Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8W0_LEIMA

TriTrypDb:

LmjF.26.2310 , LMJLV39_260029800 , LMJSD75_260028200

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8W0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.693
CLV_NRD_NRD_1	121	123	PF00675	0.489
CLV_NRD_NRD_1	129	131	PF00675	0.510
CLV_NRD_NRD_1	208	210	PF00675	0.639
CLV_NRD_NRD_1	221	223	PF00675	0.576
CLV_NRD_NRD_1	274	276	PF00675	0.660
CLV_NRD_NRD_1	37	39	PF00675	0.511
CLV_NRD_NRD_1	58	60	PF00675	0.594
CLV_NRD_NRD_1	78	80	PF00675	0.302
CLV_PCSK_FUR_1	38	42	PF00082	0.596
CLV_PCSK_KEX2_1	121	123	PF00082	0.492
CLV_PCSK_KEX2_1	129	131	PF00082	0.522
CLV_PCSK_KEX2_1	208	210	PF00082	0.634
CLV_PCSK_KEX2_1	40	42	PF00082	0.509
CLV_PCSK_KEX2_1	58	60	PF00082	0.321
CLV_PCSK_KEX2_1	78	80	PF00082	0.302
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.594
CLV_PCSK_SKI1_1	104	108	PF00082	0.529
CLV_PCSK_SKI1_1	129	133	PF00082	0.581
CLV_PCSK_SKI1_1	158	162	PF00082	0.788
CLV_PCSK_SKI1_1	208	212	PF00082	0.627
CLV_PCSK_SKI1_1	232	236	PF00082	0.634
CLV_PCSK_SKI1_1	239	243	PF00082	0.559
CLV_PCSK_SKI1_1	83	87	PF00082	0.523
CLV_Separin_Metazoa	75	79	PF03568	0.568
DEG_APCC_DBOX_1	253	261	PF00400	0.563
DOC_MAPK_DCC_7	193	202	PF00069	0.631
DOC_MAPK_gen_1	193	202	PF00069	0.697
DOC_MAPK_gen_1	222	229	PF00069	0.700
DOC_MAPK_gen_1	251	259	PF00069	0.652
DOC_MAPK_MEF2A_6	193	202	PF00069	0.631
DOC_MAPK_MEF2A_6	251	259	PF00069	0.656
DOC_USP7_MATH_1	153	157	PF00917	0.714
DOC_USP7_MATH_1	169	173	PF00917	0.669
DOC_USP7_MATH_1	19	23	PF00917	0.573
DOC_USP7_MATH_1	198	202	PF00917	0.665
DOC_USP7_MATH_1	241	245	PF00917	0.553
DOC_USP7_UBL2_3	136	140	PF12436	0.645
DOC_USP7_UBL2_3	189	193	PF12436	0.677
DOC_WW_Pin1_4	161	166	PF00397	0.752
DOC_WW_Pin1_4	17	22	PF00397	0.515
DOC_WW_Pin1_4	57	62	PF00397	0.640
DOC_WW_Pin1_4	94	99	PF00397	0.625
LIG_14-3-3_CanoR_1	151	160	PF00244	0.740
LIG_14-3-3_CanoR_1	209	218	PF00244	0.675
LIG_14-3-3_CanoR_1	222	231	PF00244	0.705
LIG_14-3-3_CanoR_1	99	106	PF00244	0.530
LIG_FHA_1	105	111	PF00498	0.570
LIG_FHA_2	132	138	PF00498	0.682
LIG_FHA_2	233	239	PF00498	0.669
LIG_LIR_Apic_2	192	198	PF02991	0.587
LIG_LIR_Apic_2	216	221	PF02991	0.628
LIG_LIR_Nem_3	213	218	PF02991	0.672
LIG_PCNA_yPIPBox_3	25	39	PF02747	0.584
LIG_SH2_CRK	149	153	PF00017	0.703
LIG_SH2_CRK	18	22	PF00017	0.508
LIG_SH2_GRB2like	67	70	PF00017	0.517
LIG_SH2_NCK_1	18	22	PF00017	0.540
LIG_SH2_SRC	114	117	PF00017	0.627
LIG_SH2_SRC	147	150	PF00017	0.652
LIG_SH2_SRC	218	221	PF00017	0.657
LIG_SH2_STAP1	215	219	PF00017	0.677
LIG_SH2_STAT3	187	190	PF00017	0.662
LIG_SH2_STAT5	187	190	PF00017	0.635
LIG_SH2_STAT5	224	227	PF00017	0.692
LIG_SH2_STAT5	67	70	PF00017	0.516
LIG_SH3_3	252	258	PF00018	0.614
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.604
LIG_TRAF2_1	261	264	PF00917	0.681
LIG_TRAF2_1	46	49	PF00917	0.574
LIG_TYR_ITIM	31	36	PF00017	0.598
MOD_CDK_SPK_2	161	166	PF00069	0.794
MOD_CDK_SPK_2	94	99	PF00069	0.703
MOD_CK1_1	164	170	PF00069	0.792
MOD_CK2_1	232	238	PF00069	0.599
MOD_CK2_1	241	247	PF00069	0.570
MOD_CK2_1	99	105	PF00069	0.559
MOD_GlcNHglycan	155	158	PF01048	0.697
MOD_GlcNHglycan	166	169	PF01048	0.694
MOD_GlcNHglycan	171	174	PF01048	0.617
MOD_GlcNHglycan	55	58	PF01048	0.644
MOD_GSK3_1	100	107	PF00069	0.568
MOD_GSK3_1	160	167	PF00069	0.759
MOD_GSK3_1	19	26	PF00069	0.533
MOD_GSK3_1	237	244	PF00069	0.647
MOD_GSK3_1	53	60	PF00069	0.625
MOD_N-GLC_1	24	29	PF02516	0.573
MOD_N-GLC_2	186	188	PF02516	0.583
MOD_N-GLC_2	69	71	PF02516	0.548
MOD_NEK2_1	210	215	PF00069	0.658
MOD_NEK2_1	23	28	PF00069	0.533
MOD_PIKK_1	210	216	PF00454	0.675
MOD_PK_1	196	202	PF00069	0.634
MOD_PKA_1	142	148	PF00069	0.684
MOD_PKA_1	222	228	PF00069	0.672
MOD_PKA_2	250	256	PF00069	0.676
MOD_PKB_1	230	238	PF00069	0.687
MOD_Plk_1	225	231	PF00069	0.715
MOD_Plk_1	237	243	PF00069	0.622
MOD_Plk_1	24	30	PF00069	0.579
MOD_Plk_4	142	148	PF00069	0.684
MOD_Plk_4	19	25	PF00069	0.532
MOD_ProDKin_1	161	167	PF00069	0.755
MOD_ProDKin_1	17	23	PF00069	0.513
MOD_ProDKin_1	57	63	PF00069	0.636
MOD_ProDKin_1	94	100	PF00069	0.622
MOD_SUMO_for_1	141	144	PF00179	0.659
TRG_DiLeu_BaEn_3	95	101	PF01217	0.614
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.695
TRG_ENDOCYTIC_2	149	152	PF00928	0.708
TRG_ENDOCYTIC_2	224	227	PF00928	0.692
TRG_ENDOCYTIC_2	33	36	PF00928	0.587
TRG_ER_diArg_1	120	122	PF00400	0.507
TRG_ER_diArg_1	128	130	PF00400	0.516
TRG_ER_diArg_1	208	210	PF00400	0.636
TRG_ER_diArg_1	229	232	PF00400	0.731
TRG_ER_diArg_1	77	79	PF00400	0.506
TRG_NLS_MonoExtN_4	272	279	PF00514	0.690
TRG_Pf-PMV_PEXEL_1	209	214	PF00026	0.692

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P3	Leptomonas seymouri	64%	100%
A0A0S4J034	Bodo saltans	27%	100%
A0A1X0P7J6	Trypanosomatidae	34%	100%
A0A3R7NVA4	Trypanosoma rangeli	31%	100%
A0A3S7X062	Leishmania donovani	95%	100%
A4HF76	Leishmania braziliensis	84%	100%
A4I2F9	Leishmania infantum	96%	100%
C9ZX38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AYL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5D9J1	Trypanosoma cruzi	32%	100%