Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8S6_LEIMA

TriTrypDb:

LmjF.26.2650 , LMJLV39_260033800 , LMJSD75_260032200

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.533
CLV_NRD_NRD_1	340	342	PF00675	0.582
CLV_NRD_NRD_1	366	368	PF00675	0.495
CLV_NRD_NRD_1	433	435	PF00675	0.497
CLV_NRD_NRD_1	546	548	PF00675	0.519
CLV_PCSK_KEX2_1	27	29	PF00082	0.579
CLV_PCSK_KEX2_1	340	342	PF00082	0.703
CLV_PCSK_KEX2_1	366	368	PF00082	0.563
CLV_PCSK_KEX2_1	546	548	PF00082	0.519
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.580
CLV_PCSK_SKI1_1	113	117	PF00082	0.484
CLV_PCSK_SKI1_1	211	215	PF00082	0.542
CLV_PCSK_SKI1_1	95	99	PF00082	0.570
DEG_APCC_DBOX_1	546	554	PF00400	0.465
DEG_APCC_DBOX_1	94	102	PF00400	0.435
DEG_COP1_1	272	281	PF00400	0.487
DEG_SPOP_SBC_1	56	60	PF00917	0.534
DOC_CKS1_1	273	278	PF01111	0.485
DOC_CKS1_1	540	545	PF01111	0.645
DOC_MAPK_gen_1	475	484	PF00069	0.667
DOC_MAPK_MEF2A_6	475	484	PF00069	0.685
DOC_MAPK_MEF2A_6	68	75	PF00069	0.548
DOC_MAPK_MEF2A_6	77	84	PF00069	0.485
DOC_PP1_RVXF_1	565	571	PF00149	0.389
DOC_PP2B_LxvP_1	458	461	PF13499	0.655
DOC_PP4_FxxP_1	382	385	PF00568	0.362
DOC_PP4_FxxP_1	531	534	PF00568	0.332
DOC_USP7_MATH_1	124	128	PF00917	0.764
DOC_USP7_MATH_1	139	143	PF00917	0.815
DOC_USP7_MATH_1	233	237	PF00917	0.656
DOC_USP7_MATH_1	269	273	PF00917	0.655
DOC_USP7_MATH_1	274	278	PF00917	0.615
DOC_USP7_MATH_1	311	315	PF00917	0.582
DOC_USP7_MATH_1	369	373	PF00917	0.633
DOC_USP7_MATH_1	405	409	PF00917	0.503
DOC_USP7_MATH_1	465	469	PF00917	0.523
DOC_USP7_MATH_1	501	505	PF00917	0.601
DOC_USP7_MATH_1	56	60	PF00917	0.691
DOC_USP7_MATH_2	543	549	PF00917	0.461
DOC_USP7_UBL2_3	189	193	PF12436	0.498
DOC_WW_Pin1_4	238	243	PF00397	0.734
DOC_WW_Pin1_4	272	277	PF00397	0.487
DOC_WW_Pin1_4	295	300	PF00397	0.565
DOC_WW_Pin1_4	305	310	PF00397	0.542
DOC_WW_Pin1_4	447	452	PF00397	0.456
DOC_WW_Pin1_4	487	492	PF00397	0.648
DOC_WW_Pin1_4	539	544	PF00397	0.638
DOC_WW_Pin1_4	61	66	PF00397	0.483
LIG_14-3-3_CanoR_1	211	216	PF00244	0.516
LIG_14-3-3_CanoR_1	234	238	PF00244	0.615
LIG_14-3-3_CanoR_1	312	319	PF00244	0.762
LIG_14-3-3_CanoR_1	429	434	PF00244	0.638
LIG_14-3-3_CanoR_1	440	449	PF00244	0.654
LIG_Actin_WH2_2	90	108	PF00022	0.431
LIG_APCC_ABBA_1	459	464	PF00400	0.505
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_FHA_1	105	111	PF00498	0.588
LIG_FHA_1	273	279	PF00498	0.710
LIG_FHA_1	316	322	PF00498	0.705
LIG_FHA_1	379	385	PF00498	0.398
LIG_FHA_1	428	434	PF00498	0.625
LIG_FHA_1	464	470	PF00498	0.537
LIG_FHA_1	492	498	PF00498	0.521
LIG_FHA_1	528	534	PF00498	0.336
LIG_FHA_2	121	127	PF00498	0.786
LIG_FHA_2	154	160	PF00498	0.706
LIG_FHA_2	165	171	PF00498	0.674
LIG_FHA_2	200	206	PF00498	0.436
LIG_FHA_2	540	546	PF00498	0.453
LIG_FHA_2	6	12	PF00498	0.602
LIG_FXI_DFP_1	217	221	PF00024	0.509
LIG_GBD_Chelix_1	38	46	PF00786	0.511
LIG_Integrin_isoDGR_2	209	211	PF01839	0.561
LIG_IRF3_LxIS_1	74	81	PF10401	0.497
LIG_LIR_Apic_2	191	197	PF02991	0.352
LIG_LIR_Apic_2	381	385	PF02991	0.361
LIG_LIR_Apic_2	530	534	PF02991	0.332
LIG_LIR_Apic_2	538	543	PF02991	0.427
LIG_LIR_Gen_1	214	225	PF02991	0.437
LIG_LIR_Gen_1	408	418	PF02991	0.422
LIG_LIR_Nem_3	170	176	PF02991	0.436
LIG_LIR_Nem_3	20	26	PF02991	0.537
LIG_LIR_Nem_3	214	220	PF02991	0.460
LIG_LIR_Nem_3	408	413	PF02991	0.403
LIG_LIR_Nem_3	467	473	PF02991	0.492
LIG_LIR_Nem_3	504	510	PF02991	0.455
LIG_LYPXL_yS_3	507	510	PF13949	0.376
LIG_LYPXL_yS_3	578	581	PF13949	0.433
LIG_SH2_NCK_1	540	544	PF00017	0.552
LIG_SH2_SRC	462	465	PF00017	0.518
LIG_SH2_STAT5	100	103	PF00017	0.549
LIG_SH2_STAT5	223	226	PF00017	0.446
LIG_SH2_STAT5	470	473	PF00017	0.559
LIG_SH2_STAT5	483	486	PF00017	0.481
LIG_SH2_STAT5	498	501	PF00017	0.284
LIG_SH3_3	144	150	PF00018	0.810
LIG_SH3_3	237	243	PF00018	0.591
LIG_SH3_3	270	276	PF00018	0.523
LIG_SH3_3	318	324	PF00018	0.646
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.418
LIG_TRAF2_1	202	205	PF00917	0.480
LIG_TRAF2_1	461	464	PF00917	0.598
LIG_TRAF2_1	542	545	PF00917	0.449
LIG_UBA3_1	479	485	PF00899	0.577
LIG_WRC_WIRS_1	355	360	PF05994	0.496
MOD_CDK_SPxxK_3	305	312	PF00069	0.609
MOD_CDK_SPxxK_3	539	546	PF00069	0.459
MOD_CDK_SPxxK_3	61	68	PF00069	0.588
MOD_CK1_1	127	133	PF00069	0.705
MOD_CK1_1	241	247	PF00069	0.718
MOD_CK1_1	272	278	PF00069	0.630
MOD_CK1_1	34	40	PF00069	0.488
MOD_CK1_1	452	458	PF00069	0.654
MOD_CK1_1	522	528	PF00069	0.468
MOD_CK1_1	532	538	PF00069	0.409
MOD_CK1_1	61	67	PF00069	0.571
MOD_CK2_1	120	126	PF00069	0.669
MOD_CK2_1	139	145	PF00069	0.548
MOD_CK2_1	153	159	PF00069	0.643
MOD_CK2_1	199	205	PF00069	0.493
MOD_CK2_1	5	11	PF00069	0.637
MOD_CK2_1	532	538	PF00069	0.391
MOD_CK2_1	539	545	PF00069	0.410
MOD_CK2_1	61	67	PF00069	0.493
MOD_GlcNHglycan	130	133	PF01048	0.644
MOD_GlcNHglycan	33	36	PF01048	0.452
MOD_GlcNHglycan	371	374	PF01048	0.565
MOD_GlcNHglycan	423	426	PF01048	0.693
MOD_GlcNHglycan	499	502	PF01048	0.438
MOD_GlcNHglycan	503	506	PF01048	0.594
MOD_GlcNHglycan	521	524	PF01048	0.367
MOD_GlcNHglycan	547	550	PF01048	0.581
MOD_GlcNHglycan	556	559	PF01048	0.500
MOD_GlcNHglycan	60	63	PF01048	0.568
MOD_GSK3_1	104	111	PF00069	0.484
MOD_GSK3_1	120	127	PF00069	0.605
MOD_GSK3_1	238	245	PF00069	0.722
MOD_GSK3_1	291	298	PF00069	0.592
MOD_GSK3_1	311	318	PF00069	0.641
MOD_GSK3_1	34	41	PF00069	0.584
MOD_GSK3_1	445	452	PF00069	0.501
MOD_GSK3_1	487	494	PF00069	0.522
MOD_GSK3_1	497	504	PF00069	0.365
MOD_GSK3_1	51	58	PF00069	0.481
MOD_GSK3_1	529	536	PF00069	0.476
MOD_N-GLC_1	199	204	PF02516	0.511
MOD_N-GLC_1	405	410	PF02516	0.495
MOD_N-GLC_2	118	120	PF02516	0.624
MOD_NEK2_1	378	383	PF00069	0.390
MOD_NEK2_1	497	502	PF00069	0.445
MOD_NEK2_1	55	60	PF00069	0.555
MOD_NEK2_1	78	83	PF00069	0.499
MOD_NEK2_2	465	470	PF00069	0.488
MOD_PIKK_1	108	114	PF00454	0.643
MOD_PIKK_1	233	239	PF00454	0.609
MOD_PK_1	158	164	PF00069	0.561
MOD_PK_1	429	435	PF00069	0.494
MOD_PKA_2	233	239	PF00069	0.604
MOD_PKA_2	29	35	PF00069	0.451
MOD_PKA_2	291	297	PF00069	0.652
MOD_PKA_2	311	317	PF00069	0.753
MOD_PKA_2	339	345	PF00069	0.751
MOD_PKA_2	545	551	PF00069	0.589
MOD_Plk_1	158	164	PF00069	0.582
MOD_Plk_1	292	298	PF00069	0.664
MOD_Plk_1	353	359	PF00069	0.614
MOD_Plk_1	50	56	PF00069	0.442
MOD_Plk_1	69	75	PF00069	0.589
MOD_Plk_2-3	354	360	PF00069	0.504
MOD_Plk_2-3	506	512	PF00069	0.520
MOD_Plk_4	277	283	PF00069	0.553
MOD_Plk_4	292	298	PF00069	0.605
MOD_Plk_4	317	323	PF00069	0.694
MOD_Plk_4	38	44	PF00069	0.435
MOD_Plk_4	465	471	PF00069	0.508
MOD_Plk_4	69	75	PF00069	0.551
MOD_ProDKin_1	238	244	PF00069	0.733
MOD_ProDKin_1	272	278	PF00069	0.486
MOD_ProDKin_1	295	301	PF00069	0.566
MOD_ProDKin_1	305	311	PF00069	0.543
MOD_ProDKin_1	447	453	PF00069	0.457
MOD_ProDKin_1	487	493	PF00069	0.643
MOD_ProDKin_1	539	545	PF00069	0.633
MOD_ProDKin_1	61	67	PF00069	0.475
MOD_SUMO_rev_2	185	195	PF00179	0.374
MOD_SUMO_rev_2	511	519	PF00179	0.512
MOD_SUMO_rev_2	9	15	PF00179	0.627
TRG_DiLeu_BaEn_1	409	414	PF01217	0.393
TRG_DiLeu_BaEn_1	70	75	PF01217	0.467
TRG_DiLeu_LyEn_5	409	414	PF01217	0.393
TRG_ENDOCYTIC_2	217	220	PF00928	0.390
TRG_ENDOCYTIC_2	507	510	PF00928	0.447
TRG_ENDOCYTIC_2	578	581	PF00928	0.433
TRG_ER_diArg_1	340	343	PF00400	0.580
TRG_ER_diArg_1	365	367	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I848	Leptomonas seymouri	56%	100%
A0A1X0P7D0	Trypanosomatidae	32%	100%
A0A3R7MCE3	Trypanosoma rangeli	35%	100%
A0A3S7X099	Leishmania donovani	94%	100%
A4HFA9	Leishmania braziliensis	79%	100%
A4I2J1	Leishmania infantum	94%	100%
C9ZWZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AYP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B7P2	Trypanosoma cruzi	34%	100%