LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q8V6_LEIMA
TriTrypDb:
LmjF.26.2350 , LMJLV39_260030200 * , LMJSD75_260028600 *
Length:
887

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8V6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8V6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 540 544 PF00656 0.695
CLV_C14_Caspase3-7 616 620 PF00656 0.661
CLV_C14_Caspase3-7 797 801 PF00656 0.667
CLV_NRD_NRD_1 228 230 PF00675 0.499
CLV_NRD_NRD_1 315 317 PF00675 0.615
CLV_NRD_NRD_1 322 324 PF00675 0.607
CLV_NRD_NRD_1 374 376 PF00675 0.665
CLV_NRD_NRD_1 561 563 PF00675 0.702
CLV_NRD_NRD_1 606 608 PF00675 0.702
CLV_NRD_NRD_1 702 704 PF00675 0.703
CLV_NRD_NRD_1 735 737 PF00675 0.773
CLV_NRD_NRD_1 789 791 PF00675 0.708
CLV_NRD_NRD_1 795 797 PF00675 0.677
CLV_PCSK_FUR_1 313 317 PF00082 0.562
CLV_PCSK_FUR_1 695 699 PF00082 0.589
CLV_PCSK_FUR_1 787 791 PF00082 0.671
CLV_PCSK_KEX2_1 228 230 PF00082 0.499
CLV_PCSK_KEX2_1 315 317 PF00082 0.615
CLV_PCSK_KEX2_1 322 324 PF00082 0.607
CLV_PCSK_KEX2_1 374 376 PF00082 0.665
CLV_PCSK_KEX2_1 396 398 PF00082 0.617
CLV_PCSK_KEX2_1 561 563 PF00082 0.702
CLV_PCSK_KEX2_1 606 608 PF00082 0.707
CLV_PCSK_KEX2_1 630 632 PF00082 0.663
CLV_PCSK_KEX2_1 697 699 PF00082 0.718
CLV_PCSK_KEX2_1 702 704 PF00082 0.670
CLV_PCSK_KEX2_1 733 735 PF00082 0.703
CLV_PCSK_KEX2_1 789 791 PF00082 0.708
CLV_PCSK_KEX2_1 795 797 PF00082 0.677
CLV_PCSK_PC1ET2_1 396 398 PF00082 0.617
CLV_PCSK_PC1ET2_1 630 632 PF00082 0.663
CLV_PCSK_PC1ET2_1 697 699 PF00082 0.718
CLV_PCSK_PC1ET2_1 733 735 PF00082 0.681
CLV_PCSK_PC7_1 698 704 PF00082 0.694
CLV_PCSK_PC7_1 729 735 PF00082 0.667
CLV_PCSK_SKI1_1 132 136 PF00082 0.510
CLV_PCSK_SKI1_1 177 181 PF00082 0.601
CLV_PCSK_SKI1_1 228 232 PF00082 0.497
CLV_PCSK_SKI1_1 533 537 PF00082 0.583
CLV_PCSK_SKI1_1 58 62 PF00082 0.549
CLV_PCSK_SKI1_1 668 672 PF00082 0.545
CLV_PCSK_SKI1_1 790 794 PF00082 0.629
CLV_PCSK_SKI1_1 804 808 PF00082 0.590
CLV_PCSK_SKI1_1 93 97 PF00082 0.546
DEG_APCC_DBOX_1 176 184 PF00400 0.666
DEG_COP1_1 65 73 PF00400 0.656
DEG_SPOP_SBC_1 42 46 PF00917 0.554
DEG_SPOP_SBC_1 635 639 PF00917 0.658
DEG_SPOP_SBC_1 685 689 PF00917 0.647
DEG_SPOP_SBC_1 845 849 PF00917 0.564
DOC_ANK_TNKS_1 432 439 PF00023 0.658
DOC_CDC14_PxL_1 15 23 PF14671 0.497
DOC_CDC14_PxL_1 483 491 PF14671 0.524
DOC_CDC14_PxL_1 757 765 PF14671 0.664
DOC_CKS1_1 514 519 PF01111 0.696
DOC_CKS1_1 663 668 PF01111 0.563
DOC_CKS1_1 875 880 PF01111 0.670
DOC_CKS1_1 96 101 PF01111 0.538
DOC_CYCLIN_RxL_1 604 614 PF00134 0.654
DOC_CYCLIN_yCln2_LP_2 96 102 PF00134 0.532
DOC_MAPK_gen_1 396 404 PF00069 0.562
DOC_MAPK_MEF2A_6 397 406 PF00069 0.564
DOC_PP1_RVXF_1 605 612 PF00149 0.657
DOC_PP2B_LxvP_1 406 409 PF13499 0.598
DOC_PP4_FxxP_1 235 238 PF00568 0.590
DOC_PP4_FxxP_1 551 554 PF00568 0.681
DOC_USP7_MATH_1 10 14 PF00917 0.476
DOC_USP7_MATH_1 158 162 PF00917 0.637
DOC_USP7_MATH_1 23 27 PF00917 0.515
DOC_USP7_MATH_1 249 253 PF00917 0.645
DOC_USP7_MATH_1 273 277 PF00917 0.642
DOC_USP7_MATH_1 304 308 PF00917 0.632
DOC_USP7_MATH_1 338 342 PF00917 0.704
DOC_USP7_MATH_1 356 360 PF00917 0.534
DOC_USP7_MATH_1 449 453 PF00917 0.653
DOC_USP7_MATH_1 499 503 PF00917 0.658
DOC_USP7_MATH_1 598 602 PF00917 0.596
DOC_USP7_MATH_1 610 614 PF00917 0.566
DOC_USP7_MATH_1 635 639 PF00917 0.658
DOC_USP7_MATH_1 683 687 PF00917 0.639
DOC_USP7_MATH_1 69 73 PF00917 0.654
DOC_USP7_MATH_1 845 849 PF00917 0.654
DOC_USP7_MATH_2 508 514 PF00917 0.586
DOC_WW_Pin1_4 253 258 PF00397 0.719
DOC_WW_Pin1_4 271 276 PF00397 0.540
DOC_WW_Pin1_4 340 345 PF00397 0.665
DOC_WW_Pin1_4 376 381 PF00397 0.668
DOC_WW_Pin1_4 409 414 PF00397 0.623
DOC_WW_Pin1_4 451 456 PF00397 0.665
DOC_WW_Pin1_4 467 472 PF00397 0.509
DOC_WW_Pin1_4 513 518 PF00397 0.718
DOC_WW_Pin1_4 522 527 PF00397 0.596
DOC_WW_Pin1_4 533 538 PF00397 0.613
DOC_WW_Pin1_4 594 599 PF00397 0.573
DOC_WW_Pin1_4 65 70 PF00397 0.668
DOC_WW_Pin1_4 662 667 PF00397 0.688
DOC_WW_Pin1_4 717 722 PF00397 0.671
DOC_WW_Pin1_4 839 844 PF00397 0.602
DOC_WW_Pin1_4 848 853 PF00397 0.628
DOC_WW_Pin1_4 865 870 PF00397 0.653
DOC_WW_Pin1_4 874 879 PF00397 0.672
DOC_WW_Pin1_4 95 100 PF00397 0.621
LIG_14-3-3_CanoR_1 11 15 PF00244 0.480
LIG_14-3-3_CanoR_1 111 117 PF00244 0.530
LIG_14-3-3_CanoR_1 132 141 PF00244 0.539
LIG_14-3-3_CanoR_1 203 207 PF00244 0.644
LIG_14-3-3_CanoR_1 255 265 PF00244 0.652
LIG_14-3-3_CanoR_1 279 286 PF00244 0.578
LIG_14-3-3_CanoR_1 325 334 PF00244 0.638
LIG_14-3-3_CanoR_1 368 377 PF00244 0.576
LIG_14-3-3_CanoR_1 493 500 PF00244 0.685
LIG_14-3-3_CanoR_1 528 532 PF00244 0.672
LIG_14-3-3_CanoR_1 624 634 PF00244 0.636
LIG_14-3-3_CanoR_1 668 676 PF00244 0.548
LIG_14-3-3_CanoR_1 684 694 PF00244 0.593
LIG_Actin_WH2_2 103 120 PF00022 0.481
LIG_ActinCP_TwfCPI_2 551 561 PF01115 0.582
LIG_BIR_III_4 292 296 PF00653 0.586
LIG_BRCT_BRCA1_1 125 129 PF00533 0.469
LIG_BRCT_BRCA1_1 457 461 PF00533 0.616
LIG_BRCT_BRCA1_1 479 483 PF00533 0.524
LIG_BRCT_BRCA1_1 569 573 PF00533 0.620
LIG_BRCT_BRCA1_1 589 593 PF00533 0.503
LIG_CaM_IQ_9 317 333 PF13499 0.537
LIG_EVH1_1 551 555 PF00568 0.678
LIG_FHA_1 133 139 PF00498 0.530
LIG_FHA_1 187 193 PF00498 0.537
LIG_FHA_1 272 278 PF00498 0.668
LIG_FHA_1 280 286 PF00498 0.650
LIG_FHA_1 294 300 PF00498 0.585
LIG_FHA_1 403 409 PF00498 0.624
LIG_FHA_1 452 458 PF00498 0.617
LIG_FHA_1 492 498 PF00498 0.635
LIG_FHA_1 665 671 PF00498 0.653
LIG_FHA_1 712 718 PF00498 0.747
LIG_FHA_1 828 834 PF00498 0.465
LIG_FHA_2 188 194 PF00498 0.624
LIG_FHA_2 496 502 PF00498 0.650
LIG_FHA_2 538 544 PF00498 0.698
LIG_FHA_2 582 588 PF00498 0.643
LIG_FHA_2 669 675 PF00498 0.639
LIG_FHA_2 781 787 PF00498 0.635
LIG_FHA_2 795 801 PF00498 0.607
LIG_FHA_2 803 809 PF00498 0.628
LIG_FHA_2 858 864 PF00498 0.624
LIG_Integrin_RGD_1 738 740 PF01839 0.541
LIG_LIR_Apic_2 329 335 PF02991 0.659
LIG_LIR_Gen_1 13 22 PF02991 0.490
LIG_LIR_Gen_1 324 335 PF02991 0.623
LIG_LIR_Gen_1 458 465 PF02991 0.575
LIG_LIR_Gen_1 831 840 PF02991 0.494
LIG_LIR_Nem_3 13 17 PF02991 0.470
LIG_LIR_Nem_3 324 330 PF02991 0.623
LIG_LIR_Nem_3 458 464 PF02991 0.555
LIG_LIR_Nem_3 480 486 PF02991 0.567
LIG_LIR_Nem_3 6 12 PF02991 0.475
LIG_LIR_Nem_3 740 745 PF02991 0.672
LIG_LIR_Nem_3 831 837 PF02991 0.490
LIG_MLH1_MIPbox_1 589 593 PF16413 0.557
LIG_Pex14_1 882 886 PF04695 0.666
LIG_SH2_CRK 224 228 PF00017 0.525
LIG_SH2_CRK 332 336 PF00017 0.623
LIG_SH2_STAT5 14 17 PF00017 0.485
LIG_SH2_STAT5 332 335 PF00017 0.621
LIG_SH2_STAT5 415 418 PF00017 0.620
LIG_SH2_STAT5 453 456 PF00017 0.556
LIG_SH2_STAT5 550 553 PF00017 0.690
LIG_SH2_STAT5 816 819 PF00017 0.549
LIG_SH3_1 332 338 PF00018 0.622
LIG_SH3_1 374 380 PF00018 0.642
LIG_SH3_2 335 340 PF14604 0.642
LIG_SH3_2 663 668 PF14604 0.563
LIG_SH3_3 16 22 PF00018 0.495
LIG_SH3_3 164 170 PF00018 0.574
LIG_SH3_3 206 212 PF00018 0.645
LIG_SH3_3 259 265 PF00018 0.651
LIG_SH3_3 332 338 PF00018 0.622
LIG_SH3_3 374 380 PF00018 0.679
LIG_SH3_3 481 487 PF00018 0.614
LIG_SH3_3 514 520 PF00018 0.678
LIG_SH3_3 549 555 PF00018 0.684
LIG_SH3_3 660 666 PF00018 0.647
LIG_SH3_3 866 872 PF00018 0.636
LIG_SH3_3 96 102 PF00018 0.532
LIG_SUMO_SIM_anti_2 124 129 PF11976 0.487
LIG_TRAF2_1 544 547 PF00917 0.684
LIG_TRAF2_2 878 883 PF00917 0.674
LIG_WRC_WIRS_1 14 19 PF05994 0.487
LIG_WW_3 851 855 PF00397 0.667
MOD_CDC14_SPxK_1 525 528 PF00782 0.648
MOD_CDK_SPK_2 340 345 PF00069 0.667
MOD_CDK_SPK_2 874 879 PF00069 0.668
MOD_CDK_SPxK_1 522 528 PF00069 0.653
MOD_CDK_SPxK_1 662 668 PF00069 0.587
MOD_CDK_SPxK_1 848 854 PF00069 0.691
MOD_CK1_1 13 19 PF00069 0.485
MOD_CK1_1 172 178 PF00069 0.614
MOD_CK1_1 253 259 PF00069 0.691
MOD_CK1_1 280 286 PF00069 0.665
MOD_CK1_1 350 356 PF00069 0.665
MOD_CK1_1 379 385 PF00069 0.603
MOD_CK1_1 46 52 PF00069 0.663
MOD_CK1_1 460 466 PF00069 0.668
MOD_CK1_1 469 475 PF00069 0.571
MOD_CK1_1 495 501 PF00069 0.581
MOD_CK1_1 513 519 PF00069 0.545
MOD_CK1_1 581 587 PF00069 0.644
MOD_CK1_1 596 602 PF00069 0.522
MOD_CK1_1 686 692 PF00069 0.700
MOD_CK1_1 848 854 PF00069 0.684
MOD_CK1_1 874 880 PF00069 0.668
MOD_CK2_1 187 193 PF00069 0.533
MOD_CK2_1 340 346 PF00069 0.579
MOD_CK2_1 416 422 PF00069 0.673
MOD_CK2_1 495 501 PF00069 0.647
MOD_CK2_1 615 621 PF00069 0.597
MOD_CK2_1 643 649 PF00069 0.670
MOD_CK2_1 717 723 PF00069 0.683
MOD_CK2_1 802 808 PF00069 0.693
MOD_Cter_Amidation 372 375 PF01082 0.674
MOD_DYRK1A_RPxSP_1 340 344 PF00069 0.666
MOD_DYRK1A_RPxSP_1 533 537 PF00069 0.583
MOD_GlcNHglycan 160 163 PF01048 0.650
MOD_GlcNHglycan 165 170 PF01048 0.625
MOD_GlcNHglycan 216 219 PF01048 0.579
MOD_GlcNHglycan 252 255 PF01048 0.680
MOD_GlcNHglycan 368 371 PF01048 0.689
MOD_GlcNHglycan 422 425 PF01048 0.609
MOD_GlcNHglycan 489 492 PF01048 0.617
MOD_GlcNHglycan 494 497 PF01048 0.600
MOD_GlcNHglycan 50 53 PF01048 0.639
MOD_GlcNHglycan 533 536 PF01048 0.714
MOD_GlcNHglycan 580 583 PF01048 0.684
MOD_GlcNHglycan 600 603 PF01048 0.505
MOD_GlcNHglycan 621 624 PF01048 0.682
MOD_GlcNHglycan 654 657 PF01048 0.715
MOD_GlcNHglycan 71 74 PF01048 0.715
MOD_GlcNHglycan 769 772 PF01048 0.663
MOD_GlcNHglycan 790 793 PF01048 0.617
MOD_GlcNHglycan 834 837 PF01048 0.555
MOD_GlcNHglycan 93 96 PF01048 0.718
MOD_GSK3_1 165 172 PF00069 0.651
MOD_GSK3_1 249 256 PF00069 0.664
MOD_GSK3_1 273 280 PF00069 0.642
MOD_GSK3_1 317 324 PF00069 0.625
MOD_GSK3_1 364 371 PF00069 0.674
MOD_GSK3_1 376 383 PF00069 0.554
MOD_GSK3_1 416 423 PF00069 0.565
MOD_GSK3_1 42 49 PF00069 0.629
MOD_GSK3_1 451 458 PF00069 0.659
MOD_GSK3_1 463 470 PF00069 0.549
MOD_GSK3_1 487 494 PF00069 0.595
MOD_GSK3_1 495 502 PF00069 0.568
MOD_GSK3_1 518 525 PF00069 0.711
MOD_GSK3_1 527 534 PF00069 0.605
MOD_GSK3_1 587 594 PF00069 0.679
MOD_GSK3_1 597 604 PF00069 0.593
MOD_GSK3_1 615 622 PF00069 0.551
MOD_GSK3_1 65 72 PF00069 0.627
MOD_GSK3_1 664 671 PF00069 0.631
MOD_GSK3_1 683 690 PF00069 0.614
MOD_GSK3_1 790 797 PF00069 0.701
MOD_GSK3_1 839 846 PF00069 0.623
MOD_GSK3_1 867 874 PF00069 0.760
MOD_GSK3_1 91 98 PF00069 0.631
MOD_LATS_1 788 794 PF00433 0.674
MOD_N-GLC_1 288 293 PF02516 0.592
MOD_N-GLC_1 717 722 PF02516 0.675
MOD_N-GLC_1 75 80 PF02516 0.641
MOD_NEK2_1 392 397 PF00069 0.623
MOD_NEK2_1 43 48 PF00069 0.591
MOD_NEK2_1 593 598 PF00069 0.619
MOD_NEK2_2 103 108 PF00069 0.468
MOD_NEK2_2 478 483 PF00069 0.524
MOD_NEK2_2 636 641 PF00069 0.593
MOD_NEK2_2 643 648 PF00069 0.557
MOD_PIKK_1 317 323 PF00454 0.553
MOD_PIKK_1 368 374 PF00454 0.585
MOD_PIKK_1 510 516 PF00454 0.679
MOD_PIKK_1 527 533 PF00454 0.718
MOD_PIKK_1 846 852 PF00454 0.636
MOD_PIKK_1 871 877 PF00454 0.666
MOD_PKA_1 697 703 PF00069 0.674
MOD_PKA_2 10 16 PF00069 0.478
MOD_PKA_2 110 116 PF00069 0.556
MOD_PKA_2 202 208 PF00069 0.604
MOD_PKA_2 280 286 PF00069 0.687
MOD_PKA_2 321 327 PF00069 0.646
MOD_PKA_2 492 498 PF00069 0.635
MOD_PKA_2 527 533 PF00069 0.652
MOD_PKA_2 683 689 PF00069 0.633
MOD_PKA_2 697 703 PF00069 0.624
MOD_PKA_2 788 794 PF00069 0.667
MOD_PKB_1 130 138 PF00069 0.524
MOD_PKB_1 323 331 PF00069 0.624
MOD_Plk_1 123 129 PF00069 0.516
MOD_Plk_1 356 362 PF00069 0.571
MOD_Plk_1 586 592 PF00069 0.599
MOD_Plk_1 765 771 PF00069 0.644
MOD_Plk_4 10 16 PF00069 0.478
MOD_Plk_4 123 129 PF00069 0.494
MOD_Plk_4 273 279 PF00069 0.634
MOD_Plk_4 43 49 PF00069 0.618
MOD_Plk_4 460 466 PF00069 0.564
MOD_Plk_4 469 475 PF00069 0.515
MOD_Plk_4 478 484 PF00069 0.475
MOD_Plk_4 587 593 PF00069 0.645
MOD_ProDKin_1 253 259 PF00069 0.720
MOD_ProDKin_1 271 277 PF00069 0.538
MOD_ProDKin_1 340 346 PF00069 0.664
MOD_ProDKin_1 376 382 PF00069 0.670
MOD_ProDKin_1 409 415 PF00069 0.625
MOD_ProDKin_1 451 457 PF00069 0.665
MOD_ProDKin_1 467 473 PF00069 0.508
MOD_ProDKin_1 513 519 PF00069 0.717
MOD_ProDKin_1 522 528 PF00069 0.597
MOD_ProDKin_1 533 539 PF00069 0.610
MOD_ProDKin_1 594 600 PF00069 0.572
MOD_ProDKin_1 65 71 PF00069 0.664
MOD_ProDKin_1 662 668 PF00069 0.687
MOD_ProDKin_1 717 723 PF00069 0.672
MOD_ProDKin_1 839 845 PF00069 0.605
MOD_ProDKin_1 848 854 PF00069 0.631
MOD_ProDKin_1 865 871 PF00069 0.651
MOD_ProDKin_1 874 880 PF00069 0.672
MOD_ProDKin_1 95 101 PF00069 0.620
TRG_DiLeu_BaEn_4 427 433 PF01217 0.565
TRG_DiLeu_BaLyEn_6 129 134 PF01217 0.472
TRG_ENDOCYTIC_2 14 17 PF00928 0.485
TRG_ENDOCYTIC_2 224 227 PF00928 0.543
TRG_ER_diArg_1 129 132 PF00400 0.516
TRG_ER_diArg_1 227 229 PF00400 0.497
TRG_ER_diArg_1 278 281 PF00400 0.569
TRG_ER_diArg_1 313 316 PF00400 0.619
TRG_ER_diArg_1 322 325 PF00400 0.602
TRG_ER_diArg_1 374 376 PF00400 0.656
TRG_ER_diArg_1 605 607 PF00400 0.697
TRG_ER_diArg_1 631 634 PF00400 0.605
TRG_ER_diArg_1 734 736 PF00400 0.651
TRG_ER_diArg_1 787 790 PF00400 0.669
TRG_ER_diArg_1 817 820 PF00400 0.537
TRG_NES_CRM1_1 124 136 PF08389 0.451
TRG_NLS_MonoCore_2 732 737 PF00514 0.632
TRG_Pf-PMV_PEXEL_1 132 136 PF00026 0.517
TRG_Pf-PMV_PEXEL_1 854 859 PF00026 0.636

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X067 Leishmania donovani 84% 100%
A4HF80 Leishmania braziliensis 54% 100%
A4I2G3 Leishmania infantum 83% 100%
E9AYL6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS