Putative GDP-mannose 4,6 dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GDP-mannose 4,6 dehydratase, putative

Species:

Leishmania major

UniProt:

Q4Q8W9_LEIMA

TriTrypDb:

LmjF.26.2230 , LMJLV39_260028900 , LMJSD75_260027300

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q8W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8W9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009225	nucleotide-sugar metabolic process	4	9
GO:0009987	cellular process	1	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044281	small molecule metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0055086	nucleobase-containing small molecule metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:1901135	carbohydrate derivative metabolic process	3	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008460	dTDP-glucose 4,6-dehydratase activity	5	9
GO:0016829	lyase activity	2	9
GO:0016835	carbon-oxygen lyase activity	3	9
GO:0016836	hydro-lyase activity	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.368
CLV_NRD_NRD_1	298	300	PF00675	0.272
CLV_NRD_NRD_1	312	314	PF00675	0.179
CLV_NRD_NRD_1	415	417	PF00675	0.296
CLV_NRD_NRD_1	422	424	PF00675	0.341
CLV_PCSK_KEX2_1	298	300	PF00082	0.356
CLV_PCSK_KEX2_1	312	314	PF00082	0.192
CLV_PCSK_KEX2_1	415	417	PF00082	0.296
CLV_PCSK_KEX2_1	422	424	PF00082	0.341
CLV_PCSK_SKI1_1	188	192	PF00082	0.344
CLV_PCSK_SKI1_1	51	55	PF00082	0.404
CLV_PCSK_SKI1_1	77	81	PF00082	0.483
DEG_APCC_DBOX_1	50	58	PF00400	0.389
DOC_MAPK_gen_1	298	304	PF00069	0.339
DOC_MAPK_MEF2A_6	166	174	PF00069	0.362
DOC_PP1_RVXF_1	186	193	PF00149	0.344
DOC_PP1_RVXF_1	414	421	PF00149	0.392
DOC_PP4_FxxP_1	266	269	PF00568	0.277
DOC_USP7_MATH_1	118	122	PF00917	0.627
DOC_USP7_MATH_1	123	127	PF00917	0.578
DOC_USP7_MATH_1	134	138	PF00917	0.428
DOC_USP7_MATH_1	14	18	PF00917	0.611
DOC_WW_Pin1_4	12	17	PF00397	0.606
DOC_WW_Pin1_4	140	145	PF00397	0.527
LIG_14-3-3_CanoR_1	391	399	PF00244	0.408
LIG_14-3-3_CanoR_1	415	419	PF00244	0.350
LIG_Actin_WH2_2	399	417	PF00022	0.228
LIG_APCC_ABBA_1	302	307	PF00400	0.296
LIG_APCC_ABBAyCdc20_2	301	307	PF00400	0.409
LIG_APCC_ABBAyCdc20_2	312	318	PF00400	0.316
LIG_BIR_III_4	128	132	PF00653	0.443
LIG_BRCT_BRCA1_1	188	192	PF00533	0.268
LIG_EH1_1	167	175	PF00400	0.303
LIG_FHA_1	157	163	PF00498	0.344
LIG_FHA_1	165	171	PF00498	0.262
LIG_FHA_1	198	204	PF00498	0.268
LIG_FHA_1	212	218	PF00498	0.268
LIG_FHA_1	219	225	PF00498	0.235
LIG_FHA_1	30	36	PF00498	0.637
LIG_FHA_1	324	330	PF00498	0.365
LIG_FHA_2	109	115	PF00498	0.497
LIG_FHA_2	178	184	PF00498	0.362
LIG_FHA_2	200	206	PF00498	0.465
LIG_FHA_2	392	398	PF00498	0.296
LIG_GBD_Chelix_1	320	328	PF00786	0.344
LIG_IBAR_NPY_1	246	248	PF08397	0.268
LIG_LIR_Apic_2	265	269	PF02991	0.268
LIG_LIR_Gen_1	146	156	PF02991	0.305
LIG_LIR_Gen_1	189	198	PF02991	0.312
LIG_LIR_Gen_1	214	224	PF02991	0.303
LIG_LIR_Gen_1	260	271	PF02991	0.296
LIG_LIR_Nem_3	146	151	PF02991	0.305
LIG_LIR_Nem_3	189	195	PF02991	0.312
LIG_LIR_Nem_3	222	228	PF02991	0.343
LIG_LIR_Nem_3	260	266	PF02991	0.296
LIG_LIR_Nem_3	375	381	PF02991	0.371
LIG_SH2_CRK	148	152	PF00017	0.268
LIG_SH2_CRK	210	214	PF00017	0.334
LIG_SH2_NCK_1	337	341	PF00017	0.352
LIG_SH2_NCK_1	82	86	PF00017	0.391
LIG_SH2_SRC	82	85	PF00017	0.386
LIG_SH2_STAT5	316	319	PF00017	0.344
LIG_SH2_STAT5	378	381	PF00017	0.392
LIG_SH2_STAT5	392	395	PF00017	0.379
LIG_SH2_STAT5	97	100	PF00017	0.382
LIG_SH3_3	10	16	PF00018	0.712
LIG_SH3_3	101	107	PF00018	0.407
LIG_SH3_3	238	244	PF00018	0.312
LIG_SUMO_SIM_par_1	157	164	PF11976	0.374
LIG_SUMO_SIM_par_1	268	273	PF11976	0.325
LIG_TRAF2_1	409	412	PF00917	0.296
LIG_WRC_WIRS_1	263	268	PF05994	0.340
LIG_WRC_WIRS_1	289	294	PF05994	0.296
MOD_CDK_SPxxK_3	140	147	PF00069	0.472
MOD_CK1_1	121	127	PF00069	0.584
MOD_CK1_1	143	149	PF00069	0.304
MOD_CK1_1	164	170	PF00069	0.200
MOD_CK2_1	121	127	PF00069	0.642
MOD_CK2_1	199	205	PF00069	0.455
MOD_CK2_1	217	223	PF00069	0.169
MOD_CK2_1	338	344	PF00069	0.293
MOD_CK2_1	391	397	PF00069	0.344
MOD_CK2_1	406	412	PF00069	0.207
MOD_GlcNHglycan	120	123	PF01048	0.632
MOD_GlcNHglycan	16	19	PF01048	0.652
MOD_GlcNHglycan	259	262	PF01048	0.296
MOD_GlcNHglycan	72	75	PF01048	0.465
MOD_GSK3_1	132	139	PF00069	0.626
MOD_GSK3_1	182	189	PF00069	0.277
MOD_GSK3_1	25	32	PF00069	0.767
MOD_GSK3_1	438	445	PF00069	0.618
MOD_N-GLC_1	129	134	PF02516	0.534
MOD_N-GLC_1	29	34	PF02516	0.653
MOD_N-GLC_1	3	8	PF02516	0.637
MOD_NEK2_1	156	161	PF00069	0.429
MOD_NEK2_1	186	191	PF00069	0.280
MOD_NEK2_1	3	8	PF00069	0.641
MOD_NEK2_1	374	379	PF00069	0.344
MOD_NEK2_1	414	419	PF00069	0.315
MOD_NEK2_1	70	75	PF00069	0.305
MOD_NEK2_2	262	267	PF00069	0.362
MOD_PIKK_1	190	196	PF00454	0.369
MOD_PK_1	343	349	PF00069	0.296
MOD_PKA_2	414	420	PF00069	0.328
MOD_Plk_1	156	162	PF00069	0.364
MOD_Plk_1	182	188	PF00069	0.308
MOD_Plk_1	236	242	PF00069	0.344
MOD_Plk_1	343	349	PF00069	0.268
MOD_Plk_1	374	380	PF00069	0.344
MOD_Plk_1	406	412	PF00069	0.422
MOD_Plk_4	151	157	PF00069	0.348
MOD_Plk_4	199	205	PF00069	0.391
MOD_Plk_4	237	243	PF00069	0.352
MOD_Plk_4	288	294	PF00069	0.296
MOD_Plk_4	323	329	PF00069	0.362
MOD_Plk_4	374	380	PF00069	0.344
MOD_ProDKin_1	12	18	PF00069	0.605
MOD_ProDKin_1	140	146	PF00069	0.519
TRG_ENDOCYTIC_2	148	151	PF00928	0.268
TRG_ENDOCYTIC_2	210	213	PF00928	0.334
TRG_ENDOCYTIC_2	225	228	PF00928	0.211
TRG_ENDOCYTIC_2	263	266	PF00928	0.296
TRG_ER_diArg_1	297	299	PF00400	0.272
TRG_ER_diArg_1	312	314	PF00400	0.172
TRG_ER_diArg_1	414	416	PF00400	0.296
TRG_ER_diArg_1	421	423	PF00400	0.322
TRG_NES_CRM1_1	397	412	PF08389	0.199
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L5	Leptomonas seymouri	59%	100%
A0A0S4JG28	Bodo saltans	23%	100%
A0A1X0NTG2	Trypanosomatidae	25%	100%
A0A1X0P7H6	Trypanosomatidae	40%	100%
A0A3Q8IH81	Leishmania donovani	91%	99%
A0A3Q8IHM5	Leishmania donovani	24%	100%
A0A3R7NVB4	Trypanosoma rangeli	43%	100%
A0QSK6	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	34%	100%
A0R5C5	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	28%	100%
A4HF67	Leishmania braziliensis	76%	99%
A4I2F0	Leishmania infantum	92%	99%
A6QLW2	Bos taurus	36%	100%
B0RVL0	Xanthomonas campestris pv. campestris (strain B100)	36%	100%
B9J8R3	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)	25%	100%
D4GU72	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	37%	100%
E9AHP8	Leishmania infantum	24%	100%
E9AYK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B469	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
O95455	Homo sapiens	37%	100%
P0C7J0	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	36%	100%
P13226	Streptomyces lividans	27%	100%
P18645	Rattus norvegicus	23%	100%
P24325	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	100%
P26391	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	100%
P27830	Escherichia coli (strain K12)	34%	100%
P29782	Streptomyces griseus	34%	100%
P33119	Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)	27%	100%
P35673	Erwinia amylovora	24%	100%
P37759	Escherichia coli (strain K12)	34%	100%
P37761	Neisseria gonorrhoeae	35%	100%
P37777	Shigella flexneri	34%	100%
P39630	Bacillus subtilis (strain 168)	33%	100%
P44914	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	34%	100%
P55293	Escherichia coli	33%	100%
P55294	Neisseria meningitidis serogroup B (strain MC58)	33%	100%
P55462	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	36%	100%
P55579	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	25%	100%
P75517	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	23%	100%
P95780	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	32%	100%
P9WN64	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	33%	100%
P9WN65	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	33%	100%
P9WN66	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WN67	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q04973	Salmonella typhi	24%	100%
Q05026	Neisseria gonorrhoeae	25%	100%
Q14376	Homo sapiens	23%	100%
Q2SYH7	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	28%	100%
Q331Q7	Streptomyces sp.	27%	100%
Q3T105	Bos taurus	24%	100%
Q4Q3V7	Leishmania major	24%	92%
Q54WS6	Dictyostelium discoideum	34%	100%
Q57301	Yersinia enterocolitica	24%	100%
Q57664	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	25%	100%
Q58455	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	23%	100%
Q59083	Azospirillum brasilense	27%	100%
Q5R8D0	Pongo abelii	23%	100%
Q5SFA6	Streptomyces bikiniensis	27%	100%
Q5UR12	Acanthamoeba polyphaga mimivirus	40%	100%
Q652A8	Oryza sativa subsp. japonica	24%	100%
Q6E7F4	Escherichia coli	32%	100%
Q6K2E1	Oryza sativa subsp. japonica	26%	100%
Q8LNZ3	Oryza sativa subsp. japonica	25%	100%
Q8R059	Mus musculus	24%	100%
Q8S8T4	Arabidopsis thaliana	25%	100%
Q8VDR7	Mus musculus	37%	100%
Q8VZC0	Arabidopsis thaliana	25%	100%
Q9CNY5	Pasteurella multocida (strain Pm70)	24%	100%
Q9F7D4	Yersinia pestis	27%	100%
Q9FIE8	Arabidopsis thaliana	24%	100%
Q9HDU4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q9KDV3	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	28%	100%
Q9L9E8	Streptomyces niveus	35%	100%
Q9LH76	Arabidopsis thaliana	40%	67%
Q9LPG6	Arabidopsis thaliana	39%	67%
Q9LZI2	Arabidopsis thaliana	25%	100%
Q9RR28	Streptomyces antibioticus	33%	100%
Q9S642	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	34%	100%
Q9SN58	Arabidopsis thaliana	26%	100%
Q9SN95	Arabidopsis thaliana	24%	100%
Q9SYM5	Arabidopsis thaliana	39%	67%
Q9T0A7	Arabidopsis thaliana	25%	100%
Q9W0P5	Drosophila melanogaster	26%	100%
Q9ZAE8	Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)	34%	100%
Q9ZV36	Arabidopsis thaliana	25%	100%
V5BEL1	Trypanosoma cruzi	41%	79%