Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8T1_LEIMA

TriTrypDb:

LmjF.26.2600 , LMJLV39_260033200 , LMJSD75_260031600

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8T1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.595
CLV_C14_Caspase3-7	628	632	PF00656	0.765
CLV_NRD_NRD_1	188	190	PF00675	0.560
CLV_NRD_NRD_1	199	201	PF00675	0.561
CLV_NRD_NRD_1	247	249	PF00675	0.519
CLV_NRD_NRD_1	256	258	PF00675	0.589
CLV_NRD_NRD_1	313	315	PF00675	0.652
CLV_PCSK_FUR_1	254	258	PF00082	0.560
CLV_PCSK_FUR_1	58	62	PF00082	0.668
CLV_PCSK_KEX2_1	188	190	PF00082	0.560
CLV_PCSK_KEX2_1	247	249	PF00082	0.519
CLV_PCSK_KEX2_1	256	258	PF00082	0.589
CLV_PCSK_KEX2_1	315	317	PF00082	0.544
CLV_PCSK_KEX2_1	329	331	PF00082	0.471
CLV_PCSK_KEX2_1	39	41	PF00082	0.654
CLV_PCSK_KEX2_1	428	430	PF00082	0.450
CLV_PCSK_KEX2_1	57	59	PF00082	0.717
CLV_PCSK_KEX2_1	60	62	PF00082	0.704
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.544
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.471
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.654
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.450
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.717
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.704
CLV_PCSK_SKI1_1	121	125	PF00082	0.703
CLV_PCSK_SKI1_1	158	162	PF00082	0.501
CLV_PCSK_SKI1_1	57	61	PF00082	0.732
DEG_Nend_UBRbox_2	1	3	PF02207	0.720
DEG_SCF_FBW7_1	147	154	PF00400	0.677
DEG_SPOP_SBC_1	461	465	PF00917	0.748
DOC_ANK_TNKS_1	313	320	PF00023	0.534
DOC_CKS1_1	677	682	PF01111	0.642
DOC_MAPK_DCC_7	236	244	PF00069	0.606
DOC_MAPK_gen_1	118	126	PF00069	0.637
DOC_MAPK_gen_1	171	180	PF00069	0.635
DOC_PP1_RVXF_1	375	381	PF00149	0.567
DOC_PP2B_LxvP_1	124	127	PF13499	0.622
DOC_PP2B_LxvP_1	267	270	PF13499	0.691
DOC_PP2B_LxvP_1	282	285	PF13499	0.564
DOC_USP7_MATH_1	141	145	PF00917	0.723
DOC_USP7_MATH_1	19	23	PF00917	0.632
DOC_USP7_MATH_1	473	477	PF00917	0.726
DOC_USP7_MATH_1	497	501	PF00917	0.594
DOC_USP7_MATH_1	515	519	PF00917	0.666
DOC_USP7_MATH_1	575	579	PF00917	0.782
DOC_USP7_MATH_1	596	600	PF00917	0.728
DOC_USP7_MATH_1	685	689	PF00917	0.701
DOC_USP7_MATH_1	79	83	PF00917	0.748
DOC_WW_Pin1_4	101	106	PF00397	0.733
DOC_WW_Pin1_4	147	152	PF00397	0.738
DOC_WW_Pin1_4	15	20	PF00397	0.545
DOC_WW_Pin1_4	513	518	PF00397	0.754
DOC_WW_Pin1_4	562	567	PF00397	0.810
DOC_WW_Pin1_4	676	681	PF00397	0.789
DOC_WW_Pin1_4	73	78	PF00397	0.674
LIG_14-3-3_CanoR_1	116	121	PF00244	0.697
LIG_14-3-3_CanoR_1	305	313	PF00244	0.585
LIG_14-3-3_CanoR_1	525	529	PF00244	0.728
LIG_14-3-3_CanoR_1	569	574	PF00244	0.613
LIG_Actin_WH2_2	199	214	PF00022	0.620
LIG_APCC_ABBA_1	178	183	PF00400	0.711
LIG_BRCT_BRCA1_1	103	107	PF00533	0.663
LIG_DLG_GKlike_1	116	124	PF00625	0.689
LIG_FHA_1	128	134	PF00498	0.786
LIG_FHA_1	172	178	PF00498	0.626
LIG_FHA_1	212	218	PF00498	0.662
LIG_FHA_1	277	283	PF00498	0.724
LIG_FHA_1	384	390	PF00498	0.516
LIG_FHA_1	398	404	PF00498	0.535
LIG_FHA_1	422	428	PF00498	0.429
LIG_FHA_1	541	547	PF00498	0.603
LIG_FHA_1	581	587	PF00498	0.607
LIG_FHA_1	655	661	PF00498	0.793
LIG_FHA_2	45	51	PF00498	0.710
LIG_FHA_2	453	459	PF00498	0.724
LIG_GBD_Chelix_1	374	382	PF00786	0.642
LIG_LIR_Gen_1	207	216	PF02991	0.559
LIG_LIR_Gen_1	386	395	PF02991	0.555
LIG_LIR_Gen_1	68	78	PF02991	0.779
LIG_LIR_Nem_3	207	211	PF02991	0.568
LIG_LIR_Nem_3	386	390	PF02991	0.563
LIG_LIR_Nem_3	68	73	PF02991	0.766
LIG_PTB_Apo_2	381	388	PF02174	0.558
LIG_SH2_CRK	407	411	PF00017	0.545
LIG_SH2_CRK	645	649	PF00017	0.744
LIG_SH2_GRB2like	645	648	PF00017	0.721
LIG_SH2_NCK_1	338	342	PF00017	0.456
LIG_SH2_NCK_1	407	411	PF00017	0.545
LIG_SH2_NCK_1	645	649	PF00017	0.691
LIG_SH2_STAP1	686	690	PF00017	0.819
LIG_SH2_STAT5	338	341	PF00017	0.632
LIG_SH2_STAT5	354	357	PF00017	0.567
LIG_SH2_STAT5	425	428	PF00017	0.564
LIG_SH2_STAT5	477	480	PF00017	0.731
LIG_SH2_STAT5	616	619	PF00017	0.609
LIG_SH3_3	135	141	PF00018	0.705
LIG_SH3_3	271	277	PF00018	0.660
LIG_SH3_3	523	529	PF00018	0.666
LIG_SH3_3	543	549	PF00018	0.535
LIG_SH3_3	677	683	PF00018	0.835
LIG_SH3_3	75	81	PF00018	0.703
LIG_SH3_3	99	105	PF00018	0.493
LIG_SxIP_EBH_1	80	90	PF03271	0.669
LIG_TRAF2_1	637	640	PF00917	0.723
LIG_UBA3_1	266	272	PF00899	0.692
LIG_WRC_WIRS_1	686	691	PF05994	0.820
MOD_CDC14_SPxK_1	18	21	PF00782	0.527
MOD_CDK_SPxK_1	15	21	PF00069	0.544
MOD_CDK_SPxxK_3	562	569	PF00069	0.600
MOD_CDK_SPxxK_3	73	80	PF00069	0.548
MOD_CK1_1	397	403	PF00069	0.565
MOD_CK1_1	462	468	PF00069	0.770
MOD_CK1_1	502	508	PF00069	0.604
MOD_CK1_1	527	533	PF00069	0.747
MOD_CK1_1	535	541	PF00069	0.726
MOD_CK1_1	565	571	PF00069	0.760
MOD_CK1_1	600	606	PF00069	0.756
MOD_CK1_1	654	660	PF00069	0.784
MOD_CK1_1	668	674	PF00069	0.799
MOD_CK1_1	688	694	PF00069	0.566
MOD_CK2_1	27	33	PF00069	0.602
MOD_CK2_1	452	458	PF00069	0.738
MOD_CK2_1	527	533	PF00069	0.808
MOD_CK2_1	535	541	PF00069	0.768
MOD_CK2_1	553	559	PF00069	0.622
MOD_CK2_1	575	581	PF00069	0.752
MOD_CK2_1	632	638	PF00069	0.730
MOD_CK2_1	695	701	PF00069	0.741
MOD_GlcNHglycan	127	130	PF01048	0.711
MOD_GlcNHglycan	13	16	PF01048	0.675
MOD_GlcNHglycan	133	136	PF01048	0.679
MOD_GlcNHglycan	143	146	PF01048	0.552
MOD_GlcNHglycan	21	24	PF01048	0.637
MOD_GlcNHglycan	396	399	PF01048	0.665
MOD_GlcNHglycan	479	482	PF01048	0.735
MOD_GlcNHglycan	501	504	PF01048	0.664
MOD_GlcNHglycan	513	516	PF01048	0.812
MOD_GlcNHglycan	517	520	PF01048	0.773
MOD_GlcNHglycan	526	529	PF01048	0.547
MOD_GlcNHglycan	533	537	PF01048	0.805
MOD_GlcNHglycan	553	556	PF01048	0.552
MOD_GlcNHglycan	651	656	PF01048	0.751
MOD_GlcNHglycan	662	665	PF01048	0.690
MOD_GlcNHglycan	668	671	PF01048	0.831
MOD_GSK3_1	11	18	PF00069	0.783
MOD_GSK3_1	127	134	PF00069	0.664
MOD_GSK3_1	143	150	PF00069	0.773
MOD_GSK3_1	167	174	PF00069	0.641
MOD_GSK3_1	300	307	PF00069	0.620
MOD_GSK3_1	441	448	PF00069	0.643
MOD_GSK3_1	462	469	PF00069	0.783
MOD_GSK3_1	473	480	PF00069	0.667
MOD_GSK3_1	511	518	PF00069	0.835
MOD_GSK3_1	524	531	PF00069	0.802
MOD_GSK3_1	565	572	PF00069	0.747
MOD_GSK3_1	576	583	PF00069	0.802
MOD_GSK3_1	596	603	PF00069	0.591
MOD_GSK3_1	643	650	PF00069	0.733
MOD_GSK3_1	651	658	PF00069	0.744
MOD_GSK3_1	685	692	PF00069	0.699
MOD_N-GLC_1	383	388	PF02516	0.541
MOD_N-GLC_1	445	450	PF02516	0.653
MOD_N-GLC_1	655	660	PF02516	0.793
MOD_NEK2_1	133	138	PF00069	0.740
MOD_NEK2_1	226	231	PF00069	0.646
MOD_NEK2_1	378	383	PF00069	0.523
MOD_NEK2_1	532	537	PF00069	0.610
MOD_NEK2_1	660	665	PF00069	0.826
MOD_NEK2_1	689	694	PF00069	0.718
MOD_NEK2_2	685	690	PF00069	0.702
MOD_PIKK_1	300	306	PF00454	0.693
MOD_PIKK_1	336	342	PF00454	0.429
MOD_PIKK_1	491	497	PF00454	0.759
MOD_PK_1	569	575	PF00069	0.612
MOD_PKA_2	211	217	PF00069	0.666
MOD_PKA_2	304	310	PF00069	0.592
MOD_PKA_2	524	530	PF00069	0.763
MOD_PKA_2	568	574	PF00069	0.611
MOD_PKA_2	79	85	PF00069	0.681
MOD_PKB_1	171	179	PF00069	0.636
MOD_Plk_1	383	389	PF00069	0.562
MOD_Plk_1	505	511	PF00069	0.590
MOD_Plk_1	655	661	PF00069	0.789
MOD_Plk_4	173	179	PF00069	0.659
MOD_Plk_4	421	427	PF00069	0.419
MOD_Plk_4	473	479	PF00069	0.728
MOD_Plk_4	685	691	PF00069	0.819
MOD_ProDKin_1	101	107	PF00069	0.735
MOD_ProDKin_1	147	153	PF00069	0.734
MOD_ProDKin_1	15	21	PF00069	0.544
MOD_ProDKin_1	513	519	PF00069	0.755
MOD_ProDKin_1	562	568	PF00069	0.808
MOD_ProDKin_1	676	682	PF00069	0.789
MOD_ProDKin_1	73	79	PF00069	0.672
MOD_SUMO_for_1	59	62	PF00179	0.743
TRG_ENDOCYTIC_2	181	184	PF00928	0.604
TRG_ENDOCYTIC_2	407	410	PF00928	0.544
TRG_ENDOCYTIC_2	645	648	PF00928	0.743
TRG_ENDOCYTIC_2	686	689	PF00928	0.717
TRG_ER_diArg_1	187	189	PF00400	0.560
TRG_ER_diArg_1	247	249	PF00400	0.523
TRG_ER_diArg_1	255	257	PF00400	0.583
TRG_ER_diArg_1	313	316	PF00400	0.531
TRG_NLS_Bipartite_1	314	332	PF00514	0.652
TRG_NLS_Bipartite_1	39	61	PF00514	0.671
TRG_NLS_MonoExtC_3	327	333	PF00514	0.661
TRG_NLS_MonoExtC_3	38	44	PF00514	0.653
TRG_NLS_MonoExtC_3	56	61	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6M7	Leptomonas seymouri	34%	86%
A0A3S5H7H0	Leishmania donovani	90%	100%
A4HFA4	Leishmania braziliensis	62%	100%
A4I2I1	Leishmania infantum	90%	100%
E9AYP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%