Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q8S9_LEIMA

TriTrypDb:

LmjF.26.2620 , LMJLV39_260033400 , LMJSD75_260031800

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8S9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.597
CLV_PCSK_KEX2_1	147	149	PF00082	0.597
CLV_PCSK_SKI1_1	100	104	PF00082	0.438
CLV_PCSK_SKI1_1	47	51	PF00082	0.489
CLV_Separin_Metazoa	223	227	PF03568	0.470
DEG_APCC_DBOX_1	46	54	PF00400	0.479
DOC_MAPK_gen_1	147	154	PF00069	0.477
DOC_MAPK_MEF2A_6	117	125	PF00069	0.540
DOC_MAPK_MEF2A_6	147	154	PF00069	0.477
DOC_USP7_MATH_1	171	175	PF00917	0.642
DOC_USP7_MATH_1	38	42	PF00917	0.601
DOC_WW_Pin1_4	189	194	PF00397	0.550
DOC_WW_Pin1_4	81	86	PF00397	0.564
DOC_WW_Pin1_4	93	98	PF00397	0.485
LIG_14-3-3_CanoR_1	100	106	PF00244	0.439
LIG_14-3-3_CanoR_1	147	151	PF00244	0.625
LIG_14-3-3_CanoR_1	226	232	PF00244	0.457
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_Clathr_ClatBox_1	53	57	PF01394	0.586
LIG_FHA_1	118	124	PF00498	0.432
LIG_FHA_1	165	171	PF00498	0.661
LIG_FHA_1	175	181	PF00498	0.473
LIG_FHA_1	248	254	PF00498	0.438
LIG_FHA_1	97	103	PF00498	0.438
LIG_FHA_2	244	250	PF00498	0.536
LIG_FHA_2	41	47	PF00498	0.644
LIG_FHA_2	65	71	PF00498	0.720
LIG_GBD_Chelix_1	160	168	PF00786	0.608
LIG_Integrin_RGD_1	134	136	PF01839	0.531
LIG_LIR_Gen_1	108	118	PF02991	0.506
LIG_LIR_Gen_1	195	204	PF02991	0.445
LIG_LIR_Gen_1	96	106	PF02991	0.443
LIG_LIR_Nem_3	108	114	PF02991	0.516
LIG_LIR_Nem_3	195	199	PF02991	0.431
LIG_LIR_Nem_3	96	101	PF02991	0.446
LIG_NRBOX	49	55	PF00104	0.497
LIG_Pex14_2	101	105	PF04695	0.430
LIG_Pex14_2	235	239	PF04695	0.546
LIG_Pex14_2	272	276	PF04695	0.473
LIG_SH2_CRK	111	115	PF00017	0.606
LIG_SH2_NCK_1	111	115	PF00017	0.606
LIG_SH2_SRC	196	199	PF00017	0.425
LIG_SH2_STAP1	106	110	PF00017	0.499
LIG_SH2_STAP1	98	102	PF00017	0.436
LIG_SH2_STAT3	186	189	PF00017	0.597
LIG_SH2_STAT3	206	209	PF00017	0.277
LIG_SH2_STAT5	196	199	PF00017	0.459
LIG_SH2_STAT5	206	209	PF00017	0.505
LIG_SH2_STAT5	63	66	PF00017	0.676
LIG_SH2_STAT5	98	101	PF00017	0.475
LIG_SH3_3	196	202	PF00018	0.571
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.459
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.212
LIG_SUMO_SIM_anti_2	248	257	PF11976	0.641
LIG_SUMO_SIM_anti_2	52	57	PF11976	0.594
LIG_SUMO_SIM_par_1	229	236	PF11976	0.418
LIG_SUMO_SIM_par_1	248	257	PF11976	0.507
LIG_SUMO_SIM_par_1	52	57	PF11976	0.594
LIG_TRAF2_1	220	223	PF00917	0.469
LIG_TYR_ITIM	194	199	PF00017	0.455
LIG_TYR_ITSM	107	114	PF00017	0.610
LIG_UBA3_1	53	59	PF00899	0.588
LIG_WRC_WIRS_1	102	107	PF05994	0.451
MOD_CDK_SPxxK_3	93	100	PF00069	0.476
MOD_CK1_1	104	110	PF00069	0.251
MOD_CK1_1	174	180	PF00069	0.479
MOD_CK1_1	205	211	PF00069	0.552
MOD_CK1_1	40	46	PF00069	0.654
MOD_CK1_1	84	90	PF00069	0.588
MOD_CK1_1	96	102	PF00069	0.440
MOD_CK2_1	254	260	PF00069	0.599
MOD_CK2_1	40	46	PF00069	0.552
MOD_Cter_Amidation	145	148	PF01082	0.554
MOD_GSK3_1	101	108	PF00069	0.546
MOD_GSK3_1	113	120	PF00069	0.472
MOD_GSK3_1	233	240	PF00069	0.380
MOD_GSK3_1	243	250	PF00069	0.502
MOD_GSK3_1	38	45	PF00069	0.593
MOD_GSK3_1	64	71	PF00069	0.591
MOD_N-GLC_1	162	167	PF02516	0.607
MOD_NEK2_1	101	106	PF00069	0.434
MOD_NEK2_1	11	16	PF00069	0.620
MOD_NEK2_1	164	169	PF00069	0.555
MOD_NEK2_1	253	258	PF00069	0.491
MOD_NEK2_2	106	111	PF00069	0.598
MOD_PIKK_1	205	211	PF00454	0.499
MOD_PKA_1	58	64	PF00069	0.399
MOD_PKA_2	146	152	PF00069	0.557
MOD_Plk_1	247	253	PF00069	0.408
MOD_Plk_4	101	107	PF00069	0.447
MOD_Plk_4	212	218	PF00069	0.459
MOD_Plk_4	227	233	PF00069	0.446
MOD_Plk_4	249	255	PF00069	0.548
MOD_ProDKin_1	189	195	PF00069	0.551
MOD_ProDKin_1	81	87	PF00069	0.559
MOD_ProDKin_1	93	99	PF00069	0.476
MOD_SUMO_rev_2	52	61	PF00179	0.373
TRG_DiLeu_BaEn_1	175	180	PF01217	0.495
TRG_DiLeu_BaEn_1	8	13	PF01217	0.500
TRG_ENDOCYTIC_2	111	114	PF00928	0.506
TRG_ENDOCYTIC_2	196	199	PF00928	0.425
TRG_ENDOCYTIC_2	98	101	PF00928	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K2	Leptomonas seymouri	62%	100%
A0A3S7X096	Leishmania donovani	95%	100%
A4HFA6	Leishmania braziliensis	86%	100%
A4I2I3	Leishmania infantum	95%	100%
E9AYP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%