Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8V9_LEIMA

TriTrypDb:

LmjF.26.2320 , LMJLV39_260029900 , LMJSD75_260028300

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005840	ribosome	5	9
GO:0005868	cytoplasmic dynein complex	4	2
GO:0005875	microtubule associated complex	2	2
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	9
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	9

Expansion

Sequence features

Q4Q8V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8V9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	5
GO:0010970	transport along microtubule	4	2
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0031503	protein-containing complex localization	2	2
GO:0042073	intraciliary transport	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0099111	microtubule-based transport	4	2
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	3
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0016310	phosphorylation	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005515	protein binding	2	2
GO:0045503	dynein light chain binding	3	2
GO:0045504	dynein heavy chain binding	3	2
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0030515	snoRNA binding	5	1
GO:0034511	U3 snoRNA binding	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.637
CLV_C14_Caspase3-7	41	45	PF00656	0.435
CLV_C14_Caspase3-7	437	441	PF00656	0.548
CLV_C14_Caspase3-7	492	496	PF00656	0.512
CLV_C14_Caspase3-7	552	556	PF00656	0.568
CLV_NRD_NRD_1	151	153	PF00675	0.457
CLV_NRD_NRD_1	302	304	PF00675	0.515
CLV_NRD_NRD_1	314	316	PF00675	0.736
CLV_NRD_NRD_1	411	413	PF00675	0.527
CLV_NRD_NRD_1	541	543	PF00675	0.605
CLV_NRD_NRD_1	545	547	PF00675	0.617
CLV_NRD_NRD_1	58	60	PF00675	0.464
CLV_NRD_NRD_1	618	620	PF00675	0.607
CLV_PCSK_FUR_1	222	226	PF00082	0.560
CLV_PCSK_KEX2_1	151	153	PF00082	0.457
CLV_PCSK_KEX2_1	224	226	PF00082	0.573
CLV_PCSK_KEX2_1	314	316	PF00082	0.615
CLV_PCSK_KEX2_1	411	413	PF00082	0.527
CLV_PCSK_KEX2_1	541	543	PF00082	0.645
CLV_PCSK_KEX2_1	545	547	PF00082	0.609
CLV_PCSK_KEX2_1	58	60	PF00082	0.386
CLV_PCSK_KEX2_1	618	620	PF00082	0.614
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.573
CLV_PCSK_PC7_1	541	547	PF00082	0.663
CLV_PCSK_SKI1_1	134	138	PF00082	0.461
CLV_PCSK_SKI1_1	246	250	PF00082	0.548
CLV_PCSK_SKI1_1	398	402	PF00082	0.610
CLV_PCSK_SKI1_1	403	407	PF00082	0.641
CLV_PCSK_SKI1_1	491	495	PF00082	0.580
CLV_PCSK_SKI1_1	514	518	PF00082	0.492
CLV_PCSK_SKI1_1	531	535	PF00082	0.398
CLV_PCSK_SKI1_1	59	63	PF00082	0.333
DEG_SPOP_SBC_1	108	112	PF00917	0.495
DEG_SPOP_SBC_1	376	380	PF00917	0.481
DEG_SPOP_SBC_1	682	686	PF00917	0.427
DOC_ANK_TNKS_1	121	128	PF00023	0.370
DOC_CKS1_1	426	431	PF01111	0.488
DOC_MAPK_DCC_7	224	233	PF00069	0.445
DOC_MAPK_gen_1	312	321	PF00069	0.608
DOC_MAPK_gen_1	491	499	PF00069	0.464
DOC_MAPK_MEF2A_6	312	321	PF00069	0.608
DOC_MAPK_RevD_3	209	225	PF00069	0.455
DOC_PP1_RVXF_1	387	393	PF00149	0.517
DOC_PP2B_LxvP_1	406	409	PF13499	0.612
DOC_PP2B_LxvP_1	47	50	PF13499	0.512
DOC_PP4_FxxP_1	210	213	PF00568	0.388
DOC_USP7_MATH_1	213	217	PF00917	0.554
DOC_USP7_MATH_1	344	348	PF00917	0.610
DOC_USP7_MATH_1	376	380	PF00917	0.678
DOC_USP7_MATH_1	415	419	PF00917	0.497
DOC_USP7_MATH_1	485	489	PF00917	0.462
DOC_USP7_MATH_1	50	54	PF00917	0.564
DOC_USP7_MATH_1	694	698	PF00917	0.546
DOC_USP7_MATH_1	699	703	PF00917	0.502
DOC_USP7_MATH_1	712	716	PF00917	0.259
DOC_USP7_UBL2_3	403	407	PF12436	0.590
DOC_USP7_UBL2_3	494	498	PF12436	0.461
DOC_USP7_UBL2_3	517	521	PF12436	0.658
DOC_USP7_UBL2_3	531	535	PF12436	0.526
DOC_WW_Pin1_4	370	375	PF00397	0.734
DOC_WW_Pin1_4	425	430	PF00397	0.494
DOC_WW_Pin1_4	666	671	PF00397	0.488
DOC_WW_Pin1_4	92	97	PF00397	0.529
LIG_14-3-3_CanoR_1	102	108	PF00244	0.458
LIG_14-3-3_CanoR_1	151	156	PF00244	0.446
LIG_14-3-3_CanoR_1	314	318	PF00244	0.553
LIG_14-3-3_CanoR_1	473	479	PF00244	0.508
LIG_14-3-3_CanoR_1	58	67	PF00244	0.531
LIG_14-3-3_CanoR_1	618	624	PF00244	0.602
LIG_14-3-3_CanoR_1	631	635	PF00244	0.543
LIG_14-3-3_CanoR_1	648	656	PF00244	0.425
LIG_Actin_WH2_2	479	496	PF00022	0.517
LIG_Actin_WH2_2	504	519	PF00022	0.476
LIG_APCC_ABBA_1	248	253	PF00400	0.512
LIG_BIR_III_4	19	23	PF00653	0.424
LIG_BIR_III_4	348	352	PF00653	0.590
LIG_BRCT_BRCA1_1	382	386	PF00533	0.650
LIG_CaM_IQ_9	390	405	PF13499	0.538
LIG_EH1_1	114	122	PF00400	0.500
LIG_FHA_1	108	114	PF00498	0.471
LIG_FHA_1	201	207	PF00498	0.398
LIG_FHA_1	272	278	PF00498	0.372
LIG_FHA_1	336	342	PF00498	0.642
LIG_FHA_1	420	426	PF00498	0.406
LIG_FHA_1	60	66	PF00498	0.354
LIG_FHA_1	684	690	PF00498	0.425
LIG_FHA_1	72	78	PF00498	0.385
LIG_FHA_1	98	104	PF00498	0.608
LIG_FHA_2	143	149	PF00498	0.449
LIG_FHA_2	490	496	PF00498	0.518
LIG_FHA_2	567	573	PF00498	0.666
LIG_FHA_2	83	89	PF00498	0.366
LIG_LIR_Apic_2	207	213	PF02991	0.423
LIG_LIR_Gen_1	37	47	PF02991	0.515
LIG_LIR_Gen_1	622	629	PF02991	0.391
LIG_LIR_Gen_1	676	683	PF02991	0.563
LIG_LIR_Nem_3	622	626	PF02991	0.573
LIG_LIR_Nem_3	676	681	PF02991	0.479
LIG_LIR_Nem_3	80	86	PF02991	0.485
LIG_PCNA_PIPBox_1	653	662	PF02747	0.413
LIG_PCNA_TLS_4	631	638	PF02747	0.476
LIG_PTB_Apo_2	677	684	PF02174	0.527
LIG_PTB_Phospho_1	677	683	PF10480	0.532
LIG_RPA_C_Fungi	53	65	PF08784	0.450
LIG_SH2_CRK	707	711	PF00017	0.429
LIG_SH2_NCK_1	251	255	PF00017	0.554
LIG_SH2_NCK_1	500	504	PF00017	0.519
LIG_SH2_NCK_1	707	711	PF00017	0.429
LIG_SH2_SRC	251	254	PF00017	0.544
LIG_SH2_STAP1	500	504	PF00017	0.509
LIG_SH2_STAP1	707	711	PF00017	0.429
LIG_SH2_STAT3	711	714	PF00017	0.406
LIG_SH2_STAT5	13	16	PF00017	0.540
LIG_SH2_STAT5	186	189	PF00017	0.389
LIG_SH2_STAT5	500	503	PF00017	0.528
LIG_SH2_STAT5	683	686	PF00017	0.506
LIG_SH3_1	224	230	PF00018	0.557
LIG_SH3_3	209	215	PF00018	0.493
LIG_SH3_3	224	230	PF00018	0.684
LIG_SH3_3	420	426	PF00018	0.432
LIG_SUMO_SIM_anti_2	143	148	PF11976	0.476
LIG_SUMO_SIM_par_1	62	68	PF11976	0.444
LIG_SxIP_EBH_1	211	225	PF03271	0.460
LIG_TRAF2_1	362	365	PF00917	0.602
LIG_TRAF2_1	537	540	PF00917	0.596
LIG_TRAF2_1	549	552	PF00917	0.512
LIG_TRAF2_1	565	568	PF00917	0.518
LIG_TRAF2_1	569	572	PF00917	0.712
LIG_TRAF2_1	581	584	PF00917	0.677
LIG_TRAF2_1	596	599	PF00917	0.567
LIG_TRAF2_1	639	642	PF00917	0.527
LIG_TRAF2_1	85	88	PF00917	0.493
MOD_CDK_SPxxK_3	666	673	PF00069	0.485
MOD_CK1_1	232	238	PF00069	0.568
MOD_CK1_1	3	9	PF00069	0.512
MOD_CK1_1	372	378	PF00069	0.647
MOD_CK1_1	433	439	PF00069	0.653
MOD_CK1_1	697	703	PF00069	0.477
MOD_CK1_1	94	100	PF00069	0.658
MOD_CK2_1	142	148	PF00069	0.453
MOD_CK2_1	265	271	PF00069	0.569
MOD_CK2_1	359	365	PF00069	0.547
MOD_CK2_1	534	540	PF00069	0.399
MOD_CK2_1	566	572	PF00069	0.701
MOD_CK2_1	65	71	PF00069	0.358
MOD_CK2_1	82	88	PF00069	0.377
MOD_GlcNHglycan	172	175	PF01048	0.399
MOD_GlcNHglycan	191	194	PF01048	0.450
MOD_GlcNHglycan	255	261	PF01048	0.547
MOD_GlcNHglycan	360	364	PF01048	0.776
MOD_GlcNHglycan	403	406	PF01048	0.583
MOD_GlcNHglycan	417	420	PF01048	0.430
MOD_GlcNHglycan	432	435	PF01048	0.501
MOD_GlcNHglycan	436	439	PF01048	0.562
MOD_GlcNHglycan	536	539	PF01048	0.395
MOD_GlcNHglycan	67	70	PF01048	0.460
MOD_GlcNHglycan	692	695	PF01048	0.530
MOD_GlcNHglycan	699	702	PF01048	0.501
MOD_GSK3_1	103	110	PF00069	0.343
MOD_GSK3_1	200	207	PF00069	0.438
MOD_GSK3_1	229	236	PF00069	0.573
MOD_GSK3_1	261	268	PF00069	0.540
MOD_GSK3_1	303	310	PF00069	0.665
MOD_GSK3_1	372	379	PF00069	0.714
MOD_GSK3_1	394	401	PF00069	0.610
MOD_GSK3_1	415	422	PF00069	0.501
MOD_GSK3_1	430	437	PF00069	0.552
MOD_GSK3_1	485	492	PF00069	0.457
MOD_GSK3_1	566	573	PF00069	0.589
MOD_GSK3_1	690	697	PF00069	0.485
MOD_GSK3_1	710	717	PF00069	0.461
MOD_GSK3_1	73	80	PF00069	0.432
MOD_GSK3_1	91	98	PF00069	0.461
MOD_LATS_1	57	63	PF00433	0.317
MOD_N-GLC_1	140	145	PF02516	0.430
MOD_N-GLC_1	170	175	PF02516	0.341
MOD_NEK2_1	107	112	PF00069	0.421
MOD_NEK2_1	233	238	PF00069	0.618
MOD_NEK2_1	335	340	PF00069	0.595
MOD_NEK2_1	430	435	PF00069	0.493
MOD_NEK2_1	77	82	PF00069	0.336
MOD_NEK2_2	50	55	PF00069	0.434
MOD_NEK2_2	504	509	PF00069	0.396
MOD_PIKK_1	710	716	PF00454	0.401
MOD_PKA_1	151	157	PF00069	0.300
MOD_PKA_1	303	309	PF00069	0.533
MOD_PKA_1	534	540	PF00069	0.399
MOD_PKA_2	103	109	PF00069	0.488
MOD_PKA_2	150	156	PF00069	0.431
MOD_PKA_2	3	9	PF00069	0.439
MOD_PKA_2	313	319	PF00069	0.582
MOD_PKA_2	472	478	PF00069	0.417
MOD_PKA_2	630	636	PF00069	0.615
MOD_PKA_2	647	653	PF00069	0.423
MOD_Plk_1	335	341	PF00069	0.642
MOD_Plk_2-3	32	38	PF00069	0.383
MOD_Plk_2-3	551	557	PF00069	0.634
MOD_Plk_2-3	566	572	PF00069	0.662
MOD_Plk_4	103	109	PF00069	0.569
MOD_Plk_4	142	148	PF00069	0.471
MOD_Plk_4	172	178	PF00069	0.480
MOD_Plk_4	50	56	PF00069	0.393
MOD_Plk_4	699	705	PF00069	0.552
MOD_ProDKin_1	370	376	PF00069	0.729
MOD_ProDKin_1	425	431	PF00069	0.495
MOD_ProDKin_1	666	672	PF00069	0.488
MOD_ProDKin_1	92	98	PF00069	0.527
MOD_SUMO_rev_2	37	45	PF00179	0.414
MOD_SUMO_rev_2	383	390	PF00179	0.496
MOD_SUMO_rev_2	512	519	PF00179	0.487
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.496
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.487
TRG_ENDOCYTIC_2	39	42	PF00928	0.519
TRG_ENDOCYTIC_2	707	710	PF00928	0.441
TRG_ER_diArg_1	101	104	PF00400	0.503
TRG_ER_diArg_1	411	413	PF00400	0.506
TRG_ER_diArg_1	617	619	PF00400	0.627
TRG_NLS_MonoExtC_3	533	539	PF00514	0.398
TRG_NLS_MonoExtN_4	531	538	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	465	470	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTI6	Leptomonas seymouri	52%	100%
A0A1X0P7A3	Trypanosomatidae	27%	100%
A0A3Q8IDU6	Leishmania donovani	94%	99%
A0A422P3R9	Trypanosoma rangeli	26%	100%
A4HF77	Leishmania braziliensis	73%	99%
A4I2G0	Leishmania infantum	94%	100%
E9AYL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
V5ATI5	Trypanosoma cruzi	26%	100%