ZZ-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8U4_LEIMA

TriTrypDb:

LmjF.26.2470 , LMJLV39_260031400 , LMJSD75_260029800

Length:

122

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q8U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8U4

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	1
GO:0005198	structural molecule activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.501
CLV_NRD_NRD_1	106	108	PF00675	0.521
CLV_NRD_NRD_1	12	14	PF00675	0.466
CLV_PCSK_KEX2_1	11	13	PF00082	0.630
CLV_PCSK_KEX2_1	32	34	PF00082	0.622
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.659
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.641
DEG_Nend_Nbox_1	1	3	PF02207	0.672
DOC_CDC14_PxL_1	84	92	PF14671	0.537
DOC_MAPK_FxFP_2	85	88	PF00069	0.507
DOC_PP1_RVXF_1	10	17	PF00149	0.426
DOC_PP2B_LxvP_1	118	121	PF13499	0.660
DOC_PP4_FxxP_1	85	88	PF00568	0.507
DOC_USP7_MATH_1	31	35	PF00917	0.542
LIG_14-3-3_CanoR_1	58	68	PF00244	0.523
LIG_BRCT_BRCA1_1	26	30	PF00533	0.528
LIG_BRCT_BRCA1_2	26	32	PF00533	0.597
LIG_FHA_1	2	8	PF00498	0.596
LIG_FHA_1	20	26	PF00498	0.530
LIG_LIR_Nem_3	81	87	PF02991	0.469
LIG_LYPXL_yS_3	87	90	PF13949	0.537
LIG_Pex14_2	2	6	PF04695	0.642
LIG_SH2_STAT5	84	87	PF00017	0.476
LIG_ULM_U2AF65_1	11	17	PF00076	0.385
MOD_CK1_1	59	65	PF00069	0.548
MOD_CK2_1	95	101	PF00069	0.590
MOD_GlcNHglycan	33	36	PF01048	0.643
MOD_GSK3_1	57	64	PF00069	0.538
MOD_N-GLC_2	67	69	PF02516	0.561
MOD_NEK2_1	1	6	PF00069	0.565
MOD_NEK2_1	56	61	PF00069	0.491
MOD_NEK2_1	7	12	PF00069	0.450
MOD_PKA_2	57	63	PF00069	0.564
MOD_Plk_4	36	42	PF00069	0.443
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.432
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.333
TRG_ENDOCYTIC_2	87	90	PF00928	0.537
TRG_ER_diArg_1	12	15	PF00400	0.476
TRG_NLS_MonoExtC_3	10	15	PF00514	0.401
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZX2	Leptomonas seymouri	68%	90%
A0A1X0P889	Trypanosomatidae	56%	100%
A0A3S5H7G9	Leishmania donovani	89%	100%
A0A422P3V1	Trypanosoma rangeli	55%	100%
A4HF92	Leishmania braziliensis	80%	100%
A4I2H4	Leishmania infantum	88%	100%
C9ZX20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	94%
E9AYM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%