Putative CAAX prenyl protease 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CAAX prenyl protease 2, putative

Species:

Leishmania major

UniProt:

Q4Q8S2_LEIMA

TriTrypDb:

LmjF.26.2690 , LMJLV39_260034400 , LMJSD75_260032800

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8S2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0016485	protein processing	5	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071586	CAAX-box protein processing	6	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	88	90	PF00675	0.444
CLV_PCSK_KEX2_1	88	90	PF00082	0.444
CLV_PCSK_SKI1_1	79	83	PF00082	0.479
DEG_APCC_DBOX_1	78	86	PF00400	0.244
DEG_Nend_UBRbox_4	1	3	PF02207	0.579
DOC_CKS1_1	54	59	PF01111	0.316
DOC_PP1_RVXF_1	77	84	PF00149	0.270
DOC_PP4_FxxP_1	41	44	PF00568	0.397
DOC_PP4_FxxP_1	54	57	PF00568	0.435
DOC_WW_Pin1_4	53	58	PF00397	0.435
DOC_WW_Pin1_4	88	93	PF00397	0.251
LIG_14-3-3_CanoR_1	196	201	PF00244	0.632
LIG_14-3-3_CanoR_1	22	27	PF00244	0.604
LIG_14-3-3_CanoR_1	32	41	PF00244	0.448
LIG_14-3-3_CanoR_1	88	92	PF00244	0.242
LIG_14-3-3_CanoR_1	94	104	PF00244	0.273
LIG_EH1_1	143	151	PF00400	0.366
LIG_FHA_1	35	41	PF00498	0.267
LIG_FHA_1	58	64	PF00498	0.261
LIG_FHA_2	197	203	PF00498	0.535
LIG_LIR_Apic_2	53	57	PF02991	0.447
LIG_LIR_Gen_1	6	17	PF02991	0.630
LIG_LIR_Nem_3	153	159	PF02991	0.320
LIG_LIR_Nem_3	189	193	PF02991	0.515
LIG_LIR_Nem_3	6	12	PF02991	0.618
LIG_LIR_Nem_3	75	81	PF02991	0.253
LIG_NRBOX	154	160	PF00104	0.397
LIG_NRBOX	81	87	PF00104	0.262
LIG_Pex14_2	152	156	PF04695	0.355
LIG_Pex14_2	96	100	PF04695	0.486
LIG_SH2_CRK	78	82	PF00017	0.366
LIG_SH2_SRC	164	167	PF00017	0.326
LIG_SH2_STAT5	210	213	PF00017	0.309
LIG_SH2_STAT5	67	70	PF00017	0.301
LIG_SH2_STAT5	9	12	PF00017	0.624
LIG_SH3_3	65	71	PF00018	0.320
LIG_TYR_ITIM	76	81	PF00017	0.360
LIG_WW_3	15	19	PF00397	0.570
MOD_CDC14_SPxK_1	91	94	PF00782	0.195
MOD_CDK_SPxK_1	88	94	PF00069	0.182
MOD_CK1_1	33	39	PF00069	0.430
MOD_CK2_1	196	202	PF00069	0.544
MOD_CMANNOS	219	222	PF00535	0.172
MOD_GlcNHglycan	140	143	PF01048	0.349
MOD_GlcNHglycan	159	162	PF01048	0.371
MOD_GlcNHglycan	205	208	PF01048	0.342
MOD_GlcNHglycan	5	8	PF01048	0.417
MOD_GlcNHglycan	97	100	PF01048	0.374
MOD_GSK3_1	192	199	PF00069	0.529
MOD_GSK3_1	30	37	PF00069	0.472
MOD_GSK3_1	53	60	PF00069	0.312
MOD_NEK2_1	100	105	PF00069	0.299
MOD_NEK2_2	57	62	PF00069	0.246
MOD_PKA_2	21	27	PF00069	0.661
MOD_PKA_2	31	37	PF00069	0.521
MOD_PKA_2	87	93	PF00069	0.286
MOD_PKB_1	194	202	PF00069	0.503
MOD_Plk_1	168	174	PF00069	0.311
MOD_Plk_1	57	63	PF00069	0.336
MOD_Plk_4	22	28	PF00069	0.668
MOD_Plk_4	34	40	PF00069	0.255
MOD_ProDKin_1	53	59	PF00069	0.427
MOD_ProDKin_1	88	94	PF00069	0.251
MOD_SUMO_rev_2	116	126	PF00179	0.594
TRG_ENDOCYTIC_2	164	167	PF00928	0.261
TRG_ENDOCYTIC_2	78	81	PF00928	0.375
TRG_ENDOCYTIC_2	9	12	PF00928	0.662
TRG_ER_diArg_1	193	196	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYS3	Leptomonas seymouri	48%	79%
A0A0S4JSY4	Bodo saltans	35%	72%
A0A1X0NYX6	Trypanosomatidae	36%	74%
A0A3S7X0B2	Leishmania donovani	92%	100%
A4HFB3	Leishmania braziliensis	70%	79%
A4I2J5	Leishmania infantum	91%	100%
C9ZK27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	74%
E9AYQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BHT4	Trypanosoma cruzi	30%	93%