DPH-type MB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CSL zinc finger, putative

Species:

Leishmania major

UniProt:

Q4Q8S8_LEIMA

TriTrypDb:

LmjF.26.2630 , LMJLV39_260033500 , LMJSD75_260031900

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8S8

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006417	regulation of translation	6	8
GO:0006448	regulation of translational elongation	7	8
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009451	RNA modification	5	2
GO:0009889	regulation of biosynthetic process	4	8
GO:0009987	cellular process	1	8
GO:0010468	regulation of gene expression	5	8
GO:0010556	regulation of macromolecule biosynthetic process	5	8
GO:0010608	post-transcriptional regulation of gene expression	6	8
GO:0016070	RNA metabolic process	5	2
GO:0017182	peptidyl-diphthamide metabolic process	7	8
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	4	8
GO:0018193	peptidyl-amino acid modification	5	8
GO:0018202	peptidyl-histidine modification	6	8
GO:0019222	regulation of metabolic process	3	8
GO:0019538	protein metabolic process	3	8
GO:0031323	regulation of cellular metabolic process	4	8
GO:0031326	regulation of cellular biosynthetic process	5	8
GO:0034248	regulation of amide metabolic process	5	8
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0046483	heterocycle metabolic process	3	2
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0051171	regulation of nitrogen compound metabolic process	4	8
GO:0051246	regulation of protein metabolic process	5	8
GO:0060255	regulation of macromolecule metabolic process	4	8
GO:0065007	biological regulation	1	8
GO:0071704	organic substance metabolic process	2	8
GO:0080090	regulation of primary metabolic process	4	8
GO:0090304	nucleic acid metabolic process	4	2
GO:1900247	regulation of cytoplasmic translational elongation	8	8
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	8
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	8

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	55	59	PF00082	0.269
DEG_Nend_UBRbox_2	1	3	PF02207	0.600
DOC_CYCLIN_RxL_1	52	62	PF00134	0.519
DOC_MAPK_gen_1	60	69	PF00069	0.462
DOC_PP1_RVXF_1	53	59	PF00149	0.485
DOC_PP4_FxxP_1	23	26	PF00568	0.519
DOC_USP7_MATH_1	48	52	PF00917	0.481
LIG_FHA_1	47	53	PF00498	0.473
LIG_FHA_2	13	19	PF00498	0.519
LIG_FHA_2	69	75	PF00498	0.541
LIG_LIR_Gen_1	29	39	PF02991	0.481
LIG_LIR_Gen_1	3	14	PF02991	0.343
LIG_LIR_Nem_3	29	34	PF02991	0.481
LIG_LIR_Nem_3	3	9	PF02991	0.512
LIG_NRBOX	29	35	PF00104	0.489
LIG_SH2_NCK_1	6	10	PF00017	0.339
LIG_SH2_SRC	6	9	PF00017	0.339
LIG_TRAF2_1	59	62	PF00917	0.498
MOD_CK1_1	12	18	PF00069	0.519
MOD_CK2_1	56	62	PF00069	0.571
MOD_GlcNHglycan	39	42	PF01048	0.378
MOD_GSK3_1	46	53	PF00069	0.481
MOD_NEK2_2	50	55	PF00069	0.481
MOD_Plk_1	12	18	PF00069	0.481
TRG_DiLeu_BaEn_3	61	67	PF01217	0.482
TRG_ENDOCYTIC_2	6	9	PF00928	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEJ4	Leptomonas seymouri	85%	100%
A0A0S4ILF7	Bodo saltans	51%	93%
A0A3S7X095	Leishmania donovani	98%	100%
A4HFA7	Leishmania braziliensis	85%	100%
A4I2I4	Leishmania infantum	98%	100%
E9AYP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P0C0V4	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	44%	96%
Q1LZC9	Bos taurus	42%	98%
Q21102	Caenorhabditis elegans	48%	100%
Q3E840	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	98%
Q4I9U7	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	47%	93%
Q4P8G2	Ustilago maydis (strain 521 / FGSC 9021)	45%	90%
Q4R312	Macaca fascicularis	42%	98%
Q4WPU8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	42%	75%
Q5R7N8	Pongo abelii	42%	98%
Q6BTW5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	36%	100%
Q6C0G3	Yarrowia lipolytica (strain CLIB 122 / E 150)	44%	100%
Q6CMG4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	44%	98%
Q6FXS6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	40%	98%
Q6VUC1	Cricetulus griseus	40%	98%
Q74Z32	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	38%	98%
Q7SC15	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	45%	98%
Q8K0W9	Mus musculus	40%	98%
Q8STR6	Encephalitozoon cuniculi (strain GB-M1)	41%	86%
Q96FX2	Homo sapiens	42%	98%
Q9H4G8	Homo sapiens	44%	100%
Q9UT33	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
Q9VGQ9	Drosophila melanogaster	47%	93%