Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Serine/threonine-protein kinase NEK15, putative

Species:

Leishmania major

UniProt:

Q4Q8T4_LEIMA

TriTrypDb:

LmjF.26.2570 , LMJLV39_260032800 , LMJSD75_260031200

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8T4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	17
GO:0006793	phosphorus metabolic process	3	17
GO:0006796	phosphate-containing compound metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016310	phosphorylation	5	17
GO:0019538	protein metabolic process	3	17
GO:0036211	protein modification process	4	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043412	macromolecule modification	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0004672	protein kinase activity	3	17
GO:0004674	protein serine/threonine kinase activity	4	11
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016301	kinase activity	4	17
GO:0016740	transferase activity	2	17
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	17
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	17
GO:0017076	purine nucleotide binding	4	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:0140096	catalytic activity, acting on a protein	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.565
CLV_C14_Caspase3-7	340	344	PF00656	0.588
CLV_MEL_PAP_1	195	201	PF00089	0.436
CLV_NRD_NRD_1	152	154	PF00675	0.302
CLV_NRD_NRD_1	361	363	PF00675	0.541
CLV_NRD_NRD_1	58	60	PF00675	0.333
CLV_PCSK_KEX2_1	152	154	PF00082	0.422
CLV_PCSK_KEX2_1	240	242	PF00082	0.412
CLV_PCSK_KEX2_1	58	60	PF00082	0.401
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.441
CLV_PCSK_PC7_1	236	242	PF00082	0.302
CLV_PCSK_SKI1_1	157	161	PF00082	0.310
CLV_PCSK_SKI1_1	241	245	PF00082	0.370
CLV_PCSK_SKI1_1	250	254	PF00082	0.385
CLV_PCSK_SKI1_1	317	321	PF00082	0.557
CLV_PCSK_SKI1_1	357	361	PF00082	0.576
CLV_PCSK_SKI1_1	37	41	PF00082	0.302
DEG_APCC_DBOX_1	351	359	PF00400	0.632
DEG_SPOP_SBC_1	263	267	PF00917	0.263
DOC_CKS1_1	1	6	PF01111	0.668
DOC_CKS1_1	199	204	PF01111	0.320
DOC_CYCLIN_RxL_1	10	19	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	298	304	PF00134	0.454
DOC_MAPK_DCC_7	125	134	PF00069	0.302
DOC_MAPK_FxFP_2	46	49	PF00069	0.261
DOC_MAPK_gen_1	125	134	PF00069	0.441
DOC_MAPK_gen_1	157	166	PF00069	0.320
DOC_MAPK_gen_1	352	360	PF00069	0.529
DOC_MAPK_MEF2A_6	125	134	PF00069	0.429
DOC_MAPK_MEF2A_6	160	168	PF00069	0.302
DOC_PP4_FxxP_1	46	49	PF00568	0.261
DOC_USP7_MATH_1	263	267	PF00917	0.466
DOC_USP7_MATH_1	329	333	PF00917	0.768
DOC_USP7_MATH_1	390	394	PF00917	0.513
DOC_WW_Pin1_4	198	203	PF00397	0.320
DOC_WW_Pin1_4	297	302	PF00397	0.505
DOC_WW_Pin1_4	321	326	PF00397	0.634
LIG_14-3-3_CanoR_1	241	249	PF00244	0.343
LIG_14-3-3_CanoR_1	262	269	PF00244	0.448
LIG_14-3-3_CanoR_1	288	296	PF00244	0.356
LIG_14-3-3_CanoR_1	297	301	PF00244	0.372
LIG_14-3-3_CanoR_1	373	382	PF00244	0.657
LIG_14-3-3_CanoR_1	59	67	PF00244	0.474
LIG_APCC_ABBA_1	311	316	PF00400	0.511
LIG_APCC_ABBAyCdc20_2	152	158	PF00400	0.441
LIG_APCC_ABBAyCdc20_2	250	256	PF00400	0.405
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_BIR_III_1	1	5	PF00653	0.578
LIG_BIR_III_3	1	5	PF00653	0.578
LIG_BIR_III_4	343	347	PF00653	0.725
LIG_BRCT_BRCA1_1	23	27	PF00533	0.407
LIG_deltaCOP1_diTrp_1	405	410	PF00928	0.501
LIG_EH1_1	382	390	PF00400	0.466
LIG_FHA_1	189	195	PF00498	0.269
LIG_FHA_1	263	269	PF00498	0.361
LIG_FHA_1	297	303	PF00498	0.395
LIG_FHA_1	370	376	PF00498	0.549
LIG_FHA_1	394	400	PF00498	0.638
LIG_FHA_2	215	221	PF00498	0.307
LIG_FHA_2	280	286	PF00498	0.316
LIG_FHA_2	288	294	PF00498	0.242
LIG_FHA_2	61	67	PF00498	0.426
LIG_GBD_Chelix_1	273	281	PF00786	0.302
LIG_HCF-1_HBM_1	81	84	PF13415	0.302
LIG_LIR_Apic_2	201	207	PF02991	0.320
LIG_LIR_Apic_2	405	411	PF02991	0.503
LIG_LIR_Gen_1	226	237	PF02991	0.280
LIG_LIR_Gen_1	29	39	PF02991	0.302
LIG_LIR_Gen_1	290	298	PF02991	0.261
LIG_LIR_Gen_1	414	425	PF02991	0.486
LIG_LIR_Nem_3	181	185	PF02991	0.436
LIG_LIR_Nem_3	226	232	PF02991	0.280
LIG_LIR_Nem_3	24	30	PF02991	0.302
LIG_LIR_Nem_3	290	295	PF02991	0.261
LIG_LIR_Nem_3	414	420	PF02991	0.492
LIG_LIR_Nem_3	426	431	PF02991	0.412
LIG_NRBOX	370	376	PF00104	0.451
LIG_NRBOX	402	408	PF00104	0.487
LIG_SH2_CRK	182	186	PF00017	0.302
LIG_SH2_CRK	292	296	PF00017	0.320
LIG_SH2_CRK	309	313	PF00017	0.419
LIG_SH2_CRK	428	432	PF00017	0.527
LIG_SH2_PTP2	204	207	PF00017	0.405
LIG_SH2_SRC	309	312	PF00017	0.402
LIG_SH2_STAP1	264	268	PF00017	0.349
LIG_SH2_STAP1	292	296	PF00017	0.320
LIG_SH2_STAT5	104	107	PF00017	0.367
LIG_SH2_STAT5	110	113	PF00017	0.365
LIG_SH2_STAT5	204	207	PF00017	0.313
LIG_SH2_STAT5	264	267	PF00017	0.302
LIG_SH2_STAT5	305	308	PF00017	0.375
LIG_SH2_STAT5	31	34	PF00017	0.377
LIG_SH2_STAT5	84	87	PF00017	0.328
LIG_SH2_STAT5	88	91	PF00017	0.269
LIG_SH3_1	309	315	PF00018	0.538
LIG_SH3_2	312	317	PF14604	0.437
LIG_SH3_3	196	202	PF00018	0.317
LIG_SH3_3	2	8	PF00018	0.560
LIG_SH3_3	309	315	PF00018	0.552
LIG_SH3_3	322	328	PF00018	0.637
LIG_SUMO_SIM_anti_2	419	426	PF11976	0.481
LIG_TRAF2_1	416	419	PF00917	0.494
LIG_WW_3	324	328	PF00397	0.753
MOD_CDC14_SPxK_1	324	327	PF00782	0.588
MOD_CDK_SPxK_1	321	327	PF00069	0.575
MOD_CK1_1	216	222	PF00069	0.341
MOD_CK1_1	223	229	PF00069	0.360
MOD_CK1_1	287	293	PF00069	0.363
MOD_CK1_1	300	306	PF00069	0.327
MOD_CK1_1	393	399	PF00069	0.500
MOD_CK2_1	279	285	PF00069	0.353
MOD_DYRK1A_RPxSP_1	198	202	PF00069	0.320
MOD_GlcNHglycan	143	146	PF01048	0.261
MOD_GlcNHglycan	170	173	PF01048	0.359
MOD_GlcNHglycan	222	225	PF01048	0.279
MOD_GlcNHglycan	23	26	PF01048	0.295
MOD_GlcNHglycan	332	335	PF01048	0.636
MOD_GlcNHglycan	339	342	PF01048	0.598
MOD_GlcNHglycan	425	428	PF01048	0.458
MOD_GSK3_1	164	171	PF00069	0.426
MOD_GSK3_1	184	191	PF00069	0.332
MOD_GSK3_1	194	201	PF00069	0.289
MOD_GSK3_1	216	223	PF00069	0.264
MOD_GSK3_1	264	271	PF00069	0.480
MOD_GSK3_1	296	303	PF00069	0.360
MOD_GSK3_1	33	40	PF00069	0.336
MOD_GSK3_1	369	376	PF00069	0.491
MOD_N-GLC_1	146	151	PF02516	0.276
MOD_N-GLC_1	44	49	PF02516	0.422
MOD_NEK2_1	146	151	PF00069	0.280
MOD_NEK2_1	168	173	PF00069	0.440
MOD_NEK2_1	188	193	PF00069	0.307
MOD_NEK2_1	194	199	PF00069	0.248
MOD_NEK2_1	21	26	PF00069	0.317
MOD_NEK2_1	320	325	PF00069	0.764
MOD_NEK2_1	423	428	PF00069	0.521
MOD_NEK2_2	264	269	PF00069	0.263
MOD_PKA_1	362	368	PF00069	0.455
MOD_PKA_2	287	293	PF00069	0.282
MOD_PKA_2	296	302	PF00069	0.377
MOD_PKA_2	369	375	PF00069	0.491
MOD_Plk_1	44	50	PF00069	0.440
MOD_Plk_4	200	206	PF00069	0.357
MOD_Plk_4	223	229	PF00069	0.280
MOD_Plk_4	264	270	PF00069	0.263
MOD_ProDKin_1	198	204	PF00069	0.320
MOD_ProDKin_1	297	303	PF00069	0.502
MOD_ProDKin_1	321	327	PF00069	0.638
TRG_DiLeu_BaEn_1	356	361	PF01217	0.531
TRG_DiLeu_BaEn_1	419	424	PF01217	0.479
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.302
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.302
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.596
TRG_ENDOCYTIC_2	182	185	PF00928	0.302
TRG_ENDOCYTIC_2	229	232	PF00928	0.441
TRG_ENDOCYTIC_2	292	295	PF00928	0.276
TRG_ENDOCYTIC_2	31	34	PF00928	0.405
TRG_ENDOCYTIC_2	428	431	PF00928	0.524
TRG_ER_diArg_1	152	154	PF00400	0.429
TRG_ER_diArg_1	352	355	PF00400	0.703
TRG_ER_diArg_1	57	59	PF00400	0.371
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT76	Leptomonas seymouri	26%	97%
A0A0N1HZW6	Leptomonas seymouri	50%	98%
A0A0N1IM47	Leptomonas seymouri	27%	100%
A0A0S4JF22	Bodo saltans	25%	100%
A0A0S4JIY0	Bodo saltans	24%	67%
A0A0S4JNA1	Bodo saltans	29%	87%
A0A0S4JP91	Bodo saltans	29%	72%
A0A0S4KN74	Bodo saltans	24%	100%
A0A1X0NIA0	Trypanosomatidae	28%	100%
A0A1X0NJV4	Trypanosomatidae	24%	84%
A0A1X0NVR3	Trypanosomatidae	25%	100%
A0A1X0NWR7	Trypanosomatidae	23%	84%
A0A1X0NY93	Trypanosomatidae	24%	100%
A0A1X0P1A2	Trypanosomatidae	25%	94%
A0A1X0P3P4	Trypanosomatidae	26%	89%
A0A1X0P765	Trypanosomatidae	45%	80%
A0A1X0P919	Trypanosomatidae	29%	100%
A0A1X0P994	Trypanosomatidae	29%	87%
A0A2I0BVG8	Plasmodium falciparum (isolate NF54)	27%	83%
A0A3Q8IAQ1	Leishmania donovani	28%	100%
A0A3Q8IIG1	Leishmania donovani	33%	100%
A0A3Q8IPJ5	Leishmania donovani	99%	100%
A0A3R7M848	Trypanosoma rangeli	39%	93%
A0A3R7NLI6	Trypanosoma rangeli	28%	100%
A0A3S5H4Z4	Leishmania donovani	26%	82%
A0A3S5IRC3	Trypanosoma rangeli	27%	100%
A0A3S7X7Y2	Leishmania donovani	28%	100%
A0A422N215	Trypanosoma rangeli	24%	70%
A0A422NDD2	Trypanosoma rangeli	29%	100%
A0A509AHB6	Plasmodium berghei (strain Anka)	27%	83%
A2ZMH2	Oryza sativa subsp. indica	29%	73%
A4H3C7	Leishmania braziliensis	27%	82%
A4HAS1	Leishmania braziliensis	28%	100%
A4HCE6	Leishmania braziliensis	26%	100%
A4HFA1	Leishmania braziliensis	92%	100%
A4HH03	Leishmania braziliensis	31%	100%
A4HRM6	Leishmania infantum	26%	82%
A4HZW8	Leishmania infantum	28%	100%
A4I2H8	Leishmania infantum	98%	100%
A4I435	Leishmania infantum	33%	100%
A4I9Y5	Leishmania infantum	28%	100%
A7MB74	Bos taurus	25%	100%
B0LT89	Rattus norvegicus	27%	100%
C9ZIN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	87%
C9ZX04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	93%
C9ZX09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	93%
D0A8X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D3ZBE5	Rattus norvegicus	29%	100%
E9ACA4	Leishmania major	26%	82%
E9AJJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	80%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AYN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
G5EFM9	Caenorhabditis elegans	27%	100%
O00141	Homo sapiens	25%	100%
O00506	Homo sapiens	28%	100%
O61122	Dictyostelium discoideum	27%	91%
P08458	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	88%
P22209	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P62343	Plasmodium falciparum (isolate K1 / Thailand)	27%	83%
P62344	Plasmodium falciparum (isolate 3D7)	27%	83%
P62345	Plasmodium berghei (strain Anka)	26%	82%
Q06226	Rattus norvegicus	26%	100%
Q0JI49	Oryza sativa subsp. japonica	27%	86%
Q10GB1	Oryza sativa subsp. japonica	30%	72%
Q2MHE4	Arabidopsis thaliana	25%	100%
Q2QMH1	Oryza sativa subsp. japonica	29%	73%
Q3SWY6	Bos taurus	28%	100%
Q4Q2Z2	Leishmania major	28%	100%
Q4Q7W2	Leishmania major	33%	100%
Q4QBQ2	Leishmania major	28%	100%
Q4QCR2	Leishmania major	26%	100%
Q4QCR3	Leishmania major	25%	100%
Q4R633	Macaca fascicularis	25%	100%
Q4V3C8	Arabidopsis thaliana	28%	89%
Q54EY4	Dictyostelium discoideum	29%	77%
Q5Q0U5	Fundulus heteroclitus	26%	100%
Q6YY75	Oryza sativa subsp. japonica	29%	81%
Q7RAH3	Plasmodium yoelii yoelii	27%	81%
Q7RJG2	Plasmodium yoelii yoelii	26%	82%
Q8RX66	Arabidopsis thaliana	31%	76%
Q8TDX7	Homo sapiens	29%	100%
Q8W490	Arabidopsis thaliana	29%	92%
Q94A06	Arabidopsis thaliana	26%	100%
Q99JT2	Mus musculus	27%	100%
Q99KH8	Mus musculus	26%	100%
Q9ES74	Mus musculus	29%	100%
Q9LHI7	Arabidopsis thaliana	27%	76%
Q9P289	Homo sapiens	27%	100%
Q9WVC6	Mus musculus	26%	100%
Q9XT18	Oryctolagus cuniculus	25%	100%
Q9Y6E0	Homo sapiens	26%	98%
Q9Z2W1	Mus musculus	28%	100%
Q9ZUZ2	Arabidopsis thaliana	27%	73%
Q9ZV15	Arabidopsis thaliana	28%	74%
V5BCN4	Trypanosoma cruzi	26%	70%
V5BI43	Trypanosoma cruzi	26%	86%
V5BJT8	Trypanosoma cruzi	28%	100%
V5CI11	Trypanosoma cruzi	46%	90%
V5D179	Trypanosoma cruzi	25%	71%
V5D9M1	Trypanosoma cruzi	30%	100%