Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Serine/threonine-protein kinase NEK15, putative

Species:

Leishmania major

UniProt:

Q4Q8T4_LEIMA

TriTrypDb:

LmjF.26.2570 , LMJLV39_260032800 , LMJSD75_260031200

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8T4

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	17
GO:0006793	phosphorus metabolic process	3	17
GO:0006796	phosphate-containing compound metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016310	phosphorylation	5	17
GO:0019538	protein metabolic process	3	17
GO:0036211	protein modification process	4	17
GO:0043170	macromolecule metabolic process	3	17

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0004672	protein kinase activity	3	17
GO:0004674	protein serine/threonine kinase activity	4	11
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016301	kinase activity	4	17
GO:0016740	transferase activity	2	17
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	17
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	17

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.565
CLV_C14_Caspase3-7	340	344	PF00656	0.588
CLV_MEL_PAP_1	195	201	PF00089	0.436
CLV_NRD_NRD_1	152	154	PF00675	0.302
CLV_NRD_NRD_1	361	363	PF00675	0.541
CLV_NRD_NRD_1	58	60	PF00675	0.333
CLV_PCSK_KEX2_1	152	154	PF00082	0.422
CLV_PCSK_KEX2_1	240	242	PF00082	0.412
CLV_PCSK_KEX2_1	58	60	PF00082	0.401
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.441

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT76	Leptomonas seymouri	26%	97%
A0A0N1HZW6	Leptomonas seymouri	50%	98%
A0A0N1IM47	Leptomonas seymouri	27%	100%
A0A0S4JF22	Bodo saltans	25%	100%
A0A0S4JIY0	Bodo saltans	24%	67%
A0A0S4JNA1	Bodo saltans	29%	87%
A0A0S4JP91	Bodo saltans	29%	72%
A0A0S4KN74	Bodo saltans	24%	100%
A0A1X0NIA0	Trypanosomatidae	28%	100%
A0A1X0NJV4	Trypanosomatidae	24%	84%

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