Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8U5_LEIMA

TriTrypDb:

LmjF.26.2460 , LMJLV39_260031300 , LMJSD75_260029700

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q8U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8U5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	428	434	PF00089	0.500
CLV_NRD_NRD_1	16	18	PF00675	0.466
CLV_NRD_NRD_1	217	219	PF00675	0.682
CLV_NRD_NRD_1	270	272	PF00675	0.590
CLV_NRD_NRD_1	291	293	PF00675	0.734
CLV_NRD_NRD_1	389	391	PF00675	0.629
CLV_NRD_NRD_1	46	48	PF00675	0.595
CLV_NRD_NRD_1	5	7	PF00675	0.505
CLV_PCSK_FUR_1	14	18	PF00082	0.463
CLV_PCSK_KEX2_1	16	18	PF00082	0.466
CLV_PCSK_KEX2_1	179	181	PF00082	0.669
CLV_PCSK_KEX2_1	217	219	PF00082	0.635
CLV_PCSK_KEX2_1	291	293	PF00082	0.730
CLV_PCSK_KEX2_1	46	48	PF00082	0.591
CLV_PCSK_KEX2_1	5	7	PF00082	0.505
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.650
CLV_PCSK_PC7_1	175	181	PF00082	0.613
CLV_PCSK_SKI1_1	227	231	PF00082	0.643
CLV_PCSK_SKI1_1	334	338	PF00082	0.629
CLV_PCSK_SKI1_1	6	10	PF00082	0.517
DEG_Nend_Nbox_1	1	3	PF02207	0.652
DEG_SPOP_SBC_1	22	26	PF00917	0.763
DOC_CKS1_1	326	331	PF01111	0.483
DOC_CYCLIN_RxL_1	331	340	PF00134	0.428
DOC_MAPK_FxFP_2	163	166	PF00069	0.490
DOC_MAPK_gen_1	14	22	PF00069	0.718
DOC_MAPK_gen_1	179	185	PF00069	0.435
DOC_MAPK_gen_1	261	269	PF00069	0.535
DOC_MAPK_gen_1	429	438	PF00069	0.316
DOC_MAPK_gen_1	5	13	PF00069	0.687
DOC_MAPK_MEF2A_6	120	129	PF00069	0.542
DOC_MAPK_MEF2A_6	5	13	PF00069	0.633
DOC_MAPK_NFAT4_5	6	14	PF00069	0.571
DOC_PP4_FxxP_1	163	166	PF00568	0.490
DOC_PP4_FxxP_1	207	210	PF00568	0.450
DOC_USP7_MATH_1	312	316	PF00917	0.524
DOC_USP7_MATH_1	36	40	PF00917	0.704
DOC_USP7_MATH_1	384	388	PF00917	0.365
DOC_USP7_MATH_1	55	59	PF00917	0.769
DOC_WW_Pin1_4	152	157	PF00397	0.514
DOC_WW_Pin1_4	325	330	PF00397	0.590
DOC_WW_Pin1_4	39	44	PF00397	0.760
DOC_WW_Pin1_4	84	89	PF00397	0.702
LIG_14-3-3_CanoR_1	108	116	PF00244	0.724
LIG_14-3-3_CanoR_1	14	22	PF00244	0.691
LIG_14-3-3_CanoR_1	158	162	PF00244	0.481
LIG_14-3-3_CanoR_1	175	183	PF00244	0.350
LIG_14-3-3_CanoR_1	264	268	PF00244	0.542
LIG_14-3-3_CanoR_1	299	309	PF00244	0.533
LIG_14-3-3_CanoR_1	338	342	PF00244	0.404
LIG_Actin_WH2_2	376	392	PF00022	0.449
LIG_ActinCP_TwfCPI_2	207	217	PF01115	0.413
LIG_BRCT_BRCA1_1	159	163	PF00533	0.530
LIG_BRCT_BRCA1_1	265	269	PF00533	0.541
LIG_Clathr_ClatBox_1	238	242	PF01394	0.464
LIG_FHA_1	124	130	PF00498	0.399
LIG_FHA_1	145	151	PF00498	0.411
LIG_FHA_1	16	22	PF00498	0.594
LIG_FHA_1	180	186	PF00498	0.492
LIG_FHA_1	233	239	PF00498	0.423
LIG_FHA_1	331	337	PF00498	0.477
LIG_FHA_1	409	415	PF00498	0.422
LIG_FHA_2	319	325	PF00498	0.547
LIG_LIR_Apic_2	160	166	PF02991	0.506
LIG_LIR_Gen_1	356	366	PF02991	0.453
LIG_LIR_Gen_1	422	432	PF02991	0.401
LIG_LIR_Nem_3	160	165	PF02991	0.394
LIG_LIR_Nem_3	356	361	PF02991	0.439
LIG_LIR_Nem_3	422	428	PF02991	0.393
LIG_LYPXL_yS_3	103	106	PF13949	0.649
LIG_MLH1_MIPbox_1	159	163	PF16413	0.530
LIG_PCNA_yPIPBox_3	217	229	PF02747	0.438
LIG_PTAP_UEV_1	328	333	PF05743	0.367
LIG_SH2_CRK	375	379	PF00017	0.399
LIG_SH2_SRC	375	378	PF00017	0.371
LIG_SH2_STAP1	318	322	PF00017	0.519
LIG_SH2_STAP1	358	362	PF00017	0.364
LIG_SH2_STAP1	375	379	PF00017	0.353
LIG_SH2_STAP1	393	397	PF00017	0.298
LIG_SH2_STAP1	439	443	PF00017	0.417
LIG_SH2_STAT3	393	396	PF00017	0.298
LIG_SH2_STAT5	128	131	PF00017	0.448
LIG_SH2_STAT5	138	141	PF00017	0.318
LIG_SH2_STAT5	142	145	PF00017	0.374
LIG_SH2_STAT5	148	151	PF00017	0.226
LIG_SH2_STAT5	231	234	PF00017	0.362
LIG_SH2_STAT5	377	380	PF00017	0.397
LIG_SH2_STAT5	441	444	PF00017	0.446
LIG_SH3_2	329	334	PF14604	0.518
LIG_SH3_3	323	329	PF00018	0.567
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.518
LIG_SUMO_SIM_par_1	235	242	PF11976	0.390
LIG_TRAF2_1	88	91	PF00917	0.778
MOD_CDC14_SPxK_1	155	158	PF00782	0.526
MOD_CDK_SPxK_1	152	158	PF00069	0.518
MOD_CDK_SPxxK_3	39	46	PF00069	0.729
MOD_CK1_1	237	243	PF00069	0.461
MOD_CK1_1	25	31	PF00069	0.703
MOD_CK1_1	263	269	PF00069	0.507
MOD_CK1_1	285	291	PF00069	0.564
MOD_CK1_1	313	319	PF00069	0.548
MOD_CK1_1	38	44	PF00069	0.669
MOD_CK1_1	84	90	PF00069	0.664
MOD_CK2_1	318	324	PF00069	0.574
MOD_CK2_1	353	359	PF00069	0.413
MOD_CMANNOS	293	296	PF00535	0.729
MOD_GlcNHglycan	111	114	PF01048	0.555
MOD_GlcNHglycan	27	30	PF01048	0.487
MOD_GlcNHglycan	310	313	PF01048	0.701
MOD_GlcNHglycan	315	318	PF01048	0.702
MOD_GlcNHglycan	38	41	PF01048	0.499
MOD_GlcNHglycan	386	389	PF01048	0.704
MOD_GlcNHglycan	403	406	PF01048	0.540
MOD_GlcNHglycan	50	53	PF01048	0.610
MOD_GlcNHglycan	70	73	PF01048	0.540
MOD_GSK3_1	144	151	PF00069	0.372
MOD_GSK3_1	21	28	PF00069	0.752
MOD_GSK3_1	282	289	PF00069	0.540
MOD_GSK3_1	308	315	PF00069	0.524
MOD_GSK3_1	35	42	PF00069	0.651
MOD_N-GLC_1	152	157	PF02516	0.714
MOD_NEK2_1	109	114	PF00069	0.721
MOD_NEK2_1	130	135	PF00069	0.367
MOD_NEK2_1	21	26	PF00069	0.781
MOD_NEK2_1	310	315	PF00069	0.502
MOD_NEK2_1	336	341	PF00069	0.385
MOD_NEK2_1	343	348	PF00069	0.435
MOD_NEK2_1	383	388	PF00069	0.450
MOD_NEK2_2	123	128	PF00069	0.447
MOD_NEK2_2	157	162	PF00069	0.452
MOD_PIKK_1	286	292	PF00454	0.584
MOD_PKA_1	179	185	PF00069	0.516
MOD_PKA_2	109	115	PF00069	0.666
MOD_PKA_2	15	21	PF00069	0.725
MOD_PKA_2	157	163	PF00069	0.498
MOD_PKA_2	174	180	PF00069	0.342
MOD_PKA_2	263	269	PF00069	0.561
MOD_PKA_2	282	288	PF00069	0.361
MOD_PKA_2	337	343	PF00069	0.431
MOD_Plk_4	123	129	PF00069	0.485
MOD_Plk_4	144	150	PF00069	0.392
MOD_Plk_4	157	163	PF00069	0.461
MOD_Plk_4	234	240	PF00069	0.351
MOD_ProDKin_1	152	158	PF00069	0.518
MOD_ProDKin_1	325	331	PF00069	0.581
MOD_ProDKin_1	39	45	PF00069	0.761
MOD_ProDKin_1	84	90	PF00069	0.702
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.601
TRG_ENDOCYTIC_2	103	106	PF00928	0.655
TRG_ENDOCYTIC_2	250	253	PF00928	0.439
TRG_ENDOCYTIC_2	358	361	PF00928	0.471
TRG_ENDOCYTIC_2	375	378	PF00928	0.308
TRG_ER_diArg_1	13	16	PF00400	0.660
TRG_ER_diArg_1	217	219	PF00400	0.482
TRG_ER_diArg_1	291	293	PF00400	0.534
TRG_ER_diArg_1	341	344	PF00400	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV3	Leptomonas seymouri	49%	100%
A0A1X0P8N3	Trypanosomatidae	24%	100%
A0A3S7X083	Leishmania donovani	84%	100%
A4HF91	Leishmania braziliensis	66%	82%
A4I2H3	Leishmania infantum	84%	100%
C9ZX21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AYM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%