LeishMANIAdb
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zf-primase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
zf-primase domain-containing protein
Gene product:
Primase zinc finger/Mcm10 replication factor, putative
Species:
Leishmania major
UniProt:
Q4Q8V2_LEIMA
TriTrypDb:
LmjF.26.2390 , LMJLV39_260030600 * , LMJSD75_260029000 *
Length:
927

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0031298 replication fork protection complex 3 2
GO:0032991 protein-containing complex 1 2
GO:0140513 nuclear protein-containing complex 2 2
GO:0005634 nucleus 5 6
GO:0043226 organelle 2 6
GO:0043227 membrane-bounded organelle 3 6
GO:0043229 intracellular organelle 3 6
GO:0043231 intracellular membrane-bounded organelle 4 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

Q4Q8V2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8V2

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 8
GO:0006259 DNA metabolic process 4 8
GO:0006270 DNA replication initiation 5 8
GO:0006725 cellular aromatic compound metabolic process 3 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0009987 cellular process 1 8
GO:0034641 cellular nitrogen compound metabolic process 3 8
GO:0043170 macromolecule metabolic process 3 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0044260 obsolete cellular macromolecule metabolic process 3 8
GO:0046483 heterocycle metabolic process 3 8
GO:0071704 organic substance metabolic process 2 8
GO:0090304 nucleic acid metabolic process 4 8
GO:1901360 organic cyclic compound metabolic process 3 8
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 8
GO:0003677 DNA binding 4 8
GO:0003688 DNA replication origin binding 7 2
GO:0003690 double-stranded DNA binding 5 8
GO:0003697 single-stranded DNA binding 5 8
GO:0005488 binding 1 8
GO:0043565 sequence-specific DNA binding 5 2
GO:0097159 organic cyclic compound binding 2 8
GO:1901363 heterocyclic compound binding 2 8
GO:1990837 sequence-specific double-stranded DNA binding 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 25 29 PF00656 0.810
CLV_C14_Caspase3-7 594 598 PF00656 0.805
CLV_C14_Caspase3-7 791 795 PF00656 0.679
CLV_NRD_NRD_1 202 204 PF00675 0.512
CLV_NRD_NRD_1 231 233 PF00675 0.579
CLV_NRD_NRD_1 246 248 PF00675 0.481
CLV_NRD_NRD_1 314 316 PF00675 0.658
CLV_NRD_NRD_1 378 380 PF00675 0.365
CLV_NRD_NRD_1 563 565 PF00675 0.668
CLV_PCSK_FUR_1 200 204 PF00082 0.493
CLV_PCSK_KEX2_1 202 204 PF00082 0.512
CLV_PCSK_KEX2_1 231 233 PF00082 0.579
CLV_PCSK_KEX2_1 314 316 PF00082 0.727
CLV_PCSK_KEX2_1 563 565 PF00082 0.638
CLV_PCSK_KEX2_1 626 628 PF00082 0.752
CLV_PCSK_KEX2_1 702 704 PF00082 0.754
CLV_PCSK_PC1ET2_1 626 628 PF00082 0.756
CLV_PCSK_PC1ET2_1 702 704 PF00082 0.574
CLV_PCSK_PC7_1 198 204 PF00082 0.495
CLV_PCSK_PC7_1 227 233 PF00082 0.597
CLV_PCSK_SKI1_1 127 131 PF00082 0.692
CLV_PCSK_SKI1_1 202 206 PF00082 0.518
CLV_PCSK_SKI1_1 297 301 PF00082 0.487
CLV_PCSK_SKI1_1 392 396 PF00082 0.748
CLV_PCSK_SKI1_1 454 458 PF00082 0.584
CLV_PCSK_SKI1_1 483 487 PF00082 0.689
CLV_PCSK_SKI1_1 543 547 PF00082 0.574
CLV_PCSK_SKI1_1 751 755 PF00082 0.733
CLV_PCSK_SKI1_1 866 870 PF00082 0.499
CLV_PCSK_SKI1_1 871 875 PF00082 0.484
DEG_SPOP_SBC_1 39 43 PF00917 0.606
DEG_SPOP_SBC_1 632 636 PF00917 0.698
DEG_SPOP_SBC_1 660 664 PF00917 0.643
DEG_SPOP_SBC_1 81 85 PF00917 0.702
DOC_CKS1_1 697 702 PF01111 0.796
DOC_CYCLIN_RxL_1 334 344 PF00134 0.563
DOC_CYCLIN_yCln2_LP_2 406 412 PF00134 0.713
DOC_CYCLIN_yCln2_LP_2 915 921 PF00134 0.648
DOC_MAPK_gen_1 125 134 PF00069 0.699
DOC_MAPK_gen_1 200 208 PF00069 0.485
DOC_MAPK_gen_1 626 632 PF00069 0.739
DOC_PP1_RVXF_1 196 202 PF00149 0.483
DOC_PP1_RVXF_1 335 342 PF00149 0.486
DOC_PP2B_LxvP_1 132 135 PF13499 0.728
DOC_PP2B_LxvP_1 406 409 PF13499 0.718
DOC_PP2B_LxvP_1 915 918 PF13499 0.615
DOC_PP4_FxxP_1 102 105 PF00568 0.696
DOC_USP7_MATH_1 119 123 PF00917 0.733
DOC_USP7_MATH_1 149 153 PF00917 0.764
DOC_USP7_MATH_1 204 208 PF00917 0.483
DOC_USP7_MATH_1 219 223 PF00917 0.415
DOC_USP7_MATH_1 251 255 PF00917 0.602
DOC_USP7_MATH_1 257 261 PF00917 0.642
DOC_USP7_MATH_1 381 385 PF00917 0.678
DOC_USP7_MATH_1 39 43 PF00917 0.583
DOC_USP7_MATH_1 401 405 PF00917 0.738
DOC_USP7_MATH_1 448 452 PF00917 0.727
DOC_USP7_MATH_1 526 530 PF00917 0.784
DOC_USP7_MATH_1 603 607 PF00917 0.712
DOC_USP7_MATH_1 633 637 PF00917 0.714
DOC_USP7_MATH_1 659 663 PF00917 0.681
DOC_USP7_MATH_1 675 679 PF00917 0.556
DOC_USP7_MATH_1 728 732 PF00917 0.763
DOC_USP7_MATH_1 735 739 PF00917 0.661
DOC_USP7_MATH_1 765 769 PF00917 0.808
DOC_USP7_MATH_1 81 85 PF00917 0.720
DOC_USP7_UBL2_3 248 252 PF12436 0.443
DOC_USP7_UBL2_3 866 870 PF12436 0.506
DOC_WW_Pin1_4 101 106 PF00397 0.629
DOC_WW_Pin1_4 11 16 PF00397 0.648
DOC_WW_Pin1_4 272 277 PF00397 0.454
DOC_WW_Pin1_4 45 50 PF00397 0.737
DOC_WW_Pin1_4 58 63 PF00397 0.545
DOC_WW_Pin1_4 615 620 PF00397 0.811
DOC_WW_Pin1_4 644 649 PF00397 0.744
DOC_WW_Pin1_4 65 70 PF00397 0.738
DOC_WW_Pin1_4 693 698 PF00397 0.726
DOC_WW_Pin1_4 710 715 PF00397 0.814
DOC_WW_Pin1_4 760 765 PF00397 0.806
DOC_WW_Pin1_4 86 91 PF00397 0.730
LIG_14-3-3_CanoR_1 127 133 PF00244 0.728
LIG_14-3-3_CanoR_1 181 186 PF00244 0.723
LIG_14-3-3_CanoR_1 202 207 PF00244 0.523
LIG_14-3-3_CanoR_1 231 237 PF00244 0.640
LIG_14-3-3_CanoR_1 247 251 PF00244 0.488
LIG_14-3-3_CanoR_1 399 406 PF00244 0.723
LIG_14-3-3_CanoR_1 40 45 PF00244 0.606
LIG_14-3-3_CanoR_1 466 474 PF00244 0.672
LIG_14-3-3_CanoR_1 475 480 PF00244 0.713
LIG_14-3-3_CanoR_1 525 531 PF00244 0.782
LIG_14-3-3_CanoR_1 570 580 PF00244 0.765
LIG_14-3-3_CanoR_1 692 697 PF00244 0.712
LIG_14-3-3_CanoR_1 720 724 PF00244 0.737
LIG_14-3-3_CanoR_1 82 92 PF00244 0.604
LIG_14-3-3_CanoR_1 901 909 PF00244 0.531
LIG_APCC_ABBA_1 6 11 PF00400 0.656
LIG_BIR_II_1 1 5 PF00653 0.708
LIG_BRCT_BRCA1_1 694 698 PF00533 0.708
LIG_EVH1_1 132 136 PF00568 0.649
LIG_FHA_1 11 17 PF00498 0.677
LIG_FHA_1 191 197 PF00498 0.596
LIG_FHA_1 203 209 PF00498 0.474
LIG_FHA_1 298 304 PF00498 0.463
LIG_FHA_1 321 327 PF00498 0.571
LIG_FHA_1 370 376 PF00498 0.268
LIG_FHA_1 39 45 PF00498 0.744
LIG_FHA_1 416 422 PF00498 0.743
LIG_FHA_1 59 65 PF00498 0.784
LIG_FHA_1 666 672 PF00498 0.731
LIG_FHA_1 852 858 PF00498 0.530
LIG_FHA_1 880 886 PF00498 0.436
LIG_FHA_1 93 99 PF00498 0.734
LIG_FHA_2 572 578 PF00498 0.753
LIG_FHA_2 638 644 PF00498 0.763
LIG_FHA_2 853 859 PF00498 0.609
LIG_Integrin_RGD_1 910 912 PF01839 0.506
LIG_LIR_Apic_2 100 105 PF02991 0.699
LIG_LIR_Gen_1 217 226 PF02991 0.495
LIG_LIR_Gen_1 260 271 PF02991 0.458
LIG_LIR_Gen_1 289 299 PF02991 0.423
LIG_LIR_Gen_1 4 12 PF02991 0.670
LIG_LIR_Nem_3 111 115 PF02991 0.691
LIG_LIR_Nem_3 217 223 PF02991 0.435
LIG_LIR_Nem_3 260 266 PF02991 0.480
LIG_LIR_Nem_3 289 294 PF02991 0.418
LIG_LIR_Nem_3 4 9 PF02991 0.668
LIG_LIR_Nem_3 477 482 PF02991 0.717
LIG_LIR_Nem_3 504 510 PF02991 0.704
LIG_LIR_Nem_3 695 701 PF02991 0.716
LIG_NRBOX 281 287 PF00104 0.542
LIG_NRBOX 74 80 PF00104 0.560
LIG_REV1ctd_RIR_1 477 487 PF16727 0.692
LIG_SH2_CRK 263 267 PF00017 0.438
LIG_SH2_CRK 295 299 PF00017 0.395
LIG_SH2_CRK 507 511 PF00017 0.656
LIG_SH2_CRK 849 853 PF00017 0.509
LIG_SH2_STAP1 295 299 PF00017 0.446
LIG_SH2_STAT5 841 844 PF00017 0.493
LIG_SH2_STAT5 872 875 PF00017 0.475
LIG_SH3_1 894 900 PF00018 0.487
LIG_SH3_2 697 702 PF14604 0.718
LIG_SH3_3 118 124 PF00018 0.735
LIG_SH3_3 130 136 PF00018 0.609
LIG_SH3_3 429 435 PF00018 0.583
LIG_SH3_3 57 63 PF00018 0.697
LIG_SH3_3 66 72 PF00018 0.593
LIG_SH3_3 694 700 PF00018 0.722
LIG_SH3_3 894 900 PF00018 0.487
LIG_SH3_3 918 924 PF00018 0.668
LIG_SH3_4 866 873 PF00018 0.495
LIG_SUMO_SIM_anti_2 279 286 PF11976 0.476
LIG_SUMO_SIM_anti_2 784 791 PF11976 0.702
LIG_SUMO_SIM_par_1 20 28 PF11976 0.797
LIG_SUMO_SIM_par_1 204 209 PF11976 0.528
LIG_SUMO_SIM_par_1 302 307 PF11976 0.455
LIG_TRAF2_2 319 324 PF00917 0.499
LIG_TYR_ITIM 293 298 PF00017 0.405
LIG_UBA3_1 5 10 PF00899 0.562
LIG_WRC_WIRS_1 220 225 PF05994 0.441
LIG_WRC_WIRS_1 638 643 PF05994 0.691
LIG_WRC_WIRS_1 880 885 PF05994 0.492
LIG_WW_2 62 65 PF00397 0.604
MOD_CDK_SPK_2 710 715 PF00069 0.623
MOD_CDK_SPxK_1 696 702 PF00069 0.718
MOD_CDK_SPxxK_3 45 52 PF00069 0.735
MOD_CDK_SPxxK_3 696 703 PF00069 0.611
MOD_CDK_SPxxK_3 710 717 PF00069 0.670
MOD_CK1_1 104 110 PF00069 0.542
MOD_CK1_1 151 157 PF00069 0.805
MOD_CK1_1 230 236 PF00069 0.629
MOD_CK1_1 27 33 PF00069 0.797
MOD_CK1_1 352 358 PF00069 0.372
MOD_CK1_1 384 390 PF00069 0.713
MOD_CK1_1 402 408 PF00069 0.647
MOD_CK1_1 415 421 PF00069 0.645
MOD_CK1_1 42 48 PF00069 0.672
MOD_CK1_1 501 507 PF00069 0.656
MOD_CK1_1 529 535 PF00069 0.761
MOD_CK1_1 613 619 PF00069 0.844
MOD_CK1_1 637 643 PF00069 0.688
MOD_CK1_1 647 653 PF00069 0.714
MOD_CK1_1 654 660 PF00069 0.683
MOD_CK1_1 68 74 PF00069 0.714
MOD_CK1_1 696 702 PF00069 0.644
MOD_CK1_1 727 733 PF00069 0.683
MOD_CK1_1 755 761 PF00069 0.772
MOD_CK1_1 784 790 PF00069 0.713
MOD_CK1_1 85 91 PF00069 0.785
MOD_CK2_1 110 116 PF00069 0.816
MOD_CK2_1 152 158 PF00069 0.788
MOD_CK2_1 571 577 PF00069 0.742
MOD_CK2_1 637 643 PF00069 0.765
MOD_CK2_1 675 681 PF00069 0.573
MOD_CK2_1 760 766 PF00069 0.783
MOD_CK2_1 852 858 PF00069 0.530
MOD_GlcNHglycan 136 139 PF01048 0.649
MOD_GlcNHglycan 151 154 PF01048 0.695
MOD_GlcNHglycan 183 186 PF01048 0.698
MOD_GlcNHglycan 188 191 PF01048 0.564
MOD_GlcNHglycan 232 235 PF01048 0.479
MOD_GlcNHglycan 28 32 PF01048 0.809
MOD_GlcNHglycan 288 291 PF01048 0.484
MOD_GlcNHglycan 316 319 PF01048 0.654
MOD_GlcNHglycan 383 386 PF01048 0.681
MOD_GlcNHglycan 401 404 PF01048 0.665
MOD_GlcNHglycan 423 426 PF01048 0.697
MOD_GlcNHglycan 451 454 PF01048 0.809
MOD_GlcNHglycan 500 503 PF01048 0.654
MOD_GlcNHglycan 531 534 PF01048 0.672
MOD_GlcNHglycan 656 659 PF01048 0.784
MOD_GlcNHglycan 726 729 PF01048 0.726
MOD_GlcNHglycan 735 738 PF01048 0.561
MOD_GlcNHglycan 759 762 PF01048 0.758
MOD_GlcNHglycan 769 772 PF01048 0.712
MOD_GlcNHglycan 783 786 PF01048 0.706
MOD_GlcNHglycan 797 800 PF01048 0.675
MOD_GlcNHglycan 85 88 PF01048 0.697
MOD_GSK3_1 104 111 PF00069 0.667
MOD_GSK3_1 119 126 PF00069 0.556
MOD_GSK3_1 148 155 PF00069 0.767
MOD_GSK3_1 177 184 PF00069 0.731
MOD_GSK3_1 186 193 PF00069 0.597
MOD_GSK3_1 251 258 PF00069 0.709
MOD_GSK3_1 293 300 PF00069 0.494
MOD_GSK3_1 365 372 PF00069 0.320
MOD_GSK3_1 38 45 PF00069 0.799
MOD_GSK3_1 408 415 PF00069 0.724
MOD_GSK3_1 604 611 PF00069 0.784
MOD_GSK3_1 613 620 PF00069 0.847
MOD_GSK3_1 633 640 PF00069 0.573
MOD_GSK3_1 643 650 PF00069 0.717
MOD_GSK3_1 661 668 PF00069 0.529
MOD_GSK3_1 675 682 PF00069 0.640
MOD_GSK3_1 692 699 PF00069 0.694
MOD_GSK3_1 719 726 PF00069 0.733
MOD_GSK3_1 751 758 PF00069 0.696
MOD_GSK3_1 765 772 PF00069 0.613
MOD_GSK3_1 77 84 PF00069 0.651
MOD_GSK3_1 784 791 PF00069 0.606
MOD_GSK3_1 86 93 PF00069 0.719
MOD_LATS_1 802 808 PF00433 0.561
MOD_N-GLC_1 392 397 PF02516 0.686
MOD_N-GLC_1 603 608 PF02516 0.620
MOD_N-GLC_1 755 760 PF02516 0.680
MOD_NEK2_1 161 166 PF00069 0.594
MOD_NEK2_1 225 230 PF00069 0.413
MOD_NEK2_1 286 291 PF00069 0.444
MOD_NEK2_1 293 298 PF00069 0.413
MOD_NEK2_1 365 370 PF00069 0.418
MOD_NEK2_1 412 417 PF00069 0.763
MOD_NEK2_1 421 426 PF00069 0.609
MOD_NEK2_1 44 49 PF00069 0.815
MOD_NEK2_1 467 472 PF00069 0.712
MOD_NEK2_1 474 479 PF00069 0.711
MOD_NEK2_1 536 541 PF00069 0.588
MOD_NEK2_1 77 82 PF00069 0.640
MOD_NEK2_1 788 793 PF00069 0.685
MOD_PIKK_1 365 371 PF00454 0.424
MOD_PIKK_1 467 473 PF00454 0.711
MOD_PIKK_1 735 741 PF00454 0.725
MOD_PKA_1 202 208 PF00069 0.498
MOD_PKA_1 314 320 PF00069 0.669
MOD_PKA_2 161 167 PF00069 0.759
MOD_PKA_2 202 208 PF00069 0.480
MOD_PKA_2 230 236 PF00069 0.642
MOD_PKA_2 246 252 PF00069 0.504
MOD_PKA_2 314 320 PF00069 0.732
MOD_PKA_2 39 45 PF00069 0.586
MOD_PKA_2 474 480 PF00069 0.784
MOD_PKA_2 604 610 PF00069 0.706
MOD_PKA_2 613 619 PF00069 0.626
MOD_PKA_2 719 725 PF00069 0.738
MOD_PKA_2 81 87 PF00069 0.608
MOD_PKB_1 125 133 PF00069 0.566
MOD_PKB_1 200 208 PF00069 0.523
MOD_Plk_1 280 286 PF00069 0.544
MOD_Plk_4 140 146 PF00069 0.729
MOD_Plk_4 264 270 PF00069 0.440
MOD_Plk_4 280 286 PF00069 0.473
MOD_Plk_4 475 481 PF00069 0.712
MOD_Plk_4 719 725 PF00069 0.780
MOD_Plk_4 784 790 PF00069 0.580
MOD_Plk_4 879 885 PF00069 0.497
MOD_Plk_4 903 909 PF00069 0.480
MOD_ProDKin_1 101 107 PF00069 0.628
MOD_ProDKin_1 11 17 PF00069 0.650
MOD_ProDKin_1 272 278 PF00069 0.462
MOD_ProDKin_1 45 51 PF00069 0.737
MOD_ProDKin_1 58 64 PF00069 0.549
MOD_ProDKin_1 615 621 PF00069 0.809
MOD_ProDKin_1 644 650 PF00069 0.744
MOD_ProDKin_1 65 71 PF00069 0.736
MOD_ProDKin_1 693 699 PF00069 0.725
MOD_ProDKin_1 710 716 PF00069 0.814
MOD_ProDKin_1 760 766 PF00069 0.809
MOD_ProDKin_1 86 92 PF00069 0.727
MOD_SUMO_for_1 873 876 PF00179 0.487
MOD_SUMO_rev_2 249 254 PF00179 0.514
MOD_SUMO_rev_2 557 562 PF00179 0.578
MOD_SUMO_rev_2 858 868 PF00179 0.540
TRG_AP2beta_CARGO_1 217 227 PF09066 0.565
TRG_DiLeu_BaEn_1 281 286 PF01217 0.471
TRG_DiLeu_BaEn_1 557 562 PF01217 0.561
TRG_DiLeu_BaEn_4 557 563 PF01217 0.625
TRG_ENDOCYTIC_2 263 266 PF00928 0.440
TRG_ENDOCYTIC_2 295 298 PF00928 0.415
TRG_ENDOCYTIC_2 507 510 PF00928 0.654
TRG_ENDOCYTIC_2 880 883 PF00928 0.501
TRG_ER_diArg_1 124 127 PF00400 0.688
TRG_ER_diArg_1 198 201 PF00400 0.514
TRG_ER_diArg_1 562 564 PF00400 0.659
TRG_ER_diArg_1 627 630 PF00400 0.819
TRG_ER_diArg_1 714 717 PF00400 0.703
TRG_NLS_MonoExtC_3 625 631 PF00514 0.743
TRG_NLS_MonoExtN_4 625 630 PF00514 0.699

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I857 Leptomonas seymouri 55% 100%
A0A1X0P7F7 Trypanosomatidae 28% 100%
A0A3S7X073 Leishmania donovani 88% 100%
A4HF84 Leishmania braziliensis 71% 100%
A4I2G7 Leishmania infantum 88% 100%
E9AYM0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS