Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8U5_LEIMA

TriTrypDb:

LmjF.26.2460 , LMJLV39_260031300 , LMJSD75_260029700

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

Q4Q8U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8U5

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	428	434	PF00089	0.500
CLV_NRD_NRD_1	16	18	PF00675	0.466
CLV_NRD_NRD_1	217	219	PF00675	0.682
CLV_NRD_NRD_1	270	272	PF00675	0.590
CLV_NRD_NRD_1	291	293	PF00675	0.734
CLV_NRD_NRD_1	389	391	PF00675	0.629
CLV_NRD_NRD_1	46	48	PF00675	0.595
CLV_NRD_NRD_1	5	7	PF00675	0.505
CLV_PCSK_FUR_1	14	18	PF00082	0.463
CLV_PCSK_KEX2_1	16	18	PF00082	0.466

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV3	Leptomonas seymouri	49%	100%
A0A1X0P8N3	Trypanosomatidae	24%	100%
A0A3S7X083	Leishmania donovani	84%	100%
A4HF91	Leishmania braziliensis	66%	82%
A4I2H3	Leishmania infantum	84%	100%
C9ZX21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AYM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%

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