6-phosphogluconolactonase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

6-phosphogluconolactonase

Species:

Leishmania major

UniProt:

Q4Q8S1_LEIMA

TriTrypDb:

LmjF.26.2700 , LMJLV39_260034500 , LMJSD75_260032900

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8S1

PDB structure(s): 3ch7_A , 3css_A

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006739	NADP metabolic process	7	12
GO:0006740	NADPH regeneration	4	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009051	pentose-phosphate shunt, oxidative branch	5	2
GO:0009117	nucleotide metabolic process	5	12
GO:0009987	cellular process	1	12
GO:0019362	pyridine nucleotide metabolic process	5	12
GO:0019637	organophosphate metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0046496	nicotinamide nucleotide metabolic process	6	12
GO:0051156	glucose 6-phosphate metabolic process	4	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072524	pyridine-containing compound metabolic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006098	pentose-phosphate shunt	5	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0017057	6-phosphogluconolactonase activity	5	12
GO:0052689	carboxylic ester hydrolase activity	4	12
GO:0016853	isomerase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	50	52	PF00082	0.428
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.427
CLV_PCSK_SKI1_1	59	63	PF00082	0.269
CLV_PCSK_SKI1_1	93	97	PF00082	0.289
DOC_CYCLIN_RxL_1	90	98	PF00134	0.424
DOC_MAPK_gen_1	247	257	PF00069	0.398
DOC_MAPK_gen_1	32	41	PF00069	0.377
DOC_MAPK_MEF2A_6	35	43	PF00069	0.288
DOC_PP4_FxxP_1	190	193	PF00568	0.299
DOC_WW_Pin1_4	189	194	PF00397	0.342
DOC_WW_Pin1_4	45	50	PF00397	0.279
LIG_14-3-3_CanoR_1	201	205	PF00244	0.336
LIG_14-3-3_CanoR_1	250	256	PF00244	0.487
LIG_BIR_II_1	1	5	PF00653	0.433
LIG_BRCT_BRCA1_1	186	190	PF00533	0.313
LIG_FHA_1	167	173	PF00498	0.307
LIG_FHA_1	235	241	PF00498	0.267
LIG_FHA_1	252	258	PF00498	0.350
LIG_FHA_1	90	96	PF00498	0.389
LIG_FHA_2	113	119	PF00498	0.369
LIG_FHA_2	79	85	PF00498	0.288
LIG_LIR_Apic_2	187	193	PF02991	0.300
LIG_PCNA_yPIPBox_3	222	232	PF02747	0.424
LIG_PDZ_Class_2	262	267	PF00595	0.517
LIG_SH2_STAP1	133	137	PF00017	0.313
LIG_SH3_3	185	191	PF00018	0.305
LIG_SH3_3	233	239	PF00018	0.423
LIG_SUMO_SIM_anti_2	157	162	PF11976	0.281
LIG_SUMO_SIM_anti_2	60	65	PF11976	0.417
LIG_SUMO_SIM_par_1	102	108	PF11976	0.392
LIG_SUMO_SIM_par_1	180	189	PF11976	0.451
LIG_SUMO_SIM_par_1	39	44	PF11976	0.424
LIG_WRC_WIRS_1	1	6	PF05994	0.482
MOD_CDK_SPK_2	45	50	PF00069	0.279
MOD_CDK_SPxK_1	45	51	PF00069	0.424
MOD_CK1_1	15	21	PF00069	0.427
MOD_CK1_1	189	195	PF00069	0.391
MOD_CK1_1	44	50	PF00069	0.300
MOD_CK1_1	86	92	PF00069	0.386
MOD_CK2_1	113	119	PF00069	0.369
MOD_CK2_1	78	84	PF00069	0.357
MOD_GlcNHglycan	108	112	PF01048	0.296
MOD_GlcNHglycan	18	21	PF01048	0.354
MOD_GlcNHglycan	260	263	PF01048	0.461
MOD_GlcNHglycan	34	38	PF01048	0.398
MOD_GlcNHglycan	43	46	PF01048	0.303
MOD_GSK3_1	12	19	PF00069	0.385
MOD_GSK3_1	173	180	PF00069	0.353
MOD_GSK3_1	200	207	PF00069	0.325
MOD_GSK3_1	41	48	PF00069	0.301
MOD_LATS_1	57	63	PF00433	0.206
MOD_N-GLC_1	146	151	PF02516	0.433
MOD_N-GLC_1	86	91	PF02516	0.349
MOD_NEK2_1	204	209	PF00069	0.396
MOD_NEK2_1	41	46	PF00069	0.328
MOD_PIKK_1	141	147	PF00454	0.365
MOD_PKA_2	200	206	PF00069	0.279
MOD_PKA_2	249	255	PF00069	0.488
MOD_Plk_1	12	18	PF00069	0.386
MOD_Plk_1	149	155	PF00069	0.226
MOD_Plk_1	180	186	PF00069	0.209
MOD_Plk_1	59	65	PF00069	0.206
MOD_Plk_1	86	92	PF00069	0.349
MOD_Plk_4	168	174	PF00069	0.292
MOD_Plk_4	204	210	PF00069	0.318
MOD_Plk_4	251	257	PF00069	0.342
MOD_Plk_4	59	65	PF00069	0.295
MOD_ProDKin_1	189	195	PF00069	0.342
MOD_ProDKin_1	45	51	PF00069	0.279
MOD_SUMO_rev_2	132	137	PF00179	0.349
TRG_ENDOCYTIC_2	53	56	PF00928	0.323
TRG_ER_diArg_1	137	140	PF00400	0.206
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Y4	Leptomonas seymouri	69%	98%
A0A0S4J8H1	Bodo saltans	36%	100%
A0A1X0NX24	Trypanosomatidae	49%	100%
A0A3Q8IG46	Leishmania donovani	93%	100%
A0A3R7NAW7	Trypanosoma rangeli	47%	100%
A2XI04	Oryza sativa subsp. indica	26%	90%
A2YNH4	Oryza sativa subsp. indica	26%	95%
A2YXS5	Oryza sativa subsp. indica	29%	82%
A2Z3C4	Oryza sativa subsp. indica	29%	82%
A4HFB4	Leishmania braziliensis	84%	100%
A6ZT71	Saccharomyces cerevisiae (strain YJM789)	27%	100%
B3LSS7	Saccharomyces cerevisiae (strain RM11-1a)	27%	100%
B5VK90	Saccharomyces cerevisiae (strain AWRI1631)	27%	100%
D0A7E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AHB9	Leishmania infantum	94%	100%
E9AYQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O18229	Caenorhabditis elegans	29%	99%
O51240	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	24%	100%
O74455	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O83490	Treponema pallidum (strain Nichols)	33%	100%
O84189	Chlamydia trachomatis (strain D/UW-3/Cx)	25%	100%
O95336	Homo sapiens	32%	100%
P37262	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	85%
P38858	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P46016	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	31%	100%
P50278	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	83%
P53315	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P63339	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	100%
P74618	Synechocystis sp. (strain PCC 6803 / Kazusa)	35%	100%
P85971	Rattus norvegicus	30%	100%
P9WQP4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	100%
P9WQP5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
Q2TBQ8	Bos taurus	30%	100%
Q49700	Mycobacterium leprae (strain TN)	27%	100%
Q57039	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
Q69NG5	Oryza sativa subsp. japonica	29%	82%
Q6Z4H0	Oryza sativa subsp. japonica	26%	95%
Q6Z9C3	Oryza sativa subsp. japonica	29%	82%
Q75IV7	Oryza sativa subsp. japonica	26%	90%
Q84WW2	Arabidopsis thaliana	29%	82%
Q8LG70	Arabidopsis thaliana	27%	100%
Q989A3	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	27%	100%
Q9CQ60	Mus musculus	30%	100%
Q9FIN1	Arabidopsis thaliana	31%	100%
Q9LMX8	Arabidopsis thaliana	26%	100%
Q9PKK7	Chlamydia muridarum (strain MoPn / Nigg)	28%	100%
Q9VZ64	Drosophila melanogaster	28%	100%
Q9X0N8	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	28%	100%
Q9XAB7	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	28%	100%
Q9Z8U5	Chlamydia pneumoniae	29%	100%
V5D050	Trypanosoma cruzi	45%	100%