MATH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8U9_LEIMA

TriTrypDb:

LmjF.26.2420 , LMJLV39_260030900 , LMJSD75_260029300

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q8U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8U9

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.729
CLV_NRD_NRD_1	240	242	PF00675	0.699
CLV_NRD_NRD_1	438	440	PF00675	0.380
CLV_NRD_NRD_1	539	541	PF00675	0.502
CLV_PCSK_KEX2_1	196	198	PF00082	0.729
CLV_PCSK_KEX2_1	240	242	PF00082	0.699
CLV_PCSK_KEX2_1	438	440	PF00082	0.373
CLV_PCSK_KEX2_1	539	541	PF00082	0.502
CLV_PCSK_KEX2_1	570	572	PF00082	0.474
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.474
CLV_PCSK_PC7_1	192	198	PF00082	0.542
CLV_PCSK_SKI1_1	158	162	PF00082	0.753
CLV_PCSK_SKI1_1	385	389	PF00082	0.384
CLV_PCSK_SKI1_1	493	497	PF00082	0.334
CLV_PCSK_SKI1_1	499	503	PF00082	0.359
CLV_PCSK_SKI1_1	636	640	PF00082	0.517
DEG_Nend_UBRbox_2	1	3	PF02207	0.485
DEG_SCF_FBW7_1	164	169	PF00400	0.733
DOC_CKS1_1	387	392	PF01111	0.480
DOC_CYCLIN_RxL_1	382	391	PF00134	0.381
DOC_CYCLIN_RxL_1	435	446	PF00134	0.371
DOC_CYCLIN_RxL_1	54	68	PF00134	0.233
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.395
DOC_CYCLIN_yCln2_LP_2	454	457	PF00134	0.358
DOC_MAPK_gen_1	16	25	PF00069	0.362
DOC_MAPK_gen_1	438	444	PF00069	0.390
DOC_MAPK_MEF2A_6	16	25	PF00069	0.475
DOC_PP1_RVXF_1	133	140	PF00149	0.483
DOC_PP1_RVXF_1	462	469	PF00149	0.355
DOC_PP1_RVXF_1	497	504	PF00149	0.347
DOC_PP2B_LxvP_1	454	457	PF13499	0.358
DOC_SPAK_OSR1_1	48	52	PF12202	0.430
DOC_USP7_MATH_1	156	160	PF00917	0.712
DOC_USP7_MATH_1	166	170	PF00917	0.620
DOC_USP7_MATH_1	231	235	PF00917	0.667
DOC_USP7_MATH_1	630	634	PF00917	0.482
DOC_USP7_MATH_1	88	92	PF00917	0.384
DOC_WW_Pin1_4	162	167	PF00397	0.673
DOC_WW_Pin1_4	198	203	PF00397	0.720
DOC_WW_Pin1_4	209	214	PF00397	0.616
DOC_WW_Pin1_4	386	391	PF00397	0.488
DOC_WW_Pin1_4	508	513	PF00397	0.533
DOC_WW_Pin1_4	67	72	PF00397	0.430
LIG_14-3-3_CanoR_1	20	26	PF00244	0.377
LIG_14-3-3_CanoR_1	208	212	PF00244	0.702
LIG_14-3-3_CanoR_1	215	224	PF00244	0.666
LIG_14-3-3_CanoR_1	230	239	PF00244	0.583
LIG_14-3-3_CanoR_1	241	247	PF00244	0.486
LIG_14-3-3_CanoR_1	343	351	PF00244	0.364
LIG_14-3-3_CanoR_1	438	443	PF00244	0.369
LIG_14-3-3_CanoR_1	600	605	PF00244	0.413
LIG_14-3-3_CanoR_1	636	644	PF00244	0.553
LIG_14-3-3_CanoR_1	92	97	PF00244	0.351
LIG_Actin_WH2_2	330	345	PF00022	0.369
LIG_APCC_ABBA_1	7	12	PF00400	0.531
LIG_BRCT_BRCA1_1	36	40	PF00533	0.306
LIG_BRCT_BRCA1_1	74	78	PF00533	0.475
LIG_BRCT_BRCA1_1	92	96	PF00533	0.191
LIG_Clathr_ClatBox_1	221	225	PF01394	0.741
LIG_FHA_1	132	138	PF00498	0.490
LIG_FHA_1	159	165	PF00498	0.729
LIG_FHA_1	216	222	PF00498	0.667
LIG_FHA_1	337	343	PF00498	0.404
LIG_FHA_1	578	584	PF00498	0.491
LIG_FHA_2	517	523	PF00498	0.370
LIG_FHA_2	542	548	PF00498	0.561
LIG_FHA_2	635	641	PF00498	0.413
LIG_Integrin_isoDGR_2	151	153	PF01839	0.714
LIG_LIR_Gen_1	122	129	PF02991	0.430
LIG_LIR_Gen_1	138	145	PF02991	0.536
LIG_LIR_Gen_1	336	346	PF02991	0.332
LIG_LIR_Gen_1	409	420	PF02991	0.392
LIG_LIR_Gen_1	426	437	PF02991	0.288
LIG_LIR_Gen_1	476	484	PF02991	0.371
LIG_LIR_Gen_1	529	538	PF02991	0.356
LIG_LIR_Gen_1	617	627	PF02991	0.445
LIG_LIR_Nem_3	138	142	PF02991	0.537
LIG_LIR_Nem_3	336	341	PF02991	0.334
LIG_LIR_Nem_3	372	376	PF02991	0.341
LIG_LIR_Nem_3	409	415	PF02991	0.382
LIG_LIR_Nem_3	418	423	PF02991	0.326
LIG_LIR_Nem_3	426	432	PF02991	0.291
LIG_LIR_Nem_3	472	478	PF02991	0.437
LIG_LIR_Nem_3	529	533	PF02991	0.358
LIG_LIR_Nem_3	617	623	PF02991	0.441
LIG_LIR_Nem_3	633	638	PF02991	0.334
LIG_MYND_1	386	390	PF01753	0.481
LIG_NRBOX	412	418	PF00104	0.337
LIG_PCNA_PIPBox_1	628	637	PF02747	0.376
LIG_PCNA_yPIPBox_3	528	538	PF02747	0.466
LIG_PCNA_yPIPBox_3	628	636	PF02747	0.378
LIG_Pex14_1	45	49	PF04695	0.430
LIG_Pex14_2	96	100	PF04695	0.306
LIG_SH2_CRK	19	23	PF00017	0.333
LIG_SH2_CRK	420	424	PF00017	0.370
LIG_SH2_NCK_1	244	248	PF00017	0.715
LIG_SH2_NCK_1	401	405	PF00017	0.516
LIG_SH2_PTP2	383	386	PF00017	0.437
LIG_SH2_SRC	412	415	PF00017	0.448
LIG_SH2_STAP1	346	350	PF00017	0.368
LIG_SH2_STAP1	36	40	PF00017	0.403
LIG_SH2_STAP1	420	424	PF00017	0.370
LIG_SH2_STAP1	478	482	PF00017	0.482
LIG_SH2_STAP1	487	491	PF00017	0.472
LIG_SH2_STAT3	127	130	PF00017	0.524
LIG_SH2_STAT5	344	347	PF00017	0.321
LIG_SH2_STAT5	365	368	PF00017	0.332
LIG_SH2_STAT5	383	386	PF00017	0.359
LIG_SH2_STAT5	412	415	PF00017	0.327
LIG_SH2_STAT5	494	497	PF00017	0.345
LIG_SH2_STAT5	604	607	PF00017	0.338
LIG_SH3_1	311	317	PF00018	0.369
LIG_SH3_3	225	231	PF00018	0.732
LIG_SH3_3	272	278	PF00018	0.580
LIG_SH3_3	311	317	PF00018	0.369
LIG_SH3_3	352	358	PF00018	0.433
LIG_SH3_3	478	484	PF00018	0.398
LIG_SH3_3	506	512	PF00018	0.479
LIG_SUMO_SIM_anti_2	551	557	PF11976	0.301
LIG_SUMO_SIM_par_1	333	340	PF11976	0.428
LIG_SUMO_SIM_par_1	394	399	PF11976	0.435
LIG_UBA3_1	454	459	PF00899	0.354
LIG_WRC_WIRS_1	338	343	PF05994	0.413
MOD_CDC14_SPxK_1	212	215	PF00782	0.732
MOD_CDK_SPxK_1	162	168	PF00069	0.740
MOD_CDK_SPxK_1	209	215	PF00069	0.736
MOD_CDK_SPxxK_3	198	205	PF00069	0.678
MOD_CK1_1	11	17	PF00069	0.417
MOD_CK1_1	257	263	PF00069	0.753
MOD_CK1_1	34	40	PF00069	0.329
MOD_CK1_1	446	452	PF00069	0.469
MOD_CK1_1	526	532	PF00069	0.344
MOD_CK2_1	473	479	PF00069	0.440
MOD_CK2_1	516	522	PF00069	0.381
MOD_CK2_1	634	640	PF00069	0.404
MOD_Cter_Amidation	194	197	PF01082	0.547
MOD_DYRK1A_RPxSP_1	162	166	PF00069	0.677
MOD_GlcNHglycan	104	107	PF01048	0.311
MOD_GlcNHglycan	12	16	PF01048	0.440
MOD_GlcNHglycan	122	125	PF01048	0.446
MOD_GlcNHglycan	148	151	PF01048	0.698
MOD_GlcNHglycan	158	161	PF01048	0.668
MOD_GlcNHglycan	205	208	PF01048	0.753
MOD_GlcNHglycan	218	221	PF01048	0.732
MOD_GlcNHglycan	233	236	PF01048	0.517
MOD_GlcNHglycan	256	259	PF01048	0.645
MOD_GlcNHglycan	271	274	PF01048	0.585
MOD_GlcNHglycan	352	355	PF01048	0.497
MOD_GlcNHglycan	36	39	PF01048	0.438
MOD_GlcNHglycan	471	474	PF01048	0.382
MOD_GlcNHglycan	53	57	PF01048	0.300
MOD_GlcNHglycan	547	551	PF01048	0.371
MOD_GlcNHglycan	609	612	PF01048	0.457
MOD_GSK3_1	156	163	PF00069	0.670
MOD_GSK3_1	183	190	PF00069	0.737
MOD_GSK3_1	203	210	PF00069	0.464
MOD_GSK3_1	469	476	PF00069	0.393
MOD_GSK3_1	630	637	PF00069	0.410
MOD_GSK3_1	88	95	PF00069	0.316
MOD_N-GLC_1	146	151	PF02516	0.637
MOD_N-GLC_1	577	582	PF02516	0.298
MOD_N-GLC_1	607	612	PF02516	0.450
MOD_N-GLC_1	614	619	PF02516	0.470
MOD_N-GLC_1	96	101	PF02516	0.392
MOD_NEK2_1	203	208	PF00069	0.651
MOD_NEK2_1	458	463	PF00069	0.514
MOD_NEK2_1	523	528	PF00069	0.357
MOD_NEK2_1	577	582	PF00069	0.522
MOD_NEK2_1	586	591	PF00069	0.433
MOD_NEK2_1	634	639	PF00069	0.398
MOD_NEK2_1	78	83	PF00069	0.378
MOD_NEK2_1	96	101	PF00069	0.206
MOD_NEK2_2	630	635	PF00069	0.441
MOD_NEK2_2	72	77	PF00069	0.448
MOD_PIKK_1	501	507	PF00454	0.362
MOD_PIKK_1	614	620	PF00454	0.454
MOD_PK_1	187	193	PF00069	0.758
MOD_PKA_1	438	444	PF00069	0.371
MOD_PKA_2	207	213	PF00069	0.710
MOD_PKA_2	438	444	PF00069	0.371
MOD_PKB_1	598	606	PF00069	0.290
MOD_Plk_1	290	296	PF00069	0.336
MOD_Plk_1	523	529	PF00069	0.475
MOD_Plk_1	607	613	PF00069	0.448
MOD_Plk_1	96	102	PF00069	0.430
MOD_Plk_4	21	27	PF00069	0.473
MOD_Plk_4	337	343	PF00069	0.410
MOD_Plk_4	357	363	PF00069	0.186
MOD_Plk_4	407	413	PF00069	0.429
MOD_Plk_4	438	444	PF00069	0.389
MOD_Plk_4	630	636	PF00069	0.419
MOD_ProDKin_1	162	168	PF00069	0.674
MOD_ProDKin_1	198	204	PF00069	0.720
MOD_ProDKin_1	209	215	PF00069	0.617
MOD_ProDKin_1	386	392	PF00069	0.486
MOD_ProDKin_1	508	514	PF00069	0.538
MOD_ProDKin_1	67	73	PF00069	0.430
MOD_SUMO_for_1	569	572	PF00179	0.405
TRG_DiLeu_BaEn_2	56	62	PF01217	0.433
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.385
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.354
TRG_DiLeu_BaLyEn_6	581	586	PF01217	0.355
TRG_ENDOCYTIC_2	412	415	PF00928	0.342
TRG_ENDOCYTIC_2	420	423	PF00928	0.347
TRG_ENDOCYTIC_2	478	481	PF00928	0.377
TRG_ER_diArg_1	239	241	PF00400	0.636
TRG_ER_diArg_1	437	439	PF00400	0.392
TRG_ER_diArg_1	538	540	PF00400	0.486
TRG_NES_CRM1_1	406	421	PF08389	0.389
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K5	Leptomonas seymouri	76%	97%
A0A1X0P796	Trypanosomatidae	56%	100%
A0A3Q8IPI1	Leishmania donovani	96%	100%
A0A3R7KRV6	Trypanosoma rangeli	65%	100%
A4HF87	Leishmania braziliensis	87%	100%
A4I2H0	Leishmania infantum	96%	100%
C9ZX25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AYM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5B8Y7	Trypanosoma cruzi	57%	100%