF00397	0.599
DOC_WW_Pin1_4	327	332	PF00397	0.552
DOC_WW_Pin1_4	412	417	PF00397	0.457
DOC_WW_Pin1_4	583	588	PF00397	0.527
DOC_WW_Pin1_4	6	11	PF00397	0.598
DOC_WW_Pin1_4	679	684	PF00397	0.541
DOC_WW_Pin1_4	748	753	PF00397	0.590
LIG_14-3-3_CanoR_1	101	109	PF00244	0.403
LIG_14-3-3_CanoR_1	120	124	PF00244	0.520
LIG_14-3-3_CanoR_1	203	209	PF00244	0.658
LIG_14-3-3_CanoR_1	521	531	PF00244	0.353
LIG_14-3-3_CanoR_1	558	563	PF00244	0.405
LIG_14-3-3_CanoR_1	602	607	PF00244	0.535
LIG_14-3-3_CanoR_1	817	822	PF00244	0.363
LIG_14-3-3_CanoR_1	845	853	PF00244	0.454
LIG_Actin_WH2_2	415	433	PF00022	0.380
LIG_Actin_WH2_2	800	815	PF00022	0.375
LIG_APCC_ABBA_1	476	481	PF00400	0.341
LIG_BIR_III_4	177	181	PF00653	0.593
LIG_BIR_III_4	645	649	PF00653	0.583
LIG_BRCT_BRCA1_1	632	636	PF00533	0.552
LIG_EH1_1	44	52	PF00400	0.480
LIG_FHA_1	236	242	PF00498	0.695
LIG_FHA_1	273	279	PF00498	0.545
LIG_FHA_1	371	377	PF00498	0.339
LIG_FHA_1	596	602	PF00498	0.571
LIG_FHA_1	627	633	PF00498	0.508
LIG_FHA_1	715	721	PF00498	0.299
LIG_FHA_1	763	769	PF00498	0.425
LIG_FHA_1	813	819	PF00498	0.388
LIG_FHA_1	822	828	PF00498	0.386
LIG_FHA_1	91	97	PF00498	0.334
LIG_FHA_2	120	126	PF00498	0.558
LIG_FHA_2	128	134	PF00498	0.541
LIG_FHA_2	195	201	PF00498	0.618
LIG_FHA_2	238	244	PF00498	0.609
LIG_FHA_2	277	283	PF00498	0.529
LIG_FHA_2	47	53	PF00498	0.471
LIG_FHA_2	490	496	PF00498	0.364
LIG_FHA_2	710	716	PF00498	0.347
LIG_LIR_Apic_2	824	828	PF02991	0.409
LIG_LIR_Gen_1	60	70	PF02991	0.363
LIG_LIR_Gen_1	855	866	PF02991	0.383
LIG_LIR_Nem_3	310	316	PF02991	0.385
LIG_LIR_Nem_3	333	339	PF02991	0.422
LIG_LIR_Nem_3	561	567	PF02991	0.347
LIG_LIR_Nem_3	60	66	PF02991	0.374
LIG_LIR_Nem_3	803	807	PF02991	0.361
LIG_LIR_Nem_3	855	861	PF02991	0.391
LIG_LYPXL_yS_3	313	316	PF13949	0.369
LIG_NRBOX	470	476	PF00104	0.262
LIG_PCNA_PIPBox_1	770	779	PF02747	0.387
LIG_Pex14_2	336	340	PF04695	0.376
LIG_SH2_CRK	534	538	PF00017	0.313
LIG_SH2_CRK	777	781	PF00017	0.342
LIG_SH2_GRB2like	343	346	PF00017	0.326
LIG_SH2_NCK_1	304	308	PF00017	0.431
LIG_SH2_NCK_1	479	483	PF00017	0.346
LIG_SH2_SRC	534	537	PF00017	0.317
LIG_SH2_STAP1	304	308	PF00017	0.431
LIG_SH2_STAP1	534	538	PF00017	0.313
LIG_SH2_STAP1	63	67	PF00017	0.358
LIG_SH2_STAP1	777	781	PF00017	0.342
LIG_SH2_STAT5	308	311	PF00017	0.384
LIG_SH2_STAT5	343	346	PF00017	0.326
LIG_SH2_STAT5	429	432	PF00017	0.380
LIG_SH2_STAT5	536	539	PF00017	0.322
LIG_SH2_STAT5	719	722	PF00017	0.353
LIG_SH2_STAT5	777	780	PF00017	0.348
LIG_SH3_3	346	352	PF00018	0.357
LIG_SH3_3	461	467	PF00018	0.354
LIG_SUMO_SIM_anti_2	722	728	PF11976	0.309
LIG_SUMO_SIM_par_1	350	356	PF11976	0.375
LIG_SUMO_SIM_par_1	420	426	PF11976	0.317
LIG_SUMO_SIM_par_1	722	728	PF11976	0.309
LIG_TRAF2_1	122	125	PF00917	0.632
LIG_TRAF2_1	168	171	PF00917	0.633
LIG_UBA3_1	376	385	PF00899	0.378
LIG_WW_3	295	299	PF00397	0.524
MOD_CDK_SPK_2	157	162	PF00069	0.575
MOD_CDK_SPK_2	6	11	PF00069	0.583
MOD_CDK_SPxxK_3	19	26	PF00069	0.565
MOD_CDK_SPxxK_3	6	13	PF00069	0.617
MOD_CK1_1	185	191	PF00069	0.575
MOD_CK1_1	19	25	PF00069	0.594
MOD_CK1_1	194	200	PF00069	0.571
MOD_CK1_1	202	208	PF00069	0.566
MOD_CK1_1	224	230	PF00069	0.579
MOD_CK1_1	231	237	PF00069	0.587
MOD_CK1_1	264	270	PF00069	0.504
MOD_CK1_1	28	34	PF00069	0.589
MOD_CK1_1	319	325	PF00069	0.520
MOD_CK1_1	327	333	PF00069	0.484
MOD_CK1_1	4	10	PF00069	0.546
MOD_CK1_1	407	413	PF00069	0.552
MOD_CK1_1	593	599	PF00069	0.548
MOD_CK1_1	637	643	PF00069	0.574
MOD_CK1_1	664	670	PF00069	0.535
MOD_CK1_1	679	685	PF00069	0.586
MOD_CK1_1	75	81	PF00069	0.351
MOD_CK2_1	118	124	PF00069	0.527
MOD_CK2_1	127	133	PF00069	0.556
MOD_CK2_1	165	171	PF00069	0.546
MOD_CK2_1	237	243	PF00069	0.586
MOD_CK2_1	276	282	PF00069	0.526
MOD_CK2_1	46	52	PF00069	0.464
MOD_CK2_1	489	495	PF00069	0.368
MOD_CK2_1	608	614	PF00069	0.478
MOD_CK2_1	709	715	PF00069	0.354
MOD_GlcNHglycan	103	106	PF01048	0.409
MOD_GlcNHglycan	167	170	PF01048	0.548
MOD_GlcNHglycan	18	21	PF01048	0.544
MOD_GlcNHglycan	185	188	PF01048	0.523
MOD_GlcNHglycan	204	207	PF01048	0.647
MOD_GlcNHglycan	216	219	PF01048	0.489
MOD_GlcNHglycan	266	269	PF01048	0.533
MOD_GlcNHglycan	3	6	PF01048	0.770
MOD_GlcNHglycan	30	33	PF01048	0.604
MOD_GlcNHglycan	348	352	PF01048	0.330
MOD_GlcNHglycan	406	409	PF01048	0.510
MOD_GlcNHglycan	489	492	PF01048	0.416
MOD_GlcNHglycan	514	517	PF01048	0.505
MOD_GlcNHglycan	544	548	PF01048	0.361
MOD_GlcNHglycan	636	639	PF01048	0.688
MOD_GlcNHglycan	657	660	PF01048	0.565
MOD_GlcNHglycan	684	687	PF01048	0.465
MOD_GSK3_1	139	146	PF00069	0.637
MOD_GSK3_1	152	159	PF00069	0.531
MOD_GSK3_1	161	168	PF00069	0.597
MOD_GSK3_1	179	186	PF00069	0.734
MOD_GSK3_1	191	198	PF00069	0.571
MOD_GSK3_1	201	208	PF00069	0.562
MOD_GSK3_1	21	28	PF00069	0.766
MOD_GSK3_1	210	217	PF00069	0.489
MOD_GSK3_1	221	228	PF00069	0.531
MOD_GSK3_1	230	237	PF00069	0.626
MOD_GSK3_1	272	279	PF00069	0.544
MOD_GSK3_1	315	322	PF00069	0.496
MOD_GSK3_1	326	333	PF00069	0.479
MOD_GSK3_1	358	365	PF00069	0.349
MOD_GSK3_1	366	373	PF00069	0.373
MOD_GSK3_1	398	405	PF00069	0.690
MOD_GSK3_1	507	514	PF00069	0.483
MOD_GSK3_1	578	585	PF00069	0.594
MOD_GSK3_1	590	597	PF00069	0.611
MOD_GSK3_1	626	633	PF00069	0.765
MOD_GSK3_1	636	643	PF00069	0.573
MOD_GSK3_1	651	658	PF00069	0.535
MOD_GSK3_1	677	684	PF00069	0.534
MOD_GSK3_1	68	75	PF00069	0.344
MOD_GSK3_1	686	693	PF00069	0.414
MOD_GSK3_1	733	740	PF00069	0.422
MOD_GSK3_1	817	824	PF00069	0.376
MOD_N-GLC_1	235	240	PF02516	0.587
MOD_N-GLC_1	602	607	PF02516	0.550
MOD_N-GLC_1	78	83	PF02516	0.368
MOD_N-GLC_1	821	826	PF02516	0.384
MOD_NEK2_1	193	198	PF00069	0.594
MOD_NEK2_1	636	641	PF00069	0.541
MOD_NEK2_1	690	695	PF00069	0.397
MOD_NEK2_1	821	826	PF00069	0.384
MOD_NEK2_2	143	148	PF00069	0.528
MOD_NEK2_2	307	312	PF00069	0.400
MOD_NEK2_2	714	719	PF00069	0.332
MOD_NEK2_2	764	769	PF00069	0.409
MOD_OFUCOSY	126	131	PF10250	0.511
MOD_OFUCOSY	359	366	PF10250	0.353
MOD_PIKK_1	21	27	PF00454	0.607
MOD_PIKK_1	331	337	PF00454	0.466
MOD_PIKK_1	370	376	PF00454	0.379
MOD_PIKK_1	627	633	PF00454	0.483
MOD_PIKK_1	637	643	PF00454	0.486
MOD_PK_1	558	564	PF00069	0.304
MOD_PK_1	602	608	PF00069	0.513
MOD_PKA_1	119	125	PF00069	0.464
MOD_PKA_1	72	78	PF00069	0.356
MOD_PKA_2	119	125	PF00069	0.477
MOD_PKA_2	161	167	PF00069	0.575
MOD_PKA_2	202	208	PF00069	0.616
MOD_PKA_2	228	234	PF00069	0.583
MOD_PKA_2	25	31	PF00069	0.640
MOD_PKA_2	362	368	PF00069	0.383
MOD_PKA_2	507	513	PF00069	0.509
MOD_PKA_2	522	528	PF00069	0.389
MOD_PKA_2	601	607	PF00069	0.574
MOD_PKA_2	655	661	PF00069	0.510
MOD_PKA_2	72	78	PF00069	0.428
MOD_PKA_2	812	818	PF00069	0.399
MOD_PKA_2	844	850	PF00069	0.438
MOD_Plk_1	231	237	PF00069	0.592
MOD_Plk_1	261	267	PF00069	0.460
MOD_Plk_1	602	608	PF00069	0.530
MOD_Plk_1	714	720	PF00069	0.327
MOD_Plk_1	733	739	PF00069	0.426
MOD_Plk_1	78	84	PF00069	0.366
MOD_Plk_4	237	243	PF00069	0.576
MOD_Plk_4	436	442	PF00069	0.322
MOD_Plk_4	46	52	PF00069	0.464
MOD_Plk_4	62	68	PF00069	0.359
MOD_Plk_4	714	720	PF00069	0.327
MOD_Plk_4	78	84	PF00069	0.296
MOD_ProDKin_1	153	159	PF00069	0.585
MOD_ProDKin_1	171	177	PF00069	0.548
MOD_ProDKin_1	179	185	PF00069	0.557
MOD_ProDKin_1	19	25	PF00069	0.664
MOD_ProDKin_1	195	201	PF00069	0.556
MOD_ProDKin_1	221	227	PF00069	0.599
MOD_ProDKin_1	243	249	PF00069	0.600
MOD_ProDKin_1	327	333	PF00069	0.549
MOD_ProDKin_1	412	418	PF00069	0.443
MOD_ProDKin_1	583	589	PF00069	0.532
MOD_ProDKin_1	6	12	PF00069	0.597
MOD_ProDKin_1	679	685	PF00069	0.534
MOD_ProDKin_1	748	754	PF00069	0.591
MOD_SUMO_for_1	570	573	PF00179	0.370
MOD_SUMO_rev_2	525	531	PF00179	0.345
MOD_SUMO_rev_2	566	572	PF00179	0.339
TRG_DiLeu_BaEn_1	864	869	PF01217	0.379
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.338
TRG_ENDOCYTIC_2	308	311	PF00928	0.405
TRG_ENDOCYTIC_2	313	316	PF00928	0.350
TRG_ENDOCYTIC_2	534	537	PF00928	0.317
TRG_ENDOCYTIC_2	63	66	PF00928	0.362
TRG_ENDOCYTIC_2	777	780	PF00928	0.348
TRG_ER_diArg_1	10	13	PF00400	0.604
TRG_ER_diArg_1	72	74	PF00400	0.353
TRG_NLS_Bipartite_1	508	524	PF00514	0.402
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL4	Leptomonas seymouri	54%	99%
A0A3S7X053	Leishmania donovani	91%	98%
A4HF65	Leishmania braziliensis	76%	98%
A4I2E8	Leishmania infantum	91%	98%
E9AYK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%