Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP92

Species:

Leishmania major

UniProt:

Q4Q8S5_LEIMA

TriTrypDb:

LmjF.26.2660 , LMJLV39_260033900 , LMJSD75_260032300

Length:

827

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	2
GO:0005634	nucleus	5	2
GO:0005643	nuclear pore	3	2
GO:0005815	microtubule organizing center	2	2
GO:0005816	spindle pole body	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0044615	nuclear pore nuclear basket	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4Q8S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8S5

Function

Biological processes
Term	Name	Level	Count
GO:0000278	mitotic cell cycle	3	2
GO:0007049	cell cycle	2	2
GO:0009987	cellular process	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	378	380	PF00675	0.606
CLV_NRD_NRD_1	417	419	PF00675	0.498
CLV_NRD_NRD_1	525	527	PF00675	0.563
CLV_NRD_NRD_1	565	567	PF00675	0.545
CLV_NRD_NRD_1	611	613	PF00675	0.481
CLV_PCSK_KEX2_1	118	120	PF00082	0.503
CLV_PCSK_KEX2_1	207	209	PF00082	0.473
CLV_PCSK_KEX2_1	378	380	PF00082	0.490
CLV_PCSK_KEX2_1	417	419	PF00082	0.454
CLV_PCSK_KEX2_1	564	566	PF00082	0.493
CLV_PCSK_KEX2_1	611	613	PF00082	0.503
CLV_PCSK_KEX2_1	659	661	PF00082	0.617
CLV_PCSK_KEX2_1	760	762	PF00082	0.432
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.503
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.508
CLV_PCSK_PC1ET2_1	659	661	PF00082	0.617
CLV_PCSK_PC1ET2_1	760	762	PF00082	0.432
CLV_PCSK_SKI1_1	119	123	PF00082	0.554
CLV_PCSK_SKI1_1	367	371	PF00082	0.570
CLV_PCSK_SKI1_1	385	389	PF00082	0.387
CLV_PCSK_SKI1_1	5	9	PF00082	0.707
CLV_PCSK_SKI1_1	502	506	PF00082	0.439
CLV_PCSK_SKI1_1	70	74	PF00082	0.674
CLV_PCSK_SKI1_1	716	720	PF00082	0.311
CLV_PCSK_SKI1_1	761	765	PF00082	0.464
CLV_Separin_Metazoa	447	451	PF03568	0.416
DEG_APCC_DBOX_1	384	392	PF00400	0.489
DEG_APCC_DBOX_1	416	424	PF00400	0.554
DEG_APCC_DBOX_1	563	571	PF00400	0.359
DEG_Nend_Nbox_1	1	3	PF02207	0.539
DOC_CYCLIN_RxL_1	113	126	PF00134	0.553
DOC_MAPK_DCC_7	19	28	PF00069	0.624
DOC_MAPK_DCC_7	816	826	PF00069	0.366
DOC_MAPK_gen_1	118	124	PF00069	0.556
DOC_MAPK_gen_1	168	176	PF00069	0.514
DOC_MAPK_gen_1	58	66	PF00069	0.693
DOC_MAPK_HePTP_8	56	68	PF00069	0.582
DOC_MAPK_MEF2A_6	59	68	PF00069	0.610
DOC_MAPK_MEF2A_6	684	691	PF00069	0.519
DOC_PP1_RVXF_1	127	134	PF00149	0.454
DOC_PP4_MxPP_1	48	51	PF00568	0.693
DOC_USP7_MATH_1	172	176	PF00917	0.556
DOC_USP7_MATH_1	178	182	PF00917	0.570
DOC_USP7_MATH_1	34	38	PF00917	0.580
DOC_USP7_MATH_1	402	406	PF00917	0.659
DOC_USP7_MATH_1	421	425	PF00917	0.630
DOC_USP7_MATH_1	699	703	PF00917	0.421
DOC_USP7_MATH_1	94	98	PF00917	0.590
DOC_USP7_UBL2_3	342	346	PF12436	0.574
DOC_USP7_UBL2_3	527	531	PF12436	0.557
DOC_WW_Pin1_4	19	24	PF00397	0.734
DOC_WW_Pin1_4	40	45	PF00397	0.784
DOC_WW_Pin1_4	618	623	PF00397	0.568
LIG_14-3-3_CanoR_1	111	121	PF00244	0.611
LIG_14-3-3_CanoR_1	173	177	PF00244	0.455
LIG_14-3-3_CanoR_1	223	228	PF00244	0.523
LIG_14-3-3_CanoR_1	356	366	PF00244	0.542
LIG_14-3-3_CanoR_1	488	497	PF00244	0.389
LIG_14-3-3_CanoR_1	507	512	PF00244	0.512
LIG_14-3-3_CanoR_1	598	606	PF00244	0.399
LIG_14-3-3_CanoR_1	642	650	PF00244	0.586
LIG_14-3-3_CanoR_1	660	669	PF00244	0.605
LIG_14-3-3_CanoR_1	761	769	PF00244	0.360
LIG_14-3-3_CanoR_1	80	88	PF00244	0.607
LIG_14-3-3_CanoR_1	806	814	PF00244	0.397
LIG_14-3-3_CanoR_1	93	97	PF00244	0.513
LIG_Actin_WH2_2	64	82	PF00022	0.629
LIG_BIR_III_2	46	50	PF00653	0.605
LIG_CaM_IQ_9	359	375	PF13499	0.648
LIG_eIF4E_1	774	780	PF01652	0.357
LIG_FHA_1	186	192	PF00498	0.495
LIG_FHA_1	22	28	PF00498	0.655
LIG_FHA_1	258	264	PF00498	0.521
LIG_FHA_1	538	544	PF00498	0.524
LIG_FHA_1	67	73	PF00498	0.633
LIG_FHA_1	703	709	PF00498	0.358
LIG_FHA_1	712	718	PF00498	0.347
LIG_FHA_1	774	780	PF00498	0.338
LIG_FHA_2	184	190	PF00498	0.554
LIG_FHA_2	195	201	PF00498	0.508
LIG_FHA_2	262	268	PF00498	0.604
LIG_FHA_2	345	351	PF00498	0.580
LIG_FHA_2	36	42	PF00498	0.767
LIG_FHA_2	405	411	PF00498	0.610
LIG_FHA_2	598	604	PF00498	0.459
LIG_FHA_2	6	12	PF00498	0.662
LIG_FHA_2	799	805	PF00498	0.391
LIG_LIR_Gen_1	106	114	PF02991	0.466
LIG_LIR_Gen_1	130	138	PF02991	0.536
LIG_LIR_Nem_3	106	110	PF02991	0.484
LIG_LIR_Nem_3	130	136	PF02991	0.537
LIG_MYND_1	25	29	PF01753	0.661
LIG_PTB_Apo_2	95	102	PF02174	0.518
LIG_RPA_C_Fungi	247	259	PF08784	0.505
LIG_RPA_C_Fungi	351	363	PF08784	0.582
LIG_SH2_NCK_1	774	778	PF00017	0.422
LIG_SH2_STAT3	211	214	PF00017	0.450
LIG_SH2_STAT3	748	751	PF00017	0.516
LIG_SH2_STAT5	162	165	PF00017	0.436
LIG_SH2_STAT5	308	311	PF00017	0.532
LIG_SH2_STAT5	574	577	PF00017	0.450
LIG_SH2_STAT5	732	735	PF00017	0.330
LIG_SH3_3	23	29	PF00018	0.678
LIG_SH3_3	47	53	PF00018	0.665
LIG_SH3_3	786	792	PF00018	0.489
LIG_TRAF2_1	103	106	PF00917	0.496
LIG_TRAF2_1	14	17	PF00917	0.703
LIG_TRAF2_1	141	144	PF00917	0.447
LIG_TRAF2_1	234	237	PF00917	0.497
LIG_TRAF2_1	348	351	PF00917	0.569
LIG_TRAF2_1	408	411	PF00917	0.512
LIG_TRAF2_1	444	447	PF00917	0.490
LIG_TRAF2_1	458	461	PF00917	0.540
LIG_UBA3_1	820	825	PF00899	0.508
MOD_CK1_1	257	263	PF00069	0.449
MOD_CK1_1	37	43	PF00069	0.777
MOD_CK1_1	405	411	PF00069	0.682
MOD_CK1_1	643	649	PF00069	0.574
MOD_CK1_1	702	708	PF00069	0.395
MOD_CK1_1	775	781	PF00069	0.529
MOD_CK1_1	92	98	PF00069	0.655
MOD_CK2_1	100	106	PF00069	0.482
MOD_CK2_1	138	144	PF00069	0.442
MOD_CK2_1	183	189	PF00069	0.554
MOD_CK2_1	194	200	PF00069	0.510
MOD_CK2_1	223	229	PF00069	0.475
MOD_CK2_1	261	267	PF00069	0.574
MOD_CK2_1	344	350	PF00069	0.577
MOD_CK2_1	35	41	PF00069	0.775
MOD_CK2_1	404	410	PF00069	0.510
MOD_CK2_1	488	494	PF00069	0.377
MOD_CK2_1	515	521	PF00069	0.462
MOD_CK2_1	597	603	PF00069	0.414
MOD_CK2_1	733	739	PF00069	0.446
MOD_CK2_1	798	804	PF00069	0.406
MOD_DYRK1A_RPxSP_1	19	23	PF00069	0.529
MOD_GlcNHglycan	102	105	PF01048	0.538
MOD_GlcNHglycan	180	183	PF01048	0.459
MOD_GlcNHglycan	521	525	PF01048	0.439
MOD_GlcNHglycan	531	534	PF01048	0.482
MOD_GlcNHglycan	591	595	PF01048	0.500
MOD_GlcNHglycan	645	648	PF01048	0.625
MOD_GlcNHglycan	671	674	PF01048	0.360
MOD_GlcNHglycan	81	84	PF01048	0.665
MOD_GlcNHglycan	98	101	PF01048	0.540
MOD_GSK3_1	257	264	PF00069	0.601
MOD_GSK3_1	421	428	PF00069	0.437
MOD_GSK3_1	507	514	PF00069	0.545
MOD_GSK3_1	580	587	PF00069	0.539
MOD_GSK3_1	612	619	PF00069	0.597
MOD_GSK3_1	642	649	PF00069	0.651
MOD_GSK3_1	650	657	PF00069	0.586
MOD_GSK3_1	702	709	PF00069	0.389
MOD_GSK3_1	92	99	PF00069	0.629
MOD_LATS_1	638	644	PF00433	0.776
MOD_N-GLC_1	628	633	PF02516	0.669
MOD_N-GLC_1	702	707	PF02516	0.397
MOD_NEK2_1	136	141	PF00069	0.486
MOD_NEK2_1	148	153	PF00069	0.440
MOD_NEK2_1	254	259	PF00069	0.609
MOD_NEK2_1	266	271	PF00069	0.410
MOD_NEK2_1	3	8	PF00069	0.570
MOD_NEK2_1	511	516	PF00069	0.521
MOD_NEK2_1	669	674	PF00069	0.418
MOD_NEK2_1	73	78	PF00069	0.602
MOD_NEK2_1	79	84	PF00069	0.610
MOD_NEK2_1	798	803	PF00069	0.449
MOD_NEK2_2	622	627	PF00069	0.642
MOD_NEK2_2	633	638	PF00069	0.528
MOD_NEK2_2	654	659	PF00069	0.656
MOD_NEK2_2	711	716	PF00069	0.362
MOD_PIKK_1	112	118	PF00454	0.469
MOD_PIKK_1	138	144	PF00454	0.443
MOD_PIKK_1	210	216	PF00454	0.449
MOD_PIKK_1	357	363	PF00454	0.683
MOD_PIKK_1	612	618	PF00454	0.645
MOD_PIKK_1	805	811	PF00454	0.335
MOD_PK_1	640	646	PF00069	0.613
MOD_PKA_2	112	118	PF00069	0.297
MOD_PKA_2	148	154	PF00069	0.521
MOD_PKA_2	172	178	PF00069	0.501
MOD_PKA_2	239	245	PF00069	0.620
MOD_PKA_2	402	408	PF00069	0.552
MOD_PKA_2	597	603	PF00069	0.392
MOD_PKA_2	79	85	PF00069	0.621
MOD_PKA_2	805	811	PF00069	0.432
MOD_PKA_2	92	98	PF00069	0.489
MOD_Plk_1	425	431	PF00069	0.489
MOD_Plk_1	511	517	PF00069	0.514
MOD_Plk_1	520	526	PF00069	0.471
MOD_Plk_1	552	558	PF00069	0.500
MOD_Plk_1	702	708	PF00069	0.419
MOD_Plk_1	73	79	PF00069	0.619
MOD_Plk_1	738	744	PF00069	0.462
MOD_Plk_4	511	517	PF00069	0.544
MOD_Plk_4	728	734	PF00069	0.447
MOD_Plk_4	738	744	PF00069	0.470
MOD_Plk_4	74	80	PF00069	0.708
MOD_Plk_4	775	781	PF00069	0.462
MOD_ProDKin_1	19	25	PF00069	0.732
MOD_ProDKin_1	40	46	PF00069	0.785
MOD_ProDKin_1	618	624	PF00069	0.569
MOD_SUMO_for_1	117	120	PF00179	0.504
MOD_SUMO_for_1	155	158	PF00179	0.443
MOD_SUMO_for_1	442	445	PF00179	0.595
MOD_SUMO_for_1	604	607	PF00179	0.560
MOD_SUMO_rev_2	141	148	PF00179	0.501
MOD_SUMO_rev_2	167	172	PF00179	0.489
MOD_SUMO_rev_2	175	181	PF00179	0.524
MOD_SUMO_rev_2	253	260	PF00179	0.563
MOD_SUMO_rev_2	269	278	PF00179	0.581
MOD_SUMO_rev_2	310	315	PF00179	0.529
MOD_SUMO_rev_2	360	369	PF00179	0.526
TRG_AP2beta_CARGO_1	130	140	PF09066	0.534
TRG_DiLeu_BaEn_1	143	148	PF01217	0.556
TRG_DiLeu_BaEn_2	188	194	PF01217	0.546
TRG_DiLeu_BaEn_4	143	149	PF01217	0.558
TRG_DiLeu_BaEn_4	189	195	PF01217	0.546
TRG_DiLeu_BaEn_4	236	242	PF01217	0.490
TRG_DiLeu_BaEn_4	310	316	PF01217	0.528
TRG_DiLeu_BaEn_4	411	417	PF01217	0.462
TRG_DiLeu_BaEn_4	552	558	PF01217	0.500
TRG_DiLeu_BaEn_4	753	759	PF01217	0.470
TRG_DiLeu_LyEn_5	753	758	PF01217	0.467
TRG_ENDOCYTIC_2	107	110	PF00928	0.560
TRG_ER_diArg_1	110	113	PF00400	0.431
TRG_ER_diArg_1	377	379	PF00400	0.606
TRG_ER_diArg_1	416	418	PF00400	0.504
TRG_ER_diArg_1	564	566	PF00400	0.567
TRG_ER_diArg_1	611	613	PF00400	0.484
TRG_NLS_MonoExtC_3	658	664	PF00514	0.642
TRG_NLS_MonoExtN_4	756	763	PF00514	0.434
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	541	546	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	565	569	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9T1	Leptomonas seymouri	71%	100%
A0A1X0P756	Trypanosomatidae	41%	100%
A0A3Q8IE13	Leishmania donovani	95%	100%
A0A3S5IQG3	Trypanosoma rangeli	39%	100%
A4HFB0	Leishmania braziliensis	83%	99%
A4I2J2	Leishmania infantum	95%	100%
C9ZWZ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AYP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BGQ7	Trypanosoma cruzi	39%	100%