Lytic murein transglycosylase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 15

Species:

Leishmania major

UniProt:

Q4Q8R8_LEIMA

TriTrypDb:

LmjF.28.0020 , LMJLV39_280005200 , LMJSD75_280005100

Length:

133


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Q4Q8R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8R8


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.373
CLV_NRD_NRD_1	120	122	PF00675	0.641
CLV_NRD_NRD_1	72	74	PF00675	0.407
CLV_PCSK_FUR_1	9	13	PF00082	0.424
CLV_PCSK_KEX2_1	11	13	PF00082	0.373
CLV_PCSK_KEX2_1	119	121	PF00082	0.639
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.639
CLV_PCSK_SKI1_1	116	120	PF00082	0.502
CLV_PCSK_SKI1_1	51	55	PF00082	0.443
DEG_Nend_UBRbox_2	1	3	PF02207	0.388
DOC_CYCLIN_RxL_1	96	106	PF00134	0.489
DOC_PP1_RVXF_1	97	104	PF00149	0.389
DOC_PP2B_LxvP_1	22	25	PF13499	0.502
DOC_USP7_MATH_1	25	29	PF00917	0.502
LIG_14-3-3_CanoR_1	120	124	PF00244	0.594
LIG_BIR_III_2	59	63	PF00653	0.338
LIG_LIR_Gen_1	5	13	PF02991	0.361
LIG_LIR_Nem_3	17	23	PF02991	0.405
LIG_LIR_Nem_3	5	10	PF02991	0.357
LIG_LIR_Nem_3	87	92	PF02991	0.533
LIG_PCNA_PIPBox_1	1	10	PF02747	0.363
LIG_Pex14_1	98	102	PF04695	0.354
LIG_PTB_Apo_2	83	90	PF02174	0.521
LIG_PTB_Phospho_1	83	89	PF10480	0.547
LIG_SH2_CRK	20	24	PF00017	0.443
LIG_SH2_CRK	89	93	PF00017	0.546
LIG_SH2_SRC	57	60	PF00017	0.419
LIG_SH2_STAT5	102	105	PF00017	0.372
LIG_SH2_STAT5	57	60	PF00017	0.412
MOD_GlcNHglycan	86	89	PF01048	0.541
MOD_NEK2_1	127	132	PF00069	0.470
MOD_NEK2_1	84	89	PF00069	0.582
MOD_PKA_1	119	125	PF00069	0.631
MOD_PKA_2	119	125	PF00069	0.618
MOD_SUMO_rev_2	100	109	PF00179	0.501
TRG_DiLeu_BaEn_1	18	23	PF01217	0.472
TRG_DiLeu_BaEn_4	5	11	PF01217	0.378
TRG_ENDOCYTIC_2	20	23	PF00928	0.427
TRG_ENDOCYTIC_2	89	92	PF00928	0.636
TRG_ER_diArg_1	8	11	PF00400	0.405
TRG_NLS_MonoExtN_4	116	123	PF00514	0.619


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P725	Leptomonas seymouri	81%	100%
A0A0S4J1U2	Bodo saltans	57%	100%
A0A1X0NVA8	Trypanosomatidae	76%	100%
A0A3S7X152	Leishmania donovani	95%	100%
A4HG45	Leishmania braziliensis	88%	100%
A4I375	Leishmania infantum	95%	100%
D0A7Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AZG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	98%