Origin recognition complex subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell division cycle 6 (CDC6), putative

Species:

Leishmania major

UniProt:

Q4Q8R7_LEIMA

TriTrypDb:

LmjF.28.0030 , LMJLV39_280005300 , LMJSD75_280005200

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000808	origin recognition complex	2	2
GO:0005664	nuclear origin of replication recognition complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q8R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8R7

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	2
GO:0000076	DNA replication checkpoint signaling	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006270	DNA replication initiation	5	2
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0007093	mitotic cell cycle checkpoint signaling	4	2
GO:0007165	signal transduction	2	2
GO:0007346	regulation of mitotic cell cycle	5	2
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0010389	regulation of G2/M transition of mitotic cell cycle	7	2
GO:0010564	regulation of cell cycle process	5	2
GO:0010948	negative regulation of cell cycle process	6	2
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	8	2
GO:0022402	cell cycle process	2	2
GO:0031570	DNA integrity checkpoint signaling	5	2
GO:0033314	mitotic DNA replication checkpoint signaling	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0035556	intracellular signal transduction	3	2
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044774	mitotic DNA integrity checkpoint signaling	5	2
GO:0044818	mitotic G2/M transition checkpoint	5	2
GO:0045786	negative regulation of cell cycle	5	2
GO:0045930	negative regulation of mitotic cell cycle	6	2
GO:0046483	heterocycle metabolic process	3	11
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051726	regulation of cell cycle	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901987	regulation of cell cycle phase transition	6	2
GO:1901988	negative regulation of cell cycle phase transition	7	2
GO:1901990	regulation of mitotic cell cycle phase transition	6	2
GO:1901991	negative regulation of mitotic cell cycle phase transition	7	2
GO:1902749	regulation of cell cycle G2/M phase transition	7	2
GO:1902750	negative regulation of cell cycle G2/M phase transition	8	2
GO:1903047	mitotic cell cycle process	3	2
GO:0006260	DNA replication	5	9
GO:0051301	cell division	2	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003688	DNA replication origin binding	7	2
GO:0003690	double-stranded DNA binding	5	2
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0016887	ATP hydrolysis activity	7	8
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043565	sequence-specific DNA binding	5	2
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:1990837	sequence-specific double-stranded DNA binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.499
CLV_C14_Caspase3-7	392	396	PF00656	0.400
CLV_MEL_PAP_1	219	225	PF00089	0.347
CLV_NRD_NRD_1	251	253	PF00675	0.374
CLV_NRD_NRD_1	326	328	PF00675	0.419
CLV_NRD_NRD_1	348	350	PF00675	0.470
CLV_NRD_NRD_1	5	7	PF00675	0.575
CLV_NRD_NRD_1	81	83	PF00675	0.324
CLV_PCSK_FUR_1	3	7	PF00082	0.550
CLV_PCSK_KEX2_1	132	134	PF00082	0.265
CLV_PCSK_KEX2_1	2	4	PF00082	0.545
CLV_PCSK_KEX2_1	251	253	PF00082	0.376
CLV_PCSK_KEX2_1	328	330	PF00082	0.490
CLV_PCSK_KEX2_1	5	7	PF00082	0.492
CLV_PCSK_KEX2_1	81	83	PF00082	0.291
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.256
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.535
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.490
CLV_PCSK_SKI1_1	15	19	PF00082	0.319
CLV_PCSK_SKI1_1	162	166	PF00082	0.309
CLV_PCSK_SKI1_1	179	183	PF00082	0.198
CLV_PCSK_SKI1_1	216	220	PF00082	0.371
CLV_PCSK_SKI1_1	251	255	PF00082	0.338
CLV_PCSK_SKI1_1	292	296	PF00082	0.382
CLV_PCSK_SKI1_1	360	364	PF00082	0.465
CLV_PCSK_SKI1_1	5	9	PF00082	0.655
CLV_PCSK_SKI1_1	67	71	PF00082	0.383
CLV_Separin_Metazoa	368	372	PF03568	0.323
DEG_APCC_DBOX_1	333	341	PF00400	0.353
DEG_Nend_UBRbox_1	1	4	PF02207	0.577
DOC_CYCLIN_yCln2_LP_2	404	410	PF00134	0.467
DOC_MAPK_gen_1	194	201	PF00069	0.292
DOC_MAPK_gen_1	267	275	PF00069	0.332
DOC_MAPK_gen_1	81	91	PF00069	0.267
DOC_MAPK_MEF2A_6	141	149	PF00069	0.381
DOC_MAPK_MEF2A_6	307	315	PF00069	0.305
DOC_MAPK_MEF2A_6	371	380	PF00069	0.318
DOC_MAPK_MEF2A_6	397	404	PF00069	0.400
DOC_MAPK_RevD_3	313	329	PF00069	0.448
DOC_PP1_RVXF_1	164	171	PF00149	0.248
DOC_PP1_RVXF_1	296	303	PF00149	0.358
DOC_PP2B_LxvP_1	171	174	PF13499	0.326
DOC_PP4_FxxP_1	60	63	PF00568	0.248
DOC_USP7_UBL2_3	155	159	PF12436	0.280
DOC_USP7_UBL2_3	162	166	PF12436	0.287
LIG_14-3-3_CanoR_1	252	261	PF00244	0.299
LIG_14-3-3_CanoR_1	371	376	PF00244	0.470
LIG_14-3-3_CanoR_1	5	14	PF00244	0.542
LIG_AP2alpha_1	295	299	PF02296	0.378
LIG_BIR_III_4	419	423	PF00653	0.406
LIG_BRCT_BRCA1_1	160	164	PF00533	0.255
LIG_BRCT_BRCA1_2	160	166	PF00533	0.181
LIG_eIF4E_1	175	181	PF01652	0.326
LIG_FHA_1	210	216	PF00498	0.354
LIG_FHA_1	276	282	PF00498	0.368
LIG_FHA_1	30	36	PF00498	0.506
LIG_FHA_1	312	318	PF00498	0.314
LIG_FHA_1	320	326	PF00498	0.397
LIG_FHA_1	54	60	PF00498	0.407
LIG_FHA_1	66	72	PF00498	0.243
LIG_FHA_2	281	287	PF00498	0.367
LIG_FHA_2	6	12	PF00498	0.476
LIG_Integrin_RGD_1	38	40	PF01839	0.365
LIG_LIR_Gen_1	169	176	PF02991	0.248
LIG_LIR_Gen_1	297	306	PF02991	0.344
LIG_LIR_Gen_1	398	408	PF02991	0.348
LIG_LIR_Nem_3	100	106	PF02991	0.247
LIG_LIR_Nem_3	161	167	PF02991	0.263
LIG_LIR_Nem_3	169	173	PF02991	0.238
LIG_LIR_Nem_3	245	250	PF02991	0.341
LIG_LIR_Nem_3	297	302	PF02991	0.363
LIG_LIR_Nem_3	398	404	PF02991	0.455
LIG_MAD2	166	174	PF02301	0.248
LIG_PCNA_yPIPBox_3	67	79	PF02747	0.181
LIG_PDZ_Class_2	426	431	PF00595	0.427
LIG_Pex14_2	134	138	PF04695	0.248
LIG_Pex14_2	295	299	PF04695	0.378
LIG_Pex14_2	90	94	PF04695	0.381
LIG_REV1ctd_RIR_1	162	170	PF16727	0.184
LIG_SH2_CRK	408	412	PF00017	0.451
LIG_SH2_GRB2like	175	178	PF00017	0.361
LIG_SH2_STAT3	210	213	PF00017	0.450
LIG_SH2_STAT5	104	107	PF00017	0.291
LIG_SH3_3	351	357	PF00018	0.503
LIG_SUMO_SIM_anti_2	314	319	PF11976	0.277
LIG_SUMO_SIM_anti_2	365	371	PF11976	0.328
LIG_SUMO_SIM_par_1	146	152	PF11976	0.248
LIG_SUMO_SIM_par_1	179	184	PF11976	0.248
LIG_SUMO_SIM_par_1	276	286	PF11976	0.365
LIG_SUMO_SIM_par_1	338	344	PF11976	0.378
LIG_TRAF2_1	396	399	PF00917	0.438
LIG_TRAF2_1	8	11	PF00917	0.508
LIG_UBA3_1	59	67	PF00899	0.282
MOD_CK1_1	209	215	PF00069	0.445
MOD_CK1_1	25	31	PF00069	0.413
MOD_CK2_1	125	131	PF00069	0.247
MOD_CK2_1	280	286	PF00069	0.461
MOD_CK2_1	371	377	PF00069	0.351
MOD_CK2_1	5	11	PF00069	0.529
MOD_GlcNHglycan	255	258	PF01048	0.308
MOD_GlcNHglycan	27	30	PF01048	0.512
MOD_GSK3_1	1	8	PF00069	0.631
MOD_GSK3_1	179	186	PF00069	0.248
MOD_GSK3_1	205	212	PF00069	0.447
MOD_GSK3_1	238	245	PF00069	0.455
MOD_GSK3_1	24	31	PF00069	0.465
MOD_GSK3_1	77	84	PF00069	0.254
MOD_NEK2_1	1	6	PF00069	0.658
MOD_NEK2_1	205	210	PF00069	0.354
MOD_NEK2_1	24	29	PF00069	0.400
MOD_NEK2_1	253	258	PF00069	0.292
MOD_NEK2_1	302	307	PF00069	0.328
MOD_NEK2_1	311	316	PF00069	0.278
MOD_NEK2_1	341	346	PF00069	0.330
MOD_NEK2_1	421	426	PF00069	0.482
MOD_NEK2_2	280	285	PF00069	0.375
MOD_PIKK_1	209	215	PF00454	0.445
MOD_PIKK_1	238	244	PF00454	0.448
MOD_PIKK_1	341	347	PF00454	0.459
MOD_PIKK_1	5	11	PF00454	0.490
MOD_PKA_1	5	11	PF00069	0.575
MOD_PKA_1	81	87	PF00069	0.209
MOD_PKA_2	5	11	PF00069	0.529
MOD_PKA_2	81	87	PF00069	0.203
MOD_PKB_1	3	11	PF00069	0.594
MOD_Plk_4	286	292	PF00069	0.429
MOD_Plk_4	371	377	PF00069	0.464
MOD_SUMO_for_1	396	399	PF00179	0.410
MOD_SUMO_rev_2	186	195	PF00179	0.248
TRG_DiLeu_BaEn_1	321	326	PF01217	0.526
TRG_DiLeu_BaEn_1	365	370	PF01217	0.440
TRG_DiLeu_BaEn_1	399	404	PF01217	0.245
TRG_DiLeu_BaEn_4	365	371	PF01217	0.453
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.313
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.462
TRG_ENDOCYTIC_2	103	106	PF00928	0.248
TRG_ENDOCYTIC_2	247	250	PF00928	0.328
TRG_ENDOCYTIC_2	408	411	PF00928	0.413
TRG_ER_diArg_1	250	252	PF00400	0.382
TRG_ER_diArg_1	266	269	PF00400	0.436
TRG_ER_diArg_1	3	6	PF00400	0.574
TRG_ER_diArg_1	326	329	PF00400	0.429
TRG_NES_CRM1_1	365	377	PF08389	0.350
TRG_NLS_MonoExtC_3	1	6	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M7	Leptomonas seymouri	80%	100%
A0A1X0NVQ9	Trypanosomatidae	55%	99%
A0A3S5H7I5	Leishmania donovani	94%	100%
A0A422NKR1	Trypanosoma rangeli	54%	99%
A4HG46	Leishmania braziliensis	88%	94%
A4I376	Leishmania infantum	94%	100%
D0A7Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	99%
E9AZG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O57864	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	24%	100%
O82387	Arabidopsis thaliana	23%	80%
P81413	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	24%	100%
Q4JAS8	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	24%	100%
Q5JET2	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	25%	100%
Q5N897	Oryza sativa subsp. japonica	23%	84%
Q8W032	Arabidopsis thaliana	23%	85%
Q975X3	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	23%	100%
Q980N4	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	25%	100%
V5D7Z4	Trypanosoma cruzi	55%	96%