Origin recognition complex subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell division cycle 6 (CDC6), putative

Species:

Leishmania major

UniProt:

Q4Q8R7_LEIMA

TriTrypDb:

LmjF.28.0030 , LMJLV39_280005300 , LMJSD75_280005200

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000808	origin recognition complex	2	2
GO:0005634	nucleus	5	9
GO:0005664	nuclear origin of replication recognition complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0140513	nuclear protein-containing complex	2	2

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Expansion

Sequence features

Q4Q8R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8R7

Function

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Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	2
GO:0000076	DNA replication checkpoint signaling	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006260	DNA replication	5	9
GO:0006270	DNA replication initiation	5	2
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0007093	mitotic cell cycle checkpoint signaling	4	2
GO:0007165	signal transduction	2	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003688	DNA replication origin binding	7	2
GO:0003690	double-stranded DNA binding	5	2
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.499
CLV_C14_Caspase3-7	392	396	PF00656	0.400
CLV_MEL_PAP_1	219	225	PF00089	0.347
CLV_NRD_NRD_1	251	253	PF00675	0.374
CLV_NRD_NRD_1	326	328	PF00675	0.419
CLV_NRD_NRD_1	348	350	PF00675	0.470
CLV_NRD_NRD_1	5	7	PF00675	0.575
CLV_NRD_NRD_1	81	83	PF00675	0.324
CLV_PCSK_FUR_1	3	7	PF00082	0.550
CLV_PCSK_KEX2_1	132	134	PF00082	0.265

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M7	Leptomonas seymouri	80%	100%
A0A1X0NVQ9	Trypanosomatidae	55%	99%
A0A3S5H7I5	Leishmania donovani	94%	100%
A0A422NKR1	Trypanosoma rangeli	54%	99%
A4HG46	Leishmania braziliensis	88%	94%
A4I376	Leishmania infantum	94%	100%
D0A7Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	99%
E9AZG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O57864	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	24%	100%
O82387	Arabidopsis thaliana	23%	80%

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