J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania major

UniProt:

Q4Q8T9_LEIMA

TriTrypDb:

LmjF.26.2520 , LMJLV39_260032200 , LMJSD75_260030600

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8T9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.656
CLV_C14_Caspase3-7	479	483	PF00656	0.586
CLV_NRD_NRD_1	105	107	PF00675	0.662
CLV_NRD_NRD_1	139	141	PF00675	0.725
CLV_NRD_NRD_1	142	144	PF00675	0.734
CLV_NRD_NRD_1	382	384	PF00675	0.687
CLV_NRD_NRD_1	40	42	PF00675	0.464
CLV_NRD_NRD_1	447	449	PF00675	0.684
CLV_NRD_NRD_1	81	83	PF00675	0.464
CLV_PCSK_FUR_1	140	144	PF00082	0.563
CLV_PCSK_FUR_1	275	279	PF00082	0.504
CLV_PCSK_KEX2_1	141	143	PF00082	0.726
CLV_PCSK_KEX2_1	277	279	PF00082	0.527
CLV_PCSK_KEX2_1	353	355	PF00082	0.558
CLV_PCSK_KEX2_1	40	42	PF00082	0.464
CLV_PCSK_KEX2_1	449	451	PF00082	0.695
CLV_PCSK_KEX2_1	83	85	PF00082	0.559
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.726
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.527
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.558
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.736
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.559
CLV_PCSK_SKI1_1	106	110	PF00082	0.716
CLV_PCSK_SKI1_1	142	146	PF00082	0.557
CLV_PCSK_SKI1_1	353	357	PF00082	0.558
CLV_PCSK_SKI1_1	394	398	PF00082	0.735
CLV_PCSK_SKI1_1	402	406	PF00082	0.754
CLV_PCSK_SKI1_1	413	417	PF00082	0.465
CLV_PCSK_SKI1_1	8	12	PF00082	0.561
DEG_COP1_1	93	102	PF00400	0.476
DEG_MDM2_SWIB_1	227	235	PF02201	0.550
DEG_Nend_UBRbox_2	1	3	PF02207	0.468
DEG_SCF_FBW7_2	367	373	PF00400	0.549
DEG_SPOP_SBC_1	112	116	PF00917	0.733
DOC_ANK_TNKS_1	142	149	PF00023	0.598
DOC_CKS1_1	29	34	PF01111	0.595
DOC_CKS1_1	367	372	PF01111	0.545
DOC_MAPK_FxFP_2	280	283	PF00069	0.410
DOC_MAPK_gen_1	233	241	PF00069	0.555
DOC_MAPK_gen_1	40	46	PF00069	0.457
DOC_PP4_FxxP_1	280	283	PF00568	0.410
DOC_PP4_FxxP_1	76	79	PF00568	0.576
DOC_USP7_MATH_1	120	124	PF00917	0.776
DOC_USP7_MATH_1	184	188	PF00917	0.519
DOC_USP7_MATH_1	254	258	PF00917	0.470
DOC_USP7_MATH_1	382	386	PF00917	0.655
DOC_USP7_MATH_1	39	43	PF00917	0.555
DOC_USP7_MATH_1	433	437	PF00917	0.635
DOC_USP7_MATH_1	473	477	PF00917	0.726
DOC_USP7_UBL2_3	405	409	PF12436	0.792
DOC_WW_Pin1_4	188	193	PF00397	0.641
DOC_WW_Pin1_4	28	33	PF00397	0.514
DOC_WW_Pin1_4	366	371	PF00397	0.547
DOC_WW_Pin1_4	404	409	PF00397	0.727
DOC_WW_Pin1_4	413	418	PF00397	0.743
DOC_WW_Pin1_4	431	436	PF00397	0.566
LIG_14-3-3_CanoR_1	221	227	PF00244	0.567
LIG_14-3-3_CanoR_1	383	391	PF00244	0.691
LIG_14-3-3_CanoR_1	40	44	PF00244	0.605
LIG_14-3-3_CanoR_1	402	408	PF00244	0.468
LIG_14-3-3_CanoR_1	452	459	PF00244	0.729
LIG_14-3-3_CanoR_1	61	69	PF00244	0.394
LIG_BRCT_BRCA1_1	256	260	PF00533	0.495
LIG_FHA_2	178	184	PF00498	0.549
LIG_FHA_2	327	333	PF00498	0.568
LIG_FHA_2	99	105	PF00498	0.644
LIG_LIR_Apic_2	74	79	PF02991	0.538
LIG_LIR_Gen_1	171	179	PF02991	0.573
LIG_LIR_Gen_1	42	50	PF02991	0.575
LIG_LIR_Gen_1	63	73	PF02991	0.417
LIG_LIR_Nem_3	171	177	PF02991	0.573
LIG_LIR_Nem_3	265	270	PF02991	0.470
LIG_LIR_Nem_3	42	46	PF02991	0.579
LIG_LIR_Nem_3	63	69	PF02991	0.417
LIG_LYPXL_SIV_4	283	291	PF13949	0.406
LIG_Pex14_2	227	231	PF04695	0.557
LIG_Pex14_2	23	27	PF04695	0.351
LIG_SH2_CRK	267	271	PF00017	0.463
LIG_SH2_CRK	43	47	PF00017	0.479
LIG_SH2_NCK_1	267	271	PF00017	0.565
LIG_SH2_SRC	485	488	PF00017	0.743
LIG_SH2_STAP1	224	228	PF00017	0.407
LIG_SH2_STAP1	262	266	PF00017	0.431
LIG_SH3_3	204	210	PF00018	0.433
LIG_SH3_3	26	32	PF00018	0.483
LIG_SH3_3	280	286	PF00018	0.389
LIG_SH3_3	423	429	PF00018	0.776
LIG_SH3_3	46	52	PF00018	0.239
LIG_TRAF2_1	296	299	PF00917	0.561
LIG_TRAF2_1	330	333	PF00917	0.519
LIG_WRC_WIRS_1	20	25	PF05994	0.314
MOD_CDK_SPK_2	404	409	PF00069	0.720
MOD_CDK_SPxxK_3	404	411	PF00069	0.682
MOD_CK1_1	115	121	PF00069	0.683
MOD_CK1_1	164	170	PF00069	0.715
MOD_CK1_1	457	463	PF00069	0.709
MOD_CK1_1	475	481	PF00069	0.476
MOD_CK2_1	149	155	PF00069	0.723
MOD_CK2_1	177	183	PF00069	0.434
MOD_CK2_1	211	217	PF00069	0.515
MOD_CK2_1	307	313	PF00069	0.590
MOD_CK2_1	326	332	PF00069	0.354
MOD_CK2_1	457	463	PF00069	0.675
MOD_CK2_1	464	470	PF00069	0.670
MOD_CK2_1	90	96	PF00069	0.591
MOD_Cter_Amidation	104	107	PF01082	0.709
MOD_Cter_Amidation	231	234	PF01082	0.420
MOD_Cter_Amidation	440	443	PF01082	0.778
MOD_GlcNHglycan	120	123	PF01048	0.758
MOD_GlcNHglycan	151	154	PF01048	0.634
MOD_GlcNHglycan	165	169	PF01048	0.564
MOD_GlcNHglycan	256	259	PF01048	0.499
MOD_GlcNHglycan	422	425	PF01048	0.805
MOD_GlcNHglycan	435	438	PF01048	0.728
MOD_GlcNHglycan	444	447	PF01048	0.719
MOD_GlcNHglycan	466	469	PF01048	0.594
MOD_GSK3_1	111	118	PF00069	0.753
MOD_GSK3_1	149	156	PF00069	0.714
MOD_GSK3_1	184	191	PF00069	0.567
MOD_GSK3_1	262	269	PF00069	0.431
MOD_GSK3_1	322	329	PF00069	0.618
MOD_GSK3_1	403	410	PF00069	0.719
MOD_GSK3_1	413	420	PF00069	0.741
MOD_GSK3_1	431	438	PF00069	0.553
MOD_GSK3_1	462	469	PF00069	0.702
MOD_GSK3_1	472	479	PF00069	0.735
MOD_GSK3_1	90	97	PF00069	0.595
MOD_LATS_1	352	358	PF00433	0.626
MOD_N-GLC_1	188	193	PF02516	0.669
MOD_NEK2_1	177	182	PF00069	0.480
MOD_NEK2_1	266	271	PF00069	0.468
MOD_NEK2_1	338	343	PF00069	0.480
MOD_NEK2_1	374	379	PF00069	0.719
MOD_NEK2_2	222	227	PF00069	0.552
MOD_NEK2_2	262	267	PF00069	0.424
MOD_PIKK_1	120	126	PF00454	0.752
MOD_PIKK_1	285	291	PF00454	0.469
MOD_PKA_1	142	148	PF00069	0.748
MOD_PKA_1	383	389	PF00069	0.683
MOD_PKA_1	442	448	PF00069	0.740
MOD_PKA_2	118	124	PF00069	0.731
MOD_PKA_2	142	148	PF00069	0.738
MOD_PKA_2	149	155	PF00069	0.656
MOD_PKA_2	382	388	PF00069	0.719
MOD_PKA_2	39	45	PF00069	0.593
MOD_PKA_2	60	66	PF00069	0.372
MOD_PKB_1	140	148	PF00069	0.560
MOD_PKB_1	450	458	PF00069	0.703
MOD_Plk_1	262	268	PF00069	0.429
MOD_Plk_1	462	468	PF00069	0.728
MOD_Plk_1	476	482	PF00069	0.741
MOD_Plk_2-3	151	157	PF00069	0.668
MOD_Plk_4	222	228	PF00069	0.413
MOD_Plk_4	262	268	PF00069	0.407
MOD_Plk_4	6	12	PF00069	0.449
MOD_ProDKin_1	188	194	PF00069	0.640
MOD_ProDKin_1	28	34	PF00069	0.509
MOD_ProDKin_1	366	372	PF00069	0.554
MOD_ProDKin_1	404	410	PF00069	0.728
MOD_ProDKin_1	413	419	PF00069	0.743
MOD_ProDKin_1	431	437	PF00069	0.566
MOD_SUMO_rev_2	164	173	PF00179	0.627
MOD_SUMO_rev_2	326	335	PF00179	0.432
MOD_SUMO_rev_2	74	81	PF00179	0.524
TRG_DiLeu_BaEn_1	333	338	PF01217	0.483
TRG_DiLeu_BaEn_4	345	351	PF01217	0.576
TRG_ENDOCYTIC_2	224	227	PF00928	0.409
TRG_ENDOCYTIC_2	267	270	PF00928	0.466
TRG_ENDOCYTIC_2	284	287	PF00928	0.400
TRG_ENDOCYTIC_2	43	46	PF00928	0.452
TRG_ER_diArg_1	139	142	PF00400	0.755
TRG_ER_diArg_1	447	450	PF00400	0.617
TRG_NLS_Bipartite_1	91	110	PF00514	0.610
TRG_NLS_MonoCore_2	139	144	PF00514	0.757
TRG_NLS_MonoCore_2	447	452	PF00514	0.702
TRG_NLS_MonoExtC_3	447	452	PF00514	0.704
TRG_NLS_MonoExtC_3	90	96	PF00514	0.490
TRG_NLS_MonoExtN_4	137	144	PF00514	0.762
TRG_NLS_MonoExtN_4	447	454	PF00514	0.716
TRG_NLS_MonoExtN_4	79	86	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P789	Trypanosomatidae	42%	100%
A0A3R7KYR3	Trypanosoma rangeli	45%	100%
A0A3S7X087	Leishmania donovani	91%	100%
A4HF97	Leishmania braziliensis	70%	100%
A4I2I9	Leishmania infantum	91%	100%
C9ZX14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AYN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%