Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8T7_LEIMA

TriTrypDb:

LmjF.26.2540 , LMJLV39_260032400 , LMJSD75_260030800

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8T7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.387
CLV_C14_Caspase3-7	458	462	PF00656	0.510
CLV_NRD_NRD_1	102	104	PF00675	0.537
CLV_NRD_NRD_1	13	15	PF00675	0.615
CLV_NRD_NRD_1	137	139	PF00675	0.389
CLV_NRD_NRD_1	439	441	PF00675	0.423
CLV_NRD_NRD_1	682	684	PF00675	0.547
CLV_PCSK_KEX2_1	102	104	PF00082	0.537
CLV_PCSK_KEX2_1	13	15	PF00082	0.549
CLV_PCSK_KEX2_1	682	684	PF00082	0.567
CLV_PCSK_PC7_1	678	684	PF00082	0.635
CLV_PCSK_SKI1_1	175	179	PF00082	0.543
CLV_PCSK_SKI1_1	519	523	PF00082	0.526
CLV_PCSK_SKI1_1	540	544	PF00082	0.330
CLV_PCSK_SKI1_1	552	556	PF00082	0.418
CLV_PCSK_SKI1_1	563	567	PF00082	0.677
DEG_APCC_DBOX_1	478	486	PF00400	0.405
DEG_Nend_UBRbox_1	1	4	PF02207	0.592
DOC_CYCLIN_RxL_1	574	585	PF00134	0.305
DOC_MAPK_gen_1	575	584	PF00069	0.571
DOC_MAPK_gen_1	618	627	PF00069	0.577
DOC_MAPK_MEF2A_6	205	213	PF00069	0.491
DOC_MAPK_MEF2A_6	395	404	PF00069	0.488
DOC_MAPK_MEF2A_6	528	536	PF00069	0.508
DOC_PP1_RVXF_1	575	582	PF00149	0.428
DOC_PP2B_LxvP_1	317	320	PF13499	0.445
DOC_PP2B_LxvP_1	532	535	PF13499	0.391
DOC_PP4_FxxP_1	243	246	PF00568	0.591
DOC_USP7_MATH_1	142	146	PF00917	0.536
DOC_USP7_MATH_1	201	205	PF00917	0.564
DOC_USP7_MATH_1	246	250	PF00917	0.593
DOC_USP7_MATH_1	311	315	PF00917	0.609
DOC_USP7_MATH_1	328	332	PF00917	0.448
DOC_USP7_MATH_1	455	459	PF00917	0.445
DOC_USP7_MATH_1	462	466	PF00917	0.563
DOC_USP7_UBL2_3	413	417	PF12436	0.470
DOC_WW_Pin1_4	248	253	PF00397	0.567
DOC_WW_Pin1_4	5	10	PF00397	0.509
DOC_WW_Pin1_4	639	644	PF00397	0.530
DOC_WW_Pin1_4	80	85	PF00397	0.626
LIG_14-3-3_CanoR_1	110	115	PF00244	0.567
LIG_14-3-3_CanoR_1	281	287	PF00244	0.388
LIG_14-3-3_CanoR_1	4	9	PF00244	0.671
LIG_14-3-3_CanoR_1	419	425	PF00244	0.391
LIG_14-3-3_CanoR_1	519	526	PF00244	0.573
LIG_14-3-3_CanoR_1	528	536	PF00244	0.586
LIG_14-3-3_CanoR_1	575	580	PF00244	0.577
LIG_14-3-3_CanoR_1	682	690	PF00244	0.582
LIG_Actin_WH2_2	535	551	PF00022	0.343
LIG_BIR_III_4	75	79	PF00653	0.456
LIG_BRCT_BRCA1_1	323	327	PF00533	0.370
LIG_Clathr_ClatBox_1	157	161	PF01394	0.329
LIG_deltaCOP1_diTrp_1	234	243	PF00928	0.382
LIG_FHA_1	185	191	PF00498	0.344
LIG_FHA_1	197	203	PF00498	0.461
LIG_FHA_1	228	234	PF00498	0.318
LIG_FHA_1	281	287	PF00498	0.463
LIG_FHA_1	597	603	PF00498	0.483
LIG_FHA_1	640	646	PF00498	0.506
LIG_FHA_2	176	182	PF00498	0.538
LIG_FHA_2	251	257	PF00498	0.460
LIG_FHA_2	45	51	PF00498	0.531
LIG_FHA_2	553	559	PF00498	0.606
LIG_FHA_2	586	592	PF00498	0.458
LIG_FHA_2	66	72	PF00498	0.446
LIG_GBD_Chelix_1	474	482	PF00786	0.343
LIG_LIR_Apic_2	219	225	PF02991	0.523
LIG_LIR_Apic_2	241	246	PF02991	0.577
LIG_LIR_Gen_1	150	158	PF02991	0.361
LIG_LIR_Gen_1	212	222	PF02991	0.427
LIG_LIR_Gen_1	256	265	PF02991	0.497
LIG_LIR_Gen_1	346	354	PF02991	0.404
LIG_LIR_Gen_1	578	589	PF02991	0.566
LIG_LIR_Gen_1	82	93	PF02991	0.476
LIG_LIR_Nem_3	150	154	PF02991	0.378
LIG_LIR_Nem_3	212	217	PF02991	0.407
LIG_LIR_Nem_3	256	262	PF02991	0.500
LIG_LIR_Nem_3	30	35	PF02991	0.479
LIG_LIR_Nem_3	346	351	PF02991	0.386
LIG_LIR_Nem_3	499	505	PF02991	0.451
LIG_LIR_Nem_3	578	584	PF02991	0.561
LIG_LIR_Nem_3	82	88	PF02991	0.476
LIG_PCNA_PIPBox_1	12	21	PF02747	0.540
LIG_PCNA_yPIPBox_3	6	19	PF02747	0.581
LIG_Rb_pABgroove_1	422	430	PF01858	0.402
LIG_SH2_CRK	214	218	PF00017	0.508
LIG_SH2_CRK	502	506	PF00017	0.463
LIG_SH2_SRC	69	72	PF00017	0.316
LIG_SH2_STAP1	173	177	PF00017	0.492
LIG_SH2_STAP1	214	218	PF00017	0.376
LIG_SH2_STAP1	69	73	PF00017	0.526
LIG_SH2_STAT3	517	520	PF00017	0.558
LIG_SH2_STAT5	18	21	PF00017	0.503
LIG_SH2_STAT5	352	355	PF00017	0.382
LIG_SH2_STAT5	365	368	PF00017	0.353
LIG_SH2_STAT5	481	484	PF00017	0.495
LIG_SH3_3	177	183	PF00018	0.461
LIG_SH3_3	431	437	PF00018	0.437
LIG_Sin3_3	606	613	PF02671	0.416
LIG_SUMO_SIM_par_1	128	134	PF11976	0.433
LIG_TRAF2_1	113	116	PF00917	0.493
LIG_TRAF2_1	38	41	PF00917	0.428
LIG_TRAF2_1	555	558	PF00917	0.463
LIG_TRAF2_1	68	71	PF00917	0.323
LIG_UBA3_1	190	198	PF00899	0.404
LIG_WRC_WIRS_1	345	350	PF05994	0.432
MOD_CDK_SPK_2	639	644	PF00069	0.530
MOD_CDK_SPxxK_3	248	255	PF00069	0.477
MOD_CK1_1	163	169	PF00069	0.419
MOD_CK1_1	239	245	PF00069	0.426
MOD_CK1_1	473	479	PF00069	0.370
MOD_CK1_1	49	55	PF00069	0.543
MOD_CK1_1	503	509	PF00069	0.478
MOD_CK1_1	639	645	PF00069	0.411
MOD_CK2_1	110	116	PF00069	0.576
MOD_CK2_1	21	27	PF00069	0.569
MOD_CK2_1	217	223	PF00069	0.466
MOD_CK2_1	35	41	PF00069	0.439
MOD_CK2_1	44	50	PF00069	0.466
MOD_CK2_1	552	558	PF00069	0.441
MOD_CK2_1	585	591	PF00069	0.490
MOD_CK2_1	65	71	PF00069	0.451
MOD_CK2_1	651	657	PF00069	0.391
MOD_GlcNHglycan	144	147	PF01048	0.552
MOD_GlcNHglycan	219	222	PF01048	0.385
MOD_GlcNHglycan	238	241	PF01048	0.373
MOD_GlcNHglycan	348	351	PF01048	0.470
MOD_GlcNHglycan	355	358	PF01048	0.410
MOD_GlcNHglycan	375	378	PF01048	0.267
MOD_GlcNHglycan	457	460	PF01048	0.426
MOD_GlcNHglycan	464	467	PF01048	0.591
MOD_GlcNHglycan	638	641	PF01048	0.411
MOD_GlcNHglycan	666	670	PF01048	0.531
MOD_GlcNHglycan	686	689	PF01048	0.464
MOD_GSK3_1	192	199	PF00069	0.402
MOD_GSK3_1	21	28	PF00069	0.428
MOD_GSK3_1	246	253	PF00069	0.484
MOD_GSK3_1	306	313	PF00069	0.498
MOD_GSK3_1	346	353	PF00069	0.490
MOD_GSK3_1	46	53	PF00069	0.380
MOD_GSK3_1	496	503	PF00069	0.433
MOD_GSK3_1	548	555	PF00069	0.551
MOD_LATS_1	681	687	PF00433	0.531
MOD_NEK2_1	160	165	PF00069	0.368
MOD_NEK2_1	19	24	PF00069	0.494
MOD_NEK2_1	306	311	PF00069	0.483
MOD_NEK2_1	344	349	PF00069	0.359
MOD_NEK2_1	404	409	PF00069	0.357
MOD_NEK2_1	427	432	PF00069	0.556
MOD_NEK2_1	504	509	PF00069	0.435
MOD_NEK2_1	51	56	PF00069	0.390
MOD_NEK2_1	548	553	PF00069	0.410
MOD_NEK2_1	582	587	PF00069	0.296
MOD_NEK2_2	350	355	PF00069	0.404
MOD_NEK2_2	365	370	PF00069	0.467
MOD_NEK2_2	481	486	PF00069	0.416
MOD_NEK2_2	512	517	PF00069	0.366
MOD_PIKK_1	404	410	PF00454	0.479
MOD_PIKK_1	504	510	PF00454	0.394
MOD_PIKK_1	519	525	PF00454	0.323
MOD_PKA_2	109	115	PF00069	0.561
MOD_PKA_2	19	25	PF00069	0.515
MOD_PKA_2	280	286	PF00069	0.392
MOD_PKA_2	487	493	PF00069	0.461
MOD_PKA_2	527	533	PF00069	0.568
MOD_PKA_2	548	554	PF00069	0.495
MOD_PKA_2	684	690	PF00069	0.703
MOD_PKB_1	2	10	PF00069	0.544
MOD_Plk_1	160	166	PF00069	0.346
MOD_Plk_1	175	181	PF00069	0.395
MOD_Plk_1	306	312	PF00069	0.494
MOD_Plk_4	239	245	PF00069	0.494
MOD_Plk_4	321	327	PF00069	0.357
MOD_Plk_4	420	426	PF00069	0.367
MOD_Plk_4	443	449	PF00069	0.331
MOD_Plk_4	470	476	PF00069	0.418
MOD_Plk_4	481	487	PF00069	0.479
MOD_Plk_4	500	506	PF00069	0.217
MOD_Plk_4	51	57	PF00069	0.373
MOD_Plk_4	512	518	PF00069	0.365
MOD_Plk_4	659	665	PF00069	0.579
MOD_ProDKin_1	248	254	PF00069	0.563
MOD_ProDKin_1	5	11	PF00069	0.501
MOD_ProDKin_1	639	645	PF00069	0.521
MOD_ProDKin_1	80	86	PF00069	0.617
MOD_SUMO_rev_2	384	393	PF00179	0.404
MOD_SUMO_rev_2	457	465	PF00179	0.556
TRG_AP2beta_CARGO_1	346	355	PF09066	0.431
TRG_DiLeu_BaEn_1	30	35	PF01217	0.456
TRG_DiLeu_BaEn_1	500	505	PF01217	0.467
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.573
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.431
TRG_ENDOCYTIC_2	214	217	PF00928	0.478
TRG_ENDOCYTIC_2	345	348	PF00928	0.419
TRG_ENDOCYTIC_2	502	505	PF00928	0.463
TRG_ER_diArg_1	102	104	PF00400	0.586
TRG_ER_diArg_1	13	15	PF00400	0.597
TRG_ER_diArg_1	263	266	PF00400	0.459
TRG_ER_diArg_1	617	620	PF00400	0.620
TRG_ER_diArg_1	682	685	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K6	Leptomonas seymouri	66%	89%
A0A0S4JKX7	Bodo saltans	28%	84%
A0A1X0P8M4	Trypanosomatidae	38%	92%
A0A3Q8IG37	Leishmania donovani	94%	100%
A0A3S5ISN2	Trypanosoma rangeli	43%	89%
A4HF99	Leishmania braziliensis	83%	88%
A4I2H6	Leishmania infantum	94%	100%
C9ZX12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	95%
E9AYN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5AS65	Trypanosoma cruzi	43%	89%