RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8U6_LEIMA

TriTrypDb:

LmjF.26.2450 , LMJLV39_260031200 , LMJSD75_260029600

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8U6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.582
CLV_NRD_NRD_1	117	119	PF00675	0.598
CLV_NRD_NRD_1	120	122	PF00675	0.558
CLV_NRD_NRD_1	124	126	PF00675	0.508
CLV_NRD_NRD_1	148	150	PF00675	0.472
CLV_NRD_NRD_1	218	220	PF00675	0.663
CLV_NRD_NRD_1	72	74	PF00675	0.640
CLV_PCSK_FUR_1	216	220	PF00082	0.667
CLV_PCSK_KEX2_1	117	119	PF00082	0.563
CLV_PCSK_KEX2_1	124	126	PF00082	0.477
CLV_PCSK_KEX2_1	148	150	PF00082	0.470
CLV_PCSK_KEX2_1	181	183	PF00082	0.377
CLV_PCSK_KEX2_1	200	202	PF00082	0.712
CLV_PCSK_KEX2_1	218	220	PF00082	0.708
CLV_PCSK_KEX2_1	32	34	PF00082	0.575
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.377
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.712
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.575
CLV_PCSK_SKI1_1	125	129	PF00082	0.589
CLV_PCSK_SKI1_1	148	152	PF00082	0.528
CLV_PCSK_SKI1_1	158	162	PF00082	0.403
DEG_APCC_DBOX_1	124	132	PF00400	0.622
DEG_APCC_DBOX_1	181	189	PF00400	0.501
DOC_USP7_MATH_1	19	23	PF00917	0.562
DOC_USP7_MATH_2	105	111	PF00917	0.695
DOC_WW_Pin1_4	80	85	PF00397	0.455
LIG_14-3-3_CanoR_1	149	157	PF00244	0.404
LIG_CtBP_PxDLS_1	2	6	PF00389	0.551
LIG_FHA_1	10	16	PF00498	0.439
LIG_FHA_1	140	146	PF00498	0.650
LIG_FHA_1	70	76	PF00498	0.516
LIG_FHA_1	87	93	PF00498	0.656
LIG_FHA_2	107	113	PF00498	0.685
LIG_LIR_Gen_1	67	75	PF02991	0.557
LIG_LIR_Nem_3	154	160	PF02991	0.581
LIG_LIR_Nem_3	67	71	PF02991	0.503
LIG_NRBOX	26	32	PF00104	0.523
LIG_PCNA_yPIPBox_3	23	33	PF02747	0.569
LIG_SH2_CRK	157	161	PF00017	0.581
LIG_SH2_STAT5	14	17	PF00017	0.465
LIG_TRAF2_1	110	113	PF00917	0.678
LIG_TYR_ITIM	155	160	PF00017	0.580
LIG_UBA3_1	26	32	PF00899	0.490
MOD_CK1_1	53	59	PF00069	0.457
MOD_CK2_1	106	112	PF00069	0.746
MOD_Cter_Amidation	146	149	PF01082	0.516
MOD_GlcNHglycan	133	136	PF01048	0.620
MOD_GlcNHglycan	166	169	PF01048	0.591
MOD_GlcNHglycan	205	208	PF01048	0.673
MOD_GlcNHglycan	97	100	PF01048	0.643
MOD_GSK3_1	55	62	PF00069	0.441
MOD_GSK3_1	86	93	PF00069	0.664
MOD_GSK3_1	9	16	PF00069	0.543
MOD_NEK2_1	106	111	PF00069	0.765
MOD_NEK2_1	139	144	PF00069	0.617
MOD_NEK2_1	9	14	PF00069	0.451
MOD_PIKK_1	19	25	PF00454	0.593
MOD_PIKK_1	191	197	PF00454	0.584
MOD_Plk_2-3	141	147	PF00069	0.666
MOD_Plk_4	64	70	PF00069	0.552
MOD_ProDKin_1	80	86	PF00069	0.461
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.481
TRG_ENDOCYTIC_2	157	160	PF00928	0.582
TRG_ER_diArg_1	216	219	PF00400	0.740
TRG_NES_CRM1_1	4	17	PF08389	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L0	Leptomonas seymouri	68%	100%
A0A0S4JIP0	Bodo saltans	34%	100%
A0A1X0P7J1	Trypanosomatidae	41%	78%
A0A3S7X077	Leishmania donovani	92%	100%
A0A422P3P4	Trypanosoma rangeli	47%	87%
A4HF90	Leishmania braziliensis	80%	100%
A4I2H2	Leishmania infantum	92%	100%
C9ZX22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	91%
E9AYM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%