Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8V0_LEIMA

TriTrypDb:

LmjF.26.2410 , LMJLV39_260030800 , LMJSD75_260029200

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8V0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.543
CLV_NRD_NRD_1	183	185	PF00675	0.532
CLV_NRD_NRD_1	206	208	PF00675	0.522
CLV_NRD_NRD_1	307	309	PF00675	0.505
CLV_NRD_NRD_1	51	53	PF00675	0.550
CLV_NRD_NRD_1	65	67	PF00675	0.609
CLV_NRD_NRD_1	95	97	PF00675	0.445
CLV_PCSK_FUR_1	181	185	PF00082	0.537
CLV_PCSK_FUR_1	305	309	PF00082	0.484
CLV_PCSK_KEX2_1	141	143	PF00082	0.564
CLV_PCSK_KEX2_1	183	185	PF00082	0.532
CLV_PCSK_KEX2_1	307	309	PF00082	0.462
CLV_PCSK_KEX2_1	51	53	PF00082	0.550
CLV_PCSK_KEX2_1	65	67	PF00082	0.615
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.564
CLV_PCSK_PC7_1	179	185	PF00082	0.532
CLV_PCSK_SKI1_1	11	15	PF00082	0.374
CLV_PCSK_SKI1_1	138	142	PF00082	0.531
CLV_PCSK_SKI1_1	307	311	PF00082	0.460
CLV_PCSK_SKI1_1	97	101	PF00082	0.496
DEG_APCC_DBOX_1	360	368	PF00400	0.577
DEG_APCC_DBOX_1	57	65	PF00400	0.416
DEG_APCC_KENBOX_2	18	22	PF00400	0.594
DOC_CYCLIN_RxL_1	304	312	PF00134	0.567
DOC_MAPK_gen_1	408	417	PF00069	0.641
DOC_MAPK_gen_1	96	102	PF00069	0.524
DOC_MAPK_MEF2A_6	265	272	PF00069	0.417
DOC_PP1_RVXF_1	9	15	PF00149	0.367
DOC_PP4_FxxP_1	14	17	PF00568	0.392
DOC_USP7_MATH_1	132	136	PF00917	0.471
DOC_USP7_MATH_1	249	253	PF00917	0.556
DOC_WW_Pin1_4	300	305	PF00397	0.533
LIG_14-3-3_CanoR_1	150	154	PF00244	0.544
LIG_14-3-3_CanoR_1	181	191	PF00244	0.544
LIG_14-3-3_CanoR_1	308	317	PF00244	0.553
LIG_Actin_WH2_2	247	263	PF00022	0.499
LIG_APCC_ABBA_1	360	365	PF00400	0.490
LIG_BIR_II_1	1	5	PF00653	0.555
LIG_BRCT_BRCA1_1	187	191	PF00533	0.640
LIG_BRCT_BRCA1_2	187	193	PF00533	0.432
LIG_CaM_IQ_9	166	181	PF13499	0.545
LIG_Clathr_ClatBox_1	241	245	PF01394	0.478
LIG_deltaCOP1_diTrp_1	124	130	PF00928	0.499
LIG_FHA_1	154	160	PF00498	0.479
LIG_FHA_1	22	28	PF00498	0.545
LIG_FHA_1	374	380	PF00498	0.529
LIG_FHA_1	422	428	PF00498	0.442
LIG_FHA_1	85	91	PF00498	0.478
LIG_FHA_2	216	222	PF00498	0.498
LIG_FHA_2	329	335	PF00498	0.589
LIG_FHA_2	352	358	PF00498	0.521
LIG_FHA_2	39	45	PF00498	0.589
LIG_LIR_Gen_1	124	133	PF02991	0.496
LIG_LIR_Gen_1	20	30	PF02991	0.508
LIG_LIR_Gen_1	228	236	PF02991	0.490
LIG_LIR_Gen_1	237	244	PF02991	0.365
LIG_LIR_Gen_1	266	275	PF02991	0.423
LIG_LIR_Gen_1	297	306	PF02991	0.498
LIG_LIR_Gen_1	413	421	PF02991	0.592
LIG_LIR_Gen_1	85	93	PF02991	0.442
LIG_LIR_Nem_3	109	114	PF02991	0.560
LIG_LIR_Nem_3	124	129	PF02991	0.440
LIG_LIR_Nem_3	20	25	PF02991	0.531
LIG_LIR_Nem_3	228	233	PF02991	0.484
LIG_LIR_Nem_3	237	243	PF02991	0.362
LIG_LIR_Nem_3	266	270	PF02991	0.415
LIG_LIR_Nem_3	273	278	PF02991	0.420
LIG_LIR_Nem_3	297	301	PF02991	0.371
LIG_LIR_Nem_3	381	385	PF02991	0.560
LIG_LIR_Nem_3	403	407	PF02991	0.595
LIG_LIR_Nem_3	413	417	PF02991	0.330
LIG_LIR_Nem_3	85	89	PF02991	0.393
LIG_NRBOX	305	311	PF00104	0.570
LIG_NRBOX	99	105	PF00104	0.524
LIG_Pex14_1	126	130	PF04695	0.530
LIG_Pex14_2	191	195	PF04695	0.590
LIG_Pex14_2	225	229	PF04695	0.427
LIG_PTB_Apo_2	224	231	PF02174	0.549
LIG_PTB_Phospho_1	224	230	PF10480	0.545
LIG_RPA_C_Fungi	46	58	PF08784	0.554
LIG_SH2_CRK	230	234	PF00017	0.557
LIG_SH2_CRK	275	279	PF00017	0.475
LIG_SH2_GRB2like	230	233	PF00017	0.564
LIG_SH2_NCK_1	230	234	PF00017	0.568
LIG_SH2_PTP2	414	417	PF00017	0.592
LIG_SH2_SRC	230	233	PF00017	0.513
LIG_SH2_STAP1	22	26	PF00017	0.508
LIG_SH2_STAT5	353	356	PF00017	0.504
LIG_SH2_STAT5	414	417	PF00017	0.609
LIG_SH2_STAT5	83	86	PF00017	0.547
LIG_SH3_3	152	158	PF00018	0.553
LIG_SH3_3	298	304	PF00018	0.564
LIG_SH3_3	431	437	PF00018	0.657
LIG_SUMO_SIM_par_1	112	118	PF11976	0.593
LIG_SUMO_SIM_par_1	23	28	PF11976	0.595
LIG_SUMO_SIM_par_1	268	274	PF11976	0.514
LIG_SUMO_SIM_par_1	29	34	PF11976	0.521
LIG_TRAF2_1	187	190	PF00917	0.565
LIG_UBA3_1	269	277	PF00899	0.523
LIG_UBA3_1	417	425	PF00899	0.624
LIG_WRC_WIRS_1	99	104	PF05994	0.519
MOD_CDK_SPK_2	300	305	PF00069	0.521
MOD_CDK_SPxxK_3	300	307	PF00069	0.483
MOD_CK1_1	136	142	PF00069	0.512
MOD_CK1_1	185	191	PF00069	0.609
MOD_CK1_1	312	318	PF00069	0.356
MOD_CK1_1	351	357	PF00069	0.473
MOD_CK1_1	373	379	PF00069	0.455
MOD_CK1_1	70	76	PF00069	0.423
MOD_CK2_1	183	189	PF00069	0.581
MOD_CK2_1	279	285	PF00069	0.504
MOD_CK2_1	286	292	PF00069	0.440
MOD_CK2_1	328	334	PF00069	0.564
MOD_CK2_1	351	357	PF00069	0.485
MOD_CK2_1	38	44	PF00069	0.510
MOD_CK2_1	393	399	PF00069	0.556
MOD_CK2_1	72	78	PF00069	0.609
MOD_GlcNHglycan	146	149	PF01048	0.552
MOD_GlcNHglycan	281	284	PF01048	0.351
MOD_GlcNHglycan	311	314	PF01048	0.465
MOD_GlcNHglycan	386	390	PF01048	0.602
MOD_GlcNHglycan	69	72	PF01048	0.657
MOD_GlcNHglycan	74	77	PF01048	0.572
MOD_GSK3_1	132	139	PF00069	0.467
MOD_GSK3_1	149	156	PF00069	0.564
MOD_GSK3_1	309	316	PF00069	0.503
MOD_GSK3_1	370	377	PF00069	0.538
MOD_GSK3_1	406	413	PF00069	0.603
MOD_GSK3_1	98	105	PF00069	0.431
MOD_N-GLC_1	225	230	PF02516	0.490
MOD_NEK2_1	102	107	PF00069	0.523
MOD_NEK2_1	195	200	PF00069	0.528
MOD_NEK2_1	225	230	PF00069	0.420
MOD_NEK2_1	309	314	PF00069	0.523
MOD_NEK2_1	328	333	PF00069	0.525
MOD_NEK2_1	371	376	PF00069	0.472
MOD_NEK2_1	384	389	PF00069	0.531
MOD_NEK2_1	421	426	PF00069	0.567
MOD_NEK2_2	133	138	PF00069	0.525
MOD_PIKK_1	195	201	PF00454	0.501
MOD_PIKK_1	406	412	PF00454	0.626
MOD_PKA_1	183	189	PF00069	0.629
MOD_PKA_1	65	71	PF00069	0.688
MOD_PKA_2	144	150	PF00069	0.654
MOD_PKA_2	182	188	PF00069	0.565
MOD_PKA_2	45	51	PF00069	0.581
MOD_PKA_2	65	71	PF00069	0.662
MOD_PKB_1	181	189	PF00069	0.630
MOD_Plk_1	114	120	PF00069	0.522
MOD_Plk_1	133	139	PF00069	0.461
MOD_Plk_1	225	231	PF00069	0.583
MOD_Plk_1	351	357	PF00069	0.479
MOD_Plk_4	125	131	PF00069	0.495
MOD_Plk_4	21	27	PF00069	0.598
MOD_Plk_4	225	231	PF00069	0.426
MOD_Plk_4	375	381	PF00069	0.428
MOD_Plk_4	410	416	PF00069	0.650
MOD_Plk_4	98	104	PF00069	0.473
MOD_ProDKin_1	300	306	PF00069	0.532
MOD_SUMO_for_1	367	370	PF00179	0.572
MOD_SUMO_rev_2	105	114	PF00179	0.578
MOD_SUMO_rev_2	322	329	PF00179	0.589
MOD_SUMO_rev_2	388	396	PF00179	0.411
MOD_SUMO_rev_2	400	409	PF00179	0.588
TRG_DiLeu_BaEn_1	109	114	PF01217	0.530
TRG_DiLeu_BaEn_2	97	103	PF01217	0.525
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.568
TRG_ENDOCYTIC_2	160	163	PF00928	0.447
TRG_ENDOCYTIC_2	22	25	PF00928	0.465
TRG_ENDOCYTIC_2	230	233	PF00928	0.540
TRG_ENDOCYTIC_2	275	278	PF00928	0.440
TRG_ENDOCYTIC_2	414	417	PF00928	0.538
TRG_ER_diArg_1	182	184	PF00400	0.516
TRG_ER_diArg_1	304	307	PF00400	0.490
TRG_ER_diArg_1	64	66	PF00400	0.628
TRG_NES_CRM1_1	161	172	PF08389	0.527
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM42	Leptomonas seymouri	62%	99%
A0A1X0P7I7	Trypanosomatidae	33%	92%
A0A3Q8ID54	Leishmania donovani	92%	100%
A0A3R7LDN5	Trypanosoma rangeli	30%	95%
A4HF86	Leishmania braziliensis	76%	100%
A4I2G9	Leishmania infantum	92%	100%
C9ZX27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	95%
D0A343	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	91%
E9AYM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5ATI0	Trypanosoma cruzi	31%	100%