Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8W5_LEIMA

TriTrypDb:

LmjF.26.2270 , LMJLV39_260029300 , LMJSD75_260027700

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q8W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8W5

PDB structure(s): 7ane_t

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	9
GO:0005198	structural molecule activity	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	36	38	PF00675	0.481
CLV_PCSK_KEX2_1	35	37	PF00082	0.495
CLV_PCSK_SKI1_1	11	15	PF00082	0.465
CLV_PCSK_SKI1_1	128	132	PF00082	0.359
CLV_PCSK_SKI1_1	223	227	PF00082	0.487
CLV_PCSK_SKI1_1	228	232	PF00082	0.508
CLV_PCSK_SKI1_1	4	8	PF00082	0.621
CLV_PCSK_SKI1_1	57	61	PF00082	0.394
DEG_APCC_DBOX_1	227	235	PF00400	0.600
DEG_Nend_UBRbox_1	1	4	PF02207	0.715
DOC_CYCLIN_RxL_1	1	12	PF00134	0.684
DOC_CYCLIN_yClb3_PxF_3	215	223	PF00134	0.526
DOC_MAPK_DCC_7	226	236	PF00069	0.604
DOC_MAPK_DCC_7	44	52	PF00069	0.552
DOC_MAPK_DCC_7	73	82	PF00069	0.485
DOC_MAPK_MEF2A_6	228	236	PF00069	0.613
DOC_MAPK_MEF2A_6	44	52	PF00069	0.528
DOC_USP7_MATH_1	16	20	PF00917	0.590
DOC_USP7_MATH_1	246	250	PF00917	0.704
DOC_WW_Pin1_4	165	170	PF00397	0.404
DOC_WW_Pin1_4	27	32	PF00397	0.522
LIG_14-3-3_CanoR_1	2	7	PF00244	0.708
LIG_14-3-3_CanoR_1	37	47	PF00244	0.429
LIG_14-3-3_CanoR_1	73	80	PF00244	0.412
LIG_14-3-3_CanoR_1	90	100	PF00244	0.460
LIG_BRCT_BRCA1_1	94	98	PF00533	0.534
LIG_Clathr_ClatBox_1	65	69	PF01394	0.522
LIG_FHA_1	156	162	PF00498	0.389
LIG_FHA_1	201	207	PF00498	0.504
LIG_FHA_1	3	9	PF00498	0.678
LIG_FHA_1	61	67	PF00498	0.555
LIG_LIR_Gen_1	127	137	PF02991	0.389
LIG_LIR_Gen_1	95	104	PF02991	0.422
LIG_LIR_Nem_3	125	129	PF02991	0.394
LIG_LIR_Nem_3	145	150	PF02991	0.131
LIG_LIR_Nem_3	95	101	PF02991	0.486
LIG_Pex14_1	171	175	PF04695	0.347
LIG_Pex14_2	117	121	PF04695	0.422
LIG_REV1ctd_RIR_1	114	122	PF16727	0.422
LIG_SH2_CRK	147	151	PF00017	0.373
LIG_SH2_CRK	212	216	PF00017	0.484
LIG_SH2_NCK_1	175	179	PF00017	0.572
LIG_SH2_NCK_1	212	216	PF00017	0.484
LIG_SH2_PTP2	129	132	PF00017	0.389
LIG_SH2_SRC	175	178	PF00017	0.553
LIG_SH2_SRC	46	49	PF00017	0.500
LIG_SH2_STAP1	126	130	PF00017	0.366
LIG_SH2_STAP1	175	179	PF00017	0.528
LIG_SH2_STAT5	129	132	PF00017	0.383
LIG_SH2_STAT5	149	152	PF00017	0.131
LIG_SH2_STAT5	46	49	PF00017	0.482
LIG_SH3_1	212	218	PF00018	0.519
LIG_SH3_3	184	190	PF00018	0.473
LIG_SH3_3	195	201	PF00018	0.475
LIG_SH3_3	212	218	PF00018	0.485
LIG_SH3_3	229	235	PF00018	0.471
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.680
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.485
LIG_SUMO_SIM_par_1	63	69	PF11976	0.501
LIG_TYR_ITSM	143	150	PF00017	0.389
LIG_WRC_WIRS_1	149	154	PF05994	0.347
MOD_CK1_1	142	148	PF00069	0.371
MOD_CK1_1	18	24	PF00069	0.475
MOD_CK1_1	192	198	PF00069	0.505
MOD_GlcNHglycan	237	241	PF01048	0.663
MOD_GlcNHglycan	248	251	PF01048	0.671
MOD_N-GLC_1	92	97	PF02516	0.410
MOD_NEK2_1	236	241	PF00069	0.698
MOD_NEK2_1	60	65	PF00069	0.544
MOD_NEK2_2	148	153	PF00069	0.373
MOD_PIKK_1	102	108	PF00454	0.326
MOD_PIKK_1	60	66	PF00454	0.492
MOD_PIKK_1	72	78	PF00454	0.346
MOD_PKA_2	72	78	PF00069	0.407
MOD_PKB_1	2	10	PF00069	0.693
MOD_Plk_4	4	10	PF00069	0.688
MOD_ProDKin_1	165	171	PF00069	0.404
MOD_ProDKin_1	27	33	PF00069	0.517
MOD_SUMO_rev_2	256	266	PF00179	0.655
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.491
TRG_ENDOCYTIC_2	129	132	PF00928	0.388
TRG_ENDOCYTIC_2	147	150	PF00928	0.287
TRG_ER_diArg_1	1	4	PF00400	0.646
TRG_ER_diArg_1	35	37	PF00400	0.486
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K1	Leptomonas seymouri	83%	100%
A0A0S4JH36	Bodo saltans	60%	100%
A0A1X0P8P8	Trypanosomatidae	70%	100%
A0A3Q8IPG4	Leishmania donovani	97%	100%
A0A422P3W3	Trypanosoma rangeli	70%	100%
A4HF71	Leishmania braziliensis	92%	100%
A4I2F4	Leishmania infantum	97%	100%
C9ZVZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	73%
E9AYK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5AJR6	Trypanosoma cruzi	43%	100%
V5ALQ3	Trypanosoma cruzi	40%	87%
V5ANT7	Trypanosoma cruzi	39%	91%
V5B3E1	Trypanosoma cruzi	38%	100%
V5B460	Trypanosoma cruzi	48%	97%
V5D7P9	Trypanosoma cruzi	40%	97%