Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8W7_LEIMA

TriTrypDb:

LmjF.26.2250 , LMJLV39_260029100 , LMJSD75_260027500

Length:

826

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8W7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.554
CLV_C14_Caspase3-7	539	543	PF00656	0.626
CLV_NRD_NRD_1	29	31	PF00675	0.571
CLV_NRD_NRD_1	347	349	PF00675	0.767
CLV_NRD_NRD_1	444	446	PF00675	0.715
CLV_NRD_NRD_1	506	508	PF00675	0.650
CLV_NRD_NRD_1	664	666	PF00675	0.700
CLV_NRD_NRD_1	73	75	PF00675	0.637
CLV_NRD_NRD_1	97	99	PF00675	0.720
CLV_PCSK_FUR_1	631	635	PF00082	0.656
CLV_PCSK_KEX2_1	29	31	PF00082	0.571
CLV_PCSK_KEX2_1	346	348	PF00082	0.801
CLV_PCSK_KEX2_1	444	446	PF00082	0.580
CLV_PCSK_KEX2_1	490	492	PF00082	0.617
CLV_PCSK_KEX2_1	505	507	PF00082	0.646
CLV_PCSK_KEX2_1	633	635	PF00082	0.642
CLV_PCSK_KEX2_1	663	665	PF00082	0.668
CLV_PCSK_KEX2_1	72	74	PF00082	0.624
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.617
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.660
CLV_PCSK_PC7_1	486	492	PF00082	0.606
CLV_PCSK_SKI1_1	30	34	PF00082	0.630
CLV_PCSK_SKI1_1	452	456	PF00082	0.779
CLV_PCSK_SKI1_1	466	470	PF00082	0.652
CLV_PCSK_SKI1_1	531	535	PF00082	0.733
CLV_PCSK_SKI1_1	634	638	PF00082	0.648
CLV_PCSK_SKI1_1	747	751	PF00082	0.658
CLV_PCSK_SKI1_1	787	791	PF00082	0.594
DEG_COP1_1	687	695	PF00400	0.763
DEG_SCF_FBW7_1	680	687	PF00400	0.575
DEG_SPOP_SBC_1	16	20	PF00917	0.719
DOC_CDC14_PxL_1	689	697	PF14671	0.637
DOC_CKS1_1	681	686	PF01111	0.579
DOC_CYCLIN_RxL_1	71	81	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.743
DOC_CYCLIN_yCln2_LP_2	554	560	PF00134	0.645
DOC_MAPK_gen_1	452	461	PF00069	0.706
DOC_MAPK_gen_1	490	498	PF00069	0.648
DOC_MAPK_gen_1	631	639	PF00069	0.622
DOC_MAPK_gen_1	72	84	PF00069	0.538
DOC_PP2B_LxvP_1	138	141	PF13499	0.651
DOC_PP4_FxxP_1	478	481	PF00568	0.739
DOC_USP7_MATH_1	133	137	PF00917	0.676
DOC_USP7_MATH_1	264	268	PF00917	0.585
DOC_USP7_MATH_1	580	584	PF00917	0.760
DOC_USP7_UBL2_3	339	343	PF12436	0.704
DOC_USP7_UBL2_3	787	791	PF12436	0.613
DOC_WW_Pin1_4	289	294	PF00397	0.767
DOC_WW_Pin1_4	461	466	PF00397	0.745
DOC_WW_Pin1_4	680	685	PF00397	0.628
DOC_WW_Pin1_4	739	744	PF00397	0.739
LIG_14-3-3_CanoR_1	171	177	PF00244	0.694
LIG_14-3-3_CanoR_1	363	367	PF00244	0.627
LIG_14-3-3_CanoR_1	405	411	PF00244	0.713
LIG_14-3-3_CanoR_1	445	454	PF00244	0.766
LIG_14-3-3_CanoR_1	486	490	PF00244	0.600
LIG_14-3-3_CanoR_1	531	536	PF00244	0.732
LIG_14-3-3_CanoR_1	663	671	PF00244	0.636
LIG_14-3-3_CanoR_1	799	808	PF00244	0.631
LIG_APCC_ABBA_1	271	276	PF00400	0.491
LIG_BIR_II_1	1	5	PF00653	0.736
LIG_BRCT_BRCA1_1	135	139	PF00533	0.771
LIG_BRCT_BRCA1_1	456	460	PF00533	0.640
LIG_Clathr_ClatBox_1	495	499	PF01394	0.781
LIG_eIF4E_1	183	189	PF01652	0.668
LIG_FHA_1	100	106	PF00498	0.605
LIG_FHA_1	133	139	PF00498	0.688
LIG_FHA_1	156	162	PF00498	0.715
LIG_FHA_1	17	23	PF00498	0.683
LIG_FHA_1	183	189	PF00498	0.637
LIG_FHA_1	202	208	PF00498	0.599
LIG_FHA_1	268	274	PF00498	0.606
LIG_FHA_1	300	306	PF00498	0.646
LIG_FHA_1	703	709	PF00498	0.741
LIG_FHA_1	740	746	PF00498	0.745
LIG_FHA_1	770	776	PF00498	0.690
LIG_FHA_2	19	25	PF00498	0.659
LIG_FHA_2	363	369	PF00498	0.675
LIG_FHA_2	418	424	PF00498	0.721
LIG_FHA_2	537	543	PF00498	0.688
LIG_FHA_2	615	621	PF00498	0.609
LIG_LIR_Apic_2	476	481	PF02991	0.741
LIG_LIR_Apic_2	772	777	PF02991	0.694
LIG_LIR_Gen_1	170	181	PF02991	0.690
LIG_LIR_Gen_1	190	201	PF02991	0.362
LIG_LIR_Gen_1	802	813	PF02991	0.713
LIG_LIR_Gen_1	819	826	PF02991	0.589
LIG_LIR_Nem_3	170	176	PF02991	0.654
LIG_LIR_Nem_3	190	196	PF02991	0.370
LIG_LIR_Nem_3	197	202	PF02991	0.509
LIG_LIR_Nem_3	476	482	PF02991	0.615
LIG_LIR_Nem_3	624	628	PF02991	0.639
LIG_LIR_Nem_3	802	808	PF02991	0.655
LIG_LIR_Nem_3	819	825	PF02991	0.505
LIG_LYPXL_yS_3	482	485	PF13949	0.710
LIG_MAD2	370	378	PF02301	0.739
LIG_PTAP_UEV_1	809	814	PF05743	0.668
LIG_PTB_Apo_2	49	56	PF02174	0.651
LIG_SH2_CRK	329	333	PF00017	0.680
LIG_SH2_NCK_1	193	197	PF00017	0.668
LIG_SH2_NCK_1	364	368	PF00017	0.645
LIG_SH2_NCK_1	822	826	PF00017	0.602
LIG_SH2_PTP2	173	176	PF00017	0.690
LIG_SH2_PTP2	375	378	PF00017	0.715
LIG_SH2_STAP1	818	822	PF00017	0.690
LIG_SH2_STAT5	173	176	PF00017	0.651
LIG_SH2_STAT5	261	264	PF00017	0.589
LIG_SH2_STAT5	364	367	PF00017	0.657
LIG_SH2_STAT5	375	378	PF00017	0.647
LIG_SH2_STAT5	4	7	PF00017	0.776
LIG_SH2_STAT5	419	422	PF00017	0.694
LIG_SH2_STAT5	732	735	PF00017	0.759
LIG_SH2_STAT5	774	777	PF00017	0.700
LIG_SH2_STAT5	805	808	PF00017	0.705
LIG_SH2_STAT5	818	821	PF00017	0.664
LIG_SH2_STAT5	822	825	PF00017	0.604
LIG_SH3_1	375	381	PF00018	0.792
LIG_SH3_3	138	144	PF00018	0.743
LIG_SH3_3	215	221	PF00018	0.692
LIG_SH3_3	290	296	PF00018	0.794
LIG_SH3_3	363	369	PF00018	0.672
LIG_SH3_3	375	381	PF00018	0.759
LIG_SH3_3	670	676	PF00018	0.617
LIG_SH3_3	807	813	PF00018	0.584
LIG_SUMO_SIM_par_1	556	562	PF11976	0.689
LIG_TYR_ITIM	362	367	PF00017	0.681
LIG_TYR_ITIM	820	825	PF00017	0.654
LIG_UBA3_1	27	36	PF00899	0.669
LIG_WRC_WIRS_1	196	201	PF05994	0.551
MOD_CDK_SPK_2	292	297	PF00069	0.788
MOD_CDK_SPK_2	461	466	PF00069	0.751
MOD_CK1_1	120	126	PF00069	0.732
MOD_CK1_1	18	24	PF00069	0.698
MOD_CK1_1	267	273	PF00069	0.670
MOD_CK1_1	292	298	PF00069	0.767
MOD_CK1_1	34	40	PF00069	0.574
MOD_CK1_1	63	69	PF00069	0.656
MOD_CK1_1	702	708	PF00069	0.740
MOD_CK2_1	362	368	PF00069	0.626
MOD_CK2_1	417	423	PF00069	0.772
MOD_CK2_1	514	520	PF00069	0.691
MOD_CK2_1	614	620	PF00069	0.642
MOD_CK2_1	820	826	PF00069	0.690
MOD_GlcNHglycan	107	110	PF01048	0.755
MOD_GlcNHglycan	122	125	PF01048	0.766
MOD_GlcNHglycan	217	221	PF01048	0.613
MOD_GlcNHglycan	329	332	PF01048	0.810
MOD_GlcNHglycan	33	36	PF01048	0.636
MOD_GlcNHglycan	390	394	PF01048	0.687
MOD_GlcNHglycan	511	514	PF01048	0.661
MOD_GlcNHglycan	61	65	PF01048	0.635
MOD_GlcNHglycan	643	646	PF01048	0.731
MOD_GlcNHglycan	667	670	PF01048	0.687
MOD_GlcNHglycan	701	704	PF01048	0.774
MOD_GlcNHglycan	810	813	PF01048	0.669
MOD_GSK3_1	114	121	PF00069	0.671
MOD_GSK3_1	129	136	PF00069	0.648
MOD_GSK3_1	142	149	PF00069	0.555
MOD_GSK3_1	179	186	PF00069	0.615
MOD_GSK3_1	299	306	PF00069	0.667
MOD_GSK3_1	310	317	PF00069	0.610
MOD_GSK3_1	327	334	PF00069	0.670
MOD_GSK3_1	34	41	PF00069	0.641
MOD_GSK3_1	431	438	PF00069	0.705
MOD_GSK3_1	455	462	PF00069	0.691
MOD_GSK3_1	531	538	PF00069	0.720
MOD_GSK3_1	580	587	PF00069	0.775
MOD_GSK3_1	680	687	PF00069	0.696
MOD_GSK3_1	691	698	PF00069	0.716
MOD_GSK3_1	699	706	PF00069	0.679
MOD_GSK3_1	741	748	PF00069	0.797
MOD_GSK3_1	816	823	PF00069	0.638
MOD_N-GLC_1	183	188	PF02516	0.671
MOD_N-GLC_1	406	411	PF02516	0.633
MOD_N-GLC_1	412	417	PF02516	0.637
MOD_N-GLC_1	435	440	PF02516	0.693
MOD_N-GLC_1	48	53	PF02516	0.715
MOD_N-GLC_1	546	551	PF02516	0.620
MOD_N-GLC_1	684	689	PF02516	0.764
MOD_N-GLC_1	820	825	PF02516	0.582
MOD_NEK2_1	105	110	PF00069	0.537
MOD_NEK2_1	161	166	PF00069	0.595
MOD_NEK2_1	195	200	PF00069	0.553
MOD_NEK2_1	31	36	PF00069	0.638
MOD_NEK2_1	417	422	PF00069	0.689
MOD_NEK2_1	535	540	PF00069	0.711
MOD_NEK2_1	564	569	PF00069	0.706
MOD_NEK2_1	595	600	PF00069	0.512
MOD_NEK2_1	695	700	PF00069	0.753
MOD_NEK2_1	91	96	PF00069	0.697
MOD_PIKK_1	133	139	PF00454	0.766
MOD_PIKK_1	259	265	PF00454	0.692
MOD_PIKK_1	417	423	PF00454	0.772
MOD_PIKK_1	614	620	PF00454	0.691
MOD_PIKK_1	820	826	PF00454	0.690
MOD_PKA_1	663	669	PF00069	0.598
MOD_PKA_2	10	16	PF00069	0.648
MOD_PKA_2	259	265	PF00069	0.653
MOD_PKA_2	362	368	PF00069	0.613
MOD_PKA_2	485	491	PF00069	0.601
MOD_PKA_2	540	546	PF00069	0.603
MOD_PKA_2	564	570	PF00069	0.720
MOD_PKA_2	663	669	PF00069	0.674
MOD_PKA_2	709	715	PF00069	0.645
MOD_PKA_2	91	97	PF00069	0.696
MOD_PKB_1	663	671	PF00069	0.599
MOD_Plk_1	133	139	PF00069	0.766
MOD_Plk_1	183	189	PF00069	0.647
MOD_Plk_1	406	412	PF00069	0.730
MOD_Plk_1	546	552	PF00069	0.523
MOD_Plk_1	596	602	PF00069	0.593
MOD_Plk_1	722	728	PF00069	0.659
MOD_Plk_1	820	826	PF00069	0.566
MOD_Plk_4	172	178	PF00069	0.619
MOD_Plk_4	267	273	PF00069	0.553
MOD_Plk_4	362	368	PF00069	0.752
MOD_Plk_4	455	461	PF00069	0.685
MOD_Plk_4	514	520	PF00069	0.708
MOD_Plk_4	608	614	PF00069	0.653
MOD_ProDKin_1	289	295	PF00069	0.767
MOD_ProDKin_1	461	467	PF00069	0.744
MOD_ProDKin_1	680	686	PF00069	0.628
MOD_ProDKin_1	739	745	PF00069	0.741
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.666
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.720
TRG_DiLeu_BaLyEn_6	506	511	PF01217	0.553
TRG_ENDOCYTIC_2	173	176	PF00928	0.563
TRG_ENDOCYTIC_2	193	196	PF00928	0.369
TRG_ENDOCYTIC_2	364	367	PF00928	0.623
TRG_ENDOCYTIC_2	482	485	PF00928	0.598
TRG_ENDOCYTIC_2	805	808	PF00928	0.654
TRG_ENDOCYTIC_2	822	825	PF00928	0.498
TRG_ER_diArg_1	257	260	PF00400	0.666
TRG_ER_diArg_1	28	30	PF00400	0.560
TRG_ER_diArg_1	345	348	PF00400	0.792
TRG_ER_diArg_1	505	507	PF00400	0.719
TRG_ER_diArg_1	662	665	PF00400	0.639
TRG_ER_diArg_1	72	74	PF00400	0.551
TRG_NLS_MonoExtN_4	96	102	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	552	556	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z2	Leptomonas seymouri	56%	100%
A0A1X0P794	Trypanosomatidae	33%	100%
A0A3Q8IG16	Leishmania donovani	92%	100%
A0A3R7KYT8	Trypanosoma rangeli	35%	100%
A4HF69	Leishmania braziliensis	75%	100%
A4I2F2	Leishmania infantum	93%	100%
C9ZX52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AYK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5AUK1	Trypanosoma cruzi	35%	100%