Putative Sec1/Munc18 related protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sec1/Munc18 related protein, putative

Species:

Leishmania major

UniProt:

Q4Q8W6_LEIMA

TriTrypDb:

LmjF.26.2260 , LMJLV39_260029200 , LMJSD75_260027600

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0020016	ciliary pocket	2	2
GO:0030141	secretory granule	8	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0099503	secretory vesicle	7	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8W6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	2
GO:0006904	vesicle docking involved in exocytosis	3	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	12
GO:0022406	membrane docking	2	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048278	vesicle docking	4	2
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0140029	exocytic process	2	2
GO:0140056	organelle localization by membrane tethering	3	2

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019905	syntaxin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	541	545	PF00656	0.413
CLV_NRD_NRD_1	143	145	PF00675	0.447
CLV_NRD_NRD_1	348	350	PF00675	0.252
CLV_NRD_NRD_1	393	395	PF00675	0.369
CLV_NRD_NRD_1	458	460	PF00675	0.358
CLV_NRD_NRD_1	567	569	PF00675	0.454
CLV_NRD_NRD_1	63	65	PF00675	0.508
CLV_NRD_NRD_1	651	653	PF00675	0.416
CLV_NRD_NRD_1	692	694	PF00675	0.492
CLV_PCSK_KEX2_1	143	145	PF00082	0.438
CLV_PCSK_KEX2_1	348	350	PF00082	0.297
CLV_PCSK_KEX2_1	393	395	PF00082	0.408
CLV_PCSK_KEX2_1	458	460	PF00082	0.417
CLV_PCSK_KEX2_1	567	569	PF00082	0.496
CLV_PCSK_KEX2_1	63	65	PF00082	0.561
CLV_PCSK_KEX2_1	651	653	PF00082	0.387
CLV_PCSK_KEX2_1	691	693	PF00082	0.495
CLV_PCSK_SKI1_1	185	189	PF00082	0.425
CLV_PCSK_SKI1_1	212	216	PF00082	0.382
CLV_PCSK_SKI1_1	459	463	PF00082	0.380
CLV_PCSK_SKI1_1	484	488	PF00082	0.379
CLV_PCSK_SKI1_1	503	507	PF00082	0.336
CLV_PCSK_SKI1_1	57	61	PF00082	0.681
CLV_PCSK_SKI1_1	64	68	PF00082	0.424
CLV_PCSK_SKI1_1	645	649	PF00082	0.480
CLV_PCSK_SKI1_1	685	689	PF00082	0.406
CLV_PCSK_SKI1_1	693	697	PF00082	0.371
DEG_APCC_DBOX_1	211	219	PF00400	0.252
DEG_APCC_DBOX_1	481	489	PF00400	0.373
DEG_APCC_DBOX_1	63	71	PF00400	0.470
DEG_APCC_DBOX_1	692	700	PF00400	0.396
DEG_Nend_UBRbox_1	1	4	PF02207	0.724
DOC_CKS1_1	728	733	PF01111	0.459
DOC_MAPK_DCC_7	212	220	PF00069	0.459
DOC_MAPK_gen_1	185	194	PF00069	0.384
DOC_MAPK_gen_1	363	371	PF00069	0.467
DOC_MAPK_gen_1	482	490	PF00069	0.351
DOC_MAPK_gen_1	689	698	PF00069	0.425
DOC_MAPK_MEF2A_6	185	194	PF00069	0.396
DOC_MAPK_MEF2A_6	212	220	PF00069	0.459
DOC_MAPK_MEF2A_6	424	431	PF00069	0.348
DOC_MAPK_MEF2A_6	470	479	PF00069	0.380
DOC_MAPK_MEF2A_6	482	490	PF00069	0.275
DOC_MAPK_MEF2A_6	689	698	PF00069	0.424
DOC_MAPK_NFAT4_5	482	490	PF00069	0.339
DOC_MAPK_NFAT4_5	691	699	PF00069	0.486
DOC_PP1_RVXF_1	691	698	PF00149	0.339
DOC_PP2B_LxvP_1	119	122	PF13499	0.459
DOC_PP2B_LxvP_1	213	216	PF13499	0.401
DOC_PP4_FxxP_1	194	197	PF00568	0.339
DOC_USP7_MATH_1	270	274	PF00917	0.440
DOC_USP7_MATH_1	473	477	PF00917	0.444
DOC_USP7_MATH_1	566	570	PF00917	0.379
DOC_USP7_MATH_1	593	597	PF00917	0.408
DOC_USP7_UBL2_3	685	689	PF12436	0.497
DOC_WW_Pin1_4	14	19	PF00397	0.719
DOC_WW_Pin1_4	2	7	PF00397	0.796
DOC_WW_Pin1_4	273	278	PF00397	0.322
DOC_WW_Pin1_4	284	289	PF00397	0.354
DOC_WW_Pin1_4	294	299	PF00397	0.413
DOC_WW_Pin1_4	580	585	PF00397	0.478
DOC_WW_Pin1_4	599	604	PF00397	0.488
DOC_WW_Pin1_4	727	732	PF00397	0.459
LIG_14-3-3_CanoR_1	13	18	PF00244	0.695
LIG_14-3-3_CanoR_1	234	239	PF00244	0.364
LIG_14-3-3_CanoR_1	281	288	PF00244	0.434
LIG_14-3-3_CanoR_1	470	478	PF00244	0.415
LIG_14-3-3_CanoR_1	561	566	PF00244	0.434
LIG_14-3-3_CanoR_1	567	571	PF00244	0.440
LIG_14-3-3_CanoR_1	633	637	PF00244	0.479
LIG_14-3-3_CanoR_1	651	655	PF00244	0.346
LIG_14-3-3_CanoR_1	733	739	PF00244	0.486
LIG_Actin_WH2_2	641	657	PF00022	0.459
LIG_APCC_ABBA_1	204	209	PF00400	0.486
LIG_APCC_ABBA_1	425	430	PF00400	0.339
LIG_APCC_ABBAyCdc20_2	424	430	PF00400	0.339
LIG_APCC_ABBAyCdc20_2	71	77	PF00400	0.522
LIG_BRCT_BRCA1_1	198	202	PF00533	0.427
LIG_BRCT_BRCA1_1	236	240	PF00533	0.459
LIG_Clathr_ClatBox_1	300	304	PF01394	0.373
LIG_Clathr_ClatBox_1	326	330	PF01394	0.354
LIG_deltaCOP1_diTrp_1	356	366	PF00928	0.343
LIG_DLG_GKlike_1	640	648	PF00625	0.408
LIG_FHA_1	22	28	PF00498	0.559
LIG_FHA_1	231	237	PF00498	0.465
LIG_FHA_1	470	476	PF00498	0.480
LIG_FHA_1	527	533	PF00498	0.361
LIG_FHA_1	675	681	PF00498	0.408
LIG_FHA_1	714	720	PF00498	0.383
LIG_FHA_1	724	730	PF00498	0.288
LIG_FHA_2	112	118	PF00498	0.354
LIG_FHA_2	184	190	PF00498	0.459
LIG_FHA_2	539	545	PF00498	0.457
LIG_FHA_2	701	707	PF00498	0.339
LIG_LIR_Apic_2	193	197	PF02991	0.354
LIG_LIR_Gen_1	304	314	PF02991	0.354
LIG_LIR_Gen_1	316	327	PF02991	0.354
LIG_LIR_Gen_1	463	473	PF02991	0.373
LIG_LIR_Gen_1	521	526	PF02991	0.467
LIG_LIR_Gen_1	83	90	PF02991	0.524
LIG_LIR_Nem_3	237	242	PF02991	0.424
LIG_LIR_Nem_3	304	310	PF02991	0.354
LIG_LIR_Nem_3	316	322	PF02991	0.354
LIG_LIR_Nem_3	356	362	PF02991	0.339
LIG_LIR_Nem_3	463	468	PF02991	0.378
LIG_LIR_Nem_3	521	525	PF02991	0.467
LIG_LIR_Nem_3	626	632	PF02991	0.390
LIG_LIR_Nem_3	665	669	PF02991	0.463
LIG_LIR_Nem_3	703	707	PF02991	0.424
LIG_LIR_Nem_3	83	89	PF02991	0.452
LIG_MLH1_MIPbox_1	236	240	PF16413	0.459
LIG_NRBOX	484	490	PF00104	0.360
LIG_PCNA_yPIPBox_3	317	327	PF02747	0.354
LIG_Pex14_2	161	165	PF04695	0.252
LIG_Pex14_2	632	636	PF04695	0.408
LIG_PTB_Apo_2	328	335	PF02174	0.354
LIG_PTB_Apo_2	607	614	PF02174	0.396
LIG_PTB_Phospho_1	328	334	PF10480	0.354
LIG_PTB_Phospho_1	607	613	PF10480	0.396
LIG_SH2_CRK	319	323	PF00017	0.354
LIG_SH2_CRK	465	469	PF00017	0.459
LIG_SH2_CRK	86	90	PF00017	0.424
LIG_SH2_GRB2like	465	468	PF00017	0.408
LIG_SH2_NCK_1	711	715	PF00017	0.408
LIG_SH2_SRC	465	468	PF00017	0.408
LIG_SH2_SRC	711	714	PF00017	0.373
LIG_SH2_STAP1	334	338	PF00017	0.424
LIG_SH2_STAT3	358	361	PF00017	0.396
LIG_SH2_STAT3	439	442	PF00017	0.373
LIG_SH2_STAT3	608	611	PF00017	0.459
LIG_SH2_STAT5	133	136	PF00017	0.328
LIG_SH2_STAT5	613	616	PF00017	0.400
LIG_SH3_3	119	125	PF00018	0.331
LIG_SH3_3	472	478	PF00018	0.424
LIG_SUMO_SIM_anti_2	295	304	PF11976	0.455
LIG_SUMO_SIM_par_1	295	304	PF11976	0.350
LIG_TRAF2_1	137	140	PF00917	0.430
LIG_TRAF2_1	342	345	PF00917	0.486
LIG_TYR_ITIM	702	707	PF00017	0.486
LIG_WRC_WIRS_1	162	167	PF05994	0.252
MOD_CDK_SPxK_1	727	733	PF00069	0.459
MOD_CK1_1	164	170	PF00069	0.486
MOD_CK1_1	273	279	PF00069	0.375
MOD_CK1_1	28	34	PF00069	0.749
MOD_CK1_1	284	290	PF00069	0.414
MOD_CK1_1	543	549	PF00069	0.366
MOD_CK1_1	727	733	PF00069	0.459
MOD_CK2_1	111	117	PF00069	0.354
MOD_CK2_1	339	345	PF00069	0.414
MOD_CK2_1	700	706	PF00069	0.354
MOD_Cter_Amidation	456	459	PF01082	0.363
MOD_Cter_Amidation	55	58	PF01082	0.723
MOD_DYRK1A_RPxSP_1	2	6	PF00069	0.556
MOD_GlcNHglycan	128	131	PF01048	0.459
MOD_GlcNHglycan	2	5	PF01048	0.567
MOD_GlcNHglycan	220	223	PF01048	0.459
MOD_GlcNHglycan	28	31	PF01048	0.763
MOD_GlcNHglycan	283	286	PF01048	0.456
MOD_GlcNHglycan	33	36	PF01048	0.707
MOD_GlcNHglycan	341	344	PF01048	0.403
MOD_GlcNHglycan	396	399	PF01048	0.471
MOD_GlcNHglycan	409	412	PF01048	0.367
MOD_GlcNHglycan	579	583	PF01048	0.455
MOD_GSK3_1	160	167	PF00069	0.461
MOD_GSK3_1	21	28	PF00069	0.755
MOD_GSK3_1	226	233	PF00069	0.395
MOD_GSK3_1	234	241	PF00069	0.339
MOD_GSK3_1	272	279	PF00069	0.442
MOD_GSK3_1	280	287	PF00069	0.462
MOD_GSK3_1	469	476	PF00069	0.364
MOD_GSK3_1	492	499	PF00069	0.372
MOD_GSK3_1	520	527	PF00069	0.410
MOD_GSK3_1	620	627	PF00069	0.384
MOD_GSK3_1	723	730	PF00069	0.459
MOD_GSK3_1	733	740	PF00069	0.459
MOD_N-GLC_1	14	19	PF02516	0.673
MOD_N-GLC_1	559	564	PF02516	0.307
MOD_N-GLC_1	572	577	PF02516	0.457
MOD_N-GLC_1	593	598	PF02516	0.485
MOD_N-GLC_1	620	625	PF02516	0.308
MOD_N-GLC_2	203	205	PF02516	0.408
MOD_NEK2_1	161	166	PF00069	0.447
MOD_NEK2_1	280	285	PF00069	0.472
MOD_NEK2_1	518	523	PF00069	0.455
MOD_NEK2_1	524	529	PF00069	0.438
MOD_NEK2_1	632	637	PF00069	0.408
MOD_NEK2_1	734	739	PF00069	0.408
MOD_NEK2_2	183	188	PF00069	0.486
MOD_NEK2_2	423	428	PF00069	0.339
MOD_NEK2_2	566	571	PF00069	0.408
MOD_PIKK_1	252	258	PF00454	0.502
MOD_PIKK_1	511	517	PF00454	0.491
MOD_PK_1	234	240	PF00069	0.363
MOD_PK_1	559	565	PF00069	0.369
MOD_PKA_1	57	63	PF00069	0.484
MOD_PKA_2	280	286	PF00069	0.474
MOD_PKA_2	469	475	PF00069	0.356
MOD_PKA_2	566	572	PF00069	0.454
MOD_PKA_2	632	638	PF00069	0.375
MOD_PKA_2	650	656	PF00069	0.462
MOD_Plk_1	138	144	PF00069	0.339
MOD_Plk_1	303	309	PF00069	0.373
MOD_Plk_1	315	321	PF00069	0.357
MOD_Plk_1	334	340	PF00069	0.201
MOD_Plk_1	473	479	PF00069	0.396
MOD_Plk_1	559	565	PF00069	0.252
MOD_Plk_4	111	117	PF00069	0.392
MOD_Plk_4	196	202	PF00069	0.396
MOD_Plk_4	234	240	PF00069	0.387
MOD_Plk_4	377	383	PF00069	0.443
MOD_Plk_4	724	730	PF00069	0.339
MOD_ProDKin_1	14	20	PF00069	0.719
MOD_ProDKin_1	2	8	PF00069	0.799
MOD_ProDKin_1	273	279	PF00069	0.322
MOD_ProDKin_1	284	290	PF00069	0.354
MOD_ProDKin_1	294	300	PF00069	0.413
MOD_ProDKin_1	580	586	PF00069	0.478
MOD_ProDKin_1	599	605	PF00069	0.488
MOD_ProDKin_1	727	733	PF00069	0.459
MOD_SUMO_rev_2	497	504	PF00179	0.447
MOD_SUMO_rev_2	51	59	PF00179	0.552
MOD_SUMO_rev_2	679	687	PF00179	0.439
TRG_DiLeu_BaEn_1	296	301	PF01217	0.459
TRG_DiLeu_BaEn_1	500	505	PF01217	0.459
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.408
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.442
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.363
TRG_ENDOCYTIC_2	319	322	PF00928	0.339
TRG_ENDOCYTIC_2	465	468	PF00928	0.424
TRG_ENDOCYTIC_2	613	616	PF00928	0.354
TRG_ENDOCYTIC_2	704	707	PF00928	0.459
TRG_ENDOCYTIC_2	86	89	PF00928	0.484
TRG_ER_diArg_1	142	144	PF00400	0.447
TRG_ER_diArg_1	392	394	PF00400	0.369
TRG_ER_diArg_1	458	460	PF00400	0.434
TRG_ER_diArg_1	481	484	PF00400	0.382
TRG_ER_diArg_1	691	693	PF00400	0.459
TRG_NES_CRM1_1	182	193	PF08389	0.447
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUY7	Leptomonas seymouri	64%	100%
A0A0S4J1J9	Bodo saltans	38%	100%
A0A1X0P7K8	Trypanosomatidae	39%	100%
A0A3Q8ID43	Leishmania donovani	95%	100%
A0A3R7MWF2	Trypanosoma rangeli	39%	100%
A4HF70	Leishmania braziliensis	77%	100%
A4I2F3	Leishmania infantum	95%	100%
C9ZX51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AYK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q54QC8	Dictyostelium discoideum	24%	100%
Q5VNU3	Oryza sativa subsp. japonica	23%	100%
Q9C5P7	Arabidopsis thaliana	23%	100%
Q9C5X3	Arabidopsis thaliana	25%	100%
V5AUI0	Trypanosoma cruzi	39%	100%