Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8W3_LEIMA

TriTrypDb:

LmjF.26.2290 , LMJLV39_260029500 , LMJSD75_260027900

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8W3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.593
CLV_NRD_NRD_1	114	116	PF00675	0.586
CLV_NRD_NRD_1	135	137	PF00675	0.475
CLV_NRD_NRD_1	17	19	PF00675	0.715
CLV_NRD_NRD_1	339	341	PF00675	0.467
CLV_NRD_NRD_1	83	85	PF00675	0.571
CLV_PCSK_FUR_1	112	116	PF00082	0.545
CLV_PCSK_KEX2_1	113	115	PF00082	0.574
CLV_PCSK_KEX2_1	135	137	PF00082	0.456
CLV_PCSK_KEX2_1	17	19	PF00082	0.665
CLV_PCSK_KEX2_1	75	77	PF00082	0.558
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.600
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.558
CLV_PCSK_SKI1_1	290	294	PF00082	0.487
CLV_PCSK_SKI1_1	349	353	PF00082	0.510
CLV_PCSK_SKI1_1	396	400	PF00082	0.476
DEG_APCC_DBOX_1	357	365	PF00400	0.438
DEG_Nend_Nbox_1	1	3	PF02207	0.567
DEG_SPOP_SBC_1	154	158	PF00917	0.609
DOC_CDC14_PxL_1	332	340	PF14671	0.389
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.591
DOC_MAPK_gen_1	112	120	PF00069	0.567
DOC_MAPK_gen_1	17	25	PF00069	0.731
DOC_MAPK_gen_1	75	83	PF00069	0.651
DOC_MAPK_MEF2A_6	247	254	PF00069	0.564
DOC_PP1_RVXF_1	360	367	PF00149	0.383
DOC_PP4_FxxP_1	223	226	PF00568	0.356
DOC_WW_Pin1_4	102	107	PF00397	0.633
DOC_WW_Pin1_4	178	183	PF00397	0.485
DOC_WW_Pin1_4	238	243	PF00397	0.354
DOC_WW_Pin1_4	308	313	PF00397	0.475
LIG_14-3-3_CanoR_1	17	26	PF00244	0.709
LIG_14-3-3_CanoR_1	396	405	PF00244	0.655
LIG_Actin_WH2_2	144	162	PF00022	0.576
LIG_Actin_WH2_2	347	364	PF00022	0.438
LIG_deltaCOP1_diTrp_1	263	269	PF00928	0.358
LIG_deltaCOP1_diTrp_1	343	350	PF00928	0.413
LIG_deltaCOP1_diTrp_1	382	390	PF00928	0.326
LIG_FHA_1	18	24	PF00498	0.639
LIG_FHA_1	301	307	PF00498	0.347
LIG_FHA_2	289	295	PF00498	0.368
LIG_LIR_Gen_1	198	206	PF02991	0.341
LIG_LIR_Gen_1	214	223	PF02991	0.305
LIG_LIR_Gen_1	382	390	PF02991	0.364
LIG_LIR_Nem_3	131	137	PF02991	0.448
LIG_LIR_Nem_3	198	204	PF02991	0.340
LIG_LIR_Nem_3	214	218	PF02991	0.315
LIG_LIR_Nem_3	311	316	PF02991	0.513
LIG_LIR_Nem_3	343	348	PF02991	0.406
LIG_LIR_Nem_3	382	386	PF02991	0.350
LIG_LYPXL_yS_3	199	202	PF13949	0.357
LIG_PDZ_Class_2	400	405	PF00595	0.649
LIG_Pex14_1	344	348	PF04695	0.432
LIG_PTB_Apo_2	360	367	PF02174	0.383
LIG_Rb_LxCxE_1	77	93	PF01857	0.559
LIG_REV1ctd_RIR_1	220	225	PF16727	0.344
LIG_SH2_CRK	185	189	PF00017	0.365
LIG_SH2_CRK	201	205	PF00017	0.272
LIG_SH2_CRK	326	330	PF00017	0.507
LIG_SH2_NCK_1	185	189	PF00017	0.394
LIG_SH2_PTP2	141	144	PF00017	0.564
LIG_SH2_PTP2	286	289	PF00017	0.349
LIG_SH2_SRC	141	144	PF00017	0.484
LIG_SH2_SRC	334	337	PF00017	0.485
LIG_SH2_STAP1	185	189	PF00017	0.463
LIG_SH2_STAP1	229	233	PF00017	0.420
LIG_SH2_STAT5	141	144	PF00017	0.545
LIG_SH2_STAT5	286	289	PF00017	0.349
LIG_SH2_STAT5	334	337	PF00017	0.432
LIG_SH2_STAT5	389	392	PF00017	0.375
LIG_SH3_3	115	121	PF00018	0.538
LIG_SH3_3	148	154	PF00018	0.610
LIG_SH3_3	194	200	PF00018	0.393
LIG_SH3_3	28	34	PF00018	0.778
LIG_SH3_3	309	315	PF00018	0.474
LIG_SH3_3	330	336	PF00018	0.335
LIG_SH3_3	354	360	PF00018	0.538
LIG_SUMO_SIM_par_1	201	207	PF11976	0.327
LIG_TYR_ITIM	183	188	PF00017	0.433
MOD_CDC14_SPxK_1	311	314	PF00782	0.562
MOD_CDK_SPxK_1	308	314	PF00069	0.474
MOD_CK1_1	19	25	PF00069	0.746
MOD_CK2_1	288	294	PF00069	0.359
MOD_CK2_1	51	57	PF00069	0.660
MOD_DYRK1A_RPxSP_1	308	312	PF00069	0.472
MOD_GlcNHglycan	170	174	PF01048	0.462
MOD_GlcNHglycan	27	30	PF01048	0.647
MOD_GlcNHglycan	308	311	PF01048	0.467
MOD_GlcNHglycan	400	403	PF01048	0.583
MOD_GSK3_1	47	54	PF00069	0.746
MOD_GSK3_1	8	15	PF00069	0.660
MOD_GSK3_1	98	105	PF00069	0.697
MOD_N-GLC_1	129	134	PF02516	0.509
MOD_N-GLC_1	61	66	PF02516	0.575
MOD_NEK2_1	155	160	PF00069	0.585
MOD_NEK2_1	300	305	PF00069	0.377
MOD_NEK2_1	306	311	PF00069	0.414
MOD_NEK2_1	8	13	PF00069	0.623
MOD_NEK2_1	96	101	PF00069	0.641
MOD_PIKK_1	88	94	PF00454	0.528
MOD_PIKK_1	96	102	PF00454	0.582
MOD_PK_1	61	67	PF00069	0.609
MOD_PKA_1	17	23	PF00069	0.627
MOD_PKA_2	16	22	PF00069	0.710
MOD_PKA_2	47	53	PF00069	0.635
MOD_Plk_1	129	135	PF00069	0.465
MOD_Plk_1	169	175	PF00069	0.465
MOD_Plk_1	61	67	PF00069	0.557
MOD_Plk_4	183	189	PF00069	0.387
MOD_Plk_4	328	334	PF00069	0.341
MOD_ProDKin_1	102	108	PF00069	0.630
MOD_ProDKin_1	178	184	PF00069	0.481
MOD_ProDKin_1	238	244	PF00069	0.358
MOD_ProDKin_1	308	314	PF00069	0.474
MOD_SUMO_rev_2	158	166	PF00179	0.536
MOD_SUMO_rev_2	186	195	PF00179	0.480
TRG_ENDOCYTIC_2	185	188	PF00928	0.361
TRG_ENDOCYTIC_2	199	202	PF00928	0.291
TRG_ENDOCYTIC_2	229	232	PF00928	0.421
TRG_ENDOCYTIC_2	286	289	PF00928	0.349
TRG_ENDOCYTIC_2	326	329	PF00928	0.567
TRG_ENDOCYTIC_2	345	348	PF00928	0.410
TRG_ENDOCYTIC_2	375	378	PF00928	0.347
TRG_ER_diArg_1	111	114	PF00400	0.565
TRG_ER_diArg_1	134	136	PF00400	0.473
TRG_ER_diArg_1	356	359	PF00400	0.465
TRG_NLS_MonoCore_2	111	116	PF00514	0.594
TRG_NLS_MonoExtN_4	112	117	PF00514	0.618
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P2	Leptomonas seymouri	86%	100%
A0A0S4JRL5	Bodo saltans	61%	100%
A0A1X0P7G6	Trypanosomatidae	68%	100%
A0A3S7X061	Leishmania donovani	96%	100%
A4HF73	Leishmania braziliensis	87%	100%
A4I2F6	Leishmania infantum	96%	100%
C9ZX41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AYK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BI14	Trypanosoma cruzi	65%	100%