Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q8S3_LEIMA

TriTrypDb:

LmjF.26.2680 , LMJLV39_260034100 , LMJSD75_260032500

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8S3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.502
CLV_C14_Caspase3-7	80	84	PF00656	0.594
CLV_MEL_PAP_1	123	129	PF00089	0.499
CLV_NRD_NRD_1	202	204	PF00675	0.549
CLV_PCSK_SKI1_1	204	208	PF00082	0.497
DEG_Nend_Nbox_1	1	3	PF02207	0.543
DEG_ODPH_VHL_1	44	56	PF01847	0.564
DEG_SPOP_SBC_1	56	60	PF00917	0.581
DOC_CDC14_PxL_1	161	169	PF14671	0.394
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.522
DOC_MAPK_gen_1	203	211	PF00069	0.515
DOC_MAPK_gen_1	244	250	PF00069	0.585
DOC_MAPK_MEF2A_6	203	211	PF00069	0.515
DOC_PP1_RVXF_1	206	212	PF00149	0.452
DOC_USP7_MATH_1	210	214	PF00917	0.569
DOC_USP7_MATH_1	252	256	PF00917	0.606
DOC_USP7_MATH_1	296	300	PF00917	0.492
DOC_USP7_MATH_1	345	349	PF00917	0.515
DOC_WW_Pin1_4	154	159	PF00397	0.474
DOC_WW_Pin1_4	34	39	PF00397	0.639
DOC_WW_Pin1_4	81	86	PF00397	0.533
LIG_14-3-3_CanoR_1	112	117	PF00244	0.557
LIG_14-3-3_CanoR_1	150	158	PF00244	0.446
LIG_14-3-3_CanoR_1	294	299	PF00244	0.545
LIG_14-3-3_CanoR_1	72	81	PF00244	0.607
LIG_BRCT_BRCA1_1	2	6	PF00533	0.566
LIG_BRCT_BRCA1_1	217	221	PF00533	0.520
LIG_FHA_1	150	156	PF00498	0.491
LIG_FHA_1	18	24	PF00498	0.550
LIG_FHA_1	215	221	PF00498	0.619
LIG_FHA_1	255	261	PF00498	0.616
LIG_FHA_1	35	41	PF00498	0.526
LIG_FHA_1	58	64	PF00498	0.590
LIG_FHA_1	74	80	PF00498	0.396
LIG_FHA_2	30	36	PF00498	0.632
LIG_FHA_2	337	343	PF00498	0.499
LIG_FHA_2	365	371	PF00498	0.426
LIG_FHA_2	78	84	PF00498	0.588
LIG_G3BP_FGDF_1	209	214	PF02136	0.467
LIG_GBD_Chelix_1	8	16	PF00786	0.561
LIG_LIR_Gen_1	297	307	PF02991	0.499
LIG_LIR_Nem_3	297	303	PF02991	0.507
LIG_LIR_Nem_3	358	364	PF02991	0.522
LIG_LIR_Nem_3	370	376	PF02991	0.355
LIG_LIR_Nem_3	95	100	PF02991	0.502
LIG_LYPXL_yS_3	164	167	PF13949	0.547
LIG_Pex14_2	211	215	PF04695	0.491
LIG_PTB_Apo_2	325	332	PF02174	0.442
LIG_REV1ctd_RIR_1	212	220	PF16727	0.443
LIG_SH2_CRK	124	128	PF00017	0.535
LIG_SH2_CRK	183	187	PF00017	0.566
LIG_SH2_CRK	300	304	PF00017	0.485
LIG_SH2_SRC	26	29	PF00017	0.600
LIG_SH2_SRC	373	376	PF00017	0.449
LIG_SH2_STAP1	225	229	PF00017	0.631
LIG_SH2_STAP1	300	304	PF00017	0.485
LIG_SH2_STAT5	179	182	PF00017	0.448
LIG_SH2_STAT5	373	376	PF00017	0.449
LIG_SH2_STAT5	7	10	PF00017	0.622
LIG_SH3_3	160	166	PF00018	0.472
LIG_SH3_3	264	270	PF00018	0.558
LIG_SUMO_SIM_anti_2	228	233	PF11976	0.558
LIG_SxIP_EBH_1	253	266	PF03271	0.514
LIG_TYR_ITIM	162	167	PF00017	0.614
LIG_TYR_ITIM	298	303	PF00017	0.501
LIG_WRC_WIRS_1	211	216	PF05994	0.573
MOD_CK1_1	190	196	PF00069	0.607
MOD_CK1_1	21	27	PF00069	0.537
MOD_CK1_1	255	261	PF00069	0.606
MOD_CK1_1	57	63	PF00069	0.549
MOD_CK2_1	29	35	PF00069	0.488
MOD_GlcNHglycan	127	130	PF01048	0.686
MOD_GlcNHglycan	222	225	PF01048	0.535
MOD_GlcNHglycan	345	348	PF01048	0.679
MOD_GSK3_1	10	17	PF00069	0.635
MOD_GSK3_1	210	217	PF00069	0.564
MOD_GSK3_1	236	243	PF00069	0.693
MOD_GSK3_1	252	259	PF00069	0.739
MOD_GSK3_1	314	321	PF00069	0.495
MOD_GSK3_1	341	348	PF00069	0.608
MOD_GSK3_1	351	358	PF00069	0.453
MOD_GSK3_1	48	55	PF00069	0.516
MOD_GSK3_1	73	80	PF00069	0.563
MOD_N-GLC_1	100	105	PF02516	0.531
MOD_N-GLC_1	21	26	PF02516	0.554
MOD_N-GLC_1	246	251	PF02516	0.589
MOD_N-GLC_1	253	258	PF02516	0.581
MOD_N-GLC_1	354	359	PF02516	0.559
MOD_N-GLC_1	92	97	PF02516	0.512
MOD_N-GLC_2	119	121	PF02516	0.498
MOD_N-GLC_2	143	145	PF02516	0.547
MOD_NEK2_1	100	105	PF00069	0.590
MOD_NEK2_1	11	16	PF00069	0.539
MOD_NEK2_1	125	130	PF00069	0.598
MOD_NEK2_1	214	219	PF00069	0.558
MOD_NEK2_1	220	225	PF00069	0.530
MOD_NEK2_1	311	316	PF00069	0.536
MOD_NEK2_1	341	346	PF00069	0.507
MOD_NEK2_1	363	368	PF00069	0.450
MOD_NEK2_1	54	59	PF00069	0.565
MOD_NEK2_2	210	215	PF00069	0.411
MOD_PIKK_1	110	116	PF00454	0.578
MOD_PIKK_1	132	138	PF00454	0.548
MOD_PIKK_1	187	193	PF00454	0.424
MOD_PK_1	294	300	PF00069	0.468
MOD_PKA_2	125	131	PF00069	0.533
MOD_PKA_2	149	155	PF00069	0.459
MOD_PKA_2	215	221	PF00069	0.619
MOD_Plk_1	21	27	PF00069	0.537
MOD_Plk_1	246	252	PF00069	0.590
MOD_Plk_1	281	287	PF00069	0.467
MOD_Plk_1	354	360	PF00069	0.533
MOD_Plk_1	77	83	PF00069	0.555
MOD_Plk_1	92	98	PF00069	0.462
MOD_Plk_2-3	336	342	PF00069	0.494
MOD_Plk_4	112	118	PF00069	0.404
MOD_Plk_4	175	181	PF00069	0.439
MOD_Plk_4	21	27	PF00069	0.597
MOD_Plk_4	210	216	PF00069	0.587
MOD_Plk_4	336	342	PF00069	0.494
MOD_Plk_4	92	98	PF00069	0.604
MOD_ProDKin_1	154	160	PF00069	0.475
MOD_ProDKin_1	34	40	PF00069	0.636
MOD_ProDKin_1	81	87	PF00069	0.532
MOD_SUMO_rev_2	249	255	PF00179	0.512
TRG_ENDOCYTIC_2	124	127	PF00928	0.604
TRG_ENDOCYTIC_2	164	167	PF00928	0.606
TRG_ENDOCYTIC_2	183	186	PF00928	0.350
TRG_ENDOCYTIC_2	300	303	PF00928	0.488
TRG_ENDOCYTIC_2	373	376	PF00928	0.449
TRG_ENDOCYTIC_2	97	100	PF00928	0.585
TRG_NES_CRM1_1	69	83	PF08389	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM7	Leptomonas seymouri	41%	100%
A0A3Q8IHC1	Leishmania donovani	95%	100%
A4HFB2	Leishmania braziliensis	73%	100%
A4I2J4	Leishmania infantum	95%	100%
E9AYP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%