Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8T3_LEIMA

TriTrypDb:

LmjF.26.2580 , LMJLV39_260032900 , LMJSD75_260031300

Length:

151

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8T3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.592
CLV_NRD_NRD_1	33	35	PF00675	0.522
CLV_NRD_NRD_1	70	72	PF00675	0.533
CLV_NRD_NRD_1	96	98	PF00675	0.696
CLV_PCSK_KEX2_1	131	133	PF00082	0.577
CLV_PCSK_KEX2_1	149	151	PF00082	0.515
CLV_PCSK_KEX2_1	33	35	PF00082	0.522
CLV_PCSK_KEX2_1	70	72	PF00082	0.499
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.738
CLV_PCSK_SKI1_1	18	22	PF00082	0.518
CLV_PCSK_SKI1_1	34	38	PF00082	0.571
CLV_PCSK_SKI1_1	70	74	PF00082	0.483
DOC_MAPK_gen_1	94	103	PF00069	0.463
DOC_PP2B_LxvP_1	19	22	PF13499	0.494
DOC_USP7_MATH_1	119	123	PF00917	0.704
DOC_USP7_UBL2_3	145	149	PF12436	0.685
DOC_USP7_UBL2_3	78	82	PF12436	0.593
DOC_WW_Pin1_4	57	62	PF00397	0.620
LIG_14-3-3_CanoR_1	25	30	PF00244	0.527
LIG_14-3-3_CanoR_1	45	54	PF00244	0.634
LIG_14-3-3_CanoR_1	97	103	PF00244	0.567
LIG_Actin_WH2_2	102	120	PF00022	0.578
LIG_BIR_II_1	1	5	PF00653	0.494
LIG_FHA_1	24	30	PF00498	0.545
LIG_FHA_1	49	55	PF00498	0.587
LIG_SH2_GRB2like	91	94	PF00017	0.602
LIG_SH2_STAP1	91	95	PF00017	0.604
LIG_SH3_3	113	119	PF00018	0.694
LIG_SUMO_SIM_par_1	25	31	PF11976	0.435
LIG_SUMO_SIM_par_1	51	58	PF11976	0.702
LIG_SUMO_SIM_par_1	60	67	PF11976	0.377
LIG_TRAF2_1	28	31	PF00917	0.449
LIG_UBA3_1	72	79	PF00899	0.538
MOD_CK1_1	122	128	PF00069	0.689
MOD_CK1_1	48	54	PF00069	0.624
MOD_CK2_1	25	31	PF00069	0.445
MOD_Cter_Amidation	146	149	PF01082	0.781
MOD_Cter_Amidation	31	34	PF01082	0.502
MOD_GlcNHglycan	124	127	PF01048	0.589
MOD_GlcNHglycan	98	101	PF01048	0.646
MOD_GSK3_1	118	125	PF00069	0.663
MOD_NEK2_1	64	69	PF00069	0.572
MOD_NEK2_2	124	129	PF00069	0.542
MOD_PKA_1	78	84	PF00069	0.432
MOD_PKA_2	117	123	PF00069	0.634
MOD_PKA_2	96	102	PF00069	0.680
MOD_Plk_1	48	54	PF00069	0.596
MOD_Plk_1	64	70	PF00069	0.444
MOD_ProDKin_1	57	63	PF00069	0.620
MOD_SUMO_rev_2	49	59	PF00179	0.614
TRG_DiLeu_BaEn_1	49	54	PF01217	0.647
TRG_DiLeu_BaEn_4	30	36	PF01217	0.483
TRG_DiLeu_LyEn_5	49	54	PF01217	0.536
TRG_ER_diArg_1	131	134	PF00400	0.594
TRG_ER_diArg_1	33	35	PF00400	0.522
TRG_ER_diArg_1	70	72	PF00400	0.533
TRG_ER_diLys_1	148	151	PF00400	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC7	Leptomonas seymouri	75%	100%
A0A0S4JH37	Bodo saltans	37%	100%
A0A1X0NEM8	Trypanosomatidae	51%	100%
A0A3R7R8R4	Trypanosoma rangeli	53%	100%
A0A3S7X093	Leishmania donovani	96%	100%
A4HFA2	Leishmania braziliensis	83%	100%
C9ZX03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
E9AYN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%